GenBank-Updates@genbank.bio.net (01/23/91)
LOCUS HUMBHSD 9404 bp ds-DNA PRI 23-JAN-1991
DEFINITION Human 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4-isomerase
(3-beta-HSD) gene, complete cds.
ACCESSION M38180
KEYWORDS 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4-isomerase.
SOURCE Human leucocyte DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 9404)
AUTHORS Lachance,Y., Luu-The,V., Labrie,C., Simard,J., Dumont,M.,
Launoit,Y.d., Guerin,S., Leblanc,G. and Labrie,F.
TITLE Characterization of human 3-beta-hydroxysteroid
dehydrogenase/delta-5-delta-4-isomerase gene and its expression in
mammalian cells
JOURNAL J. Biol. Chem. 265, 20469-20475 (1990)
STANDARD simple staff_entry
COMMENT Draft entry and computer-readable sequence for [J. Biol. Chem.
(1990) In press] kindly submitted
by F.Labrie, 27-AUG-1990.
FEATURES Location/Qualifiers
CDS join(1654..1798,5682..5846,
8014..8825)
/gene="3-beta-HSD"
/product="3-beta-hydroxysteroid
dehydrogenase/delta-5-delta-4-isomerase"
mRNA join(1387..1439,1569..1798,
5682..5846,8014..9231)
/gene="3-beta-HSD"
exon 1387..1439
/gene="3-beta-HSD"
/codon_start=1387
exon 1569..1798
/gene="3-beta-HSD"
/codon_start=1569
exon 5682..5846
/gene="3-beta-HSD"
/codon_start=5682
exon 8014..9231
/gene="3-beta-HSD"
/codon_start=8014
BASE COUNT 2604 a 2198 c 1938 g 2664 t
ORIGIN
1 tctgtgaact taaactagac caggagaaat ctgcaagtgc aatttgaatt gtgcccttgt
61 tcagtaaatc catctggagg gaaatccatg taagcccatt atctcctctc tcagactatc
121 atttgaaatg ttgctgctgt cttacaaaat ttagaaattt gcaatggtga cagctccaat
181 cacttagttt tatgtgaggt gactttcttt cctacccaat atatctgaaa cctcaatggt
241 catttgcccc tggagagccc tgggttccta gatgaacaac atcattgaag gaaagctatc
301 tggtgataac cacttaatga tatggcctgt atcacaagag tggggatttg tggttgtatg
361 ccccaatgac tcttatcata ggtgttcgaa cttatccata tttttggctg caaaacgatt
421 ctcagcaaat tcttgaactg gacatactgt gaatgcttct gaagcctatg ccccagaact
481 gcccaaatat caccgccata agcttcccaa gacactttac tcaaaaaaat tgaaatataa
541 tttacatgca ttaaaatgcc caggtcttca gtgttcagtt cagtggaact tgacagttat
601 atatgcccat gtaagtagca ccccaaaaaa gatatagacc atttccgtca ctccagaaag
661 ttgttttctg cctgttccct gttaattccc tgaccttccc ccaatctacc tcataggcaa
721 ctacttcctg atttttattc ccacagttct cattttattt ctatatttct ctaatttttt
781 cttctaagat ctctgtggtt ctggatatat atttaaatat aaaattattt tgaaatgaag
841 ttttgtgcag ggagtacaga aaaattgacc gttgattgtc tctgttgttt atttttctat
901 ttcatgattt tcattatttt tattattggc ttacatttat taattttgtt tttttttttc
961 actcgttttt cacatttttt tttttttttt ttgagatgga gtcttgctct gtcacccagg
1021 ctgaatggca ggggcaccat ctcagctcac tgcaacctct gctcccgggt tcaagcaatt
1081 ctcccacctc agcctccgaa gtagctggga ttacaggtgc ccgccactgc accgggctaa
1141 tttttgtatt ttcagtagag gtggggtttc atcatgttga ccagctggta tcaaactcct
1201 gactttgtga tctgcacgcc tcagcctccc aaagtgctgg gattacaggc gtgagccact
1261 gcacccagcc ccgtttttca ggatcccata ggaggagaga gcaatgagta catggccaga
1321 gatcaaagtg ataagggttg ggccagaagc cacagtgcat aaagcttcag acttgccaca
1381 ggaaatgagg tgagaagtac gtccactctt ctgtccagct tttaacaatc taactaatgg
1441 ttagagattt ttcattttct ttcagctact cctgcagtgg tggggacaca gaatgtttgc
1501 aaaaaaaatg gggtggagga aaatgaggca tctgtgtgag tatataacca tttgacatct
1561 ctttttagcc ctctccaggg tcaccctaga atcagatctg ctccccagca tcttctgttt
1621 cctggtgagt gattcctgct actttggatg gccatgacgg gctggagctg ccttgtgaca
1681 ggagcaggag ggtttctggg acagaggatc atccgcctct tggtgaagga gaaggagctg
1741 aaggagatca gggtcttgga caaggccttc ggaccagaat tgagagagga attttctagt
1801 aagtaaactt gggtcatggg tgtgtggttc catcttaaac actgcatgta tgtgggggga
1861 gatggacctt gtctagcaag ttattgaaat ttgtagccaa atctaagcca atctcacatc
1921 caaagtcatc aagaaataaa tattaaatag tataaaatgg catagtatga aagatactgg
1981 gtgggatttc cagagactag attctggccc tgacccagaa cttgagaagc agccacctca
2041 gcctccaggc ctcttttctt ctcatctaga aaatcccaca tcagttcttt gtcttgtctg
2101 caactctttt atgttctgaa gcttttgtct tggcaattgc tgtacaacat tcataaagga
2161 cactattacc ctggagacct caccaatggg tcattgtctc tctagaacgt gccaggctgt
2221 gttttgtttt gcagcttcct tagtatcctt tgtgagggca aaataaaagg aagttaaggt
2281 aaagatgagt gtataagtgg gtgtgtgtga cagagagaga ggaaaacaat aagggggaga
2341 gagagtcggg gagagagagt cggggagaga gactcagaga gagagacaat gagaaagaca
2401 gagaaataat gaaaaatata tagtgagaga gagagcatca gtgagagaat gtgtgtgcac
2461 agtgcacagc acagagcaga gacagagtaa gaggcagtat aaggccagac atgcctcatt
2521 tagattttgc atatatggct tttttttaaa aaaaaaaaaa caaaacattt acctctgttg
2581 ctcatcatca aaaagaaatt gactgcagaa ttttctgtgg caactccttg tacaaatggc
2641 cccaagaggc aggtagaaaa ggcatcacat ccaacaggac aatgaacgca tcaaggtccg
2701 gaatcacaaa gcaacatgct aaggccatct gattgatgcg tagcagagct cagaccagag
2761 ctttatccat aggctatttc acctggcccc agagctgatg cttggcaaag tggatcttca
2821 gtctctccct ttgctccttg gtgtgcccca aaacaattcc ctgtcctcct ccccaaccca
2881 ggggatttgg gggactgtgt gtctacatgt gggctctggc tgcccagagg tcctgccctg
2941 cccacagaga atcccccact tgacagcact cagggaccac acccaacact ctacttttgc
3001 tcttctctga cctcttgaaa tgttcgattt cttccaccct ctgttttaat gttgtctttg
3061 ataaacaaat atgaaatgct tataatcctt gcctgtgtct cagcaatatt tgcaatttaa
3121 catctgaagc cagaaaaaag caatgctcag cctagaggta ttgttcccct atggtaaaaa
3181 tgcagatcat ataatagaca ggcagggatc tgtatgaaga taaaaacaga gaaagcattc
3241 agtgttcttt ttgtgccagg cacttggcca aaggtttgcc aactcatttg ctcctcataa
3301 caaccctatg agatcggtaa tattatcctc cttttttaaa gatgaggaga tagaaacaga
3361 gaggttagtt aactttttga aggtcccaca gttagcatat ggcaaagcta gatttgaacc
3421 cagacagact agtgcagcat ctgtgctctt aagcagtagt ttgtcttaca gctcctttag
3481 gccttcctct agcccaactt acaccataaa agcaactcca tttagtctac ataaaacact
3541 tgccaagtct acagtgcctt ggagaagaag ggagccatga cttcatcaac aaagtacctt
3601 ttcctagtcc ctctagatcc ctgggaactc actggggaag agtccttttc tctcagcttt
3661 ggacttcttc cactttgaca ctcctttgag ccagtctgtc tgaagtggca gcaaagaaga
3721 agcagaggaa ggcagcagga agggcagagg tggaactaga accagagaac atcccactct
3781 caggctgtta cccacatcac caccagcagc ctcttccctg actcccccac tccaggacct
3841 tcttggagtt gcctgacaac gggaagaggt tgggagtaga caaaacatgg cagaggcatc
3901 aggagagcaa gtggtcctgc ttgtacccca ggaaggaatt tctccagctt cgaatttttc
3961 actctgaatt ttgctctcac tggtctttgg tctttgttgc caatttcagt taaactggct
4021 tattctttgg aaaagaatga tattaaacaa cagaaaagtt gatattaaac agccagtcct
4081 gcacctggtg tacagggtac aagcttggag gcagggtggg cgtgtttaag ccttcactag
4141 aaacgtgacc ttagatctgt cccttaacct ctctgagact cagtttcctc actgataaag
4201 tgggactcag aatacctacc tcatgagata gctgtaaaaa gaaataaata tcctgtaagt
4261 tgcatacaga tgataaagca caaacaagtg tagagtattt atccaagctc catgtagcat
4321 ggtgttcatt ttgtgggcta attccaggtg acaaccttac tggcagcgtc acttcctgtg
4381 gatttcagag gaacctgaag acattgatgt tgtaaccact gcctccagct agacagctgc
4441 gatgttagtt cattggtggt taactcattt tcagcattgc tacctgcttt tgatgatatc
4501 tgataatagt tttccaggga aattcatcat tgaagcccac ccacaattcc tgagtaatga
4561 ctccactctc ctcccagttg cccaagcagg aaactgtagg ggtgatttta tcttctcctt
4621 ttcctatcag ctcagatcca ataggtacca ggaccttcaa ggtaaggtct gaaattcaaa
4681 cctggtatat ctctcccctc ctctgcttcc actgctggac cctgcttcca gtcctcatcg
4741 aaactttggc acagacattc tgattaatca cttgatcatc agtctttctc aaatccccta
4801 taccagtcca ttttatatcc tcaagccaag attaacttcc tacaccacaa ccctgctttt
4861 gttccttttt ttgttgttgc ttgtgtggtt ttcttttttt tttttttttt tttttttttt
4921 tttttttttt tttgagacaa ggtggtcttg ctctaccacc caggctagag tgcagaggtg
4981 tgatcttggc tcactgccag gaaccagaga ccccagcctc catttatcct cccacctcag
5041 tctgcagagt agctgggact gcaggcaggc acatgccacc atgcccagct atttcatgta
5101 ttttaataga aatgggattt ccccatgttg tccaagctgg tctcaacctc ctgcgctcca
5161 gtgatccatc catcacagcc tcccaaagtg ctggaataac aggcatgagc cacggggctt
5221 ggcctttttg tcattttatt ccaaatataa ataaggggtt ttctttaaca tgatgctgga
5281 gtcccaaaat tatgattcta tacatgattt ctcattactt acagaattaa cttcaaactt
5341 ttccctcata ctctctacaa tcacactact ctccttagaa aatttgatgg gcttcccatg
5401 actctagcaa tgcttatatt ccaggcatac ctgacagctc actgctcaga ttacttttct
5461 aaaatgagat gggagagaaa cagatgtttg ctctttccaa gaaattgata cacatgctga
5521 tttctgtgcc ttttttactt gttctttccg tagaatgtac accctccact ctaacaccct
5581 actctaacca tccttgaaca cctatgtaac atcaccttta tcagaaaact tctcagccag
5641 atacagaaat cattccaatg acctgacctg tgttcacaca gaactccaga acaagaccaa
5701 gctgacagtg ctggaaggag acattctgga tgagccattc ctgaagagag cctgccagga
5761 cgtctcggtc atcatccaca ccgcctgtat cattgatgtc ttcggtgtca ctcacagaga
5821 gtctatcatg aatgtcaatg tgaaaggtat ggtaggctgg ggaggagatg cagcaaggtg
5881 gggaattaag gatcacaaag aagggccagg aagggaagag aagtccctcc actgaacacc
5941 tgctgtgctc tgggccaagt gcctttgctg atcactacga ataggagagt tcaagactgc
6001 taactttagt tttttagatg ataaaactag gactgagaga gggcaagtaa cttgtccaag
6061 gtcccccagg taagtaagca ggtaggagag ttagacttta aactcatccc tgtgtgactc
6121 caaaggctct ttctactgtg actccaaaag ctctttctac tgtggttcca atcaaaagtc
6181 aactaatttc tgacttcaga ctcttgatac ccagacaccc cttgcctccc aggccagaag
6241 cagaccttgc aggtgccact gtagtcacca ttttgaacct tgtgtgtagg ctgatgaaaa
6301 cattcagagc cctcctgccc acctcaaaca aaaagtcctc tcgagagaac tagcaaagct
6361 ggttcacaag gtctgtcagg acagaattat ccagcacatg ccttcccaca atattttttt
6421 aacagtgaga tttttccagt atcaagaata cagtctcttc agctcaccac agggcctact
6481 attccagagc cgttttcagc caggtgccca aagtgcaccc tcatttaatc ttcatccctt
6541 aaatgcttgg cgtttccttt caaagtatgg ctttccaact accttaaatt cagacacatt
6601 tccttaagga atcttctcag aaatctcacc ctctgatctc cagagtccag tctcttcagc
6661 accatagcac cccaaacccc ggcctggccc tccgcattta gtctactctg actctttttc
6721 caaagcaacc aattgctttt gagtctccag caccataaaa gaaaaaaaaa aacaacttcc
6781 agtttctact tacccatact tctaagtacc cctgctgtgc aaggagggtg ctaagagtaa
6841 ccagttttaa ttactacttc aacagctccc aaaaggaggg gatatgaaat gacaggggaa
6901 gtgttagagg catctgtttg ctaaaaccat tataactccc aagcttagaa aatacttcac
6961 aatgttggtc atttccccct tgaaggtaaa ctaactccaa attttctctg ccacaagatt
7021 aatttttgaa cacatgaggc tgtctttcca gaaactcaaa ttgcacagag acattaaaag
7081 ggctaagaat acaaaaattt gtaaataaaa atgatccttt ccctaggaaa ttccttcctt
7141 cttcaaggga aggcactatg ggtacctcca tgagctttgc ttctacacag ctcaggggag
7201 gctgcaaggt cctcccactg caggtgttac cagcagagga cacacttctc tccccagccc
7261 tccaccaggc tccacaggaa atgccagggc agggtttaaa agaaggttta tcacctccac
7321 tttacataac caggtaaaca gagtcacagc cagaattgga agcagctttc ccagggaatg
7381 cacaatcagg aagagtgtgg gtttccagca tctccccaca acccactgct tgctcagtga
7441 ctccaggatg gtccttgtga caaagtttta ttagagccca gcaaaatgag aaaagtacca
7501 acaatttcat atatattgaa gagtttatat tgcctatata caatggtgta tgtgtgtgtg
7561 tgatgtgaat tcttcaactg cccattttgc ctaaggactg gaactgtcca tattcacaga
7621 gtatagcctc ctgatttttt agattttaaa tgatctgact ttaatggtac tgattacaaa
7681 tcataatttg tcaataccct tacttggcaa aataaaaagt gataacccta ggtccctttc
7741 caaaattaaa gtacacacac acacacatcc atgaaaccca aaagtctaga aattcttact
7801 ctccagaacc cacatgtcag tttctcttca ttttggtatt tttcttatgg ctgtagtacg
7861 accaaatctc agacagaacc acagaagaat gtaccctgag tctgttacaa ccaccatatt
7921 tgggagtggg gggtggggca catagatctg tgttcgtggt tggcacctct tagggatata
7981 tcctgacagt gacaatatgc tcttcatgga caggtaccca gctcctgtta gaggcctgtg
8041 tccaagctag tgtgccagtc ttcatctaca ccagtagcat agaggtagcc gggcccaact
8101 cctacaagga aatcatccag aatggccatg aagaagagcc tctggaaaac acatggcccg
8161 ctccataccc acacagcaaa aagcttgctg agaaggctgt actggcggct aacgggtgga
8221 atctgaaaaa cggcggcacc ctgtacactt gtgccttacg acccatgtat atctatgggg
8281 aaggaagccg attcctttct gctagtataa acgaggccct gaacaacaat gggatcctgt
8341 caagtgttgg aaagttctcc actgttaacc cagtctatgt tggcaatgtg gcctgggccc
8401 acattctggc cttgagggcc ctgcaggacc ccaagaaggc cccaagcatc cgaggacagt
8461 tctactatat ctcagatgac acgcctcacc aaagctatga taaccttaat tacaccctga
8521 gcaaagagtt cggcctccgc cttgattcca gatggagctt tcctttatcc ctgatgtatt
8581 ggattggctt cctgctggaa atagtgagct tcctactcag gccaatttac acctatcgac
8641 cgcccttcaa ccgccacata gtcacattgt caaatagcgt attcaccttc tcttataaga
8701 aggctcagcg agatttggcg tataagccac tctacagctg ggaggaagcc aagcagaaaa
8761 cggtggagtg ggttggttcc cttgtggacc ggcacaagga gaacctgaag tccaagactc
8821 agtgatttaa ggatgacaga gatgtgcatg tgggtattgt taggagatgt catcaagctc
8881 caccctcctg gcctcataca gaaagtgaca agggcacaag ctcaggtcct gctgcctccc
8941 tttcatacaa tggccaactt atgttattcc tcatgtcatc aaaacctgcg cagtcattgg
9001 cccaacaaga aggtttctgt cctaatcata taccagagga aagaccatgt ggtttgctgt
9061 taccaaatct cagtagctga ttctgaacaa tttagggact cttttaactt gagggtcgtt
9121 ttgactacta gagctccatt tctactctta aatgagaaag gatttccttt ctttttaatc
9181 ttccattcct tcacatagtt tgataaaaag atcaataaat gtttgaatgt ttaatgtgga
9241 gggaggtgtg agttatgtta atacatactt tcctcctttc tccttctttt ccaggtattg
9301 ccatctccaa tttagaagag tagcataaaa cctgggttgg ggagagggca gagtagtggg
9361 agggccagga agggcgatga agactgaata agctctacta cctt
//GenBank-Updates@genbank.bio.net (04/12/91)
LOCUS HUMBHSD 9404 bp ds-DNA PRI 12-APR-1991
DEFINITION Human 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4-isomerase
(3-beta-HSD) gene, complete cds.
ACCESSION M38180
KEYWORDS 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase.
SOURCE Human leucocyte DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 9404)
AUTHORS Lachance,Y., Luu-The,V., Labrie,C., Simard,J., Dumont,M.,
Launoit,Y.d., Guerin,S., Leblanc,G. and Labrie,F.
TITLE Characterization of human 3-beta-hydroxysteroid
dehydrogenase/delta-5-delta-4-isomerase gene and its expression in
mammalian cells
JOURNAL J. Biol. Chem. 265, 20469-20475 (1990)
STANDARD simple staff_entry
COMMENT Draft entry and computer-readable sequence for [J. Biol. Chem.
(1990) In press] kindly submitted
by F.Labrie, 27-AUG-1990.
The two accession numbers, M38178 and M38179, are rodent sequences
which are published and discussed in "J. Biol. Chem." Vol. 266, pp.
583-593, 1991.
FEATURES Location/Qualifiers
mRNA join(1387..1439,1569..1798,5682..5846,8014..9231)
/gene="3-beta-HSD"
CDS join(1654..1798,5682..5846,8014..8825)
/product="3-beta-hydroxysteroid
dehydrogenase/delta-5-delta-4-isomerase"
/gene="3-beta-HSD"
/codon_start=1654
exon 1387..1439
/gene="3-beta-HSD"
exon 1569..1798
/gene="3-beta-HSD"
exon 5682..5846
/gene="3-beta-HSD"
exon 8014..9231
/gene="3-beta-HSD"
BASE COUNT 2604 a 2198 c 1938 g 2664 t
ORIGIN
1 tctgtgaact taaactagac caggagaaat ctgcaagtgc aatttgaatt gtgcccttgt
61 tcagtaaatc catctggagg gaaatccatg taagcccatt atctcctctc tcagactatc
121 atttgaaatg ttgctgctgt cttacaaaat ttagaaattt gcaatggtga cagctccaat
181 cacttagttt tatgtgaggt gactttcttt cctacccaat atatctgaaa cctcaatggt
241 catttgcccc tggagagccc tgggttccta gatgaacaac atcattgaag gaaagctatc
301 tggtgataac cacttaatga tatggcctgt atcacaagag tggggatttg tggttgtatg
361 ccccaatgac tcttatcata ggtgttcgaa cttatccata tttttggctg caaaacgatt
421 ctcagcaaat tcttgaactg gacatactgt gaatgcttct gaagcctatg ccccagaact
481 gcccaaatat caccgccata agcttcccaa gacactttac tcaaaaaaat tgaaatataa
541 tttacatgca ttaaaatgcc caggtcttca gtgttcagtt cagtggaact tgacagttat
601 atatgcccat gtaagtagca ccccaaaaaa gatatagacc atttccgtca ctccagaaag
661 ttgttttctg cctgttccct gttaattccc tgaccttccc ccaatctacc tcataggcaa
721 ctacttcctg atttttattc ccacagttct cattttattt ctatatttct ctaatttttt
781 cttctaagat ctctgtggtt ctggatatat atttaaatat aaaattattt tgaaatgaag
841 ttttgtgcag ggagtacaga aaaattgacc gttgattgtc tctgttgttt atttttctat
901 ttcatgattt tcattatttt tattattggc ttacatttat taattttgtt tttttttttc
961 actcgttttt cacatttttt tttttttttt ttgagatgga gtcttgctct gtcacccagg
1021 ctgaatggca ggggcaccat ctcagctcac tgcaacctct gctcccgggt tcaagcaatt
1081 ctcccacctc agcctccgaa gtagctggga ttacaggtgc ccgccactgc accgggctaa
1141 tttttgtatt ttcagtagag gtggggtttc atcatgttga ccagctggta tcaaactcct
1201 gactttgtga tctgcacgcc tcagcctccc aaagtgctgg gattacaggc gtgagccact
1261 gcacccagcc ccgtttttca ggatcccata ggaggagaga gcaatgagta catggccaga
1321 gatcaaagtg ataagggttg ggccagaagc cacagtgcat aaagcttcag acttgccaca
1381 ggaaatgagg tgagaagtac gtccactctt ctgtccagct tttaacaatc taactaatgg
1441 ttagagattt ttcattttct ttcagctact cctgcagtgg tggggacaca gaatgtttgc
1501 aaaaaaaatg gggtggagga aaatgaggca tctgtgtgag tatataacca tttgacatct
1561 ctttttagcc ctctccaggg tcaccctaga atcagatctg ctccccagca tcttctgttt
1621 cctggtgagt gattcctgct actttggatg gccatgacgg gctggagctg ccttgtgaca
1681 ggagcaggag ggtttctggg acagaggatc atccgcctct tggtgaagga gaaggagctg
1741 aaggagatca gggtcttgga caaggccttc ggaccagaat tgagagagga attttctagt
1801 aagtaaactt gggtcatggg tgtgtggttc catcttaaac actgcatgta tgtgggggga
1861 gatggacctt gtctagcaag ttattgaaat ttgtagccaa atctaagcca atctcacatc
1921 caaagtcatc aagaaataaa tattaaatag tataaaatgg catagtatga aagatactgg
1981 gtgggatttc cagagactag attctggccc tgacccagaa cttgagaagc agccacctca
2041 gcctccaggc ctcttttctt ctcatctaga aaatcccaca tcagttcttt gtcttgtctg
2101 caactctttt atgttctgaa gcttttgtct tggcaattgc tgtacaacat tcataaagga
2161 cactattacc ctggagacct caccaatggg tcattgtctc tctagaacgt gccaggctgt
2221 gttttgtttt gcagcttcct tagtatcctt tgtgagggca aaataaaagg aagttaaggt
2281 aaagatgagt gtataagtgg gtgtgtgtga cagagagaga ggaaaacaat aagggggaga
2341 gagagtcggg gagagagagt cggggagaga gactcagaga gagagacaat gagaaagaca
2401 gagaaataat gaaaaatata tagtgagaga gagagcatca gtgagagaat gtgtgtgcac
2461 agtgcacagc acagagcaga gacagagtaa gaggcagtat aaggccagac atgcctcatt
2521 tagattttgc atatatggct tttttttaaa aaaaaaaaaa caaaacattt acctctgttg
2581 ctcatcatca aaaagaaatt gactgcagaa ttttctgtgg caactccttg tacaaatggc
2641 cccaagaggc aggtagaaaa ggcatcacat ccaacaggac aatgaacgca tcaaggtccg
2701 gaatcacaaa gcaacatgct aaggccatct gattgatgcg tagcagagct cagaccagag
2761 ctttatccat aggctatttc acctggcccc agagctgatg cttggcaaag tggatcttca
2821 gtctctccct ttgctccttg gtgtgcccca aaacaattcc ctgtcctcct ccccaaccca
2881 ggggatttgg gggactgtgt gtctacatgt gggctctggc tgcccagagg tcctgccctg
2941 cccacagaga atcccccact tgacagcact cagggaccac acccaacact ctacttttgc
3001 tcttctctga cctcttgaaa tgttcgattt cttccaccct ctgttttaat gttgtctttg
3061 ataaacaaat atgaaatgct tataatcctt gcctgtgtct cagcaatatt tgcaatttaa
3121 catctgaagc cagaaaaaag caatgctcag cctagaggta ttgttcccct atggtaaaaa
3181 tgcagatcat ataatagaca ggcagggatc tgtatgaaga taaaaacaga gaaagcattc
3241 agtgttcttt ttgtgccagg cacttggcca aaggtttgcc aactcatttg ctcctcataa
3301 caaccctatg agatcggtaa tattatcctc cttttttaaa gatgaggaga tagaaacaga
3361 gaggttagtt aactttttga aggtcccaca gttagcatat ggcaaagcta gatttgaacc
3421 cagacagact agtgcagcat ctgtgctctt aagcagtagt ttgtcttaca gctcctttag
3481 gccttcctct agcccaactt acaccataaa agcaactcca tttagtctac ataaaacact
3541 tgccaagtct acagtgcctt ggagaagaag ggagccatga cttcatcaac aaagtacctt
3601 ttcctagtcc ctctagatcc ctgggaactc actggggaag agtccttttc tctcagcttt
3661 ggacttcttc cactttgaca ctcctttgag ccagtctgtc tgaagtggca gcaaagaaga
3721 agcagaggaa ggcagcagga agggcagagg tggaactaga accagagaac atcccactct
3781 caggctgtta cccacatcac caccagcagc ctcttccctg actcccccac tccaggacct
3841 tcttggagtt gcctgacaac gggaagaggt tgggagtaga caaaacatgg cagaggcatc
3901 aggagagcaa gtggtcctgc ttgtacccca ggaaggaatt tctccagctt cgaatttttc
3961 actctgaatt ttgctctcac tggtctttgg tctttgttgc caatttcagt taaactggct
4021 tattctttgg aaaagaatga tattaaacaa cagaaaagtt gatattaaac agccagtcct
4081 gcacctggtg tacagggtac aagcttggag gcagggtggg cgtgtttaag ccttcactag
4141 aaacgtgacc ttagatctgt cccttaacct ctctgagact cagtttcctc actgataaag
4201 tgggactcag aatacctacc tcatgagata gctgtaaaaa gaaataaata tcctgtaagt
4261 tgcatacaga tgataaagca caaacaagtg tagagtattt atccaagctc catgtagcat
4321 ggtgttcatt ttgtgggcta attccaggtg acaaccttac tggcagcgtc acttcctgtg
4381 gatttcagag gaacctgaag acattgatgt tgtaaccact gcctccagct agacagctgc
4441 gatgttagtt cattggtggt taactcattt tcagcattgc tacctgcttt tgatgatatc
4501 tgataatagt tttccaggga aattcatcat tgaagcccac ccacaattcc tgagtaatga
4561 ctccactctc ctcccagttg cccaagcagg aaactgtagg ggtgatttta tcttctcctt
4621 ttcctatcag ctcagatcca ataggtacca ggaccttcaa ggtaaggtct gaaattcaaa
4681 cctggtatat ctctcccctc ctctgcttcc actgctggac cctgcttcca gtcctcatcg
4741 aaactttggc acagacattc tgattaatca cttgatcatc agtctttctc aaatccccta
4801 taccagtcca ttttatatcc tcaagccaag attaacttcc tacaccacaa ccctgctttt
4861 gttccttttt ttgttgttgc ttgtgtggtt ttcttttttt tttttttttt tttttttttt
4921 tttttttttt tttgagacaa ggtggtcttg ctctaccacc caggctagag tgcagaggtg
4981 tgatcttggc tcactgccag gaaccagaga ccccagcctc catttatcct cccacctcag
5041 tctgcagagt agctgggact gcaggcaggc acatgccacc atgcccagct atttcatgta
5101 ttttaataga aatgggattt ccccatgttg tccaagctgg tctcaacctc ctgcgctcca
5161 gtgatccatc catcacagcc tcccaaagtg ctggaataac aggcatgagc cacggggctt
5221 ggcctttttg tcattttatt ccaaatataa ataaggggtt ttctttaaca tgatgctgga
5281 gtcccaaaat tatgattcta tacatgattt ctcattactt acagaattaa cttcaaactt
5341 ttccctcata ctctctacaa tcacactact ctccttagaa aatttgatgg gcttcccatg
5401 actctagcaa tgcttatatt ccaggcatac ctgacagctc actgctcaga ttacttttct
5461 aaaatgagat gggagagaaa cagatgtttg ctctttccaa gaaattgata cacatgctga
5521 tttctgtgcc ttttttactt gttctttccg tagaatgtac accctccact ctaacaccct
5581 actctaacca tccttgaaca cctatgtaac atcaccttta tcagaaaact tctcagccag
5641 atacagaaat cattccaatg acctgacctg tgttcacaca gaactccaga acaagaccaa
5701 gctgacagtg ctggaaggag acattctgga tgagccattc ctgaagagag cctgccagga
5761 cgtctcggtc atcatccaca ccgcctgtat cattgatgtc ttcggtgtca ctcacagaga
5821 gtctatcatg aatgtcaatg tgaaaggtat ggtaggctgg ggaggagatg cagcaaggtg
5881 gggaattaag gatcacaaag aagggccagg aagggaagag aagtccctcc actgaacacc
5941 tgctgtgctc tgggccaagt gcctttgctg atcactacga ataggagagt tcaagactgc
6001 taactttagt tttttagatg ataaaactag gactgagaga gggcaagtaa cttgtccaag
6061 gtcccccagg taagtaagca ggtaggagag ttagacttta aactcatccc tgtgtgactc
6121 caaaggctct ttctactgtg actccaaaag ctctttctac tgtggttcca atcaaaagtc
6181 aactaatttc tgacttcaga ctcttgatac ccagacaccc cttgcctccc aggccagaag
6241 cagaccttgc aggtgccact gtagtcacca ttttgaacct tgtgtgtagg ctgatgaaaa
6301 cattcagagc cctcctgccc acctcaaaca aaaagtcctc tcgagagaac tagcaaagct
6361 ggttcacaag gtctgtcagg acagaattat ccagcacatg ccttcccaca atattttttt
6421 aacagtgaga tttttccagt atcaagaata cagtctcttc agctcaccac agggcctact
6481 attccagagc cgttttcagc caggtgccca aagtgcaccc tcatttaatc ttcatccctt
6541 aaatgcttgg cgtttccttt caaagtatgg ctttccaact accttaaatt cagacacatt
6601 tccttaagga atcttctcag aaatctcacc ctctgatctc cagagtccag tctcttcagc
6661 accatagcac cccaaacccc ggcctggccc tccgcattta gtctactctg actctttttc
6721 caaagcaacc aattgctttt gagtctccag caccataaaa gaaaaaaaaa aacaacttcc
6781 agtttctact tacccatact tctaagtacc cctgctgtgc aaggagggtg ctaagagtaa
6841 ccagttttaa ttactacttc aacagctccc aaaaggaggg gatatgaaat gacaggggaa
6901 gtgttagagg catctgtttg ctaaaaccat tataactccc aagcttagaa aatacttcac
6961 aatgttggtc atttccccct tgaaggtaaa ctaactccaa attttctctg ccacaagatt
7021 aatttttgaa cacatgaggc tgtctttcca gaaactcaaa ttgcacagag acattaaaag
7081 ggctaagaat acaaaaattt gtaaataaaa atgatccttt ccctaggaaa ttccttcctt
7141 cttcaaggga aggcactatg ggtacctcca tgagctttgc ttctacacag ctcaggggag
7201 gctgcaaggt cctcccactg caggtgttac cagcagagga cacacttctc tccccagccc
7261 tccaccaggc tccacaggaa atgccagggc agggtttaaa agaaggttta tcacctccac
7321 tttacataac caggtaaaca gagtcacagc cagaattgga agcagctttc ccagggaatg
7381 cacaatcagg aagagtgtgg gtttccagca tctccccaca acccactgct tgctcagtga
7441 ctccaggatg gtccttgtga caaagtttta ttagagccca gcaaaatgag aaaagtacca
7501 acaatttcat atatattgaa gagtttatat tgcctatata caatggtgta tgtgtgtgtg
7561 tgatgtgaat tcttcaactg cccattttgc ctaaggactg gaactgtcca tattcacaga
7621 gtatagcctc ctgatttttt agattttaaa tgatctgact ttaatggtac tgattacaaa
7681 tcataatttg tcaataccct tacttggcaa aataaaaagt gataacccta ggtccctttc
7741 caaaattaaa gtacacacac acacacatcc atgaaaccca aaagtctaga aattcttact
7801 ctccagaacc cacatgtcag tttctcttca ttttggtatt tttcttatgg ctgtagtacg
7861 accaaatctc agacagaacc acagaagaat gtaccctgag tctgttacaa ccaccatatt
7921 tgggagtggg gggtggggca catagatctg tgttcgtggt tggcacctct tagggatata
7981 tcctgacagt gacaatatgc tcttcatgga caggtaccca gctcctgtta gaggcctgtg
8041 tccaagctag tgtgccagtc ttcatctaca ccagtagcat agaggtagcc gggcccaact
8101 cctacaagga aatcatccag aatggccatg aagaagagcc tctggaaaac acatggcccg
8161 ctccataccc acacagcaaa aagcttgctg agaaggctgt actggcggct aacgggtgga
8221 atctgaaaaa cggcggcacc ctgtacactt gtgccttacg acccatgtat atctatgggg
8281 aaggaagccg attcctttct gctagtataa acgaggccct gaacaacaat gggatcctgt
8341 caagtgttgg aaagttctcc actgttaacc cagtctatgt tggcaatgtg gcctgggccc
8401 acattctggc cttgagggcc ctgcaggacc ccaagaaggc cccaagcatc cgaggacagt
8461 tctactatat ctcagatgac acgcctcacc aaagctatga taaccttaat tacaccctga
8521 gcaaagagtt cggcctccgc cttgattcca gatggagctt tcctttatcc ctgatgtatt
8581 ggattggctt cctgctggaa atagtgagct tcctactcag gccaatttac acctatcgac
8641 cgcccttcaa ccgccacata gtcacattgt caaatagcgt attcaccttc tcttataaga
8701 aggctcagcg agatttggcg tataagccac tctacagctg ggaggaagcc aagcagaaaa
8761 cggtggagtg ggttggttcc cttgtggacc ggcacaagga gaacctgaag tccaagactc
8821 agtgatttaa ggatgacaga gatgtgcatg tgggtattgt taggagatgt catcaagctc
8881 caccctcctg gcctcataca gaaagtgaca agggcacaag ctcaggtcct gctgcctccc
8941 tttcatacaa tggccaactt atgttattcc tcatgtcatc aaaacctgcg cagtcattgg
9001 cccaacaaga aggtttctgt cctaatcata taccagagga aagaccatgt ggtttgctgt
9061 taccaaatct cagtagctga ttctgaacaa tttagggact cttttaactt gagggtcgtt
9121 ttgactacta gagctccatt tctactctta aatgagaaag gatttccttt ctttttaatc
9181 ttccattcct tcacatagtt tgataaaaag atcaataaat gtttgaatgt ttaatgtgga
9241 gggaggtgtg agttatgtta atacatactt tcctcctttc tccttctttt ccaggtattg
9301 ccatctccaa tttagaagag tagcataaaa cctgggttgg ggagagggca gagtagtggg
9361 agggccagga agggcgatga agactgaata agctctacta cctt
//