GenBank-Updates@genbank.bio.net (04/20/91)
LOCUS HUMMHCHLAB 3950 bp ds-DNA PRI 20-APR-1991
DEFINITION Human MHC class I HLA-B-3502 gene, complete cds.
ACCESSION M63454
KEYWORDS cell surface antigen; cell surface glycoprotein; class I gene;
integral membrane protein; major histocompatibility complex.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3950)
AUTHORS Chertkoff,L.P., Herrera,M., Fainboim,L. and Satz,M.L.
TITLE Complete nucleotide sequence of a genomic clone encoding HLA-B35
isolated from a caucasian individual of hispanic origin:
Identification of a new variant of HLA-B35
JOURNAL Hum. Immunol. (1991) In press
STANDARD full staff_entry
COMMENT A new allelic variant isolated from an individual with hispanic
background. Differs in 3 nucleotides from the oriental allele
B*3501, with substitution at residues 109, 114 and 116.
FEATURES Location/Qualifiers
exon 669..741
/number=1
/gene="HLA-B-3502"
exon 871..1140
/number=2
/gene="HLA-B-3502"
exon 1387..1662
/number=3
/gene="HLA-B-3502"
exon 2238..2513
/number=4
/gene="HLA-B-3502"
exon 2618..2734
/number=5
/gene="HLA-B-3502"
exon 3176..3208
/number=6
/gene="HLA-B-3502"
exon 3315..3358
/number=7
/gene="HLA-B-3502"
CDS join(669..741,871..1140,1387..1662,2238..2513,2618..2734,
3176..3208,3315..3358)
/gene="HLA-B-3502"
/codon_start=669
mRNA join(669..741,871..1140,1387..1662,2238..2513,2618..2734,
3176..3208,3315..3358)
/gene="HLA-B-3502"
BASE COUNT 792 a 1101 c 1201 g 856 t
ORIGIN
1 aatcattcag ggattaccaa tattgtgcta cctactgtat caataaacaa aaaggaaact
61 ggtctctatg agaatctctg tgtggtggct tcagacaaaa cttcgccagg tttagagaga
121 aaacccctgt ctctacacct ccattcccag ggcgagctca ctctctggca tcaagttctc
181 cgtgatcagt ttccctacac aagatccaag aggagaggta aggagtgaga ggcagggagt
241 ccagttcagg gacagggatt ccaggaggag aagtgaaggg gaagcgggtc gggcagcctg
301 ggggtctctc cctggtttcc acagacagat ccttgtgcag gactcaggca gacagtgtga
361 caaagaggct ggtgtaggag aagagggatc aggacgaagt cccagccgcg ggcggggctc
421 tcagggtctc aggctccgag agccttgtct gcattgggga ggcgcagcgt tggggattcc
481 ccactcccac gagtttcact tcttctccca acctatgtcg ggtccttctt ccaggatact
541 cgtgacgcgt ccccatttcc cactccattg ggtgtcggat atctagagaa gccaatcagt
601 gtcgccgggg tcccagttct aaagtcccca cgcacccacc cggactcaga atctcctcag
661 acgccgagat gcgggtcacg gcgccccgaa ccgtcctcct gctgctctgg ggggcagtgg
721 ccctgaccga gacctgggcc ggtgagtgcg gggtcgggag ggaaatggcc tctgtgggga
781 ggagcgaggg gaccgcaggc gggggcgcag gacctgagga gccgcgccgg gaggagggtc
841 gggcgggtct cagcccctcc tcgcccccag gctcccactc catgaggtat ttctacaccg
901 ccatgtcccg gcccggccgc ggggagcccc gcttcatcgc agtgggctac gtggacgaca
961 cccagttcgt gaggttcgac agcgacgccg cgagtccgag gacggagccc cgggcgccat
1021 ggatagagca ggaggggccg gagtattggg accggaacac acagatcttc aagaccaaca
1081 cacagactta ccgagagagc ctgcggaacc tgcgcggcta ctacaaccag agcgaggccg
1141 gtgagtgacc ccggcccggg gcgcaggtca cgactcccca tcccccacgt acggcccggg
1201 gtcgccccga gtctccgggt ccgagatccg cctccctgag gccgcgggac ccgcccagac
1261 cctcgaccgg cgagagcccc aggcgcgttt acccggtttc attttcagtt gaggccaaaa
1321 tccccgcggg ttggtcgggg cggggcgggg ctcgggggac ggggctgacc gcggggccgg
1381 ggccagggtc tcacatcatc cagaggatgt atggctgcga cctggggccc gacgggcgct
1441 tcctccgcgg gcataaccag tacgcctacg acggcaagga ttacatcgcc ctgaacgagg
1501 acctgagctc ctggaccgcg gcggacaccg cggctcagat cacccagcgc aagtgggagg
1561 cggcccgtgt ggcggagcag ctgagagcct acctggaggg cctgtgcgtg gagtggctcc
1621 gcagatacct ggagaacggg aaggagacgc tgcagcgcgc gggtaccagg ggcagtgggg
1681 agccttcccc atctcctata ggtcgccggg gatggcctcc cacgagaaga ggaggaaaat
1741 gggatcagcg ctagaatgtc gccctccctt gaatggagaa tggcatgagt tttcctgagt
1801 ttcctctgag ggccccctct tctctctagg acaattaagg gatgacgtct ctgaggaaat
1861 ggaggggaag acagtcccta gaatactgat caggggtccc ctttgacccc tgcagcagcc
1921 ttgggaaccg tgacttttcc tctcaggcct tgttctctgc ctcacactca gtgtgtttgg
1981 ggctctgatt ccagcacttc tgagtcactt tacctccact cagatcagga gcagaagtcc
2041 ctgttccccg ctcagagact cgaactttcc aatgaatagg agattatccc aggtgcctgc
2101 gtccaggctg gtgtctgggt tctgtgcccc ttccccacac caggtgtcct gtccattctc
2161 aggctggtca catgggtggt cctagggtgt cccatgagag atgcaaagcg cctgaatttt
2221 ctgactcttc ccatcagacc ccccaaagac acacgtgacc caccaccccg tctctgacca
2281 tgaggccacc ctgaggtgct gggccctggg cttctaccct gcggagatca cactgacctg
2341 gcagcgggat ggcgaggacc aaactcagga cactgagctt gtggagacca gaccagcagg
2401 agatagaacc ttccagaagt gggcagctgt ggtggtgcct tctggagaag agcagagata
2461 cacatgccat gtacagcatg aggggctgcc gaagcccctc accctgagat ggggtaagga
2521 gggggatgag gggtcatatc tcttctcagg gaaagcagga gcccttctgg agcccttcag
2581 cagggtcagg gcccctcgtc ttcccctcct ttcccagagc catcttccca gtccaccatc
2641 cccatcgtgg gcattgttgc tggcctggct gtcctagcag ttgtggtcat cggagctgtg
2701 gtcgctactg tgatgtgtag gaggaagagc tcaggtaggg aaggggtgag gggtggggtc
2761 tgggttttct tgtcccactg ggggtttcaa gccccaggta gaagtgttcc ctgcctcatt
2821 actgggaagc agcatccaca caggggctaa cgcagcctgg gaccctgtgt gccagcactt
2881 actcttttgt gcagcacatg tgacaatgaa ggacggatgt atcaccttga tggttgtggt
2941 gttggggtcc tgatttcagc attcatgagt caggggaagg tccctgctaa ggacagacct
3001 taggagggca gttggtccag gacccacact tgctttcctc gtgtttcctg atcctgcctt
3061 gggtctgtag tcatacttct ggaaattcct tttgggtcca agacgaggag gttcctctaa
3121 gatcttaagg ccctgcttcc tcccagtccc ctcacaggac attttcttcc cacaggtgga
3181 aaaggaggga gctactctca ggctgcgtgt aagtggtggg ggtgggagtg tggaggagct
3241 cacccacccc ataattcctc ctgtcccacg tctcctgcgg gctctgacca ggtcctgttt
3301 ttgttctact ccagccagcg acagtgccca gggctctgat gtgtctctca cagcttgaaa
3361 aggtgagatt cttggggtct agagtgggcg gggggggcgg ggagggggca gaggggaaag
3421 gcctgggtaa tggagattct ttgattggga tgtttcgcgt gtgtcgtggg ctgttcagag
3481 tgtcatcact taccatgact aaccagaatt tgttcatgac tgttgttttc tgtagcctga
3541 gacagctgtc ttgtgaggga ctgagatgca ggatttcttc actcctcccc tttgtgactt
3601 caagagcctc tggcatctct ttctgcaaac ggcacctgaa tgtgtctgcg tccctgttag
3661 cctaatgtga ggaggtggag agacagccca cccccgtgtc cactgtgacc cctgttccca
3721 tgctgacctg tgtttcctcc ccagtcatct ttcttgttcc agagaggtgg ggctggatgt
3781 ctccatctct gtctcaactt tatgtgcact gagctgcaac ttcttacttc cctactgaaa
3841 ataagaatct gaatataaac ttgttttctc aaatatttgc tatgagaggt tgatggatta
3901 attaaataag tcaattcctg gaatttgaga gagcaaataa agacctgaga
//