GenBank-Updates@genbank.bio.net (04/05/91)
LOCUS HUMCATD1 3516 bp ds-DNA PRI 05-APR-1991
DEFINITION Human cathepsin D (catD) gene, exons 1 and 2.
ACCESSION M63134
KEYWORDS aspartic proteinase; cathepsin D.
SEGMENT 1 of 5
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Redecker,B., Heckendorf,B., Grosch,H.-W., Mersmann,G. and
Hasilik,A.
TITLE Molecular organization of the human cathepsin D gene
JOURNAL DNA Cell Biol. (1991) In press
STANDARD full staff_review
FEATURES Location/Qualifiers
exon 812..947
/number
/EC_number="3.4.23.5"
/product="cathepsin D"
/gene="catD"
exon 3269..3428
/number=2
/EC_number="3.4.23.5"
/product="cathepsin D"
/gene="catD"
BASE COUNT 607 a 1050 c 1240 g 619 t
ORIGIN Map position: 11 p15.
1 gtcgacgtga gtggacaaaa ggtgcccgac ctcctaaggg aaggagcttc tctagaaaac
61 gcgaatttcg ccccctcaag agacagctgt gcagtgccat atcaaaacat gtgaaaggaa
121 tgtattttag ggtggaatac tttgcctgcc ttcgggcctg ctgtctgcca cgtgaggctg
181 tgccagtgtg aggctggaat ttgggatctg gaggctagag ccatcggtga ggcctgagtc
241 tctaagcaca gcgcccagag ggagagggcg gacgggtccg accccctttg cggcagggcc
301 tgagctggtt ttccaggttt ctctggaagc cctgtagagg agcggagggt ccattcggtg
361 ggctggggac tttgaattta accttggttt gcaagaggct tccagagagg atgtctggga
421 gcgtctggag ggggacgagg gggcgccggg aggagcaggt gcaggagccc acggcgcagg
481 ccccgcgcag gcctggacgc ggggacggcc gcggcggccg ggacaggggt caccccgcgg
541 ggccctccag ggtgggccgc cccacgaccc caggccaggc cgaaacggga atcctccaga
601 ccccagaagc tgggccgggc tgaccccgcg ggcgcgagcg gcgggaactg taggcgcggc
661 aggccaccac caccccgccc cccgcccggg cgctgtgcgt gcccgaggtt gccccgccca
721 ggccaggccc cgctccgccc cgccccgcgc acgccggccg cgcccacgtg accggtccgg
781 gtgcaaacac gcgggtcagc tgatccggcc caactgcggc gtcatcccgg ctataagcgc
841 acggcctcgg cgaccctctc cgacccggcc gccgccgcca tgcagccctc cagccttctg
901 ccgctcgccc tctgcctgct ggctgcaccc gcctccgcgc tcgtcaggtg aagcctcagg
961 ggccggggct cagggacggg caggggtcgc ggcgccgagg tcccggggcc tgtggtgact
1021 ttcgcgctcc cctgtggccc ccacgagccc cttgcgcccc ccgcgctgga atgcacctgt
1081 gccgccctgc gcggcctcct gcacggacca cccgcctacg gggcgccggg ctccggaggt
1141 gcaggggacc cggggcagag gcgccagatg cctctccccc atatgccacc ctgggttgta
1201 ccttgaggac tgcagactga ccgcagcctc cctggagacg gggcggggcg gggggaggta
1261 gtgctcattc ggggcaggtg gaattggggt ctgtactgag cgcccttgtt gctggagacc
1321 taggtcaggc ctcagagccc ccgagtctgg gcgagtccat ttccttaggg acccctttac
1381 cacctgtgaa ctgggggctt taaaagtttg ctccagcggc tcttatcaca ggccctgggc
1441 tgggagaccc ctcgagaccc taggagttcc catgtccctg agagaggagg aggcatgggg
1501 agtgggtcgg ctcacccacc ccgggcctgg ggttgtgctg tagtgaggcc cacacgctcc
1561 tcaggccgat cccctgtgcc aggtgaggcc accgattggg cctggatggg atggggcccg
1621 gccatgcctg accagctggg cagaggaggg ccatgctgca gtctgctttc ttgaccccct
1681 ccccagccct tgcaaggcag cccgcattcc caggaggggt atgctgaccc atcccattgg
1741 gcacctgccc cacccttgct ctgggccttt gtgggagacc tgggatctgc gatgggtcca
1801 ctgccttttg gcaggtgggt gaggtcagaa ggctgcaggg gctggagctg gctgggccag
1861 ctgggtagga ctgagcctca ccaaaggctg tggggaatgg cccgggggcg ggtagcccca
1921 attaaagtcg ttgtggggga gtagccacaa gcctgagcct gccttgacct tgccagccta
1981 tccacaggcc tcccctctcc aaggaggaca gacacagcag aggggaaacg atcctggggc
2041 ttcttggagg gaagggtagc tgaatccaag ccctcacccg attccagctc ttgtgcgact
2101 gatactatta cacctgcttc catggtccct ggagggcgtg tccctcccca gacaaacctg
2161 gagctcttcc agcccaccag ctcttaggca ataatctcat cttccgggat cacgcccctg
2221 acaagccagg aaaagccagc tatgaccttg tactctcaag tccctggggc agggaagagg
2281 ttttatttaa gtgattaaaa gcccagggga gcttccttgg aacaaggagt gggttcacac
2341 caaggggaag gccagtggcc ctgggggagg agcagggacc cctctctctc ttactcgctt
2401 cctgggttta gaactcagga ccccgatctc agtctggagc tccctcctgc accctggctg
2461 gcggtgtgct gggtgacagg actctggagg ggtaccctga gtgcagctgt cggaggaggc
2521 agggcggtgg ggggggcagc tcagaagcct ctaaggcccc aggtgcagtc ctggacctcg
2581 tggagccgca tggagtgagg agaggtgcgg atgcccagaa acagatgtgg gatgagggca
2641 ctgggcagcc acagggtcca tgtggaggag gacaggtagt caaggagggc ttctggaggt
2701 ggtgtggagg gcccatctga tggccagagg aggccaggca gagctgccag tgccagcctg
2761 gaggtggggc caccttcgtg caggtgtctg ggggtggaga gcaggtgtga tgggggctgg
2821 gtacagtggg ctgcctcaga ggactttggg caggagtgac aggtacccgc cagcaccctg
2881 agcagccatg ctggccacca tcctggaaga gaccagacgc aggtgcagag gaggacggga
2941 gacccttggg ggctttggag cctccagaat ggctgaggag aggagggttg ggcacactgg
3001 cccccaggtt gggtgtgtgg ggctgaggtg ggtggcgggt gaccacttct taggactgtg
3061 gcctgtgcaa cctggcgggg ggcaatgggt tgccattcac tgacttgggg ggactgggcc
3121 agcagtttcc aggtgacagg caggagtttg gttttggctg tggcgactct gagattcccc
3181 aggggcctcc aggtggatgt gcagcattgg cagcgtcggc cggcaggcgg gagggcctcc
3241 ctgatatgcc ccgacccgtg gttgacagga tcccgctgca caagttcacg tccatccgcc
3301 ggaccatgtc ggaggttggg ggctctgtgg aggacctgat tgccaaaggc cccgtctcaa
3361 agtactccca ggcggtgcca gccgtgaccg aggggcccat tcccgaggtg ctcaagaact
3421 acatggacgt gagtatgagg tcttagccct gctgcaagcg gagccactgt caggagagct
3481 ccgtggcaga tggggaacat tcccacctcc tgttct
//GenBank-Updates@genbank.bio.net (04/05/91)
LOCUS HUMCATD2 922 bp ds-DNA PRI 05-APR-1991
DEFINITION Human cathepsin D (catD) gene, exons 3 and 4.
ACCESSION M63135
KEYWORDS aspartic proteinase; cathepsin D.
SEGMENT 2 of 5
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Redecker,B., Heckendorf,B., Grosch,H.-W., Mersmann,G. and
Hasilik,A.
TITLE Molecular organization of the human cathepsin D gene
JOURNAL DNA Cell Biol. (1991) In press
STANDARD full staff_review
FEATURES Location/Qualifiers
exon 190..313
/number=3
/EC_number="3.4.23.5"
/product="cathepsin D"
/gene="catD"
exon 741..859
/number=4
/EC_number="3.4.23.5"
/product="cathepsin D"
/gene="catD"
BASE COUNT 137 a 302 c 307 g 176 t
ORIGIN Map position: 11 p15.
1 gggctgggac ctggcccatc ttccctgcag gctgagcagg tgggagtggg tggctgttgg
61 cagctgtggg ccccgtgatg cccctccctc cagtatgggc cttggctctg gggacagccg
121 ggccttctga ggcccagtgg ggagatgggg ccccctctcc catccctgac ggaccctgtc
181 ccctgccagg cccagtacta cggggagatt ggcatcggga cgccccccca gtgcttcaca
241 gtcgtcttcg acacgggctc ctccaacctg tgggtcccct ccatccactg caaactgctg
301 gacatcgctt gctgtgagtc acgaaccctg gccccgtcgc ccaggtcctg cccttccggg
361 atgtcgctgc agggctgcct caggaatcac ttgggcaacg caattctcct gcctcttggc
421 cccgtgagcc aggccagccc tccaccctgc tccagccact gactttctgg gtgaaccacc
481 agctgtggtc ttgctctcag cagggctggg gctggggtgg ccacagaggg agccggctgt
541 ggctgggagg gagccgggtc acagcccaca gtcccgggct ctggctagat ggtgggcctc
601 agatcccctc caaatcccca cccctggggg aggcagcttg gggggtgcgg gctccatggt
661 agattgtagg ggatgggagg gctaaggccg tggcgtgggc tgcgggatga ccggcgggcc
721 cccttgtcgc cgcggggcag ggatccacca caagtacaac agcgacaagt ccagcaccta
781 cgtgaagaat ggtacctcgt ttgacatcca ctatggctcg ggcagcctct ccgggtacct
841 gagccaggac actgtgtcgg tgagtccctc tggggccttt cccaggactc gagggtgcca
901 gggtgtgggg ttcacccagc tt
//GenBank-Updates@genbank.bio.net (04/05/91)
LOCUS HUMCATD3 441 bp ds-DNA PRI 05-APR-1991
DEFINITION Human cathepsin D (catD) gene, exon 5.
ACCESSION M63136
KEYWORDS aspartic proteinase; cathepsin D.
SEGMENT 3 of 5
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Redecker,B., Heckendorf,B., Grosch,H.-W., Mersmann,G. and
Hasilik,A.
TITLE Molecular organization of the human cathepsin D gene
JOURNAL DNA Cell Biol. (1991) In press
STANDARD full staff_review
FEATURES Location/Qualifiers
exon 189..421
/number=5
/EC_number="3.4.23.5"
/product="cathepsin D"
/gene="catD"
BASE COUNT 68 a 147 c 125 g 101 t
ORIGIN Map position: 11 p15.
1 ccccgccata ccccgtgtcc ccatccccag cggtgttcag ctcagggttt ccagcccttt
61 cttctgccct ctgggcccca tcgtgtgtgg gatgggcatc cattgaactg ggttttgtag
121 cctcatgctc agggagtggt gtagggctca gcctgtctgc tgcccactga ctctgccctg
181 gcctgcaggt gccctgccag tcagcgtcgt cagcctctgc cctgggcggt gtcaaagtgg
241 agaggcaggt ctttggggag gccaccaagc agccaggcat caccttcatc gcagccaagt
301 tcgatggcat cctgggcatg gcctaccccc gcatctccgt caacaacgtg ctgcccgtct
361 tcgacaacct gatgcagcag aagctggtgg accagaacat cttctccttc tacctgagca
421 ggtgggcgtg tgggttccct c
//GenBank-Updates@genbank.bio.net (04/05/91)
LOCUS HUMCATD4 257 bp ds-DNA PRI 05-APR-1991
DEFINITION Human cathepsin D (catD) gene, exon 6.
ACCESSION M63137
KEYWORDS aspartic proteinase; cathepsin D.
SEGMENT 4 of 5
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Redecker,B., Heckendorf,B., Grosch,H.-W., Mersmann,G. and
Hasilik,A.
TITLE Molecular organization of the human cathepsin D gene
JOURNAL DNA Cell Biol. (1991) In press
STANDARD full staff_review
FEATURES Location/Qualifiers
exon 118..240
/number=6
/EC_number="3.4.23.5"
/product="cathepsin D"
/gene="catD"
BASE COUNT 45 a 80 c 71 g 61 t
ORIGIN Map position: 11 p15.
1 gaaaggcccc tccttcagga agctctccct gattgccaca ttcaccctct tactcctgac
61 ctggcactct tgtgcttggg ggtggcgtgg cagctgactc ctcccttttc ctcctaggga
121 cccagatgcg cagcctgggg gtgagctgat gctgggtggc acagactcca agtattacaa
181 gggttctctg tcctacctga atgtcacccg caaggcctac tggcaggtcc acctggacca
241 gtgagtagtg gctgcag
//GenBank-Updates@genbank.bio.net (04/05/91)
LOCUS HUMCATD5 2062 bp ds-DNA PRI 05-APR-1991
DEFINITION Human cathepsin D (catD) gene, exons 7, 8, and 9.
ACCESSION M63138
KEYWORDS aspartic proteinase; cathepsin D.
SEGMENT 5 of 5
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (sites)
AUTHORS Redecker,B., Heckendorf,B., Grosch,H.-W., Mersmann,G. and
Hasilik,A.
TITLE Molecular organization of the human cathepsin D gene
JOURNAL DNA Cell Biol. (1991) In press
STANDARD full staff_review
FEATURES Location/Qualifiers
CDS join(M63134:880..947,M63134:3269..3428,M63135:190..313,
M63135:741..859,M63136:189..421,M63137:118..240,252..396,
488..586,718..885)
/product="cathepsin D"
/gene="catD"
/codon_start=880
mRNA join(M63134:812..947,M63134:3269..3428,M63135:190..313,
M63135:741..859,M63136:189..421,M63137:118..240,252..396,
488..586,718..1634)
/EC_number="3.4.23.5"
/product="cathepsin D"
/gene="catD"
exon 252..396
/number=7
/EC_number="3.4.23.5"
/product="cathepsin D"
/gene="catD"
exon 488..586
/number=8
/EC_number="3.4.23.5"
/product="cathepsin D"
/gene="catD"
exon 718..1634
/number=9
/EC_number="3.4.23.5"
/product="cathepsin D"
/gene="catD"
BASE COUNT 327 a 678 c 678 g 379 t
ORIGIN Map position: 11 p15.
1 tccatcccct ccatccctct atgcccctcc atcccctcca tccctccatg ccctcaccac
61 cacctgaggg tctcccaccc cctctaccac tctgtgtctc ctctcccacc ctcttccctg
121 agggttacag ccggctgtgc ttcaggagcc ctgaggggag gagcagccca gccaggggag
181 gggctccagg gaggggcact gggccccagg gcacacttag tccggaggct tcacgccctg
241 actccccgca gggtggaggt ggccagcggg ctgaccctgt gcaaggaggg ctgtgaggcc
301 attgtggaca caggcacttc cctcatggtg ggcccggtgg atgaggtgcg cgagctgcag
361 aaggccatcg gggccgtgcc gctgattcag ggcgaggtga gaccgggggc tggggctggg
421 gctggggctg gcagggggag cccaagggcc accactacca ccctgacact gctgtgaccc
481 ctcttagtac atgatcccct gtgagaaggt gtccaccctg cccgcgatca cactgaagct
541 gggaggcaaa ggctacaagc tgtccccaga ggactacacg ctcaaggtga gcgggcaatg
601 gggtgccgca cgccccaggt gagcgggcgg tgagggggcg cacgctccag gtgagcgggc
661 aacaggtggg ggggcgggtg gtgctagccc tgggtactga ccaccagggc cgtccaggtg
721 tcgcaggccg ggaagaccct ctgcctgagc ggcttcatgg gcatggacat cccgccaccc
781 agcgggccac tctggatcct gggcgacgtc ttcatcggcc gctactacac tgtgtttgac
841 cgtgacaaca acagggtggg cttcgccgag gctgcccgcc tctagttccc aaggcgtccg
901 cgcgccagca cagaaacaga ggagagtccc agagcaggag gcccctggcc cagcggcccc
961 tcccacacac acccacacac tcgcccgccc actgtcctgg gcgccctgga agccggcggc
1021 ccaagcccga cttgctgttt tgttctgtgg ttttcccctc cctgggttca gaaatgctgc
1081 ctgcctgtct gtctctccat ctgtttggtg ggggtagagc tgatccagag cacagatctg
1141 tttcgtgcat tggaagaccc cacccaagct tggcagccga gctcgtgtat cctggggctc
1201 ccttcatctc cagggagtcc cctccccggc cctaccagcg cccgctgggc tgagccccta
1261 ccccacacca ggccgtcctc ccgggccctc ccttggaaac ctgccctgcc tgagggcccc
1321 tctgcccagc ttgggcccag ctgggctctg ccaccctacc tgttcagtgt cccgggcccg
1381 ttgaggatga ggccgctaga ggcctgagga tgagctggaa ggagtgagag gggacaaaac
1441 ccaccttgtt ggagcctgca gggtggtgct gggactgagc cagtcccagg ggcatgtatt
1501 ggcctggagg tggggttggg attgggggct ggtgccagcc ttcctctgca gctgacctct
1561 gttgtcctcc ccttgggcgg ctgagagccc cagctgacat ggaaatacag ttgttggcct
1621 ccggcctccc ctctgtgctg gtgtgctctt gtgcctggtc aggggtggct ccaacttggg
1681 atggggaagg agggtgggta gtgcgaagcc agcacggcag ctgactcggc agcaccggga
1741 caagcatttg gggtgccccg gcctatggcc ccctgccctg ccctgcccag cccatgggct
1801 ccagcctggt cggccagcgg ggactgactt gttcccaggt ctggagcagt agccggcagg
1861 atgtggcctt ggctggggtt tcagggtgtc tagtgtgagt gccagccttg aggagtgatt
1921 tcagggaggt ggcccagcca ggcagccacg gcactcgaac agaggctatt tctgctctcg
1981 gggaccctca gagcaggcct accagtcacc ctcctcagcc ctcttgtccc gggaaataaa
2041 tggccccagg tggcgtgggg gg
//