GenBank-Updates@genbank.bio.net (04/25/91)
LOCUS HUMCFTC 4389 bp ds-DNA PRI 25-APR-1991
DEFINITION Human cystic fibrosis transmembrane conductance regulator gene, 5'
end.
ACCESSION M58478 M58479
KEYWORDS cystic fibrosis transmembrane conductance regulator;
transmembrane protein.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 4389)
AUTHORS Yoshimura,K., Nakamura,H., Trapnell,B.C., Dalemans,W., Pavirani,A.,
Lecocq,J.-P. and Crystal,R.G.
TITLE The cystic fibrosis gene has a housekeeping-type promoter and is
expressed at low levels in cells of epithelial origin
JOURNAL J. Biol. Chem. 266, 9140-9144 (1991)
STANDARD full staff_entry
FEATURES Location/Qualifiers
GC_signal 2876..2881
/number=1
/gene="CFTR gene"
GC_signal 3492..3497
/number=2
/gene="CFTR gene"
GC_signal 3571..3576
/number=3
/gene="CFTR gene"
CAAT_signal 3658..3662
/number=1
/note="CCAAT-like motif"
/gene="CFTR gene"
promoter 3724..3825
/note="minimum promoter"
/gene="CFTR gene"
/evidence=EXPERIMENTAL
CAAT_signal 3766..3770
/note="inverted CCAAT motif"
/gene="CFTR gene"
CAAT_signal 3774..3778
/number=2
/note="CCAAT-like motif"
/gene="CFTR gene"
mRNA 3826..4389
/gene="CFTR gene"
/evidence=EXPERIMENTAL
/partial
exon 3826..3949
/number=1
/gene="CFTR gene"
/evidence=EXPERIMENTAL
CDS 3897..3949
/product="cystic fibrosis transmembrane conductance
regulator"
/gene="CFTR gene"
/codon_start=3897
/partial
BASE COUNT 1284 a 803 c 1004 g 1298 t
ORIGIN chromosome 7q31
1 gaattcaaag gaaaacataa gatgcaattc gtgcctccaa ggaggttgta gggaagaggg
61 gttatgaatg tatgtaaata gaagttggtg tgcgtgtgtg tttataaaca gaattgtcag
121 accaaacatt attttggaag cagtaaaagt aaactagaat ctggcctagt catgtcccag
181 gacacctctt tcaagtcctg aaacatcttt gtaagactgt aatgtgtgtt tacatcctag
241 gtaatcactg tggcccactg ttgaagagct gtggctgttc ttacccttct agttagataa
301 acttataagc acaaccagac tacatatatg aagctgaaga gaccttgtct ttttttaacg
361 agcttttctt cccgatagga gtgactattt cttttcttct tccacatttt caggttttag
421 tgtacttgtg attgctaccc acttatcact attaaagtct actcaggaga gaatctgaga
481 aacactctca aattaagttg aacatgatgg ataagtaaag tattgtgaaa gttcactctc
541 atgatttcta atggtgaaac ctggcagggt gactaatctt tgacgagaag gttatcactt
601 ataatctttc atatattgag atcatttgta agaagcaccc agcacattgc tgaacacaaa
661 gtaggtatta aataaatgtt ggcttccttt tctcctactc atcctcgctc ttctttttaa
721 tataccttta aaatgatgcc acagaaatgg ccacccaatc ttctatattt aaggtcagtt
781 cttgcattag gaaattctat aggggaagta tgtgaagtat gtgtagtcag tcattaaatg
841 cttgggctct ggccacagat tgtttaggtt taaatcccag tttcctcttt tattattaat
901 tgtgcaactt gcttgggaaa acatgaaact tgtttttcct caggttcatt atctgtaata
961 tatagtgaat gaagaagttt cctgtcccat gaaggtgttg taaagattaa aaaaggcaaa
1021 ttaggctgtg tatttgtcat aataattggc atatatggta agtgaccaac aaccataagg
1081 tattataaaa ttgttataaa atgatatgag ctatcattga gcagcatgaa agaagagctt
1141 cactgtttca cctactatca ccctggccca ttaatctctt tcctgttcct gacatttcag
1201 agatacgttt aggatttcaa tcatgacctt aagccacatt tgaacaattt tctggtggat
1261 aagtcctcat tcccacatta tgtatgtacc tagatgcaaa tcctgaatat catgtcgcaa
1321 ttagtgcatc tggacatgct tgctaactgt gttaaagctc tgaataatgg taaagtttta
1381 tttctaccaa aacaaatttg ggctgtaatg ttttatgata aaaatctgtg gtcttcctat
1441 gtacatgtgt gtgtacatgc ttaaaatgca atgttatagt taaatgtaat tcattaaaag
1501 tatgtaactc cagtggctac ttagtttggc tacttggttt gtagatttct gctttcctgt
1561 ttcattgtta aacaggtcta gaagttatta tttcatgaaa ctaatgtgag gaaaaagact
1621 atgttgatat ataagtgaca ttatataaat acatgaggga tgatttgatt agaagcagta
1681 ttacacagtg ataggagtaa tggtttagaa ctagactcag gtttgaatct tagctctatc
1741 attataggca tttacttaac ttttcttgtt tgcttaactg aaaactgaag ataataacac
1801 ctatttacat ggttgttata agggttatat gaataatgtc tggcaaatag taagaactca
1861 agtaactgtt tcactctttc cagaaggaga ttggctgaaa aatatttgga gtctcctcca
1921 gccatattcc ttggtcagct tctatgatcc tctttggagc ttaattctta atccctttat
1981 tttcacttgc ttgttgataa caaagaagaa ctaattatta atttatttca aaatgcatgt
2041 attatatttg atgggccaca ctaacagtta taaaccaaac aacagattgg gaatggggaa
2101 gtggatgtgg tgagttcaat cacatgtctg ggaaaagtca atagtgaaga cagagtctca
2161 caattttttg tcataatgga gagatgaaaa cacaggtaga ggatttcaaa caacagagtg
2221 gatggtgagt taaaaatgct gaaattcttt cctggtgtct aacttaatgc aatgtggttt
2281 atctctttgc tcttttctct actattcaaa tttaggataa taaagattaa atgtttctaa
2341 atcttacttt acaatatcaa gaaaaaaagg tatgcttttg cccacggaag ggcaaagcag
2401 agctatgaaa acctgctgaa cacattcttt attttcaaca caggttcttg tctttccatc
2461 atgaaatgca cattttattt gtactgtatt tgggtgacca caagtcaaca acaagataat
2521 tcacaagacc cttgccttag atgtgtcggc aataaagtaa tcaggccaaa atttttactt
2581 tcctttgaat ttttcaattc aaacacaatg tatgcttgct tttacacagt agggttcagg
2641 gattagaggg ttggctcctt taaaaccgtc agagacacag gcaatcctac acaaaattct
2701 cagaaggaag gcgcctacgc ctgggaatgc ccagatgccc ctcagagagt tgaagatggc
2761 gtttctctga gtcaggtcaa agttaacaca ttaccttcgc ttcaaagact gcttggcttc
2821 ctttcggtgg attagtcaag atgttttgct gactgagact aggaaatcta taggagggcg
2881 ggttagttta cattgttcct tgtcattatc gctaaaacac tccaaagcct tccttaaaaa
2941 tgcgcactgg gctaaaaagg atagacaagg aacacatcct gggccggtaa ttacgcaaag
3001 cattatctcc tcttacctcc ttgcagattt ttttttctct ttcagtacgt gtcctaagat
3061 ttctgtgcca cccttggagt tcactcacct aaacctgaaa ctaataaagc ttggttcttt
3121 tctccgacac gcaaaggaag cgctaaggta aatgcatcag acccacactg ccgcggaact
3181 tttcggctct ctaaggctgt attttgatat acgaaaggca cattttcctt cccttttcaa
3241 aatgcacctt gcaaacgtaa caggaacccg actaggatca tcgggaaaag gaggaggagg
3301 aggaaggcag gctccgggga agctggtggc agcgggtcct gggtctggcg gaccctgacg
3361 cgaaggaggg tctaggaagc tctccgggga gccggttctc ccgccggtgg cttcttctgt
3421 cctccagcgt tgccaactgg acctaaagag aggccgcgac tgtcgcccac ctgcgggatg
3481 ggcctggtgc tgggcggtca ggacactgac ctggaaggag cgcgcgcgag ggagggaggc
3541 tgggagtcag aatcgggaaa gggaggtgcg gggcggcgag ggagcgaagg aggagaggag
3601 gaaggagcgg gaggggtgct ggcgggggtg cgtagtgggt ggagaaagcc gctagagcaa
3661 atttggggcc ggaccaggca gcactcggct tttaacctgg gcagtgaagg cgggggaaag
3721 agcaaaagga aggggtggtg tgcggagtag gggtgggtgg ggggaattgg aagcaaatga
3781 catcacagca ggtcagagaa aaagggttga gcggcaggca cccagagtag taggtctttg
3841 gcattaggag cttgagccca gacggcccta gcagggaccc cagcgcccga gagaccatgc
3901 agaggtcgcc tctggaaaag gccagcgttg tctccaaact ttttttcagg tgagaaggtg
3961 gccaaccgag cttcggaaag acacgtgccc acgaaagagg agggcgtgtg tatgggttgg
4021 gtttggggta aaggaataag cagtttttaa aaagatgcgc tatcattcat tgttttgaaa
4081 gaaaatgtgg gtattgtaga ataaaacaga aagcattaag aagagatgga agaatgaact
4141 gaagctgatt gaatagagag ccacatctac ttgcaactga aaagttagaa tctcaagact
4201 caagtacgct actatgcact tgttttattt catttttcta agaaactaaa aatacttgtt
4261 aataagtacc taagtatggt ttattggttt tcccccttca tgccttggac acttgattgt
4321 cttcttggca catacaggtg ccatgcctgc atatagtaag tgctcagaaa acatttcttg
4381 actgaattc
//