GenBank-Updates@genbank.bio.net (01/26/91)
LOCUS HUMNF1MRNB 7790 bp ss-mRNA PRI 26-JAN-1991
DEFINITION Human neurofibromatosis type 1 (NF-1) mRNA, complete cds.
ACCESSION M38107
KEYWORDS neurofibromatosis type 1 protein.
SOURCE Human fetal brain mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 7790)
AUTHORS Cawthon,R.M., Weiss,R., Xu,G., Viskochil,D., Culver,M., Stevens,J.,
Robertson,M., Dunn,D., Gesteland,R., O'Connell,P. and White,R.
TITLE A major segment of the neurofibromatosis type 1 gene: cDNA
sequence, genomic structure, and point mutations
JOURNAL Cell 62, 193-201 (1990)
STANDARD full staff_entry
REFERENCE 2 (bases 1 to 7790)
AUTHORS Gangfeng,X., O'Connell,P., Viskochil,D., Cawthon,R.M.,
Robertson,M., Culver,M., Dunn,D., Stevens,J., Gesteland,R.,
White,R. and Weiss,R.B.
TITLE The neurofibromatosis type 1 gene encodes a protein related to GAP
JOURNAL Cell 62, 599-608 (1990)
STANDARD full staff_entry
FEATURES Location/Qualifiers
CDS 1..7512
/gene="NF-1"
/codon_start=1
/partial
/product="neurofibromatosis type 1 protein"
mutation 4796..4796
/note="t in wt; c in neurofibromatosis Leu->Pro"
mutation 4840..4840
/note="c in wt; t in neurofibromatosis Arg->Stop"
BASE COUNT 2253 a 1737 c 1636 g 2163 t 1 others
ORIGIN
1 aattgggaag ataactctgt cattttccta cttgttcagt ccatggtggt tgatcttaag
61 aacctgcttt ttaatccaag taagccattc tcaagaggca gtcagcctgc agatgtggat
121 ctaatgattg actgccttgt ttcttgcttt cgtataagcc ctcacaacaa ccaacacttt
181 aagatctgcc tggctcagaa ttcaccttct acatttcact atgtgctggt aaattcactc
241 catcgaatca tcaccaattc cgcattggat tggtggccta agattgatgc tgtgtattgt
301 cactcggttg aacttcgaaa tatgtttggt gaaacacttc ataaagcagt gcaaggttgt
361 ggagcacacc cagcaatacg aatggccccg agtcttacat ttaaagaaaa agtaacaagc
421 cttaaattta aagaaaaacc tacagacctg gagacaagaa gctataagta tcttctcttg
481 tccatagtga aactaattca tgcagatcca aagctcttgc tttgtaatcc aagaaaacag
541 gggcccgaaa cccaaggcag tacagcagaa ttaattacag ggctcgtcca actggtccct
601 cagtcacaca tgccagagat tgctcaggaa gcaatggagg ctctgctggt tcttcatcag
661 ttagatagca ttgatttgtg gaatcctgat gctcctgtag aaacattttg ggagattagc
721 tcacaaatgc ttttttacat ctgcaagaaa ttaactagtc atcaaatgct tagtagcaca
781 gaaattctca agtggttgcg ggaaatattg atctgcagga ataaatttct tcttaaaaat
841 aagcaggcag atagaagttc ctgtcacttt ctcctttttt acggggtagg atgtgatatt
901 ccttctagtg gaaataccag tcaaatgtcc atggatcatg aagaattact acgtactcct
961 ggagcctctc tccggaaggg aaaagggaac tcctctatgg atagtgcagc aggatgcagc
1021 ggaacccccc cratttgccg acaagcccag accaaactag aagtggccct gtacatgttt
1081 ctgtggaacc ctgacactga agctgttctg gttgccatgt cctgtttccg ccacctctgt
1141 gaggaagcag atatccggtg tggggtggat gaagtgtcag tgcataacct cttgcccaac
1201 tataacacat tcatggagtt tgcctctgtc agcaatatga tgtcaacagg aagagcagca
1261 cttcagaaaa gagtgatggc actgctgagg cgcattgagc atcccactgc aggaaacact
1321 gaggcttggg aagatacaca tgcaaaatgg gaacaagcaa caaagctaat ccttaactat
1381 ccaaaagcca aaatggaaga tggccaggct gctgaaagcc ttcacaagac cattgttaag
1441 aggcgaatgt cccatgtgag tggaggagga tccatagatt tgtctgacac agactcccta
1501 caggaatgga tcaacatgac tggcttcctt tgtgcccttg gaggagtgtg cctccagcag
1561 agaagcaatt ctggcctggc aacctatagc ccacccatgg gtccagtcag tgaacgtaag
1621 ggttctatga tttcagtgat gtcttcagag ggaaacgcag atacacctgt cagcaaattt
1681 atggatcggc tgttgtcctt aatggtgtgt aaccatgaga aagtgggact tcaaatacgg
1741 accaatgtta aggatctggt gggtctagaa ttgagtcctg ctctgtatcc aatgctattt
1801 aacaaattga agaataccat cagcaagttt tttgactccc aaggacaggt tttattgact
1861 gataccaata ctcaatttgt agaacaaacc atagctataa tgaagaactt gctagataat
1921 catactgaag gcagctctga acatctaggg caagctagca ttgaaacaat gatgttaaat
1981 ctggtcaggt atgttcgtgt gcttgggaat atggtccatg caattcaaat aaaaacgaaa
2041 ctgtgtcaat tagttgaagt aatgatggca aggagagatg acctctcatt ttgccaagag
2101 atgaaattta ggaataagat ggtagaatac ctgacagact gggttatggg aacatcaaac
2161 caagcagcag atgatgatgt aaaatgtctt acaagagatt tggaccaggc aagcatggaa
2221 gcagtagttt cacttctagc tggtctccct ctgcagcctg aagaaggaga tggtgtggaa
2281 ttgatggaag ccaaatcaca gttatttctt aaatacttca cattatttat gaaccttttg
2341 aatgactgca gtgaagttga agatgaaagt gcgcaaacag gtggcaggaa acgtggcatg
2401 tctcggaggc tggcatcact gaggcactgt acggtccttg caatgtcaaa cttactcaat
2461 gccaacgtag acagtggtct catgcactcc ataggcttag gttaccacaa ggatctccag
2521 acaagagcta catttatgga agttctcaca aaaatccttc aacaaggcac agaatttgac
2581 acacttgcag aaacagtatt ggctgatcgg tttgagagat tggtggaact ggtcacaatg
2641 atgggtgatc aaggagaact ccctatagcg atggctctgg ccaatgtggt tccttgttct
2701 cagtgggatg aactagctcg agttctggtt actctgtttg attctcggca tttactctac
2761 caactgctct ggaacatgtt ttctaaagaa gtagaattgg cagactccat gcagactctc
2821 ttccgaggca acagcttggc cagtaaaata atgacattct gtttcaaggt atatggtgct
2881 acctatctac aaaaactcct ggatccttta ttacgaattg tgatcacatc ctctgattgg
2941 caacatgtta gctttgaagt ggatcctacc aggttagaac catcagagag ccttgaggaa
3001 aaccagcgga acctccttca gatgactgaa aagttcttcc atgccatcat cagttcctcc
3061 tcagaattcc cccctcaact tcgaagtgtg tgccactgtt tataccaggt ggttagccag
3121 cgtttccctc agaacagcat cggtgcagta ggaagtgcca tgttcctcag atttatcaat
3181 cctgccattg tctcaccgta tgaagcaggg attttagata aaaagccacc acctagaatc
3241 gaaaggggct tgaagttaat gtcaaagata cttcagagta ttgccaatca tgttctcttc
3301 acaaaagaag aacatatgcg gcctttcaat gattttgtga aaagcaactt tgatgcagca
3361 cgcaggtttt tccttgatat agcatctgat tgtcctacaa gtgatgcagt aaatcatagt
3421 ctttccttca taagtgacgg caatgtgctt gctttacatc gtctactctg gaacaatcag
3481 gagaaaattg ggcagtatct ttccagcaac agggatcata aagctgttgg aagacgacct
3541 tttgataaga tggcaacact tcttgcatac ctgggtcctc cagagcacaa acctgtggca
3601 gatacacact ggtccagcct taaccttacc agttcaaagt ttgaggaatt tatgactagg
3661 catcatcagg tacatgaaaa agaagaattc aaggctttga aaacgttaag tattttctac
3721 caagctggga cttccaaagc tgggaatcct attttttatt atgttgcacg gaggttcaaa
3781 actggtcaaa tcaatggtga tttgctgata taccatgtct tactgacttt aaagccatat
3841 tatgcaaagc catatgaaat tgtagtggac cttacccata ccgggcctag caatcgcttt
3901 aaaacagact ttctctctaa gtggtttgtt gtttttcctg gctttgctta cgacaacgtc
3961 tccgcagtct atatctataa ctgtaactcc tgggtcaggg agtacaccaa gtatcatgag
4021 cggctgctga ctggcctcaa aggtagcaaa aggcttgttt tcatagactg tcctgggaaa
4081 ctggctgagc acatagagca tgaacaacag aaactacctg ctgccacctt ggctttagaa
4141 gaggacctga aggtattcca caatgctctc aagctagctc acaaagacac caaagtttct
4201 attaaagttg gttctactgc tgtccaagta acttcagcag agcgaacaaa agtcctaggg
4261 caatcagtct ttctaaatga catttattat gcttcggaaa ttgaagaaat ctgcctagta
4321 gatgagaacc agttcacctt aaccattgca aaccagggca cgccgctcac cttcatgcac
4381 caggagtgtg aagccattgt ccagtctatc attcatatcc ggacccgctg ggaactgtca
4441 cagcccgact ctatccccca acacaccaag attcggccaa aagatgtccc tgggacactg
4501 ctcaatatcg cattacttaa tttaggcagt tctgacccga gtttacggtc agctgcctat
4561 aatcttctgt gtgccttaac ttgtaccttt aatttaaaaa tcgagggcca gttactagag
4621 acatcaggtt tatgtatccc tgccaacaac accctcttta ttgtctctat tagtaagaca
4681 ctggcagcca atgagccaca cctcacgtta gaatttttgg aagagtgtat ttctggattt
4741 agcaaatcta gtattgaatt gaaacacctt tgtttggaat acatgactcc atggctgtca
4801 aatctagttc gtttttgcaa gcataatgat gatgccaaac gacaaagagt tactgctatt
4861 cttgacaagc tgataacaat gaccatcaat gaaaaacaga tgtacccatc tattcaagca
4921 aaaatatggg gaagccttgg gcagattaca gatctgcttg atgttgtact agacagtttc
4981 atcaaaacca gtgcaacagg tggcttggga tcaataaaag ctgaggtgat ggcagatact
5041 gctgtagctt tggcttctgg aaatgtgaaa ttggtttcaa gcaaggttat tggaaggatg
5101 tgcaaaataa ttgacaagac atgcttatct ccaactccta ctttagaaca acatcttatg
5161 tgggatgata ttgctatttt agcacgctac atgctgatgc tgtccttcaa caattccctt
5221 gatgtggcag ctcatcttcc ctacctcttc cacgttgtta ctttcttagt agccacaggt
5281 ccgctctccc ttagagcttc cacacatgga ctggtcatta atatcattca ctctctgtgt
5341 acttgttcac agcttcattt tagtgaagag accaagcaag ttttgagact cagtctgaca
5401 gagttctcat tacccaaatt ttacttgctg tttggcatta gcaaagtcaa gtcagctgct
5461 gtcattgcct tccgttccag ttaccgggac aggtcattct ctcctggctc ctatgagaga
5521 gagacttttg ctttgacatc cttggaaaca gtcacagaag ctttgttgga gatcatggag
5581 gcatgcatga gagatattcc aacgtgcaag tggctggacc agtggacaga actagctcaa
5641 agatttgcat tccaatataa tccatccctg caaccaagag ctcttgttgt ctttgggtgt
5701 attagcaaac gagtgtctca tgggcagata aagcagataa tccgtattct tagcaaggca
5761 cttgagagtt gcttaaaagg acctgacact tacaacagtc aagttctgat agaagctaca
5821 gtaatagcac taaccaaatt acagccactt cttaataagg actcgcctct gcacaaagcc
5881 ctcttttggg tagctgtggc tgtgctgcag cttgatgagg tcaacttgta ttcagcaggt
5941 accgcacttc ttgaacaaaa cctgcatact ttagatagtc tccgtatatt caatgacaag
6001 agtccagagg aagtatttat ggcaatccgg aatcctctgg agtggcactg caagcaaatg
6061 gatcattttg ttggactcaa tttcaactct aactttaact ttgcattggt tggacacctt
6121 ttaaaagggt acaggcatcc ttcacctgct attgttgcaa gaacagtcag aattttacat
6181 acactactaa ctctggttaa caaacacaga aattgtgaca aatttgaagt gaatacacag
6241 agcgtggcct acttagcagc tttacttaca gtgtctgaag aagttcgaag tcgctgcagc
6301 ctaaaacata gaaagtcact tcttcttact gatatttcaa tggaaaatgt tcctatggat
6361 acatatccca ttcatcatgg tgacccttcc tataggacac taaaggagac tcagccatgg
6421 tcctctccca aaggttctga aggatacctt gcagccacct atccaactgt cggccagacc
6481 agtccccgag ccaggaaatc catgagcctg gacatggggc aaccttctca ggccaacact
6541 aagaagttgc ttggaacaag gaaaagtttt gatcacttga tatcagacac aaaggctcct
6601 aaaaggcaag aaatggaatc agggatcaca acacccccca aaatgaggag agtagcagaa
6661 actgattatg aaatggaaac tcagaggatt tcctcatcac aacagcaccc acatttacgt
6721 aaagtttcag tgtctgaatc aaatgttctc ttggatgaag aagtacttac tgatccgaag
6781 atccaggcgc tgcttcttac tgttctagct acactggtaa aatataccac agatgagttt
6841 gatcaacgaa ttctttatga atacttagca gaggccagtg ttgtgtttcc caaagtcttt
6901 cctgttgtgc ataatttgtt ggactctaag atcaacaccc tgttatcatt gtgccaagat
6961 ccaaatttgt taaatccaat ccatggaatt gtgcagagtg tggtgtacca tgaagaatcc
7021 ccaccacaat accaaacatc ttacctgcaa agttttggtt ttaatggctt gtggcggttt
7081 gcaggaccgt tttcaaagca aacacaaatt ccagactatg ctgagcttat tgttaagttt
7141 cttgatgcct tgattgacac gtacctgcct ggaattgatg aagaaaccag tgaagaatcc
7201 ctcctgactc ccacatctcc ttaccctcct gcactgcaga gccagcttag tatcactgcc
7261 aaccttaacc tttctaattc catgacctca cttgcaactt cccagcattc cccagcttct
7321 ctgccttgct ctaactcagc agttttcatg cagctgttcc ctcatcaagg aatcgacaag
7381 gagaacgttg aactctcccc taccactggc cactgtaaca gtggacgaac tcgccacgga
7441 tccgcaagcc aagtgcagaa gcaaagaagc gctggcagtt tcaaacgtaa tagcattaag
7501 aagatcgtgt gaagcttgct tgctttcttt tttaaaatca acttaacatg ggctcttcac
7561 tagtgacccc ttccctgtcc ttgccctttc cccccatgtt gtaatgctgc acttcctgtt
7621 ttataatgaa cccatccggt ttgccatgtt gccagatgat caactcttcg aagccttgcc
7681 taaatttaat gctgcctttt ctttaacttt ttttcttcta cttttggcgt gtatctggta
7741 tatgtaagtg ttcagaacaa ctgcaaagaa agtgggaggt caggaaactt
//GenBank-Updates@genbank.bio.net (01/29/91)
LOCUS HUMNF1MRNB 7790 bp ss-mRNA PRI 29-JAN-1991
DEFINITION Human neurofibromatosis type 1 (NF-1) mRNA, complete cds.
ACCESSION M38107 M57449
KEYWORDS neurofibromatosis type 1 protein.
SOURCE Human fetal brain mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 7790)
AUTHORS Cawthon,R.M., Weiss,R., Xu,G., Viskochil,D., Culver,M., Stevens,J.,
Robertson,M., Dunn,D., Gesteland,R., O'Connell,P. and White,R.
TITLE A major segment of the neurofibromatosis type 1 gene: cDNA
sequence, genomic structure, and point mutations
JOURNAL Cell 62, 193-201 (1990)
STANDARD full staff_entry
REFERENCE 2 (bases 1 to 7790)
AUTHORS Gangfeng,X., O'Connell,P., Viskochil,D., Cawthon,R.M.,
Robertson,M., Culver,M., Dunn,D., Stevens,J., Gesteland,R.,
White,R. and Weiss,R.B.
TITLE The neurofibromatosis type 1 gene encodes a protein related to GAP
JOURNAL Cell 62, 599-608 (1990)
STANDARD full staff_entry
FEATURES Location/Qualifiers
CDS 1..7512
/gene="NF-1"
/codon_start=1
/partial
/product="neurofibromatosis type 1 protein"
mutation 4796..4796
/note="t in wt; c in neurofibromatosis Leu->Pro"
mutation 4840..4840
/note="c in wt; t in neurofibromatosis Arg->Stop"
BASE COUNT 2253 a 1737 c 1636 g 2163 t 1 others
ORIGIN
1 aattgggaag ataactctgt cattttccta cttgttcagt ccatggtggt tgatcttaag
61 aacctgcttt ttaatccaag taagccattc tcaagaggca gtcagcctgc agatgtggat
121 ctaatgattg actgccttgt ttcttgcttt cgtataagcc ctcacaacaa ccaacacttt
181 aagatctgcc tggctcagaa ttcaccttct acatttcact atgtgctggt aaattcactc
241 catcgaatca tcaccaattc cgcattggat tggtggccta agattgatgc tgtgtattgt
301 cactcggttg aacttcgaaa tatgtttggt gaaacacttc ataaagcagt gcaaggttgt
361 ggagcacacc cagcaatacg aatggccccg agtcttacat ttaaagaaaa agtaacaagc
421 cttaaattta aagaaaaacc tacagacctg gagacaagaa gctataagta tcttctcttg
481 tccatagtga aactaattca tgcagatcca aagctcttgc tttgtaatcc aagaaaacag
541 gggcccgaaa cccaaggcag tacagcagaa ttaattacag ggctcgtcca actggtccct
601 cagtcacaca tgccagagat tgctcaggaa gcaatggagg ctctgctggt tcttcatcag
661 ttagatagca ttgatttgtg gaatcctgat gctcctgtag aaacattttg ggagattagc
721 tcacaaatgc ttttttacat ctgcaagaaa ttaactagtc atcaaatgct tagtagcaca
781 gaaattctca agtggttgcg ggaaatattg atctgcagga ataaatttct tcttaaaaat
841 aagcaggcag atagaagttc ctgtcacttt ctcctttttt acggggtagg atgtgatatt
901 ccttctagtg gaaataccag tcaaatgtcc atggatcatg aagaattact acgtactcct
961 ggagcctctc tccggaaggg aaaagggaac tcctctatgg atagtgcagc aggatgcagc
1021 ggaacccccc cratttgccg acaagcccag accaaactag aagtggccct gtacatgttt
1081 ctgtggaacc ctgacactga agctgttctg gttgccatgt cctgtttccg ccacctctgt
1141 gaggaagcag atatccggtg tggggtggat gaagtgtcag tgcataacct cttgcccaac
1201 tataacacat tcatggagtt tgcctctgtc agcaatatga tgtcaacagg aagagcagca
1261 cttcagaaaa gagtgatggc actgctgagg cgcattgagc atcccactgc aggaaacact
1321 gaggcttggg aagatacaca tgcaaaatgg gaacaagcaa caaagctaat ccttaactat
1381 ccaaaagcca aaatggaaga tggccaggct gctgaaagcc ttcacaagac cattgttaag
1441 aggcgaatgt cccatgtgag tggaggagga tccatagatt tgtctgacac agactcccta
1501 caggaatgga tcaacatgac tggcttcctt tgtgcccttg gaggagtgtg cctccagcag
1561 agaagcaatt ctggcctggc aacctatagc ccacccatgg gtccagtcag tgaacgtaag
1621 ggttctatga tttcagtgat gtcttcagag ggaaacgcag atacacctgt cagcaaattt
1681 atggatcggc tgttgtcctt aatggtgtgt aaccatgaga aagtgggact tcaaatacgg
1741 accaatgtta aggatctggt gggtctagaa ttgagtcctg ctctgtatcc aatgctattt
1801 aacaaattga agaataccat cagcaagttt tttgactccc aaggacaggt tttattgact
1861 gataccaata ctcaatttgt agaacaaacc atagctataa tgaagaactt gctagataat
1921 catactgaag gcagctctga acatctaggg caagctagca ttgaaacaat gatgttaaat
1981 ctggtcaggt atgttcgtgt gcttgggaat atggtccatg caattcaaat aaaaacgaaa
2041 ctgtgtcaat tagttgaagt aatgatggca aggagagatg acctctcatt ttgccaagag
2101 atgaaattta ggaataagat ggtagaatac ctgacagact gggttatggg aacatcaaac
2161 caagcagcag atgatgatgt aaaatgtctt acaagagatt tggaccaggc aagcatggaa
2221 gcagtagttt cacttctagc tggtctccct ctgcagcctg aagaaggaga tggtgtggaa
2281 ttgatggaag ccaaatcaca gttatttctt aaatacttca cattatttat gaaccttttg
2341 aatgactgca gtgaagttga agatgaaagt gcgcaaacag gtggcaggaa acgtggcatg
2401 tctcggaggc tggcatcact gaggcactgt acggtccttg caatgtcaaa cttactcaat
2461 gccaacgtag acagtggtct catgcactcc ataggcttag gttaccacaa ggatctccag
2521 acaagagcta catttatgga agttctcaca aaaatccttc aacaaggcac agaatttgac
2581 acacttgcag aaacagtatt ggctgatcgg tttgagagat tggtggaact ggtcacaatg
2641 atgggtgatc aaggagaact ccctatagcg atggctctgg ccaatgtggt tccttgttct
2701 cagtgggatg aactagctcg agttctggtt actctgtttg attctcggca tttactctac
2761 caactgctct ggaacatgtt ttctaaagaa gtagaattgg cagactccat gcagactctc
2821 ttccgaggca acagcttggc cagtaaaata atgacattct gtttcaaggt atatggtgct
2881 acctatctac aaaaactcct ggatccttta ttacgaattg tgatcacatc ctctgattgg
2941 caacatgtta gctttgaagt ggatcctacc aggttagaac catcagagag ccttgaggaa
3001 aaccagcgga acctccttca gatgactgaa aagttcttcc atgccatcat cagttcctcc
3061 tcagaattcc cccctcaact tcgaagtgtg tgccactgtt tataccaggt ggttagccag
3121 cgtttccctc agaacagcat cggtgcagta ggaagtgcca tgttcctcag atttatcaat
3181 cctgccattg tctcaccgta tgaagcaggg attttagata aaaagccacc acctagaatc
3241 gaaaggggct tgaagttaat gtcaaagata cttcagagta ttgccaatca tgttctcttc
3301 acaaaagaag aacatatgcg gcctttcaat gattttgtga aaagcaactt tgatgcagca
3361 cgcaggtttt tccttgatat agcatctgat tgtcctacaa gtgatgcagt aaatcatagt
3421 ctttccttca taagtgacgg caatgtgctt gctttacatc gtctactctg gaacaatcag
3481 gagaaaattg ggcagtatct ttccagcaac agggatcata aagctgttgg aagacgacct
3541 tttgataaga tggcaacact tcttgcatac ctgggtcctc cagagcacaa acctgtggca
3601 gatacacact ggtccagcct taaccttacc agttcaaagt ttgaggaatt tatgactagg
3661 catcatcagg tacatgaaaa agaagaattc aaggctttga aaacgttaag tattttctac
3721 caagctggga cttccaaagc tgggaatcct attttttatt atgttgcacg gaggttcaaa
3781 actggtcaaa tcaatggtga tttgctgata taccatgtct tactgacttt aaagccatat
3841 tatgcaaagc catatgaaat tgtagtggac cttacccata ccgggcctag caatcgcttt
3901 aaaacagact ttctctctaa gtggtttgtt gtttttcctg gctttgctta cgacaacgtc
3961 tccgcagtct atatctataa ctgtaactcc tgggtcaggg agtacaccaa gtatcatgag
4021 cggctgctga ctggcctcaa aggtagcaaa aggcttgttt tcatagactg tcctgggaaa
4081 ctggctgagc acatagagca tgaacaacag aaactacctg ctgccacctt ggctttagaa
4141 gaggacctga aggtattcca caatgctctc aagctagctc acaaagacac caaagtttct
4201 attaaagttg gttctactgc tgtccaagta acttcagcag agcgaacaaa agtcctaggg
4261 caatcagtct ttctaaatga catttattat gcttcggaaa ttgaagaaat ctgcctagta
4321 gatgagaacc agttcacctt aaccattgca aaccagggca cgccgctcac cttcatgcac
4381 caggagtgtg aagccattgt ccagtctatc attcatatcc ggacccgctg ggaactgtca
4441 cagcccgact ctatccccca acacaccaag attcggccaa aagatgtccc tgggacactg
4501 ctcaatatcg cattacttaa tttaggcagt tctgacccga gtttacggtc agctgcctat
4561 aatcttctgt gtgccttaac ttgtaccttt aatttaaaaa tcgagggcca gttactagag
4621 acatcaggtt tatgtatccc tgccaacaac accctcttta ttgtctctat tagtaagaca
4681 ctggcagcca atgagccaca cctcacgtta gaatttttgg aagagtgtat ttctggattt
4741 agcaaatcta gtattgaatt gaaacacctt tgtttggaat acatgactcc atggctgtca
4801 aatctagttc gtttttgcaa gcataatgat gatgccaaac gacaaagagt tactgctatt
4861 cttgacaagc tgataacaat gaccatcaat gaaaaacaga tgtacccatc tattcaagca
4921 aaaatatggg gaagccttgg gcagattaca gatctgcttg atgttgtact agacagtttc
4981 atcaaaacca gtgcaacagg tggcttggga tcaataaaag ctgaggtgat ggcagatact
5041 gctgtagctt tggcttctgg aaatgtgaaa ttggtttcaa gcaaggttat tggaaggatg
5101 tgcaaaataa ttgacaagac atgcttatct ccaactccta ctttagaaca acatcttatg
5161 tgggatgata ttgctatttt agcacgctac atgctgatgc tgtccttcaa caattccctt
5221 gatgtggcag ctcatcttcc ctacctcttc cacgttgtta ctttcttagt agccacaggt
5281 ccgctctccc ttagagcttc cacacatgga ctggtcatta atatcattca ctctctgtgt
5341 acttgttcac agcttcattt tagtgaagag accaagcaag ttttgagact cagtctgaca
5401 gagttctcat tacccaaatt ttacttgctg tttggcatta gcaaagtcaa gtcagctgct
5461 gtcattgcct tccgttccag ttaccgggac aggtcattct ctcctggctc ctatgagaga
5521 gagacttttg ctttgacatc cttggaaaca gtcacagaag ctttgttgga gatcatggag
5581 gcatgcatga gagatattcc aacgtgcaag tggctggacc agtggacaga actagctcaa
5641 agatttgcat tccaatataa tccatccctg caaccaagag ctcttgttgt ctttgggtgt
5701 attagcaaac gagtgtctca tgggcagata aagcagataa tccgtattct tagcaaggca
5761 cttgagagtt gcttaaaagg acctgacact tacaacagtc aagttctgat agaagctaca
5821 gtaatagcac taaccaaatt acagccactt cttaataagg actcgcctct gcacaaagcc
5881 ctcttttggg tagctgtggc tgtgctgcag cttgatgagg tcaacttgta ttcagcaggt
5941 accgcacttc ttgaacaaaa cctgcatact ttagatagtc tccgtatatt caatgacaag
6001 agtccagagg aagtatttat ggcaatccgg aatcctctgg agtggcactg caagcaaatg
6061 gatcattttg ttggactcaa tttcaactct aactttaact ttgcattggt tggacacctt
6121 ttaaaagggt acaggcatcc ttcacctgct attgttgcaa gaacagtcag aattttacat
6181 acactactaa ctctggttaa caaacacaga aattgtgaca aatttgaagt gaatacacag
6241 agcgtggcct acttagcagc tttacttaca gtgtctgaag aagttcgaag tcgctgcagc
6301 ctaaaacata gaaagtcact tcttcttact gatatttcaa tggaaaatgt tcctatggat
6361 acatatccca ttcatcatgg tgacccttcc tataggacac taaaggagac tcagccatgg
6421 tcctctccca aaggttctga aggatacctt gcagccacct atccaactgt cggccagacc
6481 agtccccgag ccaggaaatc catgagcctg gacatggggc aaccttctca ggccaacact
6541 aagaagttgc ttggaacaag gaaaagtttt gatcacttga tatcagacac aaaggctcct
6601 aaaaggcaag aaatggaatc agggatcaca acacccccca aaatgaggag agtagcagaa
6661 actgattatg aaatggaaac tcagaggatt tcctcatcac aacagcaccc acatttacgt
6721 aaagtttcag tgtctgaatc aaatgttctc ttggatgaag aagtacttac tgatccgaag
6781 atccaggcgc tgcttcttac tgttctagct acactggtaa aatataccac agatgagttt
6841 gatcaacgaa ttctttatga atacttagca gaggccagtg ttgtgtttcc caaagtcttt
6901 cctgttgtgc ataatttgtt ggactctaag atcaacaccc tgttatcatt gtgccaagat
6961 ccaaatttgt taaatccaat ccatggaatt gtgcagagtg tggtgtacca tgaagaatcc
7021 ccaccacaat accaaacatc ttacctgcaa agttttggtt ttaatggctt gtggcggttt
7081 gcaggaccgt tttcaaagca aacacaaatt ccagactatg ctgagcttat tgttaagttt
7141 cttgatgcct tgattgacac gtacctgcct ggaattgatg aagaaaccag tgaagaatcc
7201 ctcctgactc ccacatctcc ttaccctcct gcactgcaga gccagcttag tatcactgcc
7261 aaccttaacc tttctaattc catgacctca cttgcaactt cccagcattc cccagcttct
7321 ctgccttgct ctaactcagc agttttcatg cagctgttcc ctcatcaagg aatcgacaag
7381 gagaacgttg aactctcccc taccactggc cactgtaaca gtggacgaac tcgccacgga
7441 tccgcaagcc aagtgcagaa gcaaagaagc gctggcagtt tcaaacgtaa tagcattaag
7501 aagatcgtgt gaagcttgct tgctttcttt tttaaaatca acttaacatg ggctcttcac
7561 tagtgacccc ttccctgtcc ttgccctttc cccccatgtt gtaatgctgc acttcctgtt
7621 ttataatgaa cccatccggt ttgccatgtt gccagatgat caactcttcg aagccttgcc
7681 taaatttaat gctgcctttt ctttaacttt ttttcttcta cttttggcgt gtatctggta
7741 tatgtaagtg ttcagaacaa ctgcaaagaa agtgggaggt caggaaactt
//GenBank-Updates@genbank.bio.net (03/27/91)
LOCUS HUMNF1AA 1483 bp ss-mRNA PRI 27-MAR-1991
DEFINITION Human neurofibromatosis type 1 (NF1) mRNA, complete cds.
ACCESSION M61213
KEYWORDS neurofibromatosis type 1 protein.
SOURCE Human, cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1483)
AUTHORS Martin,G.A., Viskochil,D., Bollag,G., McCabe,P.C., Crosier,W.J.,
Haubruck,H., Conroy,L., Clark,R., O'Connell,P., Cawthon,R.M.,
Innis,M. and McCormick,F.
TITLE The GAP-related domain of the Neurofibromatosis type 1 gene product
interacts with ras p21
JOURNAL Cell 63, 843-849 (1990)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
CDS 19..1467
/product="neurofibromatosis type 1 protein"
/gene="NF1"
/codon_start=19
BASE COUNT 434 a 327 c 321 g 401 t
ORIGIN
1 ggagatggtg tgtcgaccat ggaagccaaa tcacagttat ttcttaaata cttcacatta
61 tttatgaacc ttttgaatga ctgcagtgaa gttgaagatg aaagtgcgca aacaggtggc
121 aggaaacgtg gcatgtctcg gaggctggca tcactgaggc actgtacggt ccttgcaatg
181 tcaaacttac tcaatgccaa cgtagacagt ggtctcatgc actccatagg cttaggttac
241 cacaaggatc tccagacaag agctacattt atggaagttc tgacaaaaat ccttcaacaa
301 ggcacagaat ttgacacact tgcagaaaca gtattggctg atcggtttga gagattggtg
361 gaactggtca caatgatggg tgatcaagga gaactcccta tagcgatggc tctggccaat
421 gtggttcctt gttctcagtg ggatgaacta gctcgagttc tggttactct gtttgattct
481 cggcatttac tctaccaact gctctggaac atgttttcta aagaagtaga attggcagac
541 tccatgcaga ctctcttccg aggcaacagc ttggccagta aaataatgac attctgtttc
601 aaggtatatg gtgctaccta tctacaaaaa ctcctggatc ctttattacg aattgtgatc
661 acatcctctg attggcaaca tgttagcttt gaagtggatc ctaccaggtt agaaccatca
721 gagagccttg aggaaaacca gcggaacctc cttcagatga ctgaaaagtt cttccatgcc
781 atcatcagtt cctcctcaga attcccccct caacttcgaa gtgtgtgcca ctgtttatac
841 caggtggtta gccagcgttt ccctcagaac agcatcggtg cagtaggaag tgccatgttc
901 ctcagattta tcaatcctgc cattgtctca ccgtatgaag cagggatttt agataaaaag
961 ccaccaccta gaatcgaaag gggcttgaag ttaatgtcaa agatacttca gagtattgcc
1021 aatcatgttc tcttcacaaa agaagaacat atgcggcctt tcaatgattt tgtgaaaagc
1081 aactttgatg cagcacgcag gtttttcctt gatatagcat ctgattgtcc tacaagtgat
1141 gcagtaaatc atagtctttc cttcataagt gacggcaatg tgcttgcttt acatcgtcta
1201 ctctggaaca atcaggagaa aattgggcag tatctttcca gcaacaggga tcataaagct
1261 gttggaagac gaccttttga taagatggca acacttcttg catacctggg tcctccagag
1321 cacaaacctg tggcagatac acactggtcc agccttaacc ttaccagttc aaagtttgag
1381 gaatttatga ctaggcatca ggtacatgaa aaagaagaat tcaaggcttt gaaaacgtta
1441 acaccaccac cagaaccaga aacatgagct ctagagaatc cta
//