GenBank-Updates@genbank.bio.net (04/25/91)
LOCUS HUMELAM1B 1566 bp ds-DNA PRI 25-APR-1991
DEFINITION Human endothelial leukocyte adhesion molecule I gene, exons 1 and
2.
ACCESSION M64485
KEYWORDS endothelial leukocyte adhesion molecule I.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1566)
AUTHORS Montgomery,K.F., Osborn,L., Hession,C., Tizard,R., Goff,D.,
Vassallo,C., Tarr,P.I., Bomsztyk,K., Lobb,R., Harlan,J.M. and
Pohlman,T.H.
TITLE Endothelial Leukocyte Adhesion Molecule 1 (ELAM-1) Gene Expression:
Roles of NF-kB, Protein Kinase C, and AP-1
JOURNAL Proc. Natl. Acad. Sci. (1991) In press
STANDARD full automatic
REFERENCE 2 (sites)
AUTHORS Collins,T., Williams,A., Johnston,G.I., Kim,J., Eddy,R., Shows,T.,
Gimbrone,M.A.Jr.. and Bevilacqua,M.P.
TITLE Structure and Chromosomal Location of the Gene for
Endothelial-Leukocyte Adhesion Molecule 1
JOURNAL J. Biol. Chem. 266, 2466-2473 (1991)
STANDARD full staff_review
FEATURES Location/Qualifiers
mRNA (841..948,1259..1390)
/product="endothelial leukocyte adhesion molecule I"
/partial
misc_binding 341..347
/bound_moiety="'AP-1'"
misc_binding 747..758
/bound_moiety="'NF-kappa B'"
CAAT_signal 774..777
TATA_signal 811..817
exon 841..948
/number=1
/product="endothelial leukocyte adhesion molecule I"
intron 949..1258
/number=1
exon 1259..1390
/number=2
/product="endothelial leukocyte adhesion molecule I"
intron 1391..>1566
/number=2
BASE COUNT 441 a 316 c 295 g 514 t
ORIGIN
1 gcatgcgcca ccatgcccag ctaattttgt atttttagta gagatggcgt ttctccatgt
61 tggtcaggct ggtcttgaac tcccggcctc aggtgatccg cctgcctcgg cctcccaaag
121 tggtgggatt acaggcgtga gccactgtgc ctggcctcct ttttattttt ttcactgaac
181 aaaccatgaa actttcccag atgtaaatat ctatttccca tttttctttt tttaaaataa
241 ggcattattt taaccatttg agtgttagat attattttta gataatattt taatttaggc
301 ataactgccg tgcaaaatct gaagattaat atctaccttg tgagtcattc ctctgtgaga
361 cagtgcatgt taaatatgtt gaattggcag gtgaaaaagg aagaaaaaat gagtagtgat
421 tggttatcca cagctatgaa tgagaaattg aaggtagtag actatggatg acaaacctat
481 tcttggtttc cttctgtttc tgaaattcta attactacca caactacatg agagacacta
541 ctaacaagca aagttttaca actttttaaa gacatagact ttatgttatt ataattaaaa
601 atcatgcatt tttgtcatat taataaaatt gcatatacga tataaaggca tggacaaagg
661 tgaagtagct tcaagagaca gagtttctga catcattgta attttaagca tcgtggatat
721 tcccgggaaa gtttttggat gccattgggg atttcctctt tactggatgt ggacaatatc
781 ctcctattat tcacaggaag caatccctcc tataaaaggg cctcagccga agtagtgttc
841 agctgttctt ggctgacttc acatcaaaac tcctatactg acctgagaca gaggcagcag
901 tgatacccac ctgagagatc ctgtgtttga acaactgctt cccaaaacgg taagtgcaga
961 acgctttata agggcagcct cgggccatga aacacagata tgcaaaaggc cttctaataa
1021 aaaccacatc tgtacaagct cttattgtat tgtagctaaa acctgtcttt tctctttgac
1081 ctaaataatg aaagtcttaa aatttgttta tttatttgat taaactctga aataaagatt
1141 attgcactag tgtcctttgc ccaaaatctt aggatgctgc cttaaacatc atggtagaat
1201 aatgtaacta gctacccacg atttccttct ttaattcatt ttgtgtttta tctccccagg
1261 aaagtatttc aagcctaaac ctttgggtga aaagaactct tgaagtcatg attgcttcac
1321 agtttctctc agctctcact ttgggtaagt cagtgccatt agaccaagat ttctcattct
1381 cgcactatag atatttcaga ctgaaatatc cttgcttgtc tggggctgtc ctgcacagga
1441 tatctggcag catccttgac ctctacctgc aatgtgttct tccctgggct tggggtcatt
1501 tactttacct cttggtgtct ccctttcctt aagtgtaaag tgtggatccg ttgacctgca
1561 ggtcga
//GenBank-Updates@genbank.bio.net (04/27/91)
LOCUS HUMELAM1B 1566 bp ds-DNA PRI 27-APR-1991
DEFINITION Human endothelial leukocyte adhesion molecule I gene, exons 1 and
2.
ACCESSION M64485
KEYWORDS endothelial leukocyte adhesion molecule I.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1566)
AUTHORS Montgomery,K.F., Osborn,L., Hession,C., Tizard,R., Goff,D.,
Vassallo,C., Tarr,P.I., Bomsztyk,K., Lobb,R., Harlan,J.M. and
Pohlman,T.H.
TITLE Endothelial Leukocyte Adhesion Molecule 1 (ELAM-1) Gene Expression:
Roles of NF-kB, Protein Kinase C, and AP-1
JOURNAL Proc. Natl. Acad. Sci. (1991) In press
STANDARD full automatic
REFERENCE 2 (sites)
AUTHORS Collins,T., Williams,A., Johnston,G.I., Kim,J., Eddy,R., Shows,T.,
Gimbrone,M.A.Jr.. and Bevilacqua,M.P.
TITLE Structure and Chromosomal Location of the Gene for
Endothelial-Leukocyte Adhesion Molecule 1
JOURNAL J. Biol. Chem. 266, 2466-2473 (1991)
STANDARD full staff_review
FEATURES Location/Qualifiers
mRNA (841..948,1259..1390)
/product="endothelial leukocyte adhesion molecule I"
/partial
misc_binding 341..347
/bound_moiety="'AP-1'"
misc_binding 747..758
/bound_moiety="'NF-kappa B'"
CAAT_signal 774..777
TATA_signal 811..817
exon 841..948
/number=1
/product="endothelial leukocyte adhesion molecule I"
intron 949..1258
/number=1
exon 1259..1390
/number=2
/product="endothelial leukocyte adhesion molecule I"
intron 1391..>1566
/number=2
BASE COUNT 441 a 316 c 295 g 514 t
ORIGIN
1 gcatgcgcca ccatgcccag ctaattttgt atttttagta gagatggcgt ttctccatgt
61 tggtcaggct ggtcttgaac tcccggcctc aggtgatccg cctgcctcgg cctcccaaag
121 tggtgggatt acaggcgtga gccactgtgc ctggcctcct ttttattttt ttcactgaac
181 aaaccatgaa actttcccag atgtaaatat ctatttccca tttttctttt tttaaaataa
241 ggcattattt taaccatttg agtgttagat attattttta gataatattt taatttaggc
301 ataactgccg tgcaaaatct gaagattaat atctaccttg tgagtcattc ctctgtgaga
361 cagtgcatgt taaatatgtt gaattggcag gtgaaaaagg aagaaaaaat gagtagtgat
421 tggttatcca cagctatgaa tgagaaattg aaggtagtag actatggatg acaaacctat
481 tcttggtttc cttctgtttc tgaaattcta attactacca caactacatg agagacacta
541 ctaacaagca aagttttaca actttttaaa gacatagact ttatgttatt ataattaaaa
601 atcatgcatt tttgtcatat taataaaatt gcatatacga tataaaggca tggacaaagg
661 tgaagtagct tcaagagaca gagtttctga catcattgta attttaagca tcgtggatat
721 tcccgggaaa gtttttggat gccattgggg atttcctctt tactggatgt ggacaatatc
781 ctcctattat tcacaggaag caatccctcc tataaaaggg cctcagccga agtagtgttc
841 agctgttctt ggctgacttc acatcaaaac tcctatactg acctgagaca gaggcagcag
901 tgatacccac ctgagagatc ctgtgtttga acaactgctt cccaaaacgg taagtgcaga
961 acgctttata agggcagcct cgggccatga aacacagata tgcaaaaggc cttctaataa
1021 aaaccacatc tgtacaagct cttattgtat tgtagctaaa acctgtcttt tctctttgac
1081 ctaaataatg aaagtcttaa aatttgttta tttatttgat taaactctga aataaagatt
1141 attgcactag tgtcctttgc ccaaaatctt aggatgctgc cttaaacatc atggtagaat
1201 aatgtaacta gctacccacg atttccttct ttaattcatt ttgtgtttta tctccccagg
1261 aaagtatttc aagcctaaac ctttgggtga aaagaactct tgaagtcatg attgcttcac
1321 agtttctctc agctctcact ttgggtaagt cagtgccatt agaccaagat ttctcattct
1381 cgcactatag atatttcaga ctgaaatatc cttgcttgtc tggggctgtc ctgcacagga
1441 tatctggcag catccttgac ctctacctgc aatgtgttct tccctgggct tggggtcatt
1501 tactttacct cttggtgtct ccctttcctt aagtgtaaag tgtggatccg ttgacctgca
1561 ggtcga
//GenBank-Updates@genbank.bio.net (05/01/91)
LOCUS HUMELAM1B 1566 bp ds-DNA PRI 01-MAY-1991
DEFINITION Human endothelial leukocyte adhesion molecule I gene, exons 1 and
2.
ACCESSION M64485
KEYWORDS endothelial leukocyte adhesion molecule I.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1566)
AUTHORS Montgomery,K.F., Osborn,L., Hession,C., Tizard,R., Goff,D.,
Vassallo,C., Tarr,P.I., Bomsztyk,K., Lobb,R., Harlan,J.M. and
Pohlman,T.H.
TITLE Endothelial Leukocyte Adhesion Molecule 1 (ELAM-1) Gene Expression:
Roles of NF-kB, Protein Kinase C, and AP-1
JOURNAL Proc. Natl. Acad. Sci. (1991) In press
STANDARD full staff_entry
REFERENCE 2 (sites)
AUTHORS Collins,T., Williams,A., Johnston,G.I., Kim,J., Eddy,R., Shows,T.,
Gimbrone,M.A.Jr.. and Bevilacqua,M.P.
TITLE Structure and Chromosomal Location of the Gene for
Endothelial-Leukocyte Adhesion Molecule 1
JOURNAL J. Biol. Chem. 266, 2466-2473 (1991)
STANDARD full staff_review
FEATURES Location/Qualifiers
mRNA (841..948,1259..1390)
/product="endothelial leukocyte adhesion molecule I"
/partial
misc_binding 341..347
/bound_moiety="'AP-1'"
misc_binding 747..758
/bound_moiety="'NF-kappa B'"
CAAT_signal 774..777
TATA_signal 811..817
exon 841..948
/number=1
/product="endothelial leukocyte adhesion molecule I"
intron 949..1258
/number=1
exon 1259..1390
/number=2
/product="endothelial leukocyte adhesion molecule I"
intron 1391..>1566
/number=2
BASE COUNT 441 a 316 c 295 g 514 t
ORIGIN
1 gcatgcgcca ccatgcccag ctaattttgt atttttagta gagatggcgt ttctccatgt
61 tggtcaggct ggtcttgaac tcccggcctc aggtgatccg cctgcctcgg cctcccaaag
121 tggtgggatt acaggcgtga gccactgtgc ctggcctcct ttttattttt ttcactgaac
181 aaaccatgaa actttcccag atgtaaatat ctatttccca tttttctttt tttaaaataa
241 ggcattattt taaccatttg agtgttagat attattttta gataatattt taatttaggc
301 ataactgccg tgcaaaatct gaagattaat atctaccttg tgagtcattc ctctgtgaga
361 cagtgcatgt taaatatgtt gaattggcag gtgaaaaagg aagaaaaaat gagtagtgat
421 tggttatcca cagctatgaa tgagaaattg aaggtagtag actatggatg acaaacctat
481 tcttggtttc cttctgtttc tgaaattcta attactacca caactacatg agagacacta
541 ctaacaagca aagttttaca actttttaaa gacatagact ttatgttatt ataattaaaa
601 atcatgcatt tttgtcatat taataaaatt gcatatacga tataaaggca tggacaaagg
661 tgaagtagct tcaagagaca gagtttctga catcattgta attttaagca tcgtggatat
721 tcccgggaaa gtttttggat gccattgggg atttcctctt tactggatgt ggacaatatc
781 ctcctattat tcacaggaag caatccctcc tataaaaggg cctcagccga agtagtgttc
841 agctgttctt ggctgacttc acatcaaaac tcctatactg acctgagaca gaggcagcag
901 tgatacccac ctgagagatc ctgtgtttga acaactgctt cccaaaacgg taagtgcaga
961 acgctttata agggcagcct cgggccatga aacacagata tgcaaaaggc cttctaataa
1021 aaaccacatc tgtacaagct cttattgtat tgtagctaaa acctgtcttt tctctttgac
1081 ctaaataatg aaagtcttaa aatttgttta tttatttgat taaactctga aataaagatt
1141 attgcactag tgtcctttgc ccaaaatctt aggatgctgc cttaaacatc atggtagaat
1201 aatgtaacta gctacccacg atttccttct ttaattcatt ttgtgtttta tctccccagg
1261 aaagtatttc aagcctaaac ctttgggtga aaagaactct tgaagtcatg attgcttcac
1321 agtttctctc agctctcact ttgggtaagt cagtgccatt agaccaagat ttctcattct
1381 cgcactatag atatttcaga ctgaaatatc cttgcttgtc tggggctgtc ctgcacagga
1441 tatctggcag catccttgac ctctacctgc aatgtgttct tccctgggct tggggtcatt
1501 tactttacct cttggtgtct ccctttcctt aagtgtaaag tgtggatccg ttgacctgca
1561 ggtcga
//