GenBank-Updates@genbank.bio.net (04/11/91)
LOCUS HUMALIFA 7614 bp ds-DNA PRI 11-APR-1991
DEFINITION Human leukemia inhibitory factor (LIF) gene, complete cds.
ACCESSION M63420 J05436
KEYWORDS glycoprotein; leukemia inhibitory factor.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 7614)
AUTHORS Stahl,J., Gearing,D.P., Willson,T.A., Brown,M.A., King,J.A. and
Gough,N.M.
TITLE Structural organization of the genes for murine and human leukemia
inhibitory factor: Evolutionary conservation of coding and
non-coding regions
JOURNAL J. Biol. Chem. 265, 8833-8841 (1990)
STANDARD unannotated staff_entry
FEATURES Location/Qualifiers
mRNA join(657..739,2471..2649,3343..6826)
/gene="LIF"
CDS join(721..739,2471..2649,3343..3753)
/product="leukemia inhibitory factor"
/gene="LIF"
/codon_start=721
sig_peptide join(721..739,2471..2490)
/gene="LIF"
/codon_start=721
mat_peptide join(2491..2649,3343..3750)
/product="leukemia inhibitory factor"
/gene="LIF"
/codon_start=2491
exon 657..739
/number=1
/gene="LIF"
exon 2471..2649
/number=2
/gene="LIF"
exon 3343..6826
/number=3
/gene="LIF"
BASE COUNT 1512 a 2159 c 2297 g 1646 t
ORIGIN
1 aggcctgacc ctctggggcc ctgggcaacg tgttcccctc ggagcccctt ggggcccagt
61 ggcaatgtgc agattggagg aggctacctc tggggtggct tccagcgccc atgttcagtt
121 ccactttatg accgtctaaa gtccacgccg gccccggccc ctcctcctgg agcctccttc
181 tcagccaagc cctagccctc ctcctcccac tgccccccta aagcccccca accagggggc
241 acaggggcca gtctccatct gctagtccag actcgctacc tccccaaacc caggtgagtc
301 agggccgtct ggggcgccca ctgctgggac ccctgctgac tcggccaggg gccccctcct
361 ggcgatgcca tcttcagaca actcccggga caagccaggc aggaaaacca cagggcgttt
421 tgtcgaaggc ttcattataa ttttatcaat caaattctta gaagagggaa aaagtctgtt
481 ctccccaccc tcccccctca ctcgtccccc cccttcactc tcactttctt ccattcataa
541 tttcctatga tgcacctcaa acaacttcct ggactgggga tcccggctaa atatagctgt
601 ttctgtctta caacacaggc tccagtatat aaatcaggca aattccccat ttgagcatga
661 acctctgaaa actgccggca tctgaggttt cctccaaggc cctctgaagt gcagcccata
721 atgaaggtct tggcggcagg taaatacacc cgccccgcgc cggcttcgcg tccccgctgc
781 ggggcgcggc ggcaacttgg ggcgcttggc agcgcgagcc ggacgcccac ccgccgcaga
841 cacacgaaca cttggggcgc ccgcgcagcc accggaggcg ctgggtggcg gcccggagcg
901 agcgcgggca catggtccca agcaccgcac gccccgcggc aggttggcgg cgagggaggg
961 ggcgccgagc cttcctcctc ctcctcttct tccccctctc cttctcctcc tcctcctcct
1021 cgctccggac actcgctggc tgctcttccc tctgcgcttt ctcccagatt cactctccct
1081 ctctcttttt cttttctttc tttctttccg ctttctcctt tccaaccgcg gtcccgggct
1141 gctcccaggg aggggcgcgg gcggcgagca gcttgcaaac tccggcctgg gacgggagca
1201 ggtgccgcct ccatctgctg gtgtctggaa gcgtgtggtc tgcgctaggt gagatatagg
1261 ggtgtggccc ccctcccgca gccaccccgg ggcctcagca ctgccttggg atgctgggac
1321 gaacagggga cccaggagaa gtgaacttga ggaggcccct gtccccgctg ttccagcatg
1381 ggggatccgg gggaggtctc cagcctcact cgcccgctga ccccggcccc caccatcttc
1441 aggtgccctt ctgcagagcc ctggaaaagc gtctaagggg gcctgggggg agtcgggaga
1501 acaggccccc ctgggggagg ggcaaaccag gacatgtcgg gacagctccc agctctcctg
1561 tcacctttca ctttccttcc tccccgccca cccacctgcc tatgaccttt tgccttttct
1621 ctctccattt cctctccctc cctgagccgg tgtgtgtgtg ttaggaggga ggggaacccc
1681 tgggacaagg gacagcggat gagtcgggag aaggcatgga gtcaggggct gtccggagct
1741 gggggaacag agagttttga atgatgattt ggggatggag agtggggaca gccaggcaga
1801 aatggggtga gcttgagtga gataggggac actagggaag gaagagatag aggatgatgg
1861 gggcgggggc agaattgggg gcaattggcc cagggagcca gaatcaagtg gcaggtttgg
1921 gagggagatg agggtcaacc aggactcctc cccactcccc catgccccgt ggcccccatg
1981 ggtgcctggc ttcggagatt tgggctgcaa tgggccagtg agtgggaagc gctgctgagg
2041 aacctgggcc accacgggag gtgggaagag aggggtctcc tttctcctgg tgcctgctgg
2101 cctggggcct ggtgccttcc agccagaggg ccagggggcc ttaggacctt tgccttcctg
2161 agggaaaggg tgggatggct gggagtctct cctggaccct gcaccctttg ggtggaaatg
2221 gcttgtgtct tgccctatct ttacgtcatc ccagaagaga gcagggagaa ctaaggtaga
2281 gaaagggaga cagagaaaca cacgcagtga cagagtgaag actaggcccc aggaagacag
2341 ctgcaggtgg tgagggggaa ccaggagtcc tctcccatgc ggccattgtt ggacccccat
2401 ccggtgtgcc atgaccccag gccacccttt cctgcctttc tactcatggc ttcttcctga
2461 ctgtccccag gagttgtgcc cctgctgttg gttctgcact ggaaacatgg ggcggggagc
2521 cccctcccca tcacccctgt caacgccacc tgtgccatac gccacccatg tcacaacaac
2581 ctcatgaacc agatcaggag ccaactggca cagctcaatg gcagtgccaa tgccctcttt
2641 attctctatg taagttaccc ctgggatact gacaggagat ggcagggagg gggcttgtaa
2701 atatcattag gggctgtcct gatctgggtt gaggggacct tttggggctg gaaggagaga
2761 atggggagag ggcttgatta aaccaccccc agactcctgc cacttcctgc ccaagcttcc
2821 ccagggaagc ttccccaggg tgcccagtta gcaaggggag aactgagtgc aaaggtgggg
2881 acctggcact tcttatcttg tgattgtcct gctgcaggga gcgagggatg gaggggaaat
2941 gggcgtgagg caccagggag atgcggttga gaggcagtgg gctgtgggtg ctgggcatgg
3001 aggggcgtcc cggaacattg tgagtgcagg gatggaagta cttgtgtgtg gtgccccagc
3061 tagggctaga caccgagttt tcccttctgt ccccttaggg tggtgatgat gatgatgatg
3121 ataatgatga ctgcgtgcat ggctcagtct ttgatcttta gcaagggcac tcacattaca
3181 attagttttg gctctcatga caattccaga tgcttacagg gcaaggagtt gggtcctcat
3241 gcgctagatg gggaaacaga cgcaagagct tgcccaaagg gttggcggca gggctgggac
3301 actgacccct gactcccacg tcacctccct tctgcccctc agtacacagc ccagggggag
3361 ccgttcccca acaacctgga caagctatgt ggccccaacg tgacggactt cccgcccttc
3421 cacgccaacg gcacggagaa ggccaagctg gtggagctgt accgcatagt cgtgtacctt
3481 ggcacctccc tgggcaacat cacccgggac cagaagatcc tcaaccccag tgccctcagc
3541 ctccacagca agctcaacgc caccgccgac atcctgcgag gcctccttag caacgtgctg
3601 tgccgcctgt gcagcaagta ccacgtgggc catgtggacg tgacctacgg ccctgacacc
3661 tcgggtaagg atgtcttcca gaagaagaag ctgggctgtc aactcctggg gaagtataag
3721 cagatcatcg ccgtgttggc ccaggccttc tagcaggagg tcttgaagtg tgctgtgaac
3781 cgagggatct caggagttgg gtccagatgt gggggcctgt ccaagggtgg ctgggcccag
3841 ggcatcgcta aacccaaatg ggggctgctg gctgaccccg agggtgcctg gccagtccac
3901 tccactctgg gctgggctgt gatgaagctg agcagagtgg aaacttccat agggagggag
3961 ctagaagaag gtgccccttc ctctgggaga ttgtggactg gggagcgtgg gctggacttc
4021 tgcctctact tgtccctttg gccccttgct cactttgtgc agtgaacaaa ctacacaagt
4081 catctacaag agccctgacc acagggtgag acagcagggc ccaggggagt ggaccagccc
4141 ccagcaaatt atcaccatct gtgcctttgc tgccccttag gttgggactt aggtgggcca
4201 gaggggctag gatcccaaag gactccttgt cccctagaag tttgatgagt ggaagataga
4261 gaggggcctc tgggatggaa ggctgtcttc ttttgaggat gatcagagaa cttgggcata
4321 ggaacaatct ggcagaagtt tccagaagga ggtcacttgg cattcaggct cttggggagg
4381 cagagaagcc accttcaggc ctgggaagga agacactggg aggaggagag gcctggaaag
4441 ctttggtagg ttcttcgttc tcttccccgt gatcttccct gcagcctggg atggccaggg
4501 tctgatggct ggacctgcag caggggtttg tggaggtggg tagggcaggg gcaggttgct
4561 aagtcaggtg cagaggttct gagggaccca ggctcttcct ctgggtaaag gtctgtaaga
4621 aggggctggg gtagctcaga gtagcagctc acatctgagg ccctgggagg tcttgtgagg
4681 tcacacagag gtacttgagg gggactggag gccgtctctg gtccccaggg caagggaaca
4741 gcagaactta gggtcagggt ctcagggaac cctgagctcc aagcgtgctg tgcgtctgac
4801 ctggcatgat ttctatttat tatgatatcc tatttatatt aacttattgg tgctttcagt
4861 ggccaagtta attccccttt ccctggtccc tactcaacaa aatatgatga tggctcccga
4921 cacaagcgcc agggccaggg cttagcaggg cctggtctgg aagtcgacaa tgttacaagt
4981 ggaataagcc ttacgggtga agctcagaga agggtcggat ctgagagaat ggggaggcct
5041 gagtgggagt ggggggcctt gctccacccc catcccctac tgtgacttgc tttagcgtgt
5101 cagggtccag gctgcagggg ctgggccaat ttgtggagag gccgggtgcc tttctgtctt
5161 gcttccaggg ggctggttca cactgttctt gggcgcccca gcattgtgtt gtgaggcgca
5221 ctgttcctgg cagatattgt gccccctgga gcagtgggca agacagtcct tgtggcccac
5281 cctgtccttg tttctgtgtc cccatgctgc ctctgaaata gcgccctgga acaaccctgc
5341 ccctgcaccc agcatgctcc gacacagcag ggaagctcct cctgtggccc ggacacccat
5401 agacggtgcg gggggcctgg ctgggccaga ccccaggaag gtggggtaga ctggggggat
5461 cagctgccca ttgctcccaa gaggaggaga gggaggctgc agacgcctgg gactcagacc
5521 aggaagctgt gggccctcct gctccacccc catcccactc ccacccatgt ctgggctccc
5581 aggcagggaa cccgatctct tcctttgtgc tggggccagg cgagtggaga aacgccctcc
5641 agtctgagag caggggaggg aaggaggcag cagagttggg gcagctgctc agagcagtgt
5701 tctggcttct tctcaaaccc tgagcgggct gccggcctcc aagttcctcc gacaagatga
5761 tggtactaat tatggtactt ttcactcact ttgcaccttt ccctgtcgct ctctaagcac
5821 tttacctgga tggcgcgtgg gcagtgtgca ggcaggtcct gaggcctggg gttggggtgg
5881 agggtgcggc ccggagttgt ccatctgtcc atcccaacag caagacgagg atgtggctgt
5941 tgagatgtgg gccacactca cccttgtcca ggatgcaggg actgccttct ccttcctgct
6001 tcatccggct tagcttgggg ctggctgcat tcccccagga tggcttcgag aaagacaaac
6061 ttgtctggaa accagagttg ctgattccac ccggggggcc cggctgactc gcccatcacc
6121 tcatctccct gtggacttgg gagctctgtg ccaggcccac cttgcggccc tggctctgag
6181 tcgctctccc acccagcctg gacttggccc catgggaccc atcctcagtg ctccctccag
6241 atcccgtccg gcagcttggc gtccaccctg cacagcatca ctgaatcaca gagcctttgc
6301 gtgaaacagc tctgccaggc cgggagctgg gtttctcttc cctttttatc tgctggtgtg
6361 gaccacacct gggcctggcc ggaggaagag agagtttacc aagagagatg tctccgggcc
6421 cttatttatt atttaaacat ttttttaaaa agcactgcta gtttacttgt ctctcctccc
6481 catcgtcccc atcgtcctcc ttgtccctga cttggggcac ttccaccctg acccagccag
6541 tccagctctg ccttgccggc tctccagagt agacatagtg tgtggggttg gagctctggc
6601 acccggggag gtagcatttc cctgcagatg gtacagatgt tcctgcctta gagtcatctc
6661 tagttcccca cctcaatccc ggcatccagc cttcagtccc gcccacgtgc tagctccgtg
6721 ggcccaccgt gcggccttag aggtttccct ccttcctttc cactgaaaag cacatggcct
6781 tgggtgacaa attcctcttt gatgaatgta ccctgtgggg atgtttcata ctgacagatt
6841 atttttattt attcaatgtc atatttaaaa tatttatttt ttataccaaa tgaatacttt
6901 tttttttaag aaaaaaaaga gaaatgaata aagaatctac tcttggctgg ctctccggag
6961 tgtactgatg tggggagatg ggctggaagg gctgggactg tccctgtcct gggcaccagc
7021 caagtgggac tcagcgaagg gtggaggagg gtgggggagg ggcacctggc ataggtgggg
7081 gcagttaggt ggtattttgg ccaaggcaga acaaggtggg tggtgtctag atcatggggt
7141 gcccccaagg agagagatgg attgctcaga ggtaaagggg gtgctgggca cggtgggtca
7201 ctcctgtaat cctagcactt tgggaggctg aggcaggtgg atcatttgag cccaggaatt
7261 cgagaccagc ctggccaaca tggtgaaacc ctgtctacaa aatatacaaa cagccagatg
7321 ctgtggcgtc cgcctgtggt cccagctact cggggtgctg aggtgggagg atcccttgat
7381 cccaggaggt ggaggctgcg gtgagccatg attgcgccac tgcactgcag cctgggtgac
7441 agaggaagac cctgtctcaa aaaaaaaaaa aaaaaaaaaa aagaagtaaa cggggtgccg
7501 tgtgatatct cagctcattc cctcccaact cctcacttaa cctcatggga tctccaggag
7561 ttgccatccc cacataccag aggaagaaat cgaggctcag agccatgaaa ccac
//