GenBank-Updates@genbank.bio.net (03/06/91)
LOCUS HUMVAVPO 680 bp ds-DNA PRI 06-MAR-1991
DEFINITION Human proto-oncogene vav, 5' end.
ACCESSION M59834
KEYWORDS proto-oncogene; transforming protein.
SOURCE Human lymphocyte DNA, clone pSK 111.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 680)
AUTHORS Katzav,S., Cleveland,J.L., Heslop,H.E. and Pulido,D.
TITLE Loss of the aminoterminal helix-loop-helix domain of the vav
proto-oncogene activates its transforming potential
JOURNAL Mol. Cell. Biol. (1990) In press
STANDARD full staff_entry
FEATURES Location/Qualifiers
protein_bind 206..211
/note="AP1-like sequence."
/gene="proto-vav"
protein_bind 236..242
/note="AP2-like sequence."
/gene="proto-vav"
protein_bind 254..259
/note="Sp-1 binding site."
/gene="proto-vav"
protein_bind 332..337
/note="Sp-1 binding site."
/gene="proto-vav"
mRNA 409..680
/product="transforming protein vav"
/gene="proto-vav"
/partial
mRNA 418..680
/product="transforming protein vav"
/gene="proto-vav"
/partial
mRNA 418..680
/product="transforming protein vav"
/gene="proto-vav"
/partial
protein_bind 441..446
/note="Sp-1 binding site."
/gene="proto-vav"
CDS 498..680
/product="transforming protein vav"
/gene="proto-vav"
/codon_start=498
/partial
BASE COUNT 120 a 215 c 220 g 125 t
ORIGIN
1 cggaagaaag agatgtagat tctgcatgga aggcgtgggg tggggctggg ctgcaggtgc
61 tcagctcccc cccgccccat ggctcctcct cctccacccc ctctcagggc gacagttaca
121 ggaaaggaat tctgggtata tttcagagtg tcactgccgc cgtctgcata tggaggaagc
181 tcacccatct catagtctag ctggcctgac tcccccagcc ccccaactcc ccatgcccag
241 gcctgtgtcg agtgggcgga agaaagagat gtagattctg catggaaggc gtggggtggg
301 gctgggctgc aggtgctccc ccagctcccc cccgccccat ggctcctcct cctccacccc
361 ctctcagggc gacagttaca ggaaagaaga ggaagtggta gcactagctg tcgctccaca
421 ggcgagcagg gcaggcgtgc gggcgggtgg gtggtggagg ctgcgagggt gcacggccgg
481 ccctgggcag ggtagccatg gagctgtggc gccaatgcac ccactggctc atccagtgcc
541 gggtgctgcc gcccagccac cgcgtgacct gggatggggc tcaggtgtgt gaactggccc
601 aggccctccg ggatggtgtc cttctgtgtc agctgcttaa caacctgcta ccccatgcca
661 tcaacctgcg tgaggtcaac
//GenBank-Updates@genbank.bio.net (03/20/91)
LOCUS HUMVAVPO 554 bp ds-DNA PRI 20-MAR-1991
DEFINITION Human proto-oncogene vav, 5' end.
ACCESSION M59834
KEYWORDS proto-oncogene; vav protein.
SOURCE Human lymphocyte DNA, clone pSK 111.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 554)
AUTHORS Katzav,S., Cleveland,J.L., Heslop,H.E. and Pulido,D.
TITLE Loss of the aminoterminal helix-loop-helix domain of the vav
proto-oncogene activates its transforming potential
JOURNAL Mol. Cell. Biol. (1991) In press
STANDARD full staff_entry
FEATURES Location/Qualifiers
protein_bind 80..85
/note="AP1-like sequence."
/gene="proto-vav"
protein_bind 110..116
/note="AP2-like sequence."
/gene="proto-vav"
protein_bind 128..133
/note="Sp-1 binding site."
/gene="proto-vav"
protein_bind 206..211
/note="Sp-1 binding site."
/gene="proto-vav"
mRNA 277..554
/product="protein vav"
/gene="proto-vav"
/partial
mRNA 283..554
/product="protein vav"
/gene="proto-vav"
/partial
mRNA 292..554
/product="protein vav"
/gene="proto-vav"
/partial
protein_bind 315..320
/note="Sp-1 binding site."
/gene="proto-vav"
CDS 372..554
/product="protein vav"
/gene="proto-vav"
/codon_start=372
/partial
BASE COUNT 96 a 175 c 180 g 103 t
ORIGIN
1 gaattctggg tatatttcag agtgtcactg ccgccgtctg catatggagg aagctcaccc
61 atctcatagt ctagctggcc tgactccccc agccccccaa ctccccatgc ccaggcctgt
121 gtcgagtggg cggaagaaag agatgtagat tctgcatgga aggcgtgggg tggggctggg
181 ctgcaggtgc tcccccagct cccccccgcc ccatggctcc tcctcctcca ccccctctca
241 gggcgacagt tacaggaaag aagaggaagt ggtagcacta gctgtcgctc cacaggcgag
301 cagggcaggc gtgcgggcgg gtgggtggtg gaggctgcga gggtgcacgg ccggccctgg
361 gcagggtagc catggagctg tggcgccaat gcacccactg gctcatccag tgccgggtgc
421 tgccgcccag ccaccgcgtg acctgggatg gggctcaggt gtgtgaactg gcccaggccc
481 tccgggatgg tgtccttctg tgtcagctgc ttaacaacct gctaccccat gccatcaacc
541 tgcgtgaggt caac
//