GenBank-Updates@genbank.bio.net (04/25/91)
LOCUS HUMIGGK 1244 bp ss-mRNA PRI 25-APR-1991
DEFINITION Human Ig rearranged gamma chain mRNA, V-J-C region and complete
cds.
ACCESSION M63438
KEYWORDS constant region; gamma immunoglobulin; immunoglobulin;
immunoglobulin light-chain; variable region.
SOURCE Human, cDNA to mRNA (transfected into mouse myeloma cell line
P3X63Ag8.653).
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1244)
AUTHORS Shuford,W., Raff,H.V., Finley,J.W., Esselstyn,J. and Harris,L.J.
TITLE Effect of light chain V-region duplication on IgG oligomerization
and in vivo efficacy
JOURNAL Science (1991) In press
STANDARD simple staff_entry
FEATURES Location/Qualifiers
CDS join(1..49,50..388,389..727,728..1050)
/codon_start=1
exon 1..49
/number=1
/note="encodes first part of signal peptide"
sig_peptide 1..60
/codon_start=1
exon 50..388
/number=2
/note="encodes second part of signal peptide and VJ
region"
mat_peptide 61..1047
/codon_start=61
exon 389..727
/number=3
/note="duplication of exon 2"
exon 728..1244
/number=4
/note="encodes human Kappa constant region"
polyA_signal 1223..1232
BASE COUNT 292 a 383 c 302 g 267 t
ORIGIN chromosome 2
1 atggaagccc cagctcagct tctcttcctc ctgctactct ggctcccaga taccaccgga
61 gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc
121 ctctcctgca gggccagtca gagtgttggc agctacttag cctggtacca acagaaacct
181 ggccaggctc ccaggcccct catctatgat gcatccaaca gggccactgg catcccagcc
241 aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct
301 gaagattttg cagtttatta ctgtcaacac cgtgacaatt ggcctccggg ggccactttc
361 ggcggaggga ccaaggtgga gatcaaacat accaccggag aaattgtgtt gacacagtct
421 ccagccaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag ggccagtcag
481 agtgttggca gctacttagc ctggtaccaa cagaaacctg gccaggctcc caggcccctc
541 atctatgatg catccaacag ggccactggc atcccagcca ggttcagtgg cagtgggtct
601 gggacagact tcactctcac catcagcagc ctagagcctg aagattttgc agtttattac
661 tgtcaacacc gtgacaattg gcctccgggg gccactttcg gcggagggac caaggtggag
721 atcaaacgaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg
781 aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa
841 gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag
901 caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac
961 tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc
1021 acaaagagct tcaacagggg agagtgttag agggagaagt gcccccacct gctcctcagt
1081 tccagcctga ccccctccca tcctttggcc tctgaccctt tttccacagg ggacctaccc
1141 ctattgcggt cctccagctc atctttcacc tcacccccct cctcctcctt ggctttaatt
1201 atgctaatgt tggaggagaa tgaataaata aagtgaatct ttgc
//