GenBank-Updates@genbank.bio.net (03/19/91)
LOCUS HUMMHDRARN 744 bp ss-mRNA PRI 19-MAR-1991
DEFINITION Human MHC class II HLA-DRA mRNA, complete cds.
ACCESSION M60333
KEYWORDS cell surface glycoprotein; class II gene;
integral membrane protein; major histocompatibility complex.
SOURCE Human B-lymphoblastoid cell line HMy2.DRN, cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 744)
AUTHORS Koppelman,B. and Cresswell,P.
TITLE Rapid nonlysosomal degradation of assembled HLA class II
glycorproteins incorporating a mutant DR alpha-chain
JOURNAL J. Immunol. 145, 2730-2736 (1990)
STANDARD simple staff_review
FEATURES Location/Qualifiers
CDS 28..717
/product="MHC HLA-DRA cell surface glycoprotein"
/gene="HLA-DRA"
/codon_start=28
sig_peptide 28..102
/gene="HLA-DRA"
/codon_start=28
mat_peptide 103..714
/product="MHC HLA-DRA cell surface glycoprotein"
/gene="HLA-DRA"
/codon_start=103
BASE COUNT 191 a 178 c 198 g 177 t
ORIGIN chromosome 6
1 actcccaaaa gagcgcccaa gaagaaaatg gccataagtg gagtccctgt gctaggattt
61 ttcatcatag ctgtgctgat gagcgctcag gaatcatggg ctatcaaaga agaacatgtg
121 atcatccagg ccgagttcta tctgaatcct gaccaatcag gcgagtttat gtttgacttt
181 gatggtgatg agattttcca tgtggatatg gcaaagaagg agacggtctg gcggcttgaa
241 gaatttggac gatttgccag ctttgaggct caaggtgcat tggccaacat agctgtggac
301 aaagccaact tggaaatcat gacaaagcgc tccaactata ctccgatcac caatgacaag
361 ttcaccccac cagtggtcaa tgtcacgtgg cttcgaaatg gaaaacctgt caccacagga
421 gtgtcagaga cagtcttcct gcccagggaa gaccaccttt tccgcaagtt ccactatctc
481 cccttcctgc cctcaactga ggacgtttac gactgcaggg tggagcactg gggcttggat
541 gagcctcttc tcaagcactg ggagtttgat gctccaagcc ctctcccaga gactacagag
601 aacgtggtgt gtgccctggg cctgactgtg ggtctggtgg gcatcattat tgggaccatc
661 ttcatcatca agggattgcg caaaagcaat gcagcagaac gcagggggcc tctgtaaggc
721 acatggaggt gatggtgttt ctta
//GenBank-Updates@genbank.bio.net (03/19/91)
LOCUS HUMMHDRA3M 819 bp ss-mRNA PRI 19-MAR-1991
DEFINITION Human MHC class II HLA-DRA mRNA, complete cds.
ACCESSION M60334
KEYWORDS cell surface glycoprotein; class II gene;
integral membrane protein; major histocompatibility complex.
SOURCE Human B-lymphoblastoid cell line HMy2.A3m, cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 819)
AUTHORS Koppelman,B. and Cresswell,P.
TITLE Rapid nonlysosomal degradation of assembled HLA class II
glycorproteins incorporating a mutant DR alpha-chain
JOURNAL J. Immunol. 145, 2730-2736 (1990)
STANDARD simple staff_review
FEATURES Location/Qualifiers
CDS 28..792
/product="MHC HLA-DRA cell surface glycoprotein"
/gene="HLA-DRA"
/codon_start=28
sig_peptide 28..102
/gene="HLA-DRA"
/codon_start=28
mat_peptide 103..789
/product="MHC HLA-DRA cell surface glycoprotein"
/gene="HLA-DRA"
/codon_start=103
BASE COUNT 210 a 200 c 215 g 194 t
ORIGIN chromosome 6
1 actcccaaaa gagcgcccaa gaagaaaatg gccataagtg gagtccctgt gctaggattt
61 ttcatcatag ctgtgctgat gagcgctcag gaatcatggg ctatcaaaga agaacatgtg
121 atcatccagg ccgagttcta tctgaatcct gaccaatcag gcgagtttat gtttgacttt
181 gatggtgatg agattttcca tgtggatatg gcaaagaagg agacggtctg gcggcttgaa
241 gaatttggac gatttgccag ctttgaggct caaggtgcat tggccaacat agctgtggac
301 aaagccaact tggaaatcat gacaaagcgc tccaactata ctccgatcac caatgtacct
361 ccagaggtaa ctgtgctcac gaacagccct gtggaactga gagagcccaa cgtcctcatc
421 tgtttcatag acaagttcac cccaccagtg gtcaatgtca cgtggcttcg aaatggaaaa
481 cctgtcacca caggagtgtc agagacagtc ttcctgccca gggaagacca ccttttccgc
541 aagttccact atctcccctt cctgccctca actgaggacg tttacgactg cagggtggag
601 cactggggct tggatgagcc tcttctcaag cactgggagt ttgatgctcc aagccctctc
661 ccagagacta cagagaacgt ggtgtgtgcc ctgggcctga ctgtgggtct ggtgggcatc
721 attattggga ccatcttcat catcaaggga ttgcgcaaaa gcaatgcagc agaacgcagg
781 gggcctctgt aaggcacatg gaggtgatgg tgtttctta
//