GenBank-Updates@genbank.bio.net (03/19/91)
LOCUS HUMIGHAC3 200 bp ds-DNA PRI 19-MAR-1991
DEFINITION Human germline Ig alpha mutant chain gene C-alpha-3 region of the
secreted protein, 3' end.
ACCESSION M60325
KEYWORDS constant region; immunoglobulin; immunoglobulin heavy chain.
SEGMENT 3 of 4
SOURCE Human jejunal mucosa cell hybridoma DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 200)
AUTHORS Cogne,M. and Preud'Homme,J.-L.
TITLE Gene deletions force nonsecretory alpha-chain disease plasma cells
to produce membrane-form alpha-chain only
JOURNAL J. Immunol. 145, 2455-2458 (1990)
STANDARD simple staff_review
FEATURES Location/Qualifiers
CDS join(M60323:85..130,M60323:467..550,M60324:972..985)
/note="1 of 2 possible cds's"
/product="mutant immunoglobulin alpha chain"
/gene="IgA mutant"
/codon_start=85
/partial
CDS 1..24
/number=4
/gene="IgA mutant"
/codon_start=1
/partial
mutation 32..33
/note="deletion site"
/gene="IgA mutant"
BASE COUNT 47 a 51 c 81 g 21 t
ORIGIN chromosome 14
1 gaggtggacg gcacctgcta ctgagccgcc cggagggaat agggagggta aaaggagcag
61 gctagacaag aaaggcgcag gtagtggcag gagcggcgag ggagtgaggg gctggactcc
121 agggccccac tgggaggaca agctccagga gggccccacc accctagtgg gtgggcctca
181 ggacgtccca ctgacgcatg
//