GenBank-Updates@genbank.bio.net (03/27/91)
LOCUS HUMBDNFB 1574 bp ss-mRNA PRI 27-MAR-1991
DEFINITION Human brain-derived neurotrophic factor (BDNF) mRNA, complete cds.
ACCESSION M61176
KEYWORDS brain-derived neurotrophic factor.
SOURCE Human adult retina, cDNA to mRNA, clone pSK-hB(c1).
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1574)
AUTHORS Maisonpierre,P.C., Le Beau,M.M., Espinosa,R., Ip,N.Y.,
Belluscio,L., de la Monte,S.M., Squinto,S., Furth,M.E. and
Yancopoulos,G.D.
TITLE Human and rat BDNF and NT-3: Gene structures, distributions and
chromosomal localizations
JOURNAL Unpublished (1991)
STANDARD full staff_entry
FEATURES Location/Qualifiers
CDS 551..1306
/note="prepropeptide"
/product="brain-derived neurotrophic factor"
/gene="BDNF"
/codon_start=551
allele 758..758
/note="g in cDNA; a in gene"
mat_peptide 947..1303
/product="brain-derived neurotrophic factor"
/gene="BDNF"
/codon_start=947
BASE COUNT 469 a 329 c 363 g 413 t
ORIGIN Chromosome 11p13.
1 gttccccaac tgctgtttta ttgtgctatt catgcctaga catcacatag ctagaaaggc
61 ccatcagacc cctcaggcca ctgctgttcc tgtcacacat tcctgcaaag gaccatgttg
121 ctaacttgaa aaaaattact attaattaca cttgcagttg ttgcttagta acatttatga
181 ttttgtgttt ctcgtgacag catgagcaga gatcattaaa aattaaactt acaaagctgc
241 taaagtggga agaaggagaa cttgaagcca caatttttgc acttgcttag aagccatcta
301 atctcaggtt atatgctaga tcttgggggc aaacactgca tgtctctggt ttatattaaa
361 ccacatacag cacactactg acactgattt gtgtctggtg cagctggagt ttatcaccaa
421 gacataaaaa aaccttgacc ctgcagaatg gcctggaatt acaatcagat gggccacatg
481 gcatcccggt gaaagaaagc cctaaccagt tttctgtctt gtttctgctt tctccctaca
541 gttccaccag gtgagaagag tgatgaccat ccttttcctt actatggtta tttcatactt
601 tggttgcatg aaggctgccc ccatgaaaga agcaaacatc cgaggacaag gtggcttggc
661 ctacccaggt gtgcggaccc atgggactct ggagagcgtg aatgggccca aggcaggttc
721 aagaggcttg acatcattgg ctgacacttt cgaacacgtg atagaagagc tgttggatga
781 ggaccagaaa gttcggccca atgaagaaaa caataaggac gcagacttgt acacgtccag
841 ggtgatgctc agtagtcaag tgcctttgga gcctcctctt ctctttctgc tggaggaata
901 caaaaattac ctagatgctg caaacatgtc catgagggtc cggcgccact ctgaccctgc
961 ccgccgaggg gagctgagcg tgtgtgacag tattagtgag tgggtaacgg cggcagacaa
1021 aaagactgca gtggacatgt cgggcgggac ggtcacagtc cttgaaaagg tccctgtatc
1081 aaaaggccaa ctgaagcaat acttctacga gaccaagtgc aatcccatgg gttacacaaa
1141 agaaggctgc aggggcatag acaaaaggca ttggaactcc cagtgccgaa ctacccagtc
1201 gtacgtgcgg gcccttacca tggatagcaa aaagagaatt ggctggcgat tcataaggat
1261 agacacttct tgtgtatgta cattgaccat taaaagggga agatagtgga tttatgttgt
1321 atagattaga ttatattgag acaaaaatta tctatttgta tatatacata acagggtaaa
1381 ttattcagtt aagaaaaaaa taattttatg aactgcatgt ataaatgaag tttatacagt
1441 acagtggttc tacaatctat ttattggaca tgtccatgac cagaagggaa acagtcattt
1501 gcgcacaact taaaaagtct gcattacatt ccttgataat gttgtggttt gttgccgttg
1561 ccaagaactg aaaa
//GenBank-Updates@genbank.bio.net (03/27/91)
LOCUS HUMBDNFC 1688 bp ds-DNA PRI 27-MAR-1991
DEFINITION Human brain-derived neurotrophic factor (BDNF) gene, complete cds,
from 4.3 kb BamHI fragment.
ACCESSION M61181
KEYWORDS brain-derived neurotrophic factor.
SOURCE Human DNA, clone phi-hB(G1).
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1688)
AUTHORS Maisonpierre,P.C., Le Beau,M.M., Espinosa,R., Ip,N.Y.,
Belluscio,L., de la Monte,S.M., Squinto,S., Furth,M.E. and
Yancopoulos,G.D.
TITLE Human and rat BDNF and NT-3: Gene structures, distributions and
chromosomal localizations
JOURNAL Unpublished (1991)
STANDARD full staff_entry
FEATURES Location/Qualifiers
CDS 651..1406
/note="prepropeptide"
/product="brain-derived neurotrophic factor"
/gene="BDNF"
/codon_start=651
allele 858..858
/note="a in DNA; g in cDNA"
/gene="BDNF"
mat_peptide 1047..1403
/product="brain-derived neurotrophic factor"
/gene="BDNF"
/codon_start=1047
BASE COUNT 516 a 343 c 381 g 448 t
ORIGIN Chromosome 11p13.
1 tgtaaaacag gatggctcaa tgaaattatc tttcttcttt ctataataga gtatctctgt
61 gggaagagga aaaaaaaagt caatttaaag gctccttata gttccccaac tgctgtttta
121 ttgtgctatt catgcctaga catcacatag ctagaaaggc ccatcagacc cctcaggcca
181 ctgctgttcc tgtcacacat tcctgcaaag gaccatgttg ctaacttgaa aaaaattact
241 attaattaca cttgcagttg ttgcttagta acatttatga ttttgtgttt ctcgtgacag
301 catgagcaga gatcattaaa aattaaactt acaaagctgc taaagtggga agaaggagaa
361 cttgaagcca caatttttgc acttgcttag aagccatcta atctcaggtt atatgctaga
421 tcttgggggc aaacactgca tgtctctggt ttatattaaa ccacatacag cacactactg
481 acactgattt gtgtctggtg cagctggagt ttatcaccaa gacataaaaa aaccttgacc
541 ctgcagaatg gcctggaatt acaatcagat gggccacatg gcatcccggt gaaagaaagc
601 cctaaccagt tttctgtctt gtttctgctt tctccctaca gttccaccag gtgagaagag
661 tgatgaccat ccttttcctt actatggtta tttcatactt tggttgcatg aaggctgccc
721 ccatgaaaga agcaaacatc cgaggacaag gtggcttggc ctacccaggt gtgcggaccc
781 atgggactct ggagagcgtg aatgggccca aggcaggttc aagaggcttg acatcattgg
841 ctgacacttt cgaacacatg atagaagagc tgttggatga ggaccagaaa gttcggccca
901 atgaagaaaa caataaggac gcagacttgt acacgtccag ggtgatgctc agtagtcaag
961 tgcctttgga gcctcctctt ctctttctgc tggaggaata caaaaattac ctagatgctg
1021 caaacatgtc catgagggtc cggcgccact ctgaccctgc ccgccgaggg gagctgagcg
1081 tgtgtgacag tattagtgag tgggtaacgg cggcagacaa aaagactgca gtggacatgt
1141 cgggcgggac ggtcacagtc cttgaaaagg tccctgtatc aaaaggccaa ctgaagcaat
1201 acttctacga gaccaagtgc aatcccatgg gttacacaaa agaaggctgc aggggcatag
1261 acaaaaggca ttggaactcc cagtgccgaa ctacccagtc gtacgtgcgg gcccttacca
1321 tggatagcaa aaagagaatt ggctggcgat tcataaggat agacacttct tgtgtatgta
1381 cattgaccat taaaagggga agatagtgga tttatgttgt atagattaga ttatattgag
1441 acaaaaatta tctatttgta tatatacata acagggtaaa ttattcagtt aagaaaaaaa
1501 taattttatg aactgcatgt ataaatgaag tttatacagt acagtggttc tacaatctat
1561 ttattggaca tgtccatgac cagaagggaa acagtcattt gcgcacaact taaaaagtct
1621 gcattacatt ccttgataat gttgtggttt gttgccgttg ccaagaactg aaaacataaa
1681 aagttaaa
//