GenBank-Updates@genbank.bio.net (04/05/91)
LOCUS HUMCBRG 3326 bp ds-DNA PRI 05-APR-1991
DEFINITION Homo sapiens carbonyl reductase gene, complete cds.
ACCESSION M62420
KEYWORDS carbonyl reductase.
SOURCE Human, DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3326)
AUTHORS Forrest,G.L., Akman,S., Doroshow,J., Rivera,H. and Kaplan,W.D.
TITLE Expression of a cloned genomic human carbonyl reductase gene with
daunorubicin reductase activity
JOURNAL Unpublished (1991)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
mRNA join(185..566,1112..1219,2608..3044)
/gene="CBR"
CDS join(278..566,1112..1219,2608..3044)
/EC_number="1.1.1.184"
/product="carbonyl reductase"
/gene="CBR"
/codon_start=278
exon 185..566
/number=1
/gene="CBR"
exon 1112..1219
/number=2
/gene="CBR"
exon 2608..3044
/number=3
/gene="CBR"
BASE COUNT 755 a 902 c 802 g 867 t
ORIGIN
1 gcctcggtct tcggcctgcg ggttctgcaa agtcaggcta gctggctctc cgcctgctcc
61 gcaccccggc gaggttccgg tggggagggg tagggatggt tcagccccgc cccgctaggg
121 cggggcctgc gcctgcgcgc tcagcggccg ggcgtgtaac ccacgggtgc gcgcccacga
181 ccgccagact cgagcagtct ctggaacacg ctgcggggct cccgggcctg agccaggtct
241 gttctccacg caggtgttcc gcgcgccccg ttcagccatg tcgtccggca tccatgtagc
301 gctggtgact ggaggcaaca agggcatcgg cttggccatc gtgcgcgacc tgtgccggct
361 gttctcgggg gacgtggtgc tcacggcgcg ggacgtgacg cggggccagg cggccgtaca
421 gcagctgcag gcggagggcc tgagcccgcg cttccaccag ctggacatcg acgatctgca
481 gagcatccgc gccctgcgcg acttcctgcg caaggagtac gggggcctgg acgtgctggt
541 caacaacgcg ggcatcgcct tcaagggtat ggggagggga cgtggcctcc ccgaagaaga
601 accgatgcac tggggctcct ggcgtctgcg gggtccataa cgcctcccta gggaggagag
661 ggaggagcta ggagatgcag ggagtgcaga aaccttggag aaagtgagag ttttccagcc
721 aaagggaact ttgtgtttcc ctggctggga ctcttgggga tctttttcag gttttctgca
781 gtttttctga attgagcttt aaggcaactg gatggatttt gaactgattt taaaataaac
841 gacaaattgc aaaaagaaaa aatggttatg ccaagatcca gtgtgtgcac ccttcatcct
901 ccttccccca atggtgccat cttacaaaaa tactagaaca tgatcaaacc aggagattga
961 cattggcaca atactgtaac cagatacaga cttactttag gcagagggca ctaagttttt
1021 gttttttttt tttttttttt ttagtatcat tgtatagaat tttaccccat gggtacaatg
1081 tattaactat gttctctttc tctcctaaaa gttgctgatc ccacaccctt tcatattcaa
1141 gctgaagtga cgatgaaaac aaatttcttt ggtacccgag atgtgtgcac agaattactc
1201 cctctaataa aaccccaagg tgagtctgat gggaaacagc gcaccttctc tttggggctt
1261 gatttggccc ctgcttgcct gggatttctc ctgcaggctc ctgcttcctc tccatgctgc
1321 acgtgcactg acctctgtgc tttttctcct gccagctgat atgtgccatt ttgcctcagg
1381 actttgtcct cacttctccc actcccatgg ccattcgtcc tccctgtcgc actggtcttt
1441 gcacacctgg ctgactctca tccttcaggt cttagctcaa acgtctcctg agagatgctc
1501 tttatttgct ccattcccct ccgcgtggga gtccatcctg taccctttct ctgctctttc
1561 agagagatct tattcaggct ggtggaggct ttactaccac cagttcatta ggcccttcta
1621 atacctgtca cctgtctgaa acactcctta agctcccaac cacatggttg tcttgctgcc
1681 tttccatctc ttcctgatgc ctttccccac aatctaagat atttccagag gatccctatc
1741 cttttcccta agtcgtttgg gacacagacc ccaccaccca cccaccagga tcctgcaggt
1801 caccatgccc cacccctcat aatcatttac taggtcctag gagtagtgcc cactgagttc
1861 ctcctgaatc cgtctcattg cagctctaca gcaggccctc acctgtccct ctggacaatt
1921 gcaaaccctc acaaggcacc tctggtcttg agtcttttcc tcttttcctt tcccagcatc
1981 ctgcgtactg tctgcatggt catgcctctc ccaaaatcct tcaggaggaa agtccaagcc
2041 cttagcatgg ttcacagaga tgtccataat ctgccgctgc ttaactctgg gcccatttta
2101 actccccttc aacgtgctga aggtgctgga catgactatc acatgtcttt ggttgtaaac
2161 tgctgtgata gttaccctaa gtaatgggac aggagatgaa cccacccatt aaataacaca
2221 gcaattaagc agccactttt agaaaaattt aaatgtgtgg cttcgagttg ggtacttgca
2281 tgtacagctt actctcagct tttatcctgt ttccctgtcc tgtcgtcctg ttaagttgtg
2341 ctacttctaa ggctctggtt caccaggacc tcaaagggca gctcttccaa atctcacctg
2401 actctactca gccaaaattc gaaggcagga atgaacttct tcatgcaact accaccacac
2461 tttctatgcg tattcctctt agaactcata ccagtaactg tctctcatat gaaaattttc
2521 tgctccaaaa tccctgcaaa tttggcattc acctctctac gggattgttg cacacctttc
2581 tacataatgc tttgtggtgt atcttaggga gagtggtgaa cgtatctagc atcatgagcg
2641 tcagagccct taaaagctgc agcccagagc tgcagcagaa gttccgcagt gagaccatca
2701 ctgaggagga gctggtgggg ctcatgaaca agtttgtgga ggatacaaag aagggagtgc
2761 accagaagga gggctggccc agcagcgcat acggggtgac gaagattggc gtcaccgttc
2821 tgtccaggat ccacgccagg aaactgagtg agcagaggaa aggggacaag atcctcctga
2881 atgcctgctg cccagggtgg gtgagaactg acatggcggg acccaaggcc accaagagcc
2941 cagaagaagg tgcagagacc cctgtgtact tggccctttt gcccccagat gctgagggtc
3001 cccatggaca atttgtttca gagaagagag ttgaacagtg gtgagctggg ctcacagctc
3061 catccatggg ccccattttg taccttgtcc tgagttggtc caaagggcat ttacaatgtc
3121 ataaatatcc ttatataaga aaaaaaatga tctcttatca attagcactc actaatgtac
3181 tactaattga gcaacctacg cactcagttg actacgtaaa tctgtcaggt cttttgtgat
3241 ttcctctgat gcaggagagg aaaaattgta attgatgaaa ataatgaatg aaaatcaaca
3301 gatgaataaa tggttcttta taagtg
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