GenBank-Updates@genbank.bio.net (03/29/91)
LOCUS HUMRARA 748 bp ds-DNA PRI 29-MAR-1991
DEFINITION Human retinoic acid receptor alpha (RAR-alpha) gene, exon 2.
ACCESSION M61111
KEYWORDS retinoic acid receptor alpha.
SOURCE Human embryo lung fibroblast cell line W138 DNA, clone alpha-1.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 748)
AUTHORS Alcalay,M., Zangrilli,D., Pandolfi,P.P., Longo,L., Mencarelli,A.,
Giacomucci,A., Rocchi,M., Biondi,A., Rambaldi,A., Lo Coco,F.,
Diverio,D., Donti,E., Grignani,F. and Pelicci,P.G.
TITLE Translocation breakpoint of acute promyelocytic leukemia lies
within the retinoic acid receptor alpha locus
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 88, 1977-1981 (1991)
STANDARD full staff_entry
FEATURES Location/Qualifiers
intron 1..573
/number=1
/gene="RAR-alpha"
/partial
misc_feature 201..202
/note="APL t(15:17) breakpoint in patient AML-P1"
exon 574..722
/number=2
/gene="RAR-alpha"
intron 723..748
/number=2
/gene="RAR-alpha"
/partial
BASE COUNT 134 a 202 c 238 g 174 t
ORIGIN Chromosome 17.
1 ttctttgcac cccctgcctt gggtccctgg ccctgggatt gtttgggtgg aggaggggca
61 gtggctgctg gcagaatggg gtggaggggg gagcggaagc agagggggcg ggggagtggc
121 cggctttgaa tatcctgttg accccagttt cctctgcccc cagcttatgt cctcttccct
181 ccctcctctt caagcgttaa ctccttccta actcgggggg agaacggggc caggccccca
241 ggggcaggag ctttagaatc agggtgaccc ccacccctac tccccaagca cagtcacggc
301 acacatacaa atgtgatggt ttatcattgt atctttgtgg ttttgaaggt gggggtccta
361 ggagtccaga ggagtgatgg ggtgctggag gcttcattgg cagcctcctg ccctgagtct
421 ggctggggag tcccagtttt cttaagactt gaatcctgcc agcagtggtg aggctgggag
481 aggctcttag gagggacggt gaggcagggt ggagcttggt actaaggatg gcgacctagg
541 tctctaactg cccctcccct cttctctctc tagccattga gacccagagc agcagttctg
601 aagagatagt gcccagccct ccctcgccac cccctctacc ccgcatctac aagccttgct
661 ttgtctgtca ggacaagtcc tcaggctacc actatggggt cagcgcctgt gagggctgca
721 aggtgagttg aaggggtcat tgggaagg
//