GenBank-Updates@genbank.bio.net (03/29/91)
LOCUS HPA18F 7423 bp ss-RNA VRL 29-MAR-1991
DEFINITION Hepatitis A virus polyprotein RNA, complete cds.
ACCESSION M59808
KEYWORDS hepatitis A; polyprotein.
SOURCE Hepatitis A virus (strain HM175, isolate 18f), cDNA to genomic RNA.
ORGANISM Hepatitis A virus
Viridae; ss-RNA nonenveloped viruses; Isometric ss-RNA viruses;
Picornaviridae; Enterovirus.
REFERENCE 1 (bases 1 to 7423)
AUTHORS Lemon,S.M., Murphy,P.C., Shields,P.A., Ping,L.-H., Feinstone,S.M.,
Cromeans,T. and Jansen,R.W.
TITLE Antigenic and genetic variation in cytopathic Hepatitis A virus
variants during persistent infection: Evidence for genetic
recombination
JOURNAL Unpublished (1990)
STANDARD full staff_entry
FEATURES Location/Qualifiers
mat_peptide 5929..7395
/product="viral protein"
/label=3D
/codon_start=5929
mat_peptide 5272..5928
/product="viral protein"
/label=3C
/codon_start=5272
mat_peptide 5203..5271
/product="viral protein"
/label=3B
/codon_start=5203
mat_peptide 4984..5202
/product="viral protein"
/label=3A
/codon_start=4984
mat_peptide 3979..4983
/product="viral protein"
/label=2C
/codon_start=3979
mat_peptide 3658..3978
/product="viral protein"
/label=2B
/codon_start=3658
mat_peptide 3091..3657
/product="viral protein"
/label=2A
/codon_start=3091
mat_peptide 2191..3090
/product="viral protein"
/label=vp1
/codon_start=2191
mat_peptide 1453..2190
/product="viral protein"
/label=vp3
/codon_start=1453
mat_peptide 787..1452
/product="viral protein"
/label=vp2
/codon_start=787
CDS 718..7398
/product="viral protein"
/codon_start=718
mat_peptide 718..786
/product="viral protein"
/label=vp4
/codon_start=718
BASE COUNT 2173 a 1196 c 1622 g 2432 t
ORIGIN
1 gtccctcttg gaagtccatg gtgaggggac ttgatacctc accgccgttt gcctaggcta
61 taggctaaat tttccctttc ccttttccct ttcctattcc ctttgttttg cttgtaaata
121 ttgatttgta aatattgatt cctgcaggtt cagggttctt aaatctgttt ctctataaga
181 acactcattt cacgctttct gtcttctttc ttccagggct ctccccttgc cctaggctct
241 ggccgttgcg cccggcgggg tcaactccat gattagcatg gagctgtagg agtctaaatt
301 ggggacacag atgtttggaa cgtcaccttg cagtgttaac ttggctttca tgaatctctt
361 tgatcttcca caaggggtag gctacgggtg aaacctctta ggctaatact tctatgaaga
421 gatgccttgg atagggtaac agcggcggat attggtgagt tgttaagaca aaaaccattc
481 aacgccggag gactgactct catccagtgg atgcattgag tggattgact gtcggggctg
541 tctttaggct taattccaga cctctctgtg cttggggcaa acatcatttg gccttaaatg
601 ggattctgtg agaggggatc cctccattgc cagctggact gttctttggg gccttatgtg
661 gtgtttgccg ctgaggtact caggggcatt taggtttttc ctcattctta aataataatg
721 aacatgtcta gacaaggtat tttccagact gttgggagtg gtcttgacca catcctgtct
781 ttggcagaca ttgaggaaga gcaaatgatt caatcagttg ataggactgc agtgactggt
841 gcttcttatt ttacttctgt ggatcaatct tcagttcata cagctgaggt tggatcacac
901 caggttgaac ctttgagaac ctctgttgat aaacccggtt caaagaggac tcagggagag
961 aaatttttct tgattcattc tgcagattgg cttactacac atgctctttt ccatgaagtt
1021 gcaaaattgg atgtggtgaa attattatac aatgagcagt ttgctgttca agggttgttg
1081 agataccata catatgcaag atttggcatt gaaattcaag ttcagataaa ccctacacct
1141 ttccaacagg ggggattgat ctgtgctatg gttcctggtg accagagcta tggttctata
1201 gcatcattga ctgtttatcc tcatggtttg ttaaattgca atattaacaa tgtggttaga
1261 ataaaggttc catttattta cacaagaggt gcttaccact ttaaagatcc acaataccca
1321 gtttgggaat tgacaattag agtttggtca gaattaaata ttgggacagg aacttcagct
1381 tatacttcac tcaatgtttt agctagattt acagatttgg agttgcatgg attaactcct
1441 ctttctacac aaatgatgag aaatgaattt agggtcagta ctactgagaa tgtggtgaat
1501 ctgtcaaatt atgaagatgc aagagcaaag atgtcttttg ctttggatca ggaagattgg
1561 aaatctgatc cgtcccaggg tggtgggatc aaaattactc attttactac ttggacatct
1621 attccaactt tggctgctca gtttccattt aatgcttcag actcagttgg tcaacaaatt
1681 aaagttattc cagttgaccc atattttttc caaatgacaa ataaaaatcc tgaccaaaaa
1741 tgtataactg ctttggcttc tatttgtcag atgttttgtt tttggagagg agatcttgtc
1801 tttgattttc aagtttttcc caccaaatat cattcaggta gattactgtt ttgttttgtt
1861 cctggcaatg agctaataga tgtttctgga atcacattaa agcaagcaac tactgctcct
1921 tgtgcagtaa tggatattac aggagtgcag tcaactttga gatttcgtgt tccctggatt
1981 tctgacactc cttacagagt gaacaggtat acaaagtcag cacatcagaa aggtgagtac
2041 actgccattg ggaagcttat tgtgtattgt tataacagat tgacctctcc ttctaacgtt
2101 gcttcccatg tcagagtgaa tgtttatctt tcagcaatta acttggaatg ttttgctcct
2161 ctttatcatg ctatggatgt tactacacaa gttggagatg attctggagg tttttcaaca
2221 acagtttcta cagaacagaa tgttccagat ccccaagttg gtataacaac catgaaagat
2281 ttgaaaggaa aagctaacag agggaaaatg gatgtttcag gagtacaagc acctgtggga
2341 gctatcacaa caattgagga tccagtttta gcaaagaaag tacctgagac atttcctgaa
2401 ttgaaacctg gagaatccag acatacatca gatcatatgt ccatctacaa gtttatggga
2461 aggtctcatt tcttgtgcac ttttacattc aattcaaata ataaagagta cacatttcct
2521 ataaccttgt cttcaacctc taatcctcct catggtttgc catcaacact gaggtggttt
2581 ttcaacttgt ttcagttgta tagagggcct ttagatctga caattattat tacaggagca
2641 actgatgtag atggcatggc ctggtttact ccagtaggtc ttgccgttga tactccttgg
2701 gtagagaagg agtcagcttt gtctattgac tacaaaactg ctcttggagc tgtcagattt
2761 aacacaagga gaacagggaa cattcagatt agattaccat ggtattctta tttatatgct
2821 gtgtctggag cactggatgg tttgggtgac aagacagatt ctacatttgg attggtttct
2881 attcagattg caaattacaa tcattctgat gaatacttgt cttttagttg ttatttgtct
2941 gtcacagaac aatcagagtt ttattttccc agagctccat tgaactcaaa tgccatgtta
3001 cccactgaat caatgatgag cagaattgca gctggagact tggagtcatc agtggatgat
3061 cctagatcag aggaagataa aagatttgag agtcatatag aatgcaggaa gccatataaa
3121 gaactgagat tagaagttgg gaaacaaaga ctcaagtatg ctcaggaaga attgtcaaat
3181 gaagtacttc caccccctag gaaaatgaag ggactgtttt cacaagccaa tatttctctt
3241 ttttatactg aggagcatga aatgatgaag ttttcctgga gaggtgtgac tgctgatact
3301 agagctttaa ggaggtttgg attctctttg gccgcaggca gaagtgtgtg gactcttgaa
3361 atggatgctg gggttcttac tgggagactg attagattga atgatgagaa atggacagaa
3421 atgaaggatg acaagattgt ttcattgatt gaaaagttta caagtaacaa atattggtcc
3481 aaagtgaatt tcccacatgg gatgttggat cttgaagaaa ttgctgccaa ttctaaggat
3541 tttcctaaca tgtctgaaac ggatttgtgt ttcttgctgc attggttaaa tccaaagaaa
3601 attaatttag cagatagaat gcttggattg tctggagttc aggaaattaa agaacaaggt
3661 gttggattaa tagcagagtg tagaactttc ttacattcta ttgctggaac tttaaaatct
3721 atgatgtttg gatttcatca ttctgtgact gttgaaatta taaacactgt gctctgtttt
3781 gttaagagtg gaattttgct ttatgtaata caacaattga atcaggatga acattctcac
3841 ataattggtc tgttgagagt catgaattat gtagatattg gttgttcagt tatttcatgt
3901 ggcaaagttt tttccaaaat gctggaaaca gtctttaatt ggcaaatgga ctccagaatg
3961 atggagttaa ggactcagag tttttccaac tggttaagag atatttgttc tgggatcacc
4021 atttttaaaa acttcaagga tggaatttgt tggctttata caaaattaaa ggacttttat
4081 gaagtgaatt atggcaagaa gaaggacatt ttaaatattc ttaaagataa ccaacaaaaa
4141 atagagaaag ccattgagga agccgataaa ttttgcattt tgcaaatcca agatgtggaa
4201 aaatctgaac agtatcagaa aggggttgac ttgatacaaa aattgagaac tgtttattca
4261 atggctcagg ttgatccaaa tttaatggtt catttgtcac ctttgagaga ttgtatagca
4321 agagttcatc agaaacttaa aaaccttgga tttataaatc aggcaatggt aacgagatgt
4381 gagccagttg tttgttattt acatggcaaa agagggggag gaaagagctt aacatcaatt
4441 gcattggcaa ccaaaatttg taaacattat ggtgttgagc ctgaaaagaa tatctatact
4501 aaacctgtgg cttcagatta ctgggatgga tatagtggac aattagtttg catcattgat
4561 gatattggcc aaaacacaac agatgaggac tggtcagatt tttgtcagtt agtgtcagga
4621 tgtccaatga gattaaacat ggcctctctt gaggagaagg gtaggcattt ttcttctcct
4681 tttataatag caacttcaaa ttggtcaaat ccaagtccaa aaacagttta tgttaaggaa
4741 gcaattgacc gcagactcca tttcaaggtt gaagttaaac ctgcttcatt tttcaaaaat
4801 cctcacaatg atatgttgaa tgttaattta gctaaaacaa atgatgcaat caaagatatg
4861 tcttgtgttg atttgataat ggatggacat aatgtttcat tgatggattt gctcagttct
4921 ttagtcatga cagttgatat tagaaaacaa aacatgactg aattcatgga gttgtggtct
4981 cagggaattt cagatgataa tgatagtgca gtagctgagt ttttccagtc ttttccatct
5041 ggtgaaccat cgaactctaa attatctggc tttttccaat ctgttactaa tcacaagtgg
5101 gttgctgtgg gagctgcagt tggcattctt ggagtgctcg ttggaggatg ggttgtgtat
5161 aagcatttct cccacaaaga ggaagaacca atcccagctg aaggggtata tcatggtgta
5221 actaagccca agcatgtgat taaattagat gcagatccag tagaatctca gtcaactttg
5281 gaaatagcag gactggttag gaagaacttg gttcagtttg gagttggaga gaagaatgga
5341 tgtgtgagat gggttatgaa tgccttggga gtgaaagatg attggctgct tgtgccttcc
5401 catgcttata aatttgagaa agattatgaa atgatggagt tttattttaa tagaggtgga
5461 acttactatt caatttcagc tggtaatgtt gttattcaat ctttggatgt gggattccag
5521 gatgttgttc tgatgaaggt tcctacaatt cctaagttta gagatattac tgagcatttt
5581 attaagaaag gggatgtgcc tagagctttg aatcgcctgg caacattagt gacaactgta
5641 aatggaaccc ctatgttaat ttctgagggc ccactaaaga tggaagagaa agctacttat
5701 gttcataaga aaaatgatgg tacaacagtt gatttaactg tggatcaggc atggagagga
5761 aaaggcgaag gtcttcctgg aatgtgtggt ggggccttgg tttcatcgaa tcaatctata
5821 cagaatgcaa tcttgggcat ccatgttgct ggaggaaatt caattcttgt tgcaaaattg
5881 gttactcaag aaatgttcca aaatattgat aagaaaattg aaagtcagag aattatgaaa
5941 gtggagttta ctcagtgttc aatgaatgtg gtctccaaaa cgctttttag aaagagtccc
6001 atttatcatc acattgataa aaccatgatt aattttcctg cagctatgcc cttttctaaa
6061 gctgaaattg atccaatggc tgtgatgtta tctaagtatt cattacctat tgtagaagaa
6121 ccagagggtt ataaagaggc ttcaattttt tatcaaaata aaatagtggg taagactcag
6181 ttagttgatg attttctaga tcttgatatg gccattacag gggccccagg aattgatgct
6241 atcaacatgg attcatctcc tggatttcct tatgtccagg agaagttgac caaaagagat
6301 ttaatttggt tggatgaaaa tggtttattg ctgggagttc atccaagatt ggctcagaga
6361 atcttattca atactgtcat gatggaaaat tgttctgatt tggatgttgt ttttacaacc
6421 tgtccaaaag atgaattgag gccattagag aaagtgttgg aatcaaaaac aagagctatt
6481 gatgcttgtc ctctggatta cacaattttg tgccgaatgt attggggtcc agctattagt
6541 tattttcatt tgaatccagg tttccataca ggtgttgcta ttggcataga tcctgataaa
6601 cagtgggatg aactatttaa aacaatgata agattcggag atgttggtct tgatttagat
6661 ttctctgctt ttgatgctag tcttagtcca tttatgatta gagaagcagg tagaatcatg
6721 agtgaactat ctggaactcc atcccatttt ggcacagctc ttatcaatac tatcatttat
6781 tccaagcatt tgctgtataa ctgttgttac catgtctgtg gttcaatgcc ctctgggtct
6841 ccttgtacag ctttgctaaa ttcaattatt aataatgtca atttgtatta tgtgttttct
6901 aagatatttg gaaagtctcc agttttcttt tgtcaggctt tgaagattct ctgttatgga
6961 gatgatgttt taatagtttt ctctcgagat gttcagattg ataatcttga tttgattgga
7021 caaaaaattg tagatgagtt taagaaactt ggcatgacag ctacttctgc tgacaagaat
7081 gtacctcagc tgaaaccagt ttcggaattg acttttctca aaagatcttt caatttggta
7141 gaggatagaa ttagacctgc aatttcggaa aaaacaattt ggtctttaat agcatggcag
7201 agaagtaacg ctgagtttga gcagaactta gaaaatgctc agtggtttgc ttttatgcat
7261 ggctatgagt tttatcagaa attctattat tttgttcagt cctgtttgga gaaagagatg
7321 atagaataca gacttaaatc ttatgattgg tggagaatga gattttatga ccagtgtttc
7381 atttgtgacc tttcatgatt tgtttaaatg aactttctta aaa
//GenBank-Updates@genbank.bio.net (03/29/91)
LOCUS HPA43C 7419 bp ss-RNA VRL 29-MAR-1991
DEFINITION Hepatitis A virus polyprotein RNA, complete cds.
ACCESSION M59809
KEYWORDS hepatitis A; polyprotein.
SOURCE Hepatitis A virus (strain HM175, isolate 43c), cDNA to genomic RNA.
ORGANISM Hepatitis A virus
Viridae; ss-RNA nonenveloped viruses; Isometric ss-RNA viruses;
Picornaviridae; Enterovirus.
REFERENCE 1 (bases 1 to 7419)
AUTHORS Lemon,S.M., Murphy,P.C., Shields,P.A., Ping,L.-H., Feinstone,S.M.,
Cromeans,T. and Jansen,R.W.
TITLE Antigenic and genetic variation in cytopathic Hepatitis A virus
variants during persistent infection: Evidence for genetic
recombination
JOURNAL Unpublished (1990)
STANDARD full staff_entry
FEATURES Location/Qualifiers
CDS 718..7398
/product="viral protein"
/codon_start=718
mat_peptide 718..786
/product="viral protein"
/label=vp4
/codon_start=718
mat_peptide 787..1452
/product="viral protein"
/label=vp2
/codon_start=787
mat_peptide 1453..2190
/product="viral protein"
/label=vp3
/codon_start=1453
mat_peptide 2191..3090
/product="viral protein"
/label=vp1
/codon_start=2191
mat_peptide 3091..3657
/product="viral protein"
/label=2A
/codon_start=3091
mat_peptide 3658..3978
/product="viral protein"
/label=2B
/codon_start=3658
mat_peptide 3979..4983
/product="viral protein"
/label=2C
/codon_start=3979
mat_peptide 4984..5202
/product="viral protein"
/label=3A
/codon_start=4984
mat_peptide 5203..5271
/product="viral protein"
/label=3B
/codon_start=5203
mat_peptide 5272..5928
/product="viral protein"
/label=3C
/codon_start=5272
mat_peptide 5929..7395
/product="viral protein"
/label=3D
/codon_start=5929
BASE COUNT 2162 a 1204 c 1626 g 2427 t
ORIGIN
1 gtccctcttg gaagtccatg gtgaggggac ttgatacctc accgccgttt gcctaggcta
61 taggctaaat tttccctttc ccttttccct ttcctattcc ctttgttttg cttgtaaata
121 ttgatttgta aatattgatt cctgcaggtt cagggttctt aaatctgttt ctctataaga
181 acactcattt cacgctttct gtcttctttc ttccagggct ctccccttgc cctaggctct
241 ggccgttgcg cccggcgggg tcaactccat gattagcatg gagctgtagg agtctaaatt
301 ggggacacag atgtttggaa cgtcaccttg cagtgttaac ttggctttca tgaatctctt
361 tgatcttcca caaggggtag gctacgggtg aaacctctta ggctaatact tctatgaaga
421 gatgccttgg atagggtaac agcggcggat attggtgagt tgttaagaca aaaaccattc
481 aacgccggag gactgactct catccagtgg atgcattgag tggattgact gtcggggctg
541 tctttaggct taattccaga cctctctgtg cttggggcaa acatcatttg gccttaaatg
601 ggattctgtg agaggggatc cctccattgc cagctggact gttctttggg gccttatgtg
661 gtgtttgccg ctgaggtact caggggcatt taggtttttc ctcattctta aataataatg
721 aacatgtcta gacaaggtat tttccagact gttgggagtg gtcttgacca catcctgtct
781 ttggcagaca ttgaggaaga gcaaatgatt caatcagttg ataggactgc agtgactggt
841 gcttcttatt ttacttctgt ggatcaatct tcagttcata cagctgaggt tggatcacac
901 caggttgaac ctttgagaac ctctgttgat aaacccggtt caaagaggac tcagggagag
961 aaatttttct tgattcattc tgcagattgg cttactacac atgctctttt ccatgaagtt
1021 gcaaaattgg atgtggtgaa attattatac aatgagcagt ttgctgttca agggttgttg
1081 agataccata catatgcaag atttggcatt gaaattcaag ttcagataaa ccctacacct
1141 ttccaacagg ggggattgat ctgtgctatg gttcctggtg accagagcta tggttctata
1201 gcatcattga ctgtttatcc tcatggtttg ttaaattgca atattaacaa tgtggttaga
1261 ataaaggttc catttattta cacaagaggt gcttaccact ttaaagatcc acaataccca
1321 gtttgggaat tgacaattag agtttggtca gaattaaata ttgggacagg aacttcagct
1381 tatacttcac tcaatgtttt agctagattt acagatttgg agttgcatgg attaactcct
1441 ctttctacac aaatgatgag aaatgaattt agggtcagta ctactgagaa tgtggtgaat
1501 ctgtcaaatt atgaagatgc aagagcaaag atgtcttttg ctttggatca ggaagattgg
1561 aaatctgatc cgtcccaggg tggtgggatc aaaattactc attttactac ttggacatct
1621 attccaactt tggctgctca gtttccattt aatgcttcag cctcagttgg tcaacaaatt
1681 aaagttattc cagttgaccc atattttttc caaatgacaa atacgaatcc tgaccaaaaa
1741 tgtataactg ctttggcttc tatttgtcag atgttttgtt tttggagagg agatcttgtc
1801 tttgattttc aagtttttcc caccaaatat cattcaggta gattactgtt ttgttttgtt
1861 cctggcaatg agctaataga tgtttctgga atcacattaa agcaagcaac tactgctcct
1921 tgtgcagtaa tggatattac aggagtgcag tcaactttga gatttcgtgt tccctggatt
1981 tctgacactc cttacagagt gaacaggtat acaaagtcag cacatcagaa aggtgagtac
2041 actgccattg ggaagcttat tgtgtattgt tataacagat tgacctctcc ttctaacgtt
2101 gcttcccatg tcagagtgaa tgtttatctt tcagcaatta acttggaatg ttttgctcct
2161 ctttatcatg ctatggatgt tactacacaa gttggagatg attctggagg tttttcaaca
2221 acagtttcta cagaacagaa tgttccagat ccccaagttg gtataacaac catgaaagat
2281 ttgaaaggaa aagctaacag agggaaaatg gatgtttcag gagtacaagc acctgtggga
2341 gctatcacaa caattgagga tccagtttta gcaaagaaag tacctgagac atttcctgaa
2401 ttgaaacctg gagaatccag acatacatca gatcatatgt ccatctacaa gtttatggga
2461 aggtctcatt tcttgtgcac ttttacattc aattcaaata ataaagagta cacatttcct
2521 ataaccttgt cttcaacctc taatcctcct catggtttgc catcaacact gaggtggttt
2581 ttcaacttgt ttcagttgta tagagggcct ttagatctga caattattat tacaggagca
2641 actgatgtag atggcatggc ctggttcact ccagtaggtc ttgccgttga tactccttgg
2701 gtagagaagg agtcagcttt gtctattgac tacaaaactg ctcttggagc tgtcagattt
2761 aacacaagga gaacagggag cattcagatt agattaccat ggtattctta tttatatgct
2821 gtgtctggag cactggatgg tttgggtgac aagacagatt ctacatttgg attggtttct
2881 attcagattg caaattacaa tcattctgat gaatacttgt cttttagttg ttatttgtct
2941 gtcacagaac aatcagagtt ttattttccc agagctccat tgaactcaaa tgccatgtta
3001 tccactgaat caatggtgag cagaattgca gctggagact tggagtcatc agtggatgat
3061 cctagatcag aggaagataa aagatttgag agtcatatag aatgcaggaa gccatataaa
3121 gaactgagat tagaagttgg gaaacaaaga ctcaagtatg ctcaggaaga attgtcaaat
3181 gaagtacttc caccccctag gaaaatgaag ggactgtttt cacaagccaa catttctctt
3241 ttttatactg aggagcatga aatgatgaag ttttcctgga gaggtgtgac tgctgatact
3301 agagctttaa ggaggtttgg attctctttg gccgcaggca gaagtgtgtg gactcttgaa
3361 atggatgctg gggttcttac tgggagactg attagattga atgatgagaa atggacagaa
3421 atgaaggatg acaagattgt ttcattgatt gaaaagttta caagtaacaa atattggtcc
3481 aaagtgaatt tcccacatgg gatgttggat cttgaagaaa ttgctgccaa ttctaaggat
3541 tttcctaaca tgtctgaaac ggatttgtgt ttcttgctgc attggttaaa tccaaagaaa
3601 attaatttag cagatagaat gcttggattg tctggagttc aggaaattaa agaacaaggt
3661 gttggattaa tagcagagtg tagaactttc ttacattcta ttgctggaac tttaaaatct
3721 atgatgtttg gatttcatca ttctgtgact gttgaaatta taaacactgt gctctgtttt
3781 gttaagagtg gaattttgct ttatgtaata caacaattga atcaggatga acattctcac
3841 ataattggtc tgttgagagt catgaattat gtagatattg gttgttcagt tatttcatgt
3901 ggcaaagttt tttccaaaat gctggaaaca gtctttaatt ggcaaatgga ctccagaatg
3961 atggagttaa ggactcagag tttttccaac tggttaagag atatttgttc tgggatcacc
4021 atttttaaaa acttcaagga tggaatttgt tggctttata caaaattaaa ggacttttat
4081 gaagtgaatt atggcaagaa gaaggacatt ttaaatattc ttaaagataa ccaacaaaaa
4141 atagagaaag ccattgagga agccgataaa ttttgcattt tgcaaatcca agatgtggaa
4201 aaatctgaac agtatcagaa aggggttgac ttgatacaaa aattgagaac tgtttattca
4261 atggctcagg ttgatccaaa tttaatggtt catttgtcac ctttgagaga ttgtatagca
4321 agagttcatc agaaacttaa aaaccttgga tttataaatc aggcaatggt aacgagatgt
4381 gagccagttg tttgttattt acatggcaaa agagggggag gaaagagctt aacatcaatt
4441 gcattggcaa ccaaaatttg taaacattat ggtgttgagc ctgaaaagaa tatctatact
4501 aaacctgtgg cttcagatta ctgggatgga tatagtggac aattagtttg catcattgat
4561 gatattggcc aaaacacaac agatgaggac tggtcagatt tttgtcagtt agtgtcagga
4621 tgtccaatga gattaaacat ggcctctctt gaggagaagg gtaggcattt ttcttctcct
4681 tttataatag caacttcaaa ttggtcaaat ccaagtccaa aaacagttta tgttaaggaa
4741 gcaattgacc gcagactcca tttcaaggtt gaagttaaac ctgcttcatt tttcaaaaat
4801 cctcacaatg atatgttgaa tgttaattta gctaaaacaa atgatgcaat caaagatatg
4861 tcttgtgttg atttgataat ggatggacat aatgtttcat tgatggattt gctcagttct
4921 ttagtcatga cagttgatat tagaaaacaa aacatgactg aattcatgga gttgtggtct
4981 cagggaattt cagatgataa tgatagtgca gtagctgagt ttttccagtc ttttccatct
5041 ggtgaaccat cgaactctaa attatctggc tttttccaat ctgttactaa tcacaagtgg
5101 gttgctgtgg gagctgcagt tggcattctt ggagtgctcg ttggaggatg ggttgtgtat
5161 aagcatttct cccacaaaga ggaagaacca atcccagctg aaggggtata tcatggtgta
5221 actaagccca agcatgtgat taaattagat gcagatccag tagaatctca gtcaactttg
5281 gaagtagcag gactggttag gaagaacttg gttcagtttg gagttggaga gaagaatgga
5341 tgtgtgagat gggttatgaa tgccttggga gtgaaagatg attggctgct tgtgccttcc
5401 catgcttata aatttgagaa agattatgaa atgatggagt tttattttaa tagaggtgga
5461 acttactatt caatttcagc tggtaatgtt gttattcaat ctttggatgt gggattccag
5521 gatgttgttc tgatgaaggt tcctacaatt cctaagttta gagatattac tcagcatttt
5581 attaagaaag gggatgtgcc tagagctttg aatcgcctgg caacattagt gacaactgta
5641 aatggaaccc ctatgttaat ttctgagggc ccactaaaga tggaagagaa agctacttat
5701 gttcataaga aaaatgatgg tacaacagtt gatttagctg tggatcaggc atggagagga
5761 aaaggcgaag gtcttcctgg aatgtgtggt ggggccttgg tttcatcgaa tcaatctata
5821 cagaatgcaa tcttgggcat ccatgttgct ggaggaaatt caattcttgt tgcaaaattg
5881 gttactcaag aaatgttcca aaatattgat aagaaaattg aaagtcagag aattatgaaa
5941 gtggagttta ctcagtgttc aatgaatgtg gtctccaaaa cgctttttag aaagagtccc
6001 atttatcatc acattgataa aaccatgatt aattttcctg cagctatgcc cttttctaaa
6061 gctgaaattg atccaatggc tgtgatgtta tctaagtatt cattacctat tgtagaagaa
6121 ccagagggtt ataaagaggc ttcaattttt tatcaaaata aaatagtggg taagactcag
6181 ttagttgatg attttctaga tcttgatatg gccattacag gggccccagg aattgatgct
6241 atcaacatgg attcatctcc tggatttcct tatgtccagg agaagttgac caaaagagat
6301 ttaatttggt tggatgaaaa tggtttattg ctgggagttc atccaagatt ggctcagaga
6361 atcttattca atactgtcat gatggaaaat tgttctgatt tggatgttgt ttttacaacc
6421 tgtccaaaag atgaattgag accattagag aaagtgttgg aatcaaaaac aagagctatt
6481 gatgcttgtc ctctggatta cacaattttg tgccgaatgt attggggtcc agctattagt
6541 tattttcatt tgaatccagg tttccataca ggtgttgcta ttggcataga tcctgataaa
6601 cagtgggatg aactatttaa aacaatgata agattcggag atgttggtct tgatttagat
6661 ttctctgctt ttgatgctag tcttagtcca tttatgatta gagaagcagg tagaatcatg
6721 agtgaactat ctggaactcc atcccatttt ggcacagctc tcatcaatac tatcatttat
6781 tccaagcatt tgctgtataa ctgttgctac catgtctgtg gttcaatgcc ctctgggtct
6841 ccttgtacag ctttgctaaa ttcaattatt aataatgtca atttgtatta tgtgttttcc
6901 aagatatttg gaaagtctcc agttttcttt tgtcaggctt tgaagattct ctgttatgga
6961 gatgatgttt taatagtttt ctctcgagat gttcagattg ataatcttga tttgattgga
7021 caaaaaattg tagatgagtt taagaaactt ggcatgacag ctacttctgc tgacaagaat
7081 gtacctcagc tgaaaccagt ttcggaattg acttttctca aaagatcttt caatttggta
7141 gaggatagaa ttagacctgc aatttcggaa aaaacaattt ggtctttaat agcatggcag
7201 agaagcaacg ctgagtttga gcagaattta gagaatgctc agtggtttgc ctttatgcat
7261 ggctatgagt tttatcagaa attctattat tttgttcagt cctgtttgga gaaagagatg
7321 atagaataca gacttaaatc ttatgattgg tggagaatga gattttatga ccagtgtttc
7381 atttgtgacc tttcatgatt tgtttaaatg aactttctt
//GenBank-Updates@genbank.bio.net (03/29/91)
LOCUS HPA24A 7436 bp ss-RNA VRL 29-MAR-1991
DEFINITION Hepatitis A virus polyprotein RNA, complete cds.
ACCESSION M59810
KEYWORDS hepatitis A; polyprotein.
SOURCE Hepatitis A virus (strain HM175, isolate 24a), cDNA to genomic RNA.
ORGANISM Hepatitis A virus
Viridae; ss-RNA nonenveloped viruses; Isometric ss-RNA viruses;
Picornaviridae; Enterovirus.
REFERENCE 1 (bases 1 to 7436)
AUTHORS Lemon,S.M., Murphy,P.C., Shields,P.A., Ping,L.-H., Feinstone,S.M.,
Cromeans,T. and Jansen,R.W.
TITLE Antigenic and genetic variation in cytopathic Hepatitis A virus
variants during persistent infection: Evidence for genetic
recombination
JOURNAL Unpublished (1990)
STANDARD full staff_entry
FEATURES Location/Qualifiers
CDS 719..7399
/product="viral protein"
/codon_start=719
mat_peptide 719..787
/product="viral protein"
/label=vp4
/codon_start=719
mat_peptide 788..1453
/product="viral protein"
/label=vp2
/codon_start=788
mat_peptide 1454..2191
/product="viral protein"
/label=vp3
/codon_start=1454
mat_peptide 2192..3091
/product="viral protein"
/label=vp1
/codon_start=2192
mat_peptide 3092..3658
/product="viral protein"
/label=2A
/codon_start=3092
mat_peptide 3659..3979
/product="viral protein"
/label=2B
/codon_start=3659
mat_peptide 3980..4984
/product="viral protein"
/label=2C
/codon_start=3980
mat_peptide 4985..5203
/product="viral protein"
/label=3A
/codon_start=4985
mat_peptide 5204..5272
/product="viral protein"
/label=3B
/codon_start=5204
mat_peptide 5273..5929
/product="viral protein"
/label=3C
/codon_start=5273
mat_peptide 5930..7396
/product="viral protein"
/label=3D
/codon_start=5930
BASE COUNT 2167 a 1202 c 1632 g 2435 t
ORIGIN
1 gtccctcttg gaagtccatg gtgaggggac ttgatacctc accgccgttt gcctaggcta
61 taggctaaat tttccctttc ccttttctcc tttcctattc cctttgtttt gcttgtaaat
121 attgatttgt aaatattgat tcctgcaggt tcagggttct taaatctgtt tctctataag
181 aacactcatt tcacgctttc tgtcttcttt cttccagggc tctccccttg ccctaggctc
241 tggccgttgc gcccggcggg gtcaactcca tgattagcat ggagctgtag gagtctaaat
301 tggggacaca gatgtttgga acgtcacctt gcagtgttaa cttggctttc atgaatctct
361 ttgatcttcc acaaggggta ggctacgggt gaaacctctt aggctaatac ttctatgaag
421 agatgccttg gatagggtaa cagcggcgga tattggtgag ttgttaagac aaaaaccatt
481 caacgccgga ggactgactc tcatccagtg gatgcattga gtggattgac tgtcggggct
541 gtctttaggc ttaattccag acctctctgt gcttggggca aacatcattt ggccttaaat
601 gggattctgt gagaggggat ccctccattg ccagctggac tgttctttgg ggccttatgt
661 ggtgtttgcc gctgaggtac tcaggggcat ttaggttttt cctcattctt aaataataat
721 gaacatgtct agacaaggta ttttccagac tgttgggagt ggtcttgacc acatcctgtc
781 tttggcagac attgaggaag agcaaatgat tcaatcagtt gataggactg cagtgactgg
841 tgcttcttat tttacttctg tggatcaatc ttcagttcat acagctgagg ttggatcaca
901 ccaggttgaa cctttgagaa cctctgttga taaacccggt tcaaagagga ctcagggaga
961 gaaatttttc ctgattcatt ctgcagattg gcttactaca catgctcttt tccatgaagt
1021 tgcaaaattg gatgtggtga aattattgta caatgagcag tttgctgttc aagggttgtt
1081 gagataccat acatatgcaa gatttggcat tgaaattcaa gttcagataa accctacacc
1141 tttccaacag gggggattga tctgtgctat ggttcctggt gaccagagct atggttctat
1201 agcatcattg actgtttatc ctcatggttt gttaaattgc aatattaaca atgtggttag
1261 aataaaggtt ccatttattt acacaagagg tgcttaccac tttaaagatc cacaataccc
1321 agtttgggaa ttgacaatta gagtttggtc agaattaaat attgggacag gaacttcagc
1381 ttatacttca ctcaatgttt tagctagatt tacagatttg gagttgcatg gattaactcc
1441 tctttctaca caaatgatga gaaatgaatt tagggtcagt actactgaga atgtggtgaa
1501 tctgtcaaat tatgaagatg caagagcaaa gatgtctttt gctttggatc aggaagattg
1561 gaaatctgat ccgtcccagg gtggtgggat caaaattact cattttacta cttggacatc
1621 tattccaact ttggctgctc agtttccatt taatgcttca gcctcagttg gtcaacaaat
1681 taaagttatt ccagttgacc catatttttt ccaaatgaca aatacgaatc ctgaccaaaa
1741 atgtataact gctttggctt ctatttgtca gatgttttgt ttttggagag gagatcttgt
1801 ctttgatttt caagtttttc ccaccaaata tcattcaggt agattactgt tttgttttgt
1861 tcctggcaat gagctaatag atgtttctgg aatcacatta aagcaagcaa ctactgctcc
1921 ttgtgcagta atggatatta caggagtgca gtcaactttg agatttcgtg ttccctggat
1981 ttctgacact ccttacagag tgaacaggta tacaaagtcg gcacatcaga aaggtgagta
2041 cactgccatt gggaagctta ttgtgtattg ttataacaga ttgacctctc cttctaacgt
2101 tgcttcccat gtcagagtga atgtttatct ttcagcaatt aacttggaat gttttgctcc
2161 tctttatcat gctatggatg ttactacaca agttggagat gattctggag gtttttcaac
2221 aacagtttct acagaacaga atgttccaga tccccaagtt ggtataacaa ccatgaaaga
2281 tttgaaagga aaagctaaca gagggaaaat ggatgtttca ggagtacaag cacctgtggg
2341 agctatcaca acaattgagg atccagtttt agcaaagaaa gtacctgaga catttcctga
2401 attgaaacct ggagaatcca gacatacatc agatcatatg tccatctaca agtttatggg
2461 aaggtctcat ttcttgtgca cttttacatt caattcaaat aataaagagt acacatttcc
2521 tataaccttg tcttcaacct ctaatcctcc tcatggtttg ccatcaacac tgaggtggtt
2581 tttcaacttg tttcagttgt atagagggcc tttagatctg acaattattg ttacaggagc
2641 aactgatgta gatggcatgg cctggttcac tccagtaggt cttgccgttg atactccttg
2701 ggtagagaag gagtcagctt tgtctattga ctacaaaact gctcttggag ctgtcagatt
2761 taatacaagg agaacaggga gcattcagat tagattacca tggtattctt atttatatgc
2821 tgtgtctgga gcactggatg gtttgggaga caagacagat tctacatttg gattggtttc
2881 tattcagatt gcaaattaca atcattctga tgagtacttg tcttttagtt gttatttgtc
2941 tgtcacagaa caatcagagt tttattttcc cagagctcca ttgaactcaa atgccatgtt
3001 atccactgaa tcaatggtga gcagaattgc agctggagac ttggagtcat cagtggatga
3061 tcctagatca gaggaagata aaagatttga gagtcatata gaatgcagga agccatataa
3121 agaactgaga ttagaagttg ggaaacaaag actcaagtat gctcaggaag aattgtcaaa
3181 tgaagtactt ccacccccta ggaaaatgaa gggactgttt tcacaagcca atatttctct
3241 tttttatact gaggagcatg aaatgatgaa gttttcctgg agaggtgtga ctgctgatac
3301 tagagcttta aggaggtttg gattctcttt ggccgcaggc agaagtgtgt ggactcttga
3361 aatggatgct ggggttctta ctgggagact gattagattg aatgatgaga aatggacaga
3421 aatgaaggat gacaagattg tttcattgat tgaaaagttt acaagtaaca aatattggtc
3481 caaagtgaat ttcccacatg ggatgttgga tcttgaagaa attgctgcca attctaagga
3541 gtttcctaac atgtctgaaa cggatttgtg tttcttgctg cattggttaa atccaaagaa
3601 aattaattta gcagatagaa tgcttggatt gtctggagtt caggaaatta aagaacaagg
3661 tgttggatta atagcagagt gtagaacttt cttacattct attgctggaa ctttaaaatc
3721 tatgatgttt ggatttcatc attctgtgac tgttgaaatt ataaacactg tgctctgttt
3781 tgttaagagt ggaattttgc tttatgtaat acaacaattg aatcaggatg aacattctca
3841 cataattggt ctgttgagag tcatgaatta tgtagatatt ggttgttcag ttatttcatg
3901 tggcaaagtt ttttccaaaa tgctggaaac agtctttaat tggcaaatgg actccagaat
3961 gatggagtta aggactcaga gtttttccaa ctggttaaga gatatttgtt ctgggatcac
4021 catttttaaa aacttcaagg atggaatttg ttggctttat acaaaattaa aggactttta
4081 tgaagtgaat tatggcaaga agaaggacat tttaaatatt cttaaagata accaacaaaa
4141 aatagagaaa gccattgagg aagccgataa attttgcatt ttgcaaatcc aagatgtgga
4201 aaaatctgaa cagtatcaga aaggggttga cttgatacaa aaattgagaa ctgtttattc
4261 aatggctcag gttgatccaa atttaatggt tcatttgtca cctttgagag attgtatagc
4321 aagagttcat cagaaactta aaaaccttgg atttataaat caggcaatgg taacgagatg
4381 tgagccagtt gtttgttatt tacatggcaa aagaggggga ggaaagagct taacatcaat
4441 tgcattggca accaaaattt gtaaacatta tggtgttgag cctgaaaaga atatctatac
4501 taaacctgtg gcttcagatt actgggatgg atatagtgga caattagttt gcatcattga
4561 tgatattggc caaaacacaa cagatgagga ctggtcagat ttttgtcagt tagtgtcagg
4621 atgtccaatg agattaaaca tggcctctct tgaggagaag ggtaggcatt tttcttctcc
4681 ttttataata gcaacttcaa attggtcaaa tccaagtcca aaaacagttt atgttaagga
4741 agcaattgac cgcagactcc atttcaaggt tgaagttaaa cctgcttcat ttttcaaaaa
4801 tcctcacaat gatatgttga atgttaattt agctaaaaca aatgatgcaa tcaaagatat
4861 gtcttgtgtt gatttgataa tggatggaca taatgtttca ttgatggatt tgctcagttc
4921 tttagtcatg acagttgata ttagaaaaca aaacatgact gaattcatgg agttgtggtc
4981 tcagggaatt tcagatgata atgatagtgc agtagctgag tttttccagt cttttccatc
5041 tggtgaacca tcgaactcta aattatctgg ctttttccaa tctgttacta atcacaagtg
5101 ggttgctgtg ggagctgcag ttggcattct tggagtgctc gttggaggat gggttgtgta
5161 taagcatttc tcccacaaag aggaagaacc aatcccagct gaaggggtat atcatggtgt
5221 aactaagccc aagcatgtga ttaaattaga tgcagatcca gtagaatctc agtcaacttt
5281 ggaaatagca ggactggtta ggaagaactt ggttcagttt ggagttggag agaagaatgg
5341 atgtgtgaga tgggttatga atgccttggg agtgaaagat gattggctgc ttgtgccttc
5401 ccatgcttat aaatttgaga aagattatga aatgatggag ttttatttta atagaggtgg
5461 aacttactat tcaatttcag ctggtaatgt tgttattcaa tctttggatg tgggattcca
5521 ggatgttgtt ctgatgaagg ttcctacaat tcctaagttt agagatatta ctgagcattt
5581 tattaagaaa ggggatgtgc ctagagcttt gaatcgcctg gcaacattag tgacaactgt
5641 aaatggaacc cctatgttaa tttctgaggg cccactaaag atggaagaga aagctactta
5701 tgttcataag aaaaatgatg gtacaacagt tgatttaact gtggatcagg catggagagg
5761 aaaaggcgaa ggtcttcctg gaatgtgtgg tggggccttg gtttcatcga atcaatctat
5821 acagaatgca atcttgggca tccatgttgc tggaggaaat tcaattcttg ttgcaaaatt
5881 ggttactcaa gaaatgttcc aaaatattga taagaaaatt gaaagtcaga gaattatgaa
5941 agtggagttt actcagtgtt caatgaatgt ggtctccaaa acgcttttta gaaagagtcc
6001 catttatcat cacattgata aaaccatgat taattttcct gcagctatgc ccttctctaa
6061 agctgaaatt gatccaatgg ctgtgatgtt atctaagtat tcattaccta ttgtagaaga
6121 accagagggt tataaagagg cttcaatttt ttatcaaaat aaaatagtgg gtaagactca
6181 gttagttgat gattttctag atcttgatat ggccattaca ggggccccag gaattgatgc
6241 tatcaacatg gattcatctc ctggatttcc ttatgtccag gagaagttga ccaaaagaga
6301 tttaatttgg ttggatgaaa atggtttatt gctgggagtt catccaagat tggctcagag
6361 aatcttattc aatactgtca tgatggaaaa ttgttctgat ttggatgttg tttttacaac
6421 ctgtccaaaa gatgaattga gaccattaga gaaagtgttg gaatcaaaaa caagagctat
6481 tgatgcttgt cctctggatt acacaatttt gtgccgaatg tattggggtc cagctattag
6541 ttattttcat ttgaatccag gtttccatac aggtgttgct attggcatag atcctgataa
6601 acagtgggat gaactattta aaacaatgat aagattcgga gatgttggtc ttgatttaga
6661 tttctctgct tttgatgcta gtcttagtcc atttatgatt agagaagcag gtagaatcat
6721 gagtgaacta tctggaactc catcccattt tggcacagct cttatcaata ctatcattta
6781 ttccaagcat ttgttgtata actgttgcta ccatgtctgt ggttcaatgc cctctgggtc
6841 tccttgtaca gctttgctaa attcaattat taataatgtc aatttgtatt atgtgttttc
6901 caagatattt ggaaagtctc cagttttctt ttgtcaggct ttgaagattc tctgttatgg
6961 agatgatgtt ttaatagttt tctctcgaga tgttcagatt gataatcttg atttgattgg
7021 acaaaaaatt gtagatgagt ttaagaaact tggcatgaca gctacttctg ctgacaagaa
7081 tgtacctcag ctgaaaccag tttcggaatt gacttttctc aaaagatctt tcaatttggt
7141 agaggataga attagacctg caatttcgga aaaaacaatt tggtctttaa tagcatggca
7201 gagaagcaac gctgagtttg agcagaattt agaaaatgct cagtggtttg cctttatgca
7261 tggctatgag ttttatcaga aattctatta ttttgttcag tcctgtttgg agaaagagat
7321 gatagaatac agacttaaat cttatgattg gtggagaatg agattttatg accagtgttt
7381 catttgtgac ctttcatgat ttgtttaaat gaactttctt aaaatttctg aggttt
//