GenBank-Updates@genbank.bio.net (04/30/91)
LOCUS BOVCYP17A 1725 bp ss-mRNA MAM 30-APR-1991
DEFINITION Bovine adrenocortical cytochrome P-450-17-alpha mRNA, complete cds.
ACCESSION M12547
KEYWORDS 17-alpha-hydroxylase; cytochrome P-450.
SOURCE Bovine adrenal cortex, cDNA to mRNA, clonepcD17-alpha-2.
ORGANISM Bos taurus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Artiodactyla; Ruminantia; Pecora; Bovidae.
REFERENCE 1 (bases 1 to 1725)
AUTHORS Zuber,M.X., John,M.E., Okamura,T., Simpson,E.R. and Waterman,M.R.
TITLE Bovine adrenocortical cytochrome P-450-17-alpha: Regulation of gene
expression by ACTH and elucidation of primary sequence
JOURNAL J. Biol. Chem. 261, 2475-2482 (1986)
STANDARD full staff_entry
REFERENCE 2 (sites)
AUTHORS Clark,B.J. and Waterman,M.R.
TITLE The hydrophobic amino-terminal sequence of bovine
17-alpha-hydroxylase is required for the expression of a functional
hemoprotein in COS 1 cells
JOURNAL J. Biol. Chem. 266, 5898-5904 (1991)
STANDARD full staff_review
FEATURES Location/Qualifiers
mRNA <1..1725
/note="CYP mRNA"
CDS 47..1576
/note="cytochrome P-450-17-alpha precursor"
/codon_start=47
sig_peptide 47..94
/note="cytochrome P-450-17-alpha signal peptide"
/codon_start=47
mat_peptide 95..1573
/note="cytochrome P-450-17-alpha"
/codon_start=95
BASE COUNT 409 a 511 c 412 g 393 t
ORIGIN 216 bp upstream of PstI site.
1 aagccactcc acagctcttt gtcctgactg ctgccaccca gacacaatgt ggctgctcct
61 ggctgtcttt ctgctcaccc tcgcctattt attttggccc aagaccaagc actctggtgc
121 caagtacccc aggagcctcc catccctgcc cctggtgggc agcctgccgt tcctccccag
181 acgtggccag cagcacaaga acttcttcaa gctgcaggaa aaatatggcc ccatctattc
241 ctttcgtttg ggttccaaga cgactgtgat gattggacac caccagttgg ccagggaggt
301 gcttctcaag aagggcaagg aattctctgg gcgtcccaaa gtggccactc tagacatcct
361 gtcagacaac caaaagggca ttgcctttgc cgaccatggt gcccactggc agctgcatcg
421 gaagctggca ctgaatgcct ttgccctgtt caaggatggc aacctgaagt tagagaagat
481 cattaatcag gaagccaatg tgctctgtga tttcctggcc acccagcatg gagaggccat
541 agatctgtcc gagcctctct ctctggcggt gaccaacata atcagcttta tctgcttcaa
601 cttctccttc aagaatgagg atcctgccct gaaggccata caaaatgtca atgatggcat
661 cctggaggtt ctgagcaagg aagttctgtt agacatattc cctgtgctga agattttccc
721 cagcaaagcc atggaaaaga tgaagggttg tgttcaaacg cgaaatgaat tgctgaatga
781 aatccttgaa aaatgtcagg agaacttcag cagtgattcc atcactaact tgctgcacat
841 actgatccaa gccaaggtga atgcagacaa taacaatgct ggcccagacc aggattcaaa
901 gctgctttca aatagacaca tgctcgctac tataggggac atcttcgggg ctggtgtgga
961 gaccaccacg tctgtgataa agtggatcgt ggcctacctg ctacaccatc cttcgttgaa
1021 gaagaggatc caggatgaca ttgaccagat tataggtttc aatcgcaccc caaccatcag
1081 tgaccggaac cgccttgtcc tgctggaggc gaccatcaga gaagtgctcc gaatccggcc
1141 tgtggcccct acgctgatcc cccacaaggc tgtcattgac tccagcattg gcgaccttac
1201 cattgacaaa ggcacagacg ttgtggtcaa cctgtgggca ctgcatcaca gtgagaagga
1261 gtggcagcat cccgacctgt tcatgcccga gcgcttcttg gaccccacgg ggacgcaact
1321 catctcgcca tcattaagct acttgccctt tggagcagga ccccgctcct gcgtaggtga
1381 gatgctagcc cgccaggagc tcttcctctt catgtcccgg ctgctgcaga ggttcaacct
1441 ggagatcccg gatgatggga agctaccttc tctggagggc catgccagtc tcgtcttgca
1501 gatcaaacct ttcaaggtga agatcgaggt gcgccaggcc tggaaggaag cccaggctga
1561 gggtagcacc ccatgactcc accctatgtg acccccaccg cacagaatta gaggagctcc
1621 cccaccctct cccaccattc cttcttcctc cccgcccact ctgccttctt tcccagcctg
1681 cagccctggc agtgatgtgc attaaacagt ttctttctcc aaaac
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