GenBank-Updates@genbank.bio.net (03/28/91)
LOCUS HUMPPROA 3693 bp ss-mRNA PRI 28-MAR-1991
DEFINITION Human glycine decarboxylase (P-protein) mRNA.
ACCESSION M63635
KEYWORDS P protein; glycine decarboxylase.
SOURCE Human cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3693)
AUTHORS Kure,S., Narisawa,K. and Tada,K.
TITLE Structural and expression analyses of normal and mutant mRNA
encoding glycine decarboxylase: Three-base deletion in mRNA causes
nonketotic hyperglycinemia
JOURNAL Biochem. Biophys. Res. Commun. 174, 1176-1182 (1991)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
CDS 82..3144
/product="glycine decarboxylase"
/codon_start=82
mutation 2348..2350
/note="3 bp deletion in NKH patient"
BASE COUNT 919 a 872 c 1006 g 896 t
ORIGIN
1 acccggggga ccgaggccag gagaggggcc aagagcgcgg ctgacccttg cgggccgggg
61 caggggacgg tggccgcggc catgcagtcc tgtgccaggg cgtgggggct gcgcctgggc
121 cgcggggtcg ggggcggccg ccgcctggct gggggatcgg ggccgtgctg ggcgccgcgg
181 agccgggaca gcagcagtgg cggcggggac agcgccgcgg ctggggcctc gcgcctcctg
241 gagcgccttc tgcccagaca cgacgacttc gctcggaggc acatcggccc tggggacaaa
301 gaccagagag agatgctgca gaccttgggg ctggcgagca ttgatgaatt gatcgagaag
361 acggtccctg ccaacatccg tttgaaaaga cccttgaaaa tggaagaccc tgtttgtgaa
421 aatgaaatcc ttgcaactct gcatgccatt tcaagcaaaa accagatctg gagatcgtat
481 attggcatgg gctattataa ctgctcagtg ccacagacga ttttgcggaa cttactggag
541 aactcaggat ggatcaccca gtatactcca taccagcctg aggtgtctca ggggaggctg
601 gagagtttac tcaactacca gaccatggtg tgtgacatca caggcctgga catggccaat
661 gcatccctgc tggatgaggg gactgcagcc gcagaggcac tgcagctgtg ctacagacac
721 aacaagagga ggaaatttct cgttgatccc cgttgccacc cacagacaat agctgttgtc
781 cagactcgag ccaaatatac tggagtcctc actgagctga agttaccctg tgaaatggac
841 ttcagtggaa aagatgtcag tggagtgttg ttccagtacc cagacacgga ggggaaggtg
901 gaagacttta cggaactcgt ggagagagct catcagagtg ggagcctggc ctgctgtgct
961 actgaccttt tagctttgtg catcttgagg ccacctggag aatttggggt agacatcgcc
1021 ctgggcagct cccagagatt tggagtgcca ctgggctatg ggggacccca tgcagcattt
1081 tttgctgtcc gagaaagctt ggtgagaatg atgcctggaa gaatggtggg ggtaacaaga
1141 gatgccactg ggaaagaagt gtatcgtctt gctcttcaaa ccagggagca acacattcgg
1201 agagacaagg ctaccagcaa catctgtaca gctcaggccc tcttggcgaa tatggctgcc
1261 atgtttgcaa tctaccatgg ttcccatggg ctggagcata ttgctaggag ggtacataat
1321 gccactttga ttttgtcaga aggtctcaag cgagcagggc atcaactcca gcatgacctg
1381 ttctttgata ccttgaagat tcattgtggc tgctcagtga aggaggtctt gggcagggcg
1441 gctcagcggc agatcaattt tcggcttttt gaggatggca cacttggtat ttctcttgat
1501 gaaacagtca atgaaaaaga tctggacgat ttgttgtgga tctttggttg tgagtcatct
1561 gcagaactgg ttgctgaaag catgggagag gagtgcagag gtattccagg gtctgtgttc
1621 aagaggacca gcccgttcct cacccatcaa gtgttcaaca gctaccactc tgaaacaaac
1681 attgtccggt acatgaagaa actggaaaat aaagacattt cccttgttca cagcatgatt
1741 ccactgggat cctgcaccat gaaactgaac agttcgtctg aactcgcacc tatcacatgg
1801 aaagaatttg caaacatcca cccctttgtg cctctggatc aagctcaagg atatcagcag
1861 cttttccgag agcttgagaa ggatttgtgt gaactcacag gtcatgacca ggtctgtttc
1921 cagccaaaca gcggagccca gggagaatat gctggactgg ccactatccg agcctactta
1981 aaccagaaag gagaggggca cagaacggtt tgcctcattc cgaaatcagc acatgggacc
2041 aacccagcaa gtgcccacat ggcaggcatg aagattcagc ctgtggaggt ggataaatat
2101 gggaatatcg atgcagttca cctcaaggcc atggtggata agcacaagga gaacctagca
2161 gctatcatga ttacataccc atccaccaat ggggtgtttg aagagaacat cagtgacgtg
2221 tgtgacctca tccatcaaca tggaggacag gtctacctag acggggcaaa tatgaatgct
2281 caggtgggaa tctgtcgccc tggagacttc gggtctgatg tctcgcacct aaatcttcac
2341 aagaccttct gcattcccca cggaggaggt ggtcctggca tggggcccat cggagtgaag
2401 aaacatctcg ccccgttttt gcccaatcat cccgtcattt cactaaagcg gaatgaggat
2461 gcctgtcctg tgggaaccgt cagtgcggcc ccatggggct ccagttccat cttgcccatt
2521 tcctgggctt atatcaagat gatgggaggc aagggtctta aacaagccac ggaaactgcg
2581 atattaaatg ccaactacat ggccaagcga ttagaaacac actacagaat tcttttcagg
2641 ggtgcaagag gttatgtggg tcatgaattt attttggaca cgagaccctt caaaaagtct
2701 gcaaatattg aggctgtgga tgtggccaag agactccagg attatggatt tcacgcccct
2761 accatgtcct ggcctgtggc agggaccctc atggtggagc ccactgagtc ggaggacaag
2821 gcagagctgg acagattctg tgatgccatg atcagcattc ggcaggaaat tgctgacatt
2881 gaggagggcc gcatcgaccc cagggtcaat ccgctgaaga tgtctccaca ctccctgacc
2941 tgcgttacat cttcccactg ggaccggcct tattccagag aggtggcagc attcccactc
3001 cccttcgtga aaccagagaa caaattctgg ccaacgattg cccggattga tgacatatat
3061 ggagatcagc acctggtttg tacctgccca cccatggaag tttatgagtc tccattttct
3121 gaacaaaaga gggcgtcttc ttagtcctct ctccctaagt ttaaaggact gatttgatgc
3181 ctctccccag agcatttgat aagcaagaaa gatttcatct cccaccccag cctcaagtag
3241 gagttttata tactgtgtat atctctgtaa tctctgtcaa ggtaaatgta aatacagtag
3301 ctggagggag tcgaagctga tggttggaag acggatttgc tttggtattc tgcttccaca
3361 tgtgcacgtt gcctggattg ggagccattt tgtgttttgc gtagaaagtt ttaggaactt
3421 taacttttaa tgtggcaagt ttgcagatgt catagaggct atcctggaga cttaatagac
3481 atttttttgt tccaaaagag tccatgtgga ctgtgccatc tgtgggaaat cccagggcaa
3541 atgtttacat tttgtatacc ctgaagaact ctttttcctc taatatgcct aatctgtaat
3601 cacatttctg agtgttttcc tctttttctg tgtgaggttt tttttttttt taatctgcat
3661 ttattagtat tataataaaa gcattttgat cgg
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