GenBank-Updates@genbank.bio.net (04/12/91)
LOCUS HUMFERC 2443 bp ss-mRNA PRI 12-APR-1991
DEFINITION Human mRNA for ferrochelatase (EC 4.99.1.1).
ACCESSION D00726
KEYWORDS ferrochelatase.
SOURCE Human placenta, cDNA to mRNA, clones lambda HF[1-2 and 2-1].
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2443)
AUTHORS Nakahashi,Y., Takektani,S., Okuda,M., Inoue,K. and Tokunaga,R.
TITLE Molecular cloning and sequence analysis of cDNA encoding human
ferrochelatase
JOURNAL Biochem. Biophys. Res. Commun. 173, 748-755 (1990)
STANDARD full staff_review
COMMENT These data kindly submitted in computer readable form by:
Shigeru Taketani
Department of Hygiene
Kansai Medical University
1 Fumizonocho, Moriguchi
Osaka 570
Japan
Phone: 06-992-1001 x2504
Fax: 06-992-0609
Northern blot analysis showed two mRNAs for ferrochelatase.
FEATURES Location/Qualifiers
CDS 30..1301
/EC_number="4.99.1.1"
/product="ferrochelatase"
/codon_start=30
sig_peptide 30..191
/product="ferrochelatase"
/codon_start=30
mat_peptide 192..1298
/product="ferrochelatase"
/codon_start=192
polyA_signal 1559..1564
polyA_site 1571..1571
polyA_signal 1967..1972
/note="alternate"
polyA_site 2443..2443
/note="alternate"
BASE COUNT 652 a 557 c 581 g 653 t
ORIGIN
1 gggcgggtcg ggccgaggct gcccaggcaa tgcgttcact cggcgcaaac atggctgcgg
61 ccctgcgcgc cgcgggcgtc ctgctccgcg atccgctggc atccagcagc tggagggtct
121 gtcagccatg gaggtggaag tcaggtgcag ctgcagcggc cgtcaccaca gaaacagccc
181 agcatgccca gggtgcaaaa cctcaagttc aaccgcagaa gaggaagccg aaaactggaa
241 tattaatgct aaacatggga ggccctgaaa ctcttggaga tgttcacgac ttccttctga
301 gactcttctt ggaccaagac ctcatgacac ttcctattca gaataagctg gcaccattca
361 tcgccaaacg ccgaaccccc aagattcaag agcagtaccg caggattgga ggcggatccc
421 ccatcaagat atggacttcc aagcagggag agggcatggt gaagctgctg gatgaattgt
481 cccccaacac agcccctcac aaatactata ttggatttcg gtacgtccat cctttaacag
541 aagaagcaat tgaagagatg gagagagatg gcctagaaag ggctattgct ttcacacagt
601 atccacagta cagctgctcc accacaggca gcagcttaaa tgccatttac agatactata
661 atcaagtggg acggaagccc acgatgaagt ggagcactat tgacaggtgg cccacacatc
721 acctcctcat ccagtgcttt gcagatcata ttctaaagga actggaccat tttccacttg
781 agaagagaag cgaggtggtc attctgtttt ctgctcactc actgccgatg tctgtggtca
841 acagaggcga cccatatcct caggaggtaa gcgccactgt ccaaaaagtc atggaaaggc
901 tggagtactg caacccctac cgactggtgt ggcaatccaa ggttggtccg atgccctggt
961 tgggtcctca aacagacgaa tctatcaaag ggctttgtga gagggggagg aagaatatcc
1021 tcttggttcc gatagcattt accagtgacc atattgaaac gctgtatgag ctggacatcg
1081 agtactctca agttttagcc aaggagtgtg gagttgaaaa catcagaaga gctgagtctc
1141 ttaatggaaa tccattgttc tctaaggccc tggccgactt ggtgcattca cacatccagt
1201 caaacgagct gtgttccaag cagctgaccc tgagctgtcc gctctgtgtc aatcctgtct
1261 gcagggagac taaatccttc ttcaccagcc agcagctgtg acccccgccg gtggaccccg
1321 tggcgttagg caaatgccca acctccagat acctccgatg tggagagggt gttatttaga
1381 gatcaaggaa ggaagtcatc cttccttgat atatatacag cctttgggta caaattgtgt
1441 ggtttcttga ggattggact cttgatggat ttctattttt atataactat acagtaagca
1501 tttgtatttt ctctctctag gtataagtta ctagtttgga atgtccatca ggacctttaa
1561 taaatgaggc taaaaatttg tcttatgaga cacacctatt taagcacaga ttttggcttt
1621 attgcccaaa accctcccga aagggtacgg agagtcccct ctgtgggctg gcagtgtgaa
1681 tgagatctgt ttagtctcgt gcatatagtt gctgtttttt aaatgaacac agttgagtat
1741 ttgaagtgaa tttgaaaaag aaatgttact taatctttcc ctaagcccat gggttacaga
1801 atgctaggga ggcaatttgg ttacctgcaa tggctgcttt tgccagcgag gccaccattc
1861 attggtcatc ttggtatttg tgctgtgaat ctcactttcc tcaatgtaaa aaggaatcaa
1921 gtatggattt cagaggtgct cttagattcc ccatacaccc aagggtaata aacgtgtaca
1981 agtacagtgt tcatgatacg tgccttggtg ggagtccgtg gtgccacagg gaaggggctc
2041 ccactgcttc tggtctccag ggacagtgct gctggaaagg ctagtgatga gcttcaccct
2101 ggagctcctc ccgggacctt gcaagcctct ccatccagca tcttctctat cttagttgaa
2161 tgccttcttt ctgaacattt gttttaagaa ttattttata aagtcaacaa tactttgctt
2221 gaattctttc ttaatttacg attttttatt ataaaaaagt atagtgatac aatgggacat
2281 gtgaagaata cagaaaagta accactttaa tgcaataact gttatcataa tattgtattt
2341 cgtggtagtc cttgcctgta gatattttta atgccattta atgccattgt caccttggat
2401 ttatgagtga aaagtgtttc taaaaatata gaaataatgt cag
//