GenBank-Updates@genbank.bio.net (03/30/91)
LOCUS HUMP45C17S 8673 bp ds-DNA PRI 30-MAR-1991
DEFINITION Human P450XVIIA-1 (steroid 17-alpha-hydroxylase/17,20 lyase) gene,
complete cds.
ACCESSION M63871
KEYWORDS cytochrome; cytochrome P; cytochrome P-450.
SOURCE Human DNA, Maniatis library (Lawn, et al.), clones lambda-hM171 and
lambda-hM17-2.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 8673; 1 to 8549; 1792 to 8673)
AUTHORS Picado-Leonard,J. and Miller,W.L.
TITLE Cloning and sequence of the human gene for P450c17 (steroid
17-alpha-hydroxylase/17,20 lyase): Similarity with the gene for
P450c21
JOURNAL DNA 6, 439-448 (1987)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 8673; 1667 to 1791)
AUTHORS Brentano,S.T., Picado-Leonard,J., Mellon,S.H., Moore,C.C. and
Miller,W.L.
TITLE Tissue-specific, cyclic adenosine 3',5'-monophosphate-induced, and
phorbol ester-repressed transcription from the human P450c17
promoter in mouse cells
JOURNAL Mol. Endocrinol. 4, 1972-1979 (1990)
STANDARD unannotated staff_entry
COMMENT Clean copy of sequence [DNA 6, 439-448 (1987)] kindly provided by
W.L.Miller,
08-DEC-1988.
FEATURES Location/Qualifiers
CDS join(1963..2259,3928..4066,4300..4529,5192..5278,
5973..6188,6421..6590,7488..7591,8110..8393)
/note="cytochrome P450c17"
/codon_start=1963
repeat_region 1446..1517
/note="Alu repeat"
exon 1963..2259
/note="cytochrome P450c17, exon 1 /nomgen='CYP1'
/map='15q22-q24' /hgml_locus_uid='LP0063X' (EC 1.14.99.9)"
prim_transcript 2027..8561
/note="P450c17 mRNA and introns"
intron 2260..3927
/note="cytochrome P450c17, intron A"
repeat_region 2846..3051
/note="Alu repeat"
exon 3928..4066
/note="cytochrome P450c17, exon 2"
intron 4067..4299
/note="cytochrome P450c17, intron B"
exon 4300..4529
/note="cytochrome P450c17, exon 3"
intron 4530..5191
/note="cytochrome P450c17, intron C"
exon 5192..5278
/note="cytochrome P450c17, exon 4"
intron 5279..5972
/note="cytochrome P450c17, intron D"
repeat_region 5530..5722
/note="Alu repeat"
exon 5973..6188
/note="cytochrome P450c17, exon 5"
intron 6189..6420
/note="cytochrome P450c17, intron E"
exon 6421..6590
/note="cytochrome P450c17, exon 6"
intron 6591..7487
/note="cytochrome P450c17, intron F"
repeat_region 6892..7031
/note="Alu repeat"
exon 7488..7591
/note="cytochrome P450c17, exon 7"
intron 7592..8109
/note="cytochrome P450c17, intron G"
exon 8110..8393
/note="cytochrome P450c17, exon 8"
BASE COUNT 2076 a 2350 c 2055 g 2192 t
ORIGIN 265 bp upstream of HincII site; chromosome 15q22-q24.
1 gagcaagcct tcatcccgac ggcacactta tataaaaaag aaagggagag atgtatgcgg
61 gaagtcaggg acctgaatga agggactgct ggagccatgg cagaggaaca taaattgtga
121 agatttcatt taatatggac atttatcagt tcccaaataa tacttttata atttcttatg
181 cctgtcttta ctttaatctc ttaatcctgt tatctttgta agctgaggat gtttgtcact
241 tcaggaccac tgtgataatt gtgttaactg tacaaattga ttgtaagaca tgtgtttgaa
301 caatatgaaa ttagtgcacc ttgaaaaaga acacaataag agcaattttt agggaacaag
361 ggaaaacaac cataaggtct gactgcctgc agggtcgggc agaaagagcc atattttcct
421 tcttgagaga ggctataaat ggacatgcaa gtagggaaga tatcactaaa ttcttttcct
481 agcaaggagt attattatta ataccctggg aaaggaatgc attcctgggg ggaggtctat
541 aaacagccgc tctgggaatg tctatcttgt gcagttgaga taaggactga gatacgccct
601 ggtctcctgc agtaccctca ggcttactag ggtggggaaa aactccgccc tggtaaattt
661 gtggtcagac cggttctctg ctgtcgaagg gtgtttgctg ttgtttaagg tgtttatcaa
721 gacagtatgt gcaccgctga acatagaccc tcatctgtag ttctgctttt gccctttgcc
781 ttgtgatctt tgttggaccc ttatcagtgg ttctgctttt gccctttgcc ttgtgatctt
841 tgttggaccc ttatcggtag ttctgctttt tgccctttgt cctttccctc agaagcatgt
901 gatctttgtt agacacttat tagtagttct gcttttcgcc ctttgaagca tgtgatcttt
961 gtaccctact ctccctgttc ttacaccccc tccccttttt gaaaccctta ataaaaactt
1021 gctggtttga ggctcaggtg ggtatcacag tcctaccgat atgtgatgcc acccccggcg
1081 gcccagctgt aaaattcctc tctttatact gtctctcttt atttctcagc cggctgacac
1141 ttatagaaag aacctacgtt gaaatattgg gggtgggttc ccccagtacg ctagtcctgc
1201 tgatgagcaa agaaggtgtt gatggcattt tgatcaacaa gaaatgttat gaaacggcct
1261 cccacctctg gcattcctag tactgaccta tctctccctt cccttccacc gctccccaca
1321 gcccttccac cgctccccac agcttagcac ccctttcgtt cccatacaca tgtacatttt
1381 tattttgggg accattaacc cgacagccct tatcgctgcc aaaaccacat gggctggagg
1441 gccagggctg catggacagt cacaccactg cacaccagcc tggtgatgga gcaagactct
1501 gaaaaaaaaa aaaagaagca taaaagacct ttaacagtcc ctgctacttg tgaccctcct
1561 gaatctgtca tctgtccagt gattttgatt ttgcagcatg gaaagttcca agccttgact
1621 cctgagccca gataccattc gcactctgga gtcattcaag catgggcttc cagagggttt
1681 gatcaactga cctcccttac ctagctcctc ctccggaggt ttgccctgga gttgagccag
1741 cccttgagga ggccttcact cccaccgcct ctctcccttc tggatatgag gagctcaggc
1801 ctggctgggc tccaggagaa tctttcttcc acaaggcaag agataacaca aaagtcaagg
1861 tgaagatcag ggtagccctt taaaaggcct ccttgtgccc tagagttgcc acagctcttc
1921 tactccactg ctgtctatct tgcctgccgg cacccagcca ccatgtggga gctcgtggct
1981 ctcttgctgc ttaccctagc ttatttgttt tggcccaaga gaaggtggcc tggtgccaag
2041 taccccaaga gcctcctgtc cctgcccctg gtgggcagcc tgccattcct ccccagacat
2101 ggccatatgc ataacaactt cttcaagctg cagaaaaaat atggccccat ctattctgtt
2161 cgtatgggca ccaagactac agtgattgtc ggccaccacc agctggccaa ggaggtgctt
2221 attaagaagg gcaaggactt ctctgggcgg cctcaaatgg taagtggtgc ccatctcctc
2281 cctgccccct tcaccacccc ctgggattgg ttcaggtctt cagaccatgc ctagaatggg
2341 gcttccagct ccaacaacct gtatttcttc ccaaaagtag actagtggga tgatgtgaag
2401 ggagtgaacc ttcagacccc cacccagcct ctaaattagg caggttgaat taaaggaatg
2461 tctcctctac caggctgccc aggaggtggg atgggaggac cacagtggtc tgaggggtca
2521 aggaatcctc actccactcc tctctctgag cctagacttc tctaatggac tgagaaggtg
2581 catgtacagc acttagccta gcacccagca cagtaagtgc ccttatacag ccaggattca
2641 tgttactttt catggaaaat gggggcagtg actactgtcc tccatgaaag ctgctgggga
2701 gaattagcct agctattgca ggctgggatt gctgctttcc tggtgctatt tccagctact
2761 caggctcaca ggggcagttt tctacaatga catttcaggg ttgctgatga gcctcccact
2821 cagcagggcc cccagcctct cagcattttt tttttttttt tttttttttg agacagagtc
2881 tctctctgtc gcccagcctg gagtgcagtg gccaatctca gctcactgca acctctgcct
2941 cccgggtcaa gtgattctcc tgcctcagac tcctgagtac ctgggactac aggagcatgc
3001 caccatgccc gctaattttt tgtattttta gtagagatgg tgtttcacca tgttagccag
3061 gatggtctcg atctcctgac ctcgtgatcc tcccacctta gcctcccaaa gtgctaggat
3121 tataggcgta agccactgtg ccctgccagc ctctcagctt tgatcaagcc aagggttggt
3181 ttattttttc ttggaccaat cagccaggtc tgctgaccaa ctacctagct cccacctctg
3241 ctggcttcct cccgggggca gagaagatgg agaaggctag tcatgtggat cttcagggtc
3301 aggaaatgga aaagggaggc tttggaccct tttgctttgg ggggcacctc tagaagaagc
3361 gctcgcccaa gtccagactg ggtagacaaa catctgcact ctccaaatgt gggcttgtgg
3421 ctgggtatgc aggcttgcaa tggaagggta aacctgagtg aggtgagctg tgcctttagc
3481 tcagctaagg gctcagggaa aagcagagat ctgtgcagtc ctcagcctct acaagctcac
3541 ctgctcccta ccctctggac aggcatagtt tagagagttt atcccatcca gagttgcctt
3601 cctgtggtca gaaactgatg agcaaaaaga agccagaggg caccctgtca gcgaaaagaa
3661 ccccaatgct gctgcattct aattaagggt tctttctttc tccttgatct actgtatttc
3721 tgaaggaatt gggagtagga ggccttaggg tctgtcctac caagtccttg cagtcatggt
3781 ggagtgcagt ggggctgtgc ccacatggga gtcagcatgc caggtacctc ccttctcctc
3841 caggaaggaa agcagggacc agaggtgtaa gggcaagagt ggggtggatg ggtgtgagat
3901 tcctacagcc ttgcctgctc tctaaaggca actctagaca tcgcgtccaa caaccgtaag
3961 ggtatcgcct tcgctgactc tggcgcacac tggcagctgc atcgaaggct ggcgatggcc
4021 acctttgccc tgttcaagga tggcgatcag aagctggaga agatcagtga gtgccaggct
4081 ggcccctggg gctggggctg gatcccacag gagctgctgg agggagagga gggttgggca
4141 ggggtaaggg gttaggacta gagcgcaatg cagccttttc ttggctactg ctgccatcta
4201 gtggcatctg ctatctgtcc cccgctcctg aggcaactgg tacagagagg gggtaagggt
4261 gctgattcat ttccaccctc atgccccctc tcccttcagt ttgtcaggaa atcagtacat
4321 tgtgtgatat gctggccacc cacaacggac agtccataga catctccttt cctgtcttcg
4381 tggcggtaac caatgtcatc tccttgatct gcttcaatac ctcctacaag aatggggacc
4441 ctgagttgaa tgtcatacag aattacaatg aaggcatcat agacaacctg agcaaagaca
4501 gcctggtgga cctagtcccc tggttgaagg tgagatgctg ccagccctgc cttcaggttc
4561 tagtagaccc tgacattgtc cccaatcttc cttccttttt acttccctgc tccagccgca
4621 atgacccatc tttttcctga ttacctccgc cacctctacc tcctctgcca cttaaaacct
4681 ttgccatttc tctgcagaga taagatttag ccttttaatt atgcacctta gtactccaga
4741 taatgacctt catttctttt ccaattacca tgtgccagta ctaagcattc tatacgcatt
4801 catcgctgaa ttcctttgga agtaggtttt attatcccca ttgtgcaggt gagaagcagg
4861 cttagcgggg ttaaggagct tgtctgagcc ttcaggtcat cgtctctctc actcctaagg
4921 gctggacaca tagcagagtc agcgcttgat gtttgattga atggggaagg agaggtggag
4981 accacgccct cctcccttgt ttagaattgt cttcgtcgtc atgataaacc cgttctgtgt
5041 ccccatcttg ccttccattc tggctgaagg tcaggggtgg agtaggaact tccagagaca
5101 gaaaagctaa gatccgcctc caggagagac tctggcagct ggagaagcaa aatggaagaa
5161 gggtggattt aacatttctt tttatttcca gattttcccc aacaaaaccc tggaaaaatt
5221 aaagagccat gttaaaatac gaaatgatct gctgaataaa atacttgaaa attacaaggt
5281 aggtgataga gcagaagaga atatgagtta ggctaaaagg aatcacaaga gcagggtgga
5341 gtccattcta cacactgtag aagcttcaaa accaagcaga gaacctggca catagtaggt
5401 gtacaataaa aactgactta agggctgggc gcggtggctc atgctgtaat cccaacactt
5461 tggaggccga ggtgggcaga tcacctgagg ttgggaggtt cgagaccagc ctgaccaaca
5521 tggagaaact ctgtctctac taaaaataca aaattagccg ggcacggtgg cgcatgccta
5581 taatcccagc taatttcggg aggctgaggc aggagactca cttgaacccg agaagcagag
5641 gttgcagtga gctgagatca tgccattgca ctccagcctg ggcattgcac caagattctg
5701 tctcaaaaaa aaaaaaaaaa aactgactca aggagttggg atcgaaaagt gaggaactga
5761 agaggatcct agaagagacc taacctctcc accaatttaa aaagggcccg gggctgcctc
5821 ctacctccac acgttcgtag gtcctgccca gacttgctct acttccaagt ggaaggagcc
5881 ttgttatctc tagtcaggga cagaagtatg gcaggagtgt cacagatggg gctccttcct
5941 tattaatgtc tcccaaacct cacccaaccc aggagaaatt ccggagtgac tctatcacca
6001 acatgctgga cacactgatg caagccaaga tgaactcaga taatggcaat gctggcccag
6061 atcaagattc agagctgctt tcagataacc acattctcac caccataggg gacatctttg
6121 gggctggcgt ggagaccacc acctctgtgg ttaaatggac cctggccttc ctgctgcaca
6181 atcctcaggt gtgcttcccc ctcattgatc ctagacccca gccagcccaa tctctgggct
6241 ccagagaaag ggagagccaa ttctctcagg ctttctgtgc aggaagacta ggccccagag
6301 ccactactgg gaagggactg gacaggctct tctcgatcgt cacagttgga ttattctcta
6361 agcccttgcc tctcctgggc ttacacacac tagtcacctc caacctactc tggtcttcag
6421 gtgaagaaga agctctacga ggagattgac cagaatgtgg gtttcagccg cacaccaact
6481 atcagtgacc gtaaccgtct cctcctgctg gaggccacca tccgagaggt gcttcgcctc
6541 aggcccgtgg cccctatgct catcccccac aaggccaacg ttgactccag gtgtgcctgc
6601 cctcccagtg acatctagcc ccatgatgca ttcactgctt gccagcccac ctggctcccc
6661 ctacccccgc ccctgctggc caacctaaag tcagtcaacc atcaactact aaaaatcatc
6721 ctgccggctg ggcactggct cacacctgtc atcccaacac tttgggaggt gaggcgggtg
6781 gatcatgagg tcaggggttc aagaccagcc tgaccaatta tggttgaaac ccccgtctct
6841 tacttaaaat acaaaaaatt agccatgcat cgtggcgctg tcctgtagtc ccagctactc
6901 aggaggctga ggcaggagaa tcacttgaac caaggcggcg gaggttgcag tgagccaaga
6961 ttgcaccact gcactccagc ctgggtgaca gagcgggact ctgtctcaaa ataaataatt
7021 aattaattaa atataaaaat catcctgccc ccagccccgt ggctccatat ctctaccacc
7081 tacagacacg cattgactca tccacagatc tgcctgactt cccagaggag cttcctgctg
7141 ccctcagaga catgtggtct gggatgaaag gctgggagct ccatgttcca accagctgca
7201 gcacgcacat aacatgcgct gcagctccaa acacacaccc acatacactg ccagacacca
7261 aagtccacag acacaggtgt tcagacagaa gcgcctgtta ggagggaagg gatggagaag
7321 ggctggattt aggtttgatc tggcagaagc tgaggaaaac atgagtgagt gggaatgagg
7381 gagtaaaggg cattttcctc acggcggaag aatgaggggg catgaggctg agcaaggaag
7441 ggagtacgaa gtcccagacc cacttttcct cttccactct ggagcagcat cggtgagttt
7501 gctgtggaca agggcacaga agttatcatc aatctgtggg cgctgcatca caatgagaag
7561 gagtggcacc agccggatca gttcatgcct ggtgagtctg tcctgtcctg cgccctgggc
7621 cacacagcga gcctggactc tgctccaacc accccagtac cccttcacct ctgcaaagct
7681 tccgctagaa agctcttggc tccaactata ccgacctgtt gacgccctca tcctgccata
7741 gacttaccca aactcttcac agctgggttt cccacgctct tcttccaacc aactgcaaat
7801 tcaccctcca agaagccctc tactcctctg tctgccatta agtctgtccc ttctcccctc
7861 ggatggtgct attttcatag gttaattcca cctcttttcc atccttcctg aatatttcat
7921 ttcctctgtg tcgttaaggg ctacctgaaa gcagggctgt atctctcccc aggcgggttc
7981 cccataataa ggctacatcc tcagatcagg gttccctggg agggccatgt ctccccctca
8041 accagggcag aaccatgcct ctcctccctc ctgccctaac ccctggctga tgccactcct
8101 tgccagcaga gcgtttcttg aatccagcgg ggacccagct catctcaccg tcagtaagct
8161 atttgccctt cggagcagga cctcgctcct gtataggtga gatcctggcc cgccaggagc
8221 tcttcctcat catggcctgg ctgctgcaga ggttcgacct ggaggtgcca gatgatgggc
8281 agctgccctc cctggaaggc atccccaagg tggtctttct gatcgactct ttcaaagtga
8341 agatcaaggt gcgccaggcc tggagggaag cccaggctga gggtagcacc taaaggctgt
8401 aactcacagc ccctgtccac cctatgtggc cccacaacac agatttagag atacaacccc
8461 ccacccttct ccgccattct tccctactcc caacccactc tgccttcttt ttcagcttgt
8521 ggcaatgcca gtgatgtgca taaacagttt tttttttttc cataaggtcc ctgagtagtt
8581 catttatgta ttcatttgct cactcattct ttcaacaccg attttattga gcacctacta
8641 tgtgccattc tctttctcag gacactcgag ctc
//