GenBank-Updates@genbank.bio.net (04/25/91)
LOCUS HUMIGGK 1244 bp ss-mRNA PRI 25-APR-1991 DEFINITION Human Ig rearranged gamma chain mRNA, V-J-C region and complete cds. ACCESSION M63438 KEYWORDS constant region; gamma immunoglobulin; immunoglobulin; immunoglobulin light-chain; variable region. SOURCE Human, cDNA to mRNA (transfected into mouse myeloma cell line P3X63Ag8.653). ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 1244) AUTHORS Shuford,W., Raff,H.V., Finley,J.W., Esselstyn,J. and Harris,L.J. TITLE Effect of light chain V-region duplication on IgG oligomerization and in vivo efficacy JOURNAL Science (1991) In press STANDARD simple staff_entry FEATURES Location/Qualifiers CDS join(1..49,50..388,389..727,728..1050) /codon_start=1 exon 1..49 /number=1 /note="encodes first part of signal peptide" sig_peptide 1..60 /codon_start=1 exon 50..388 /number=2 /note="encodes second part of signal peptide and VJ region" mat_peptide 61..1047 /codon_start=61 exon 389..727 /number=3 /note="duplication of exon 2" exon 728..1244 /number=4 /note="encodes human Kappa constant region" polyA_signal 1223..1232 BASE COUNT 292 a 383 c 302 g 267 t ORIGIN chromosome 2 1 atggaagccc cagctcagct tctcttcctc ctgctactct ggctcccaga taccaccgga 61 gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 121 ctctcctgca gggccagtca gagtgttggc agctacttag cctggtacca acagaaacct 181 ggccaggctc ccaggcccct catctatgat gcatccaaca gggccactgg catcccagcc 241 aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct 301 gaagattttg cagtttatta ctgtcaacac cgtgacaatt ggcctccggg ggccactttc 361 ggcggaggga ccaaggtgga gatcaaacat accaccggag aaattgtgtt gacacagtct 421 ccagccaccc tgtctttgtc tccaggggaa agagccaccc tctcctgcag ggccagtcag 481 agtgttggca gctacttagc ctggtaccaa cagaaacctg gccaggctcc caggcccctc 541 atctatgatg catccaacag ggccactggc atcccagcca ggttcagtgg cagtgggtct 601 gggacagact tcactctcac catcagcagc ctagagcctg aagattttgc agtttattac 661 tgtcaacacc gtgacaattg gcctccgggg gccactttcg gcggagggac caaggtggag 721 atcaaacgaa ctgtggctgc accatctgtc ttcatcttcc cgccatctga tgagcagttg 781 aaatctggaa ctgcctctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa 841 gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag tgtcacagag 901 caggacagca aggacagcac ctacagcctc agcagcaccc tgacgctgag caaagcagac 961 tacgagaaac acaaagtcta cgcctgcgaa gtcacccatc agggcctgag ctcgcccgtc 1021 acaaagagct tcaacagggg agagtgttag agggagaagt gcccccacct gctcctcagt 1081 tccagcctga ccccctccca tcctttggcc tctgaccctt tttccacagg ggacctaccc 1141 ctattgcggt cctccagctc atctttcacc tcacccccct cctcctcctt ggctttaatt 1201 atgctaatgt tggaggagaa tgaataaata aagtgaatct ttgc //