GenBank-Updates@genbank.bio.net (03/05/91)
LOCUS HAMPGP1124 2090 bp ss-mRNA ROD 05-MAR-1991
DEFINITION Chinese hamster p-glycoprotein mRNA (clone ADX124), complete cds.
ACCESSION M59252
KEYWORDS multidrug resistance glycoprotein; p-glycoprotein.
SOURCE Chinese hamster, cDNA to mRNA, clone ADX124.
ORGANISM Cricetulus sp.
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Cricetidae; Cricetinae;
Cricetini.
REFERENCE 1 (bases 1 to 2090)
AUTHORS Devine,S.E., Hussain,A., Davide,J.P. and Melera,P.W.
TITLE Full length and alternatively spliced pgp-1 transcripts in
multidrug resistant Chinese hamster lung cells
JOURNAL J. Biol. Chem. (1991) In press
STANDARD simple staff_review
FEATURES Location/Qualifiers
CDS 111..1727
/product="p-glycoprotein"
/gene="pgp-1"
/codon_start=111
BASE COUNT 626 a 453 c 501 g 510 t
ORIGIN Map position 1q26.
1 aagcagcggt tccaggagcc tgctcccatc tccccaggcc cgctaaactc ggaatcgctt
61 cttccaattc tacgactggg cggactttgc gaaggaaagc ggaggtcgtg atggagtttg
121 aagaggactt tagcggaaga aaagacaaga acttcttgaa gatgggcaga aagagtaaaa
181 aggagaagaa agagaagaaa ccagtgggct tcacatttgg caaagctgga gagatcctca
241 ccaagcgact ccgatacatg gttttcaaat ccatgctgag acaggatgtg agctggtttg
301 ataaccctaa aaacaccact ggagcattga ccaccaggct cgccaacgat gctggtcaag
361 ttaaaggggc tacaggagcc agacttgctg tcattaccca gaatatagca aatcttggga
421 caggaatcat catatcccta atctatggct ggcagttgac acttctactc ttagcaattg
481 tccccatcat tgcaatagca ggagtggttg agatgaaaat gttgtctgga caagcactaa
541 aagataagaa ggagctagaa ggttctggga agattgctac tgaagcaata gagaacttcc
601 gcactgtcgt ctctttgact cgggagcaga agtttgaaaa tatgtatgcc cagagcttgc
661 agataccata cagaaatgct ctgaagaaag cacacgtctt tgggatcaca ttctccttca
721 cccaggccat gatgtatttt tcgtatgctg cttgtttccg gtttggtgct tacttggtgg
781 cacgggaatt aatgacattt gaaaatgttc tattagtatt ctcagctatt gtctttggtg
841 ccatggcagt tgggcaggtc agttcatttg ctcctgacta tgccaaagcc aaagtgtcgg
901 catcgcatat catcatgatc attgaaaaag tcccttccat tgacagctac agcaccggag
961 gcctgaagcc taatacattg gaaggaaatg tgaaatttaa tgaagtcgtg ttcaactacc
1021 ccacccggcc tgacatccca gtgcttcagg ggctgaacct ggaggtgaag aagggccaga
1081 cgctggccct ggtgggcagc agtggctgcg ggaagagcac agtggtccag ctgctcgagc
1141 ggttctacga ccccatggcc ggaacagtgt ttctagatgg caaagaagta aaccaactaa
1201 atgtccagtg gctccgagca cacctaggca ttgtgtccca agagcccatc ctgtttgact
1261 gcagcatcgc tgagaacatc gcttatggag acaacagccg ggtcgtgtcc caggatgaga
1321 tcgagagggc ggcgaaggaa gccaacatcc accagttcat tgagtcactg cctgacaaat
1381 acaacaccag agtaggagac aaagggactc agctgtcggg tgggcagaaa caacgcatcg
1441 ccatagcacg cgccctcgtc agacagcctc acattttgct cctggatgaa gcaacatcag
1501 ccctggatac agagagtgaa aaggttgtcc aggaagctct ggacaaagcc agagaaggcc
1561 gcacctgcat tgtgatcgct caccgcctgt ccaccatcca gaacgcagac ttgatcgtgg
1621 tgattcagaa tggcaaggtc aaggagcatg gcacccacca gcagctgctg gcacagaaag
1681 gcatctattt ctccatggtc agtgtgcagg ctggagcaaa gcgctagtga actgtgttaa
1741 atattttttt aatatttgta ttaacacata gcatttaacc aaagttaaaa agaaagtacg
1801 taccagaata accagttatc tatttcctgt cattatgaga agcatttagt ccagtttaga
1861 gttttcagag actttgtaat taaagggaca gaaatagata tatcatcaaa tggaaaggaa
1921 tcatttaaat tgcactataa aattatacaa gaattaaaag taaatgtttc ataatatata
1981 cttttattta tactttctca tttgtaacta taactgattt ccttgctaaa caaatcatgt
2041 gtgtatcaaa aattaatgaa atgtttgtat aaagtatata tagtgaaact
//GenBank-Updates@genbank.bio.net (03/05/91)
LOCUS HAMPGP1165 4304 bp ss-mRNA ROD 05-MAR-1991
DEFINITION Chinese hamster p-glycoprotein mRNA (clone ADX165), complete cds.
ACCESSION M59253
KEYWORDS multidrug resistance glycoprotein; p-glycoprotein.
SOURCE Chinese hamster, cDNA to mRNA, clone ADX165.
ORGANISM Cricetulus sp.
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Cricetidae; Cricetinae;
Cricetini.
REFERENCE 1 (bases 1 to 4304)
AUTHORS Devine,S.E., Hussain,A., Davide,J.P. and Melera,P.W.
TITLE Full length and alternatively spliced pgp-1 transcripts in
multidrug resistant Chinese hamster lung cells
JOURNAL J. Biol. Chem. (1991) In press
STANDARD simple staff_review
FEATURES Location/Qualifiers
CDS 111..3941
/product="p-glycoprotein"
/gene="pgp-1"
/codon_start=111
BASE COUNT 1275 a 895 c 1031 g 1103 t
ORIGIN Map position 1q26.
1 aagcagcggt tccaggagcc tgctcccatc tccccaggcc cgctaaactc ggaatcgctt
61 cttccaattc tacgactggg cggactttgc gaaggaaagc ggaggtcgtg atggagtttg
121 aagaggactt tagcggaaga aaagacaaga acttcttgaa gatgggcaga aagagtaaaa
181 aggagaagaa agagaagaaa ccagtggtca gtgtgtttac aatgtttcgc tacgcaggtt
241 ggctggatag gttgtacatg ctggtgggga ctctcgcagc tattatccat ggagttgcac
301 tcccgcttat gatgctggtg tttggagaca tgacagacag ctttgcaagt gtaggaaaca
361 tcccaacaaa tgctactaat aatgccactc aagtcaatgc ttcagacatc tttggcaaac
421 tggaggaaga aatgaccacg tacgcctatt actacacagg gattggtgct ggtgtgctta
481 tagttgccta cattcaggtt tcattttggt gcctggcagc tggaagacaa atacacaaaa
541 ttagacagaa gttttttcat gctataatga atcaggagat aggctggttt gacgtgcacg
601 acgttgggga gctcaacacc cggctcacag atgatgtctc caaaattaac gaaggaattg
661 gtgacaaaat tggaatgttc tttcaggcaa tggcaacatt ttttggtggt tttataatag
721 gatttactcg aggctggaag ctaacccttg tgattttggc catcagccct gttcttggac
781 tgtcagctgg tatttgggca aagatattat cttcatttac tgataaagaa cttcaggcat
841 atgcaaaagc tggagcagtt gctgaagaag tcttagcagc catcagaact gtgattgcat
901 ttggaggaca aaagaaagaa cttgaaaggt acaacaacaa tttagaagaa gccaaaagac
961 ttgggataaa gaaagcgatc acagccaaca tttccatggg cgcagctttc cttcttatct
1021 atgcatcata tgctctggcc ttctggtatg gaacgtcctt ggtcatctca aaagaatatt
1081 ctattggaca agtgctcact gtcttctttg ctgtattaat tgcgccattc agtattggac
1141 aggcatctcc aaatatcgaa gcctttgcca atgcaagagg agcagcctat gaaatcttca
1201 acataattga taataagccc agtattgaca gcttctcaaa gaatgggtac aaaccagaca
1261 acattaaagg aaatttggaa ttcaaaaata ttcacttcag ttacccatct cgaaaagacg
1321 ttcagatctt gaagggcctc aacctgaagg tgcagagcgg acagacagtg gccctggttg
1381 gcaacagtgg ctgtgggaaa agcaccactg tccagctgct gcagaggctc tacgacccca
1441 cagagggcgt ggtcagtatc gacggacagg acatcaggac catcaatgtg aggtatctgc
1501 gggaaatcat tggggtcgtg agtcaggaac ctgtgttgtt tgccaccact atcgctgaaa
1561 acattcgcta tggccgagaa aatgtcacta tggacgagat cgagaaagct gtcaaggaag
1621 ccaatgccta tgacttcatc atgaaactgc cccataaatt tgacactctt gttggtgaga
1681 gaggagcaca gctgagtgga ggacagaaac agagaatcgc cattgctcgt gccctggtcc
1741 gcaaccccaa gatccttttg ttggatgagg cgacatcagc cttggacaca gaaagtgaag
1801 ccgtggttca ggctgctctg gataaggcta gagaaggccg gactaccatt gtgatagccc
1861 accgcttgtc tacagttcga aatgctgaca tcatagctgg gtttgatggt ggtgtcattg
1921 tggagcaagg aaatcatgaa gagctcatga gagagaaggg catttacttc aaacttgtca
1981 tgacacagac agcaggaaat gaaattgaat taggaaatga agttggtgag tctaaaaatg
2041 aaattgataa tttagacatg tcttcaaaag attcagcatc cagtctaatc agaaggagat
2101 caactcgcag aagtatccgt ggaccacatg accaagacag gaagcttagt accaaagagg
2161 ccttggatga agatgtacct ccaatttcct tttggcgtat cctaaagttg aattcatctg
2221 aatggccata ttttgtggtt ggtatattct gtgccatagt aaatggagcc ttgcaaccag
2281 cattctcaat aatattttct aaggttgtag gggttttcac aagaaatact gatgatgaaa
2341 ccaaacgaca tgatagcaac ttgttttcct tattgtttct gatccttggg gtcatttctt
2401 ttattacatt ttttcttcag ggcttcacat ttggcaaagc tggagagatc ctcaccaagc
2461 gactccgata catggttttc aaatccatgc tgagacagga tgtgagctgg tttgataacc
2521 ctaaaaacac cactggagca ttgaccacca ggctcgccaa cgatgctggt caagttaaag
2581 gggctacagg agccagactt gctgtcatta cccagaatat agcaaatctt gggacaggaa
2641 tcatcatatc cctaatctat ggctggcagt tgacacttct actcttagca attgtcccca
2701 tcattgcaat agcaggagtg gttgagatga aaatgttgtc tggacaagca ctaaaagata
2761 agaaggagct agaaggttct gggaagattg ctactgaagc aatagagaac ttccgcactg
2821 tcgtctcttt gactcgggag cagaagtttg aaaatatgta tgcccagagc ttgcagatac
2881 catacagaaa tgctctgaag aaagcacacg tctttgggat cacattctcc ttcacccagg
2941 ccatgatgta tttttcgtat gctgcttgtt tccggtttgg tgcttacttg gtggcacggg
3001 aattaatgac atttgaaaat gttctattag tattctcagc tattgtcttt ggtgccatgg
3061 cagttgggca ggtcagttca tttgctcctg actatgccaa agccaaagtg tcggcatcgc
3121 atatcatcat gatcattgaa aaagtccctt ccattgacag ctacagcacc ggaggcctga
3181 agcctaatac attggaagga aatgtgaaat ttaatgaagt cgtgttcaac taccccaccc
3241 ggcctgacat cccagtgctt caggggctga acctggaggt gaagaagggc cagacgctgg
3301 ccctggtggg cagcagtggc tgcgggaaga gcacagtggt ccagctgctc gagcggttct
3361 acgaccccat ggccggaaca gtgtttctag atggcaaaga agtaaaccaa ctaaatgtcc
3421 agtggctccg agcacaccta ggcattgtgt cccaagagcc catcctgttt gactgcagca
3481 tcgctgagaa catcgcttat ggagacaaca gccgggtcgt gtcccaggat gagatcgaga
3541 gggcggcgaa ggaagccaac atccaccagt tcattgagtc actgcctgac aaatacaaca
3601 ccagagtagg agacaaaggg actcagctgt cgggtgggca gaaacaacgc atcgccatag
3661 cacgcgccct cgtcagacag cctcacattt tgctcctgga tgaagcaaca tcagccctgg
3721 atacagagag tgaaaaggtt gtccaggaag ctctggacaa agccagagaa ggccgcacct
3781 gcattgtgat cgctcaccgc ctgtccacca tccagaacgc agacttgatc gtggtgattc
3841 agaatggcaa ggtcaaggag catggcaccc accagcagct gctggcacag aaaggcatct
3901 atttctccat ggtcagtgtg caggctggag caaagcgcta gtgaactgtg ttaaatattt
3961 ttttaatatt tgtattaaca catagcattt aaccaaagtt aaaaagaaag tacgtaccag
4021 aataaccagt tatctatttc ctgtcattat gagaagcatt tagtccagtt tagagttttc
4081 agagactttg taattaaagg gacagaaata gatatatcat caaatggaaa ggaatcattt
4141 aaattgcact ataaaattat acaagaatta aaagtaaatg tttcataata tatactttta
4201 tttatacttt ctcatttgta actataactg atttccttgc taaacaaatc atgtgtgtat
4261 caaaaattaa tgaaatgttt gtataaagta tatatagtga aact
//GenBank-Updates@genbank.bio.net (03/05/91)
LOCUS HAMPGP1185 3987 bp ss-mRNA ROD 05-MAR-1991
DEFINITION Chinese hamster p-glycoprotein mRNA (clone ADX185), complete cds.
ACCESSION M59254
KEYWORDS multidrug resistance glycoprotein; p-glycoprotein.
SOURCE Chinese hamster, cDNA to mRNA, clone ADX185.
ORGANISM Cricetulus sp.
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Cricetidae; Cricetinae;
Cricetini.
REFERENCE 1 (bases 1 to 3987)
AUTHORS Devine,S.E., Hussain,A., Davide,J.P. and Melera,P.W.
TITLE Full length and alternatively spliced pgp-1 transcripts in
multidrug resistant Chinese hamster lung cells
JOURNAL J. Biol. Chem. (1991) In press
STANDARD simple staff_review
FEATURES Location/Qualifiers
CDS 115..3624
/product="p-glycoprotein"
/gene="pgp-1"
/codon_start=115
BASE COUNT 1194 a 822 c 944 g 1027 t
ORIGIN Map position 1q26.
1 cttgaagatg ggcagaaaga gtaaaaagga gaagaaagag aagaaaccag tggtcagtgt
61 gtttacaatg ctcaagtcaa tgcttcagac atctttggca aactggagga agaaatgacc
121 acgtacgcct attactacac agggattggt gctggtgtgc ttatagttgc ctacattcag
181 gtttcatttt ggtgcctggc agctggaaga caaatacaca aaattagaca gaagtttttt
241 catgctataa tgaatcagga gataggctgg tttgacgtgc acgacgttgg ggagctcaac
301 acccggctca cagatgatgt ctccaaaatt aacgaaggaa ttggtgacaa aattggaatg
361 ttctttcagg caatggcaac attttttggt ggttttataa taggatttac tcgaggctgg
421 aagctaaccc ttgtgatttt ggccatcagc cctgttcttg gactgtcagc tggtatttgg
481 gcaaagatat tatcttcatt tactgataaa gaacttcagg catatgcaaa agctggagca
541 gttgctgaag aagtcttagc agccatcaga actgtgattg catttggagg acaaaagaaa
601 gaacttgaaa ggtacaacaa caatttagaa gaagccaaaa gacttgggat aaagaaagcg
661 atcacagcca acatttccat gggcgcagct ttccttctta tctatgcatc atatgctctg
721 gccttctggt atggaacgtc cttggtcatc tcaaaagaat attctattgg acaagtgctc
781 actgtcttct ttgctgtatt aattgcgcca ttcagtattg gacaggcatc tccaaatatc
841 gaagcctttg ccaatgcaag aggagcagcc tatgaaatct tcaacataat tgataataag
901 cccagtattg acagcttctc aaagaatggg tacaaaccag acaacattaa aggaaatttg
961 gaattcaaaa atattcactt cagttaccca tctcgaaaag acgttcagat cttgaagggc
1021 ctcaacctga aggtgcagag cggacagaca gtggccctgg ttggcaacag tggctgtggg
1081 aaaagcacca ctgtccagct gctgcagagg ctctacgacc ccacagaggg cgtggtcagt
1141 atcgacggac aggacatcag gaccatcaat gtgaggtatc tgcgggaaat cattggggtc
1201 gtgagtcagg aacctgtgtt gtttgccacc actatcgctg aaaacattcg ctatggccga
1261 gaaaatgtca ctatggacga gatcgagaaa gctgtcaagg aagccaatgc ctatgacttc
1321 atcatgaaac tgccccataa atttgacact cttgttggtg agagaggagc acagctgagt
1381 ggaggacaga aacagagaat cgccattgct cgtgccctgg tccgcaaccc caagatcctt
1441 ttgttggatg aggcgacatc agccttggac acagaaagtg aagccgtggt tcaggctgct
1501 ctggataagg ctagagaagg ccggactacc attgtgatag cccaccgctt gtctacagtt
1561 cgaaatgctg acatcatagc tgggtttgat ggtggtgtca ttgtggagca aggaaatcat
1621 gaagagctca tgagagagaa gggcatttac ttcaaacttg tcatgacaca gacagcagga
1681 aatgaaattg aattaggaaa tgaagttggt gagtctaaaa atgaaattga taatttagac
1741 atgtcttcaa aagattcagc atccagtcta atcagaagga gatcaactcg cagaagtatc
1801 cgtggaccac atgaccaaga caggaagctt agtaccaaag aggccttgga tgaagatgta
1861 cctccaattt ccttttggcg tatcctaaag ttgaattcat ctgaatggcc atattttgtg
1921 gttggtatat tctgtgccat agtaaatgga gccttgcaac cagcattctc aataatattt
1981 tctaaggttg taggggtttt cacaagaaat actgatgatg aaaccaaacg acatgatagc
2041 aacttgtttt ccttattgtt tctgatcctt ggggtcattt cttttattac attttttctt
2101 cagggcttca catttggcaa agctggagag atcctcacca agcgactccg atacatggtt
2161 ttcaaatcca tgctgagaca ggatgtgagc tggtttgata accctaaaaa caccactgga
2221 gcattgacca ccaggctcgc caacgatgct ggtcaagtta aaggggctac aggagccaga
2281 cttgctgtca ttacccagaa tatagcaaat cttgggacag gaatcatcat atccctaatc
2341 tatggctggc agttgacact tctactctta gcaattgtcc ccatcattgc aatagcagga
2401 gtggttgaga tgaaaatgtt gtctggacaa gcactaaaag ataagaagga gctagaaggt
2461 tctgggaaga ttgctactga agcaatagag aacttccgca ctgtcgtctc tttgactcgg
2521 gagcagaagt ttgaaaatat gtatgcccag agcttgcaga taccatacag aaatgctctg
2581 aagaaagcac acgtctttgg gatcacattc tccttcaccc aggccatgat gtatttttcg
2641 tatgctgctt gtttccggtt tggtgcttac ttggtggcac gggaattaat gacatttgaa
2701 aatgttctat tagtattctc agctattgtc tttggtgcca tggcagttgg gcaggtcagt
2761 tcatttgctc ctgactatgc caaagccaaa gtgtcggcat cgcatatcat catgatcatt
2821 gaaaaagtcc cttccattga cagctacagc accggaggcc tgaagcctaa tacattggaa
2881 ggaaatgtga aatttaatga agtcgtgttc aactacccca cccggcctga catcccagtg
2941 cttcaggggc tgaacctgga ggtgaagaag ggccagacgc tggccctggt gggcagcagt
3001 ggctgcggga agagcacagt ggtccagctg ctcgagcggt tctacgaccc catggccgga
3061 acagtgtttc tagatggcaa agaagtaaac caactaaatg tccagtggct ccgagcacac
3121 ctaggcattg tgtcccaaga gcccatcctg tttgactgca gcatcgctga gaacatcgct
3181 tatggagaca acagccgggt cgtgtcccag gatgagatcg agagggcggc gaaggaagcc
3241 aacatccacc agttcattga gtcactgcct gacaaataca acaccagagt aggagacaaa
3301 gggactcagc tgtcgggtgg gcagaaacaa cgcatcgcca tagcacgcgc cctcgtcaga
3361 cagcctcaca ttttgctcct ggatgaagca acatcagccc tggatacaga gagtgaaaag
3421 gttgtccagg aagctctgga caaagccaga gaaggccgca cctgcattgt gatcgctcac
3481 cgcctgtcca ccatccagaa cgcagacttg atcgtggtga ttcagaatgg caaggtcaag
3541 gagcatggca cccaccagca gctgctggca cagaaaggca tctatttctc catggtcagt
3601 gtgcaggctg gagcaaagcg ctagtgaact gtgttaaata tttttttaat atttgtatta
3661 acacatagca tttaaccaaa gttaaaaaga aagtacgtac cagaataacc agttatctat
3721 ttcctgtcat tatgagaagc atttagtcca gtttagagtt ttcagagact ttgtaattaa
3781 agggacagaa atagatatat catcaaatgg aaaggaatca tttaaattgc actataaaat
3841 tatacaagaa ttaaaagtaa atgtttcata atatatactt ttatttatac tttctcattt
3901 gtaactataa ctgatttcct tgctaaacaa atcatgtgtg tatcaaaaat taatgaaatg
3961 tttgtataaa gtatatatag tgaaact
//GenBank-Updates@genbank.bio.net (03/30/91)
LOCUS HAMPGP1124 2090 bp ss-mRNA ROD 30-MAR-1991
DEFINITION Chinese hamster p-glycoprotein mRNA (clone ADX124), complete cds.
ACCESSION M59252
KEYWORDS multidrug resistance glycoprotein; p-glycoprotein.
SOURCE Chinese hamster, cDNA to mRNA, clone ADX124.
ORGANISM Cricetulus sp.
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Cricetidae; Cricetinae;
Cricetini.
REFERENCE 1 (bases 1 to 2090)
AUTHORS Devine,S.E., Hussain,A., Davide,J.P. and Melera,P.W.
TITLE Full length and alternatively spliced pgp-1 transcripts in
multidrug resistant Chinese hamster lung cells
JOURNAL J. Biol. Chem. (1991) In press
STANDARD simple staff_entry
FEATURES Location/Qualifiers
CDS 111..1727
/product="p-glycoprotein"
/gene="pgp-1"
/codon_start=111
BASE COUNT 626 a 453 c 501 g 510 t
ORIGIN Map position 1q26.
1 aagcagcggt tccaggagcc tgctcccatc tccccaggcc cgctaaactc ggaatcgctt
61 cttccaattc tacgactggg cggactttgc gaaggaaagc ggaggtcgtg atggagtttg
121 aagaggactt tagcggaaga aaagacaaga acttcttgaa gatgggcaga aagagtaaaa
181 aggagaagaa agagaagaaa ccagtgggct tcacatttgg caaagctgga gagatcctca
241 ccaagcgact ccgatacatg gttttcaaat ccatgctgag acaggatgtg agctggtttg
301 ataaccctaa aaacaccact ggagcattga ccaccaggct cgccaacgat gctggtcaag
361 ttaaaggggc tacaggagcc agacttgctg tcattaccca gaatatagca aatcttggga
421 caggaatcat catatcccta atctatggct ggcagttgac acttctactc ttagcaattg
481 tccccatcat tgcaatagca ggagtggttg agatgaaaat gttgtctgga caagcactaa
541 aagataagaa ggagctagaa ggttctggga agattgctac tgaagcaata gagaacttcc
601 gcactgtcgt ctctttgact cgggagcaga agtttgaaaa tatgtatgcc cagagcttgc
661 agataccata cagaaatgct ctgaagaaag cacacgtctt tgggatcaca ttctccttca
721 cccaggccat gatgtatttt tcgtatgctg cttgtttccg gtttggtgct tacttggtgg
781 cacgggaatt aatgacattt gaaaatgttc tattagtatt ctcagctatt gtctttggtg
841 ccatggcagt tgggcaggtc agttcatttg ctcctgacta tgccaaagcc aaagtgtcgg
901 catcgcatat catcatgatc attgaaaaag tcccttccat tgacagctac agcaccggag
961 gcctgaagcc taatacattg gaaggaaatg tgaaatttaa tgaagtcgtg ttcaactacc
1021 ccacccggcc tgacatccca gtgcttcagg ggctgaacct ggaggtgaag aagggccaga
1081 cgctggccct ggtgggcagc agtggctgcg ggaagagcac agtggtccag ctgctcgagc
1141 ggttctacga ccccatggcc ggaacagtgt ttctagatgg caaagaagta aaccaactaa
1201 atgtccagtg gctccgagca cacctaggca ttgtgtccca agagcccatc ctgtttgact
1261 gcagcatcgc tgagaacatc gcttatggag acaacagccg ggtcgtgtcc caggatgaga
1321 tcgagagggc ggcgaaggaa gccaacatcc accagttcat tgagtcactg cctgacaaat
1381 acaacaccag agtaggagac aaagggactc agctgtcggg tgggcagaaa caacgcatcg
1441 ccatagcacg cgccctcgtc agacagcctc acattttgct cctggatgaa gcaacatcag
1501 ccctggatac agagagtgaa aaggttgtcc aggaagctct ggacaaagcc agagaaggcc
1561 gcacctgcat tgtgatcgct caccgcctgt ccaccatcca gaacgcagac ttgatcgtgg
1621 tgattcagaa tggcaaggtc aaggagcatg gcacccacca gcagctgctg gcacagaaag
1681 gcatctattt ctccatggtc agtgtgcagg ctggagcaaa gcgctagtga actgtgttaa
1741 atattttttt aatatttgta ttaacacata gcatttaacc aaagttaaaa agaaagtacg
1801 taccagaata accagttatc tatttcctgt cattatgaga agcatttagt ccagtttaga
1861 gttttcagag actttgtaat taaagggaca gaaatagata tatcatcaaa tggaaaggaa
1921 tcatttaaat tgcactataa aattatacaa gaattaaaag taaatgtttc ataatatata
1981 cttttattta tactttctca tttgtaacta taactgattt ccttgctaaa caaatcatgt
2041 gtgtatcaaa aattaatgaa atgtttgtat aaagtatata tagtgaaact
//GenBank-Updates@genbank.bio.net (03/30/91)
LOCUS HAMPGP1165 4304 bp ss-mRNA ROD 30-MAR-1991
DEFINITION Chinese hamster p-glycoprotein mRNA (clone ADX165), complete cds.
ACCESSION M59253
KEYWORDS multidrug resistance glycoprotein; p-glycoprotein.
SOURCE Chinese hamster, cDNA to mRNA, clone ADX165.
ORGANISM Cricetulus sp.
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Cricetidae; Cricetinae;
Cricetini.
REFERENCE 1 (bases 1 to 4304)
AUTHORS Devine,S.E., Hussain,A., Davide,J.P. and Melera,P.W.
TITLE Full length and alternatively spliced pgp-1 transcripts in
multidrug resistant Chinese hamster lung cells
JOURNAL J. Biol. Chem. (1991) In press
STANDARD simple staff_entry
FEATURES Location/Qualifiers
CDS 111..3941
/product="p-glycoprotein"
/gene="pgp-1"
/codon_start=111
BASE COUNT 1275 a 895 c 1031 g 1103 t
ORIGIN Map position 1q26.
1 aagcagcggt tccaggagcc tgctcccatc tccccaggcc cgctaaactc ggaatcgctt
61 cttccaattc tacgactggg cggactttgc gaaggaaagc ggaggtcgtg atggagtttg
121 aagaggactt tagcggaaga aaagacaaga acttcttgaa gatgggcaga aagagtaaaa
181 aggagaagaa agagaagaaa ccagtggtca gtgtgtttac aatgtttcgc tacgcaggtt
241 ggctggatag gttgtacatg ctggtgggga ctctcgcagc tattatccat ggagttgcac
301 tcccgcttat gatgctggtg tttggagaca tgacagacag ctttgcaagt gtaggaaaca
361 tcccaacaaa tgctactaat aatgccactc aagtcaatgc ttcagacatc tttggcaaac
421 tggaggaaga aatgaccacg tacgcctatt actacacagg gattggtgct ggtgtgctta
481 tagttgccta cattcaggtt tcattttggt gcctggcagc tggaagacaa atacacaaaa
541 ttagacagaa gttttttcat gctataatga atcaggagat aggctggttt gacgtgcacg
601 acgttgggga gctcaacacc cggctcacag atgatgtctc caaaattaac gaaggaattg
661 gtgacaaaat tggaatgttc tttcaggcaa tggcaacatt ttttggtggt tttataatag
721 gatttactcg aggctggaag ctaacccttg tgattttggc catcagccct gttcttggac
781 tgtcagctgg tatttgggca aagatattat cttcatttac tgataaagaa cttcaggcat
841 atgcaaaagc tggagcagtt gctgaagaag tcttagcagc catcagaact gtgattgcat
901 ttggaggaca aaagaaagaa cttgaaaggt acaacaacaa tttagaagaa gccaaaagac
961 ttgggataaa gaaagcgatc acagccaaca tttccatggg cgcagctttc cttcttatct
1021 atgcatcata tgctctggcc ttctggtatg gaacgtcctt ggtcatctca aaagaatatt
1081 ctattggaca agtgctcact gtcttctttg ctgtattaat tgcgccattc agtattggac
1141 aggcatctcc aaatatcgaa gcctttgcca atgcaagagg agcagcctat gaaatcttca
1201 acataattga taataagccc agtattgaca gcttctcaaa gaatgggtac aaaccagaca
1261 acattaaagg aaatttggaa ttcaaaaata ttcacttcag ttacccatct cgaaaagacg
1321 ttcagatctt gaagggcctc aacctgaagg tgcagagcgg acagacagtg gccctggttg
1381 gcaacagtgg ctgtgggaaa agcaccactg tccagctgct gcagaggctc tacgacccca
1441 cagagggcgt ggtcagtatc gacggacagg acatcaggac catcaatgtg aggtatctgc
1501 gggaaatcat tggggtcgtg agtcaggaac ctgtgttgtt tgccaccact atcgctgaaa
1561 acattcgcta tggccgagaa aatgtcacta tggacgagat cgagaaagct gtcaaggaag
1621 ccaatgccta tgacttcatc atgaaactgc cccataaatt tgacactctt gttggtgaga
1681 gaggagcaca gctgagtgga ggacagaaac agagaatcgc cattgctcgt gccctggtcc
1741 gcaaccccaa gatccttttg ttggatgagg cgacatcagc cttggacaca gaaagtgaag
1801 ccgtggttca ggctgctctg gataaggcta gagaaggccg gactaccatt gtgatagccc
1861 accgcttgtc tacagttcga aatgctgaca tcatagctgg gtttgatggt ggtgtcattg
1921 tggagcaagg aaatcatgaa gagctcatga gagagaaggg catttacttc aaacttgtca
1981 tgacacagac agcaggaaat gaaattgaat taggaaatga agttggtgag tctaaaaatg
2041 aaattgataa tttagacatg tcttcaaaag attcagcatc cagtctaatc agaaggagat
2101 caactcgcag aagtatccgt ggaccacatg accaagacag gaagcttagt accaaagagg
2161 ccttggatga agatgtacct ccaatttcct tttggcgtat cctaaagttg aattcatctg
2221 aatggccata ttttgtggtt ggtatattct gtgccatagt aaatggagcc ttgcaaccag
2281 cattctcaat aatattttct aaggttgtag gggttttcac aagaaatact gatgatgaaa
2341 ccaaacgaca tgatagcaac ttgttttcct tattgtttct gatccttggg gtcatttctt
2401 ttattacatt ttttcttcag ggcttcacat ttggcaaagc tggagagatc ctcaccaagc
2461 gactccgata catggttttc aaatccatgc tgagacagga tgtgagctgg tttgataacc
2521 ctaaaaacac cactggagca ttgaccacca ggctcgccaa cgatgctggt caagttaaag
2581 gggctacagg agccagactt gctgtcatta cccagaatat agcaaatctt gggacaggaa
2641 tcatcatatc cctaatctat ggctggcagt tgacacttct actcttagca attgtcccca
2701 tcattgcaat agcaggagtg gttgagatga aaatgttgtc tggacaagca ctaaaagata
2761 agaaggagct agaaggttct gggaagattg ctactgaagc aatagagaac ttccgcactg
2821 tcgtctcttt gactcgggag cagaagtttg aaaatatgta tgcccagagc ttgcagatac
2881 catacagaaa tgctctgaag aaagcacacg tctttgggat cacattctcc ttcacccagg
2941 ccatgatgta tttttcgtat gctgcttgtt tccggtttgg tgcttacttg gtggcacggg
3001 aattaatgac atttgaaaat gttctattag tattctcagc tattgtcttt ggtgccatgg
3061 cagttgggca ggtcagttca tttgctcctg actatgccaa agccaaagtg tcggcatcgc
3121 atatcatcat gatcattgaa aaagtccctt ccattgacag ctacagcacc ggaggcctga
3181 agcctaatac attggaagga aatgtgaaat ttaatgaagt cgtgttcaac taccccaccc
3241 ggcctgacat cccagtgctt caggggctga acctggaggt gaagaagggc cagacgctgg
3301 ccctggtggg cagcagtggc tgcgggaaga gcacagtggt ccagctgctc gagcggttct
3361 acgaccccat ggccggaaca gtgtttctag atggcaaaga agtaaaccaa ctaaatgtcc
3421 agtggctccg agcacaccta ggcattgtgt cccaagagcc catcctgttt gactgcagca
3481 tcgctgagaa catcgcttat ggagacaaca gccgggtcgt gtcccaggat gagatcgaga
3541 gggcggcgaa ggaagccaac atccaccagt tcattgagtc actgcctgac aaatacaaca
3601 ccagagtagg agacaaaggg actcagctgt cgggtgggca gaaacaacgc atcgccatag
3661 cacgcgccct cgtcagacag cctcacattt tgctcctgga tgaagcaaca tcagccctgg
3721 atacagagag tgaaaaggtt gtccaggaag ctctggacaa agccagagaa ggccgcacct
3781 gcattgtgat cgctcaccgc ctgtccacca tccagaacgc agacttgatc gtggtgattc
3841 agaatggcaa ggtcaaggag catggcaccc accagcagct gctggcacag aaaggcatct
3901 atttctccat ggtcagtgtg caggctggag caaagcgcta gtgaactgtg ttaaatattt
3961 ttttaatatt tgtattaaca catagcattt aaccaaagtt aaaaagaaag tacgtaccag
4021 aataaccagt tatctatttc ctgtcattat gagaagcatt tagtccagtt tagagttttc
4081 agagactttg taattaaagg gacagaaata gatatatcat caaatggaaa ggaatcattt
4141 aaattgcact ataaaattat acaagaatta aaagtaaatg tttcataata tatactttta
4201 tttatacttt ctcatttgta actataactg atttccttgc taaacaaatc atgtgtgtat
4261 caaaaattaa tgaaatgttt gtataaagta tatatagtga aact
//GenBank-Updates@genbank.bio.net (03/30/91)
LOCUS HAMPGP1185 3987 bp ss-mRNA ROD 30-MAR-1991
DEFINITION Chinese hamster p-glycoprotein mRNA (clone ADX185), complete cds.
ACCESSION M59254
KEYWORDS multidrug resistance glycoprotein; p-glycoprotein.
SOURCE Chinese hamster, cDNA to mRNA, clone ADX185.
ORGANISM Cricetulus sp.
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Cricetidae; Cricetinae;
Cricetini.
REFERENCE 1 (bases 1 to 3987)
AUTHORS Devine,S.E., Hussain,A., Davide,J.P. and Melera,P.W.
TITLE Full length and alternatively spliced pgp-1 transcripts in
multidrug resistant Chinese hamster lung cells
JOURNAL J. Biol. Chem. (1991) In press
STANDARD simple staff_entry
FEATURES Location/Qualifiers
CDS 115..3624
/product="p-glycoprotein"
/gene="pgp-1"
/codon_start=115
BASE COUNT 1194 a 822 c 944 g 1027 t
ORIGIN Map position 1q26.
1 cttgaagatg ggcagaaaga gtaaaaagga gaagaaagag aagaaaccag tggtcagtgt
61 gtttacaatg ctcaagtcaa tgcttcagac atctttggca aactggagga agaaatgacc
121 acgtacgcct attactacac agggattggt gctggtgtgc ttatagttgc ctacattcag
181 gtttcatttt ggtgcctggc agctggaaga caaatacaca aaattagaca gaagtttttt
241 catgctataa tgaatcagga gataggctgg tttgacgtgc acgacgttgg ggagctcaac
301 acccggctca cagatgatgt ctccaaaatt aacgaaggaa ttggtgacaa aattggaatg
361 ttctttcagg caatggcaac attttttggt ggttttataa taggatttac tcgaggctgg
421 aagctaaccc ttgtgatttt ggccatcagc cctgttcttg gactgtcagc tggtatttgg
481 gcaaagatat tatcttcatt tactgataaa gaacttcagg catatgcaaa agctggagca
541 gttgctgaag aagtcttagc agccatcaga actgtgattg catttggagg acaaaagaaa
601 gaacttgaaa ggtacaacaa caatttagaa gaagccaaaa gacttgggat aaagaaagcg
661 atcacagcca acatttccat gggcgcagct ttccttctta tctatgcatc atatgctctg
721 gccttctggt atggaacgtc cttggtcatc tcaaaagaat attctattgg acaagtgctc
781 actgtcttct ttgctgtatt aattgcgcca ttcagtattg gacaggcatc tccaaatatc
841 gaagcctttg ccaatgcaag aggagcagcc tatgaaatct tcaacataat tgataataag
901 cccagtattg acagcttctc aaagaatggg tacaaaccag acaacattaa aggaaatttg
961 gaattcaaaa atattcactt cagttaccca tctcgaaaag acgttcagat cttgaagggc
1021 ctcaacctga aggtgcagag cggacagaca gtggccctgg ttggcaacag tggctgtggg
1081 aaaagcacca ctgtccagct gctgcagagg ctctacgacc ccacagaggg cgtggtcagt
1141 atcgacggac aggacatcag gaccatcaat gtgaggtatc tgcgggaaat cattggggtc
1201 gtgagtcagg aacctgtgtt gtttgccacc actatcgctg aaaacattcg ctatggccga
1261 gaaaatgtca ctatggacga gatcgagaaa gctgtcaagg aagccaatgc ctatgacttc
1321 atcatgaaac tgccccataa atttgacact cttgttggtg agagaggagc acagctgagt
1381 ggaggacaga aacagagaat cgccattgct cgtgccctgg tccgcaaccc caagatcctt
1441 ttgttggatg aggcgacatc agccttggac acagaaagtg aagccgtggt tcaggctgct
1501 ctggataagg ctagagaagg ccggactacc attgtgatag cccaccgctt gtctacagtt
1561 cgaaatgctg acatcatagc tgggtttgat ggtggtgtca ttgtggagca aggaaatcat
1621 gaagagctca tgagagagaa gggcatttac ttcaaacttg tcatgacaca gacagcagga
1681 aatgaaattg aattaggaaa tgaagttggt gagtctaaaa atgaaattga taatttagac
1741 atgtcttcaa aagattcagc atccagtcta atcagaagga gatcaactcg cagaagtatc
1801 cgtggaccac atgaccaaga caggaagctt agtaccaaag aggccttgga tgaagatgta
1861 cctccaattt ccttttggcg tatcctaaag ttgaattcat ctgaatggcc atattttgtg
1921 gttggtatat tctgtgccat agtaaatgga gccttgcaac cagcattctc aataatattt
1981 tctaaggttg taggggtttt cacaagaaat actgatgatg aaaccaaacg acatgatagc
2041 aacttgtttt ccttattgtt tctgatcctt ggggtcattt cttttattac attttttctt
2101 cagggcttca catttggcaa agctggagag atcctcacca agcgactccg atacatggtt
2161 ttcaaatcca tgctgagaca ggatgtgagc tggtttgata accctaaaaa caccactgga
2221 gcattgacca ccaggctcgc caacgatgct ggtcaagtta aaggggctac aggagccaga
2281 cttgctgtca ttacccagaa tatagcaaat cttgggacag gaatcatcat atccctaatc
2341 tatggctggc agttgacact tctactctta gcaattgtcc ccatcattgc aatagcagga
2401 gtggttgaga tgaaaatgtt gtctggacaa gcactaaaag ataagaagga gctagaaggt
2461 tctgggaaga ttgctactga agcaatagag aacttccgca ctgtcgtctc tttgactcgg
2521 gagcagaagt ttgaaaatat gtatgcccag agcttgcaga taccatacag aaatgctctg
2581 aagaaagcac acgtctttgg gatcacattc tccttcaccc aggccatgat gtatttttcg
2641 tatgctgctt gtttccggtt tggtgcttac ttggtggcac gggaattaat gacatttgaa
2701 aatgttctat tagtattctc agctattgtc tttggtgcca tggcagttgg gcaggtcagt
2761 tcatttgctc ctgactatgc caaagccaaa gtgtcggcat cgcatatcat catgatcatt
2821 gaaaaagtcc cttccattga cagctacagc accggaggcc tgaagcctaa tacattggaa
2881 ggaaatgtga aatttaatga agtcgtgttc aactacccca cccggcctga catcccagtg
2941 cttcaggggc tgaacctgga ggtgaagaag ggccagacgc tggccctggt gggcagcagt
3001 ggctgcggga agagcacagt ggtccagctg ctcgagcggt tctacgaccc catggccgga
3061 acagtgtttc tagatggcaa agaagtaaac caactaaatg tccagtggct ccgagcacac
3121 ctaggcattg tgtcccaaga gcccatcctg tttgactgca gcatcgctga gaacatcgct
3181 tatggagaca acagccgggt cgtgtcccag gatgagatcg agagggcggc gaaggaagcc
3241 aacatccacc agttcattga gtcactgcct gacaaataca acaccagagt aggagacaaa
3301 gggactcagc tgtcgggtgg gcagaaacaa cgcatcgcca tagcacgcgc cctcgtcaga
3361 cagcctcaca ttttgctcct ggatgaagca acatcagccc tggatacaga gagtgaaaag
3421 gttgtccagg aagctctgga caaagccaga gaaggccgca cctgcattgt gatcgctcac
3481 cgcctgtcca ccatccagaa cgcagacttg atcgtggtga ttcagaatgg caaggtcaag
3541 gagcatggca cccaccagca gctgctggca cagaaaggca tctatttctc catggtcagt
3601 gtgcaggctg gagcaaagcg ctagtgaact gtgttaaata tttttttaat atttgtatta
3661 acacatagca tttaaccaaa gttaaaaaga aagtacgtac cagaataacc agttatctat
3721 ttcctgtcat tatgagaagc atttagtcca gtttagagtt ttcagagact ttgtaattaa
3781 agggacagaa atagatatat catcaaatgg aaaggaatca tttaaattgc actataaaat
3841 tatacaagaa ttaaaagtaa atgtttcata atatatactt ttatttatac tttctcattt
3901 gtaactataa ctgatttcct tgctaaacaa atcatgtgtg tatcaaaaat taatgaaatg
3961 tttgtataaa gtatatatag tgaaact
//GenBank-Updates@genbank.bio.net (05/03/91)
LOCUS HAMPGP1124 2090 bp ss-mRNA ROD 03-MAY-1991
DEFINITION Chinese hamster p-glycoprotein mRNA (clone ADX124), complete cds.
ACCESSION M59252
KEYWORDS multidrug resistance glycoprotein; p-glycoprotein.
SOURCE Chinese hamster, cDNA to mRNA, clone ADX124.
ORGANISM Cricetulus sp.
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Cricetidae; Cricetinae;
Cricetini.
REFERENCE 1 (bases 1 to 2090)
AUTHORS Devine,S.E., Hussain,A., Davide,J.P. and Melera,P.W.
TITLE Full length and alternatively spliced pgp-1 transcripts in
multidrug resistant Chinese hamster lung cells
JOURNAL J. Biol. Chem. 266, 4545-4555 (1991)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
CDS 111..1727
/product="p-glycoprotein"
/gene="pgp-1"
/codon_start=111
BASE COUNT 626 a 453 c 501 g 510 t
ORIGIN Map position 1q26.
1 aagcagcggt tccaggagcc tgctcccatc tccccaggcc cgctaaactc ggaatcgctt
61 cttccaattc tacgactggg cggactttgc gaaggaaagc ggaggtcgtg atggagtttg
121 aagaggactt tagcggaaga aaagacaaga acttcttgaa gatgggcaga aagagtaaaa
181 aggagaagaa agagaagaaa ccagtgggct tcacatttgg caaagctgga gagatcctca
241 ccaagcgact ccgatacatg gttttcaaat ccatgctgag acaggatgtg agctggtttg
301 ataaccctaa aaacaccact ggagcattga ccaccaggct cgccaacgat gctggtcaag
361 ttaaaggggc tacaggagcc agacttgctg tcattaccca gaatatagca aatcttggga
421 caggaatcat catatcccta atctatggct ggcagttgac acttctactc ttagcaattg
481 tccccatcat tgcaatagca ggagtggttg agatgaaaat gttgtctgga caagcactaa
541 aagataagaa ggagctagaa ggttctggga agattgctac tgaagcaata gagaacttcc
601 gcactgtcgt ctctttgact cgggagcaga agtttgaaaa tatgtatgcc cagagcttgc
661 agataccata cagaaatgct ctgaagaaag cacacgtctt tgggatcaca ttctccttca
721 cccaggccat gatgtatttt tcgtatgctg cttgtttccg gtttggtgct tacttggtgg
781 cacgggaatt aatgacattt gaaaatgttc tattagtatt ctcagctatt gtctttggtg
841 ccatggcagt tgggcaggtc agttcatttg ctcctgacta tgccaaagcc aaagtgtcgg
901 catcgcatat catcatgatc attgaaaaag tcccttccat tgacagctac agcaccggag
961 gcctgaagcc taatacattg gaaggaaatg tgaaatttaa tgaagtcgtg ttcaactacc
1021 ccacccggcc tgacatccca gtgcttcagg ggctgaacct ggaggtgaag aagggccaga
1081 cgctggccct ggtgggcagc agtggctgcg ggaagagcac agtggtccag ctgctcgagc
1141 ggttctacga ccccatggcc ggaacagtgt ttctagatgg caaagaagta aaccaactaa
1201 atgtccagtg gctccgagca cacctaggca ttgtgtccca agagcccatc ctgtttgact
1261 gcagcatcgc tgagaacatc gcttatggag acaacagccg ggtcgtgtcc caggatgaga
1321 tcgagagggc ggcgaaggaa gccaacatcc accagttcat tgagtcactg cctgacaaat
1381 acaacaccag agtaggagac aaagggactc agctgtcggg tgggcagaaa caacgcatcg
1441 ccatagcacg cgccctcgtc agacagcctc acattttgct cctggatgaa gcaacatcag
1501 ccctggatac agagagtgaa aaggttgtcc aggaagctct ggacaaagcc agagaaggcc
1561 gcacctgcat tgtgatcgct caccgcctgt ccaccatcca gaacgcagac ttgatcgtgg
1621 tgattcagaa tggcaaggtc aaggagcatg gcacccacca gcagctgctg gcacagaaag
1681 gcatctattt ctccatggtc agtgtgcagg ctggagcaaa gcgctagtga actgtgttaa
1741 atattttttt aatatttgta ttaacacata gcatttaacc aaagttaaaa agaaagtacg
1801 taccagaata accagttatc tatttcctgt cattatgaga agcatttagt ccagtttaga
1861 gttttcagag actttgtaat taaagggaca gaaatagata tatcatcaaa tggaaaggaa
1921 tcatttaaat tgcactataa aattatacaa gaattaaaag taaatgtttc ataatatata
1981 cttttattta tactttctca tttgtaacta taactgattt ccttgctaaa caaatcatgt
2041 gtgtatcaaa aattaatgaa atgtttgtat aaagtatata tagtgaaact
//GenBank-Updates@genbank.bio.net (05/03/91)
LOCUS HAMPGP1165 4304 bp ss-mRNA ROD 03-MAY-1991
DEFINITION Chinese hamster p-glycoprotein mRNA (clone ADX165), complete cds.
ACCESSION M59253
KEYWORDS multidrug resistance glycoprotein; p-glycoprotein.
SOURCE Chinese hamster, cDNA to mRNA, clone ADX165.
ORGANISM Cricetulus sp.
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Cricetidae; Cricetinae;
Cricetini.
REFERENCE 1 (bases 1 to 4304)
AUTHORS Devine,S.E., Hussain,A., Davide,J.P. and Melera,P.W.
TITLE Full length and alternatively spliced pgp-1 transcripts in
multidrug resistant Chinese hamster lung cells
JOURNAL J. Biol. Chem. 266, 4545-4555 (1991)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
CDS 111..3941
/product="p-glycoprotein"
/gene="pgp-1"
/codon_start=111
BASE COUNT 1275 a 895 c 1031 g 1103 t
ORIGIN Map position 1q26.
1 aagcagcggt tccaggagcc tgctcccatc tccccaggcc cgctaaactc ggaatcgctt
61 cttccaattc tacgactggg cggactttgc gaaggaaagc ggaggtcgtg atggagtttg
121 aagaggactt tagcggaaga aaagacaaga acttcttgaa gatgggcaga aagagtaaaa
181 aggagaagaa agagaagaaa ccagtggtca gtgtgtttac aatgtttcgc tacgcaggtt
241 ggctggatag gttgtacatg ctggtgggga ctctcgcagc tattatccat ggagttgcac
301 tcccgcttat gatgctggtg tttggagaca tgacagacag ctttgcaagt gtaggaaaca
361 tcccaacaaa tgctactaat aatgccactc aagtcaatgc ttcagacatc tttggcaaac
421 tggaggaaga aatgaccacg tacgcctatt actacacagg gattggtgct ggtgtgctta
481 tagttgccta cattcaggtt tcattttggt gcctggcagc tggaagacaa atacacaaaa
541 ttagacagaa gttttttcat gctataatga atcaggagat aggctggttt gacgtgcacg
601 acgttgggga gctcaacacc cggctcacag atgatgtctc caaaattaac gaaggaattg
661 gtgacaaaat tggaatgttc tttcaggcaa tggcaacatt ttttggtggt tttataatag
721 gatttactcg aggctggaag ctaacccttg tgattttggc catcagccct gttcttggac
781 tgtcagctgg tatttgggca aagatattat cttcatttac tgataaagaa cttcaggcat
841 atgcaaaagc tggagcagtt gctgaagaag tcttagcagc catcagaact gtgattgcat
901 ttggaggaca aaagaaagaa cttgaaaggt acaacaacaa tttagaagaa gccaaaagac
961 ttgggataaa gaaagcgatc acagccaaca tttccatggg cgcagctttc cttcttatct
1021 atgcatcata tgctctggcc ttctggtatg gaacgtcctt ggtcatctca aaagaatatt
1081 ctattggaca agtgctcact gtcttctttg ctgtattaat tgcgccattc agtattggac
1141 aggcatctcc aaatatcgaa gcctttgcca atgcaagagg agcagcctat gaaatcttca
1201 acataattga taataagccc agtattgaca gcttctcaaa gaatgggtac aaaccagaca
1261 acattaaagg aaatttggaa ttcaaaaata ttcacttcag ttacccatct cgaaaagacg
1321 ttcagatctt gaagggcctc aacctgaagg tgcagagcgg acagacagtg gccctggttg
1381 gcaacagtgg ctgtgggaaa agcaccactg tccagctgct gcagaggctc tacgacccca
1441 cagagggcgt ggtcagtatc gacggacagg acatcaggac catcaatgtg aggtatctgc
1501 gggaaatcat tggggtcgtg agtcaggaac ctgtgttgtt tgccaccact atcgctgaaa
1561 acattcgcta tggccgagaa aatgtcacta tggacgagat cgagaaagct gtcaaggaag
1621 ccaatgccta tgacttcatc atgaaactgc cccataaatt tgacactctt gttggtgaga
1681 gaggagcaca gctgagtgga ggacagaaac agagaatcgc cattgctcgt gccctggtcc
1741 gcaaccccaa gatccttttg ttggatgagg cgacatcagc cttggacaca gaaagtgaag
1801 ccgtggttca ggctgctctg gataaggcta gagaaggccg gactaccatt gtgatagccc
1861 accgcttgtc tacagttcga aatgctgaca tcatagctgg gtttgatggt ggtgtcattg
1921 tggagcaagg aaatcatgaa gagctcatga gagagaaggg catttacttc aaacttgtca
1981 tgacacagac agcaggaaat gaaattgaat taggaaatga agttggtgag tctaaaaatg
2041 aaattgataa tttagacatg tcttcaaaag attcagcatc cagtctaatc agaaggagat
2101 caactcgcag aagtatccgt ggaccacatg accaagacag gaagcttagt accaaagagg
2161 ccttggatga agatgtacct ccaatttcct tttggcgtat cctaaagttg aattcatctg
2221 aatggccata ttttgtggtt ggtatattct gtgccatagt aaatggagcc ttgcaaccag
2281 cattctcaat aatattttct aaggttgtag gggttttcac aagaaatact gatgatgaaa
2341 ccaaacgaca tgatagcaac ttgttttcct tattgtttct gatccttggg gtcatttctt
2401 ttattacatt ttttcttcag ggcttcacat ttggcaaagc tggagagatc ctcaccaagc
2461 gactccgata catggttttc aaatccatgc tgagacagga tgtgagctgg tttgataacc
2521 ctaaaaacac cactggagca ttgaccacca ggctcgccaa cgatgctggt caagttaaag
2581 gggctacagg agccagactt gctgtcatta cccagaatat agcaaatctt gggacaggaa
2641 tcatcatatc cctaatctat ggctggcagt tgacacttct actcttagca attgtcccca
2701 tcattgcaat agcaggagtg gttgagatga aaatgttgtc tggacaagca ctaaaagata
2761 agaaggagct agaaggttct gggaagattg ctactgaagc aatagagaac ttccgcactg
2821 tcgtctcttt gactcgggag cagaagtttg aaaatatgta tgcccagagc ttgcagatac
2881 catacagaaa tgctctgaag aaagcacacg tctttgggat cacattctcc ttcacccagg
2941 ccatgatgta tttttcgtat gctgcttgtt tccggtttgg tgcttacttg gtggcacggg
3001 aattaatgac atttgaaaat gttctattag tattctcagc tattgtcttt ggtgccatgg
3061 cagttgggca ggtcagttca tttgctcctg actatgccaa agccaaagtg tcggcatcgc
3121 atatcatcat gatcattgaa aaagtccctt ccattgacag ctacagcacc ggaggcctga
3181 agcctaatac attggaagga aatgtgaaat ttaatgaagt cgtgttcaac taccccaccc
3241 ggcctgacat cccagtgctt caggggctga acctggaggt gaagaagggc cagacgctgg
3301 ccctggtggg cagcagtggc tgcgggaaga gcacagtggt ccagctgctc gagcggttct
3361 acgaccccat ggccggaaca gtgtttctag atggcaaaga agtaaaccaa ctaaatgtcc
3421 agtggctccg agcacaccta ggcattgtgt cccaagagcc catcctgttt gactgcagca
3481 tcgctgagaa catcgcttat ggagacaaca gccgggtcgt gtcccaggat gagatcgaga
3541 gggcggcgaa ggaagccaac atccaccagt tcattgagtc actgcctgac aaatacaaca
3601 ccagagtagg agacaaaggg actcagctgt cgggtgggca gaaacaacgc atcgccatag
3661 cacgcgccct cgtcagacag cctcacattt tgctcctgga tgaagcaaca tcagccctgg
3721 atacagagag tgaaaaggtt gtccaggaag ctctggacaa agccagagaa ggccgcacct
3781 gcattgtgat cgctcaccgc ctgtccacca tccagaacgc agacttgatc gtggtgattc
3841 agaatggcaa ggtcaaggag catggcaccc accagcagct gctggcacag aaaggcatct
3901 atttctccat ggtcagtgtg caggctggag caaagcgcta gtgaactgtg ttaaatattt
3961 ttttaatatt tgtattaaca catagcattt aaccaaagtt aaaaagaaag tacgtaccag
4021 aataaccagt tatctatttc ctgtcattat gagaagcatt tagtccagtt tagagttttc
4081 agagactttg taattaaagg gacagaaata gatatatcat caaatggaaa ggaatcattt
4141 aaattgcact ataaaattat acaagaatta aaagtaaatg tttcataata tatactttta
4201 tttatacttt ctcatttgta actataactg atttccttgc taaacaaatc atgtgtgtat
4261 caaaaattaa tgaaatgttt gtataaagta tatatagtga aact
//GenBank-Updates@genbank.bio.net (05/03/91)
LOCUS HAMPGP1185 3987 bp ss-mRNA ROD 03-MAY-1991
DEFINITION Chinese hamster p-glycoprotein mRNA (clone ADX185), complete cds.
ACCESSION M59254
KEYWORDS multidrug resistance glycoprotein; p-glycoprotein.
SOURCE Chinese hamster, cDNA to mRNA, clone ADX185.
ORGANISM Cricetulus sp.
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Cricetidae; Cricetinae;
Cricetini.
REFERENCE 1 (bases 1 to 3987)
AUTHORS Devine,S.E., Hussain,A., Davide,J.P. and Melera,P.W.
TITLE Full length and alternatively spliced pgp-1 transcripts in
multidrug resistant Chinese hamster lung cells
JOURNAL J. Biol. Chem. 266, 4545-4555 (1991)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
CDS 115..3624
/product="p-glycoprotein"
/gene="pgp-1"
/codon_start=115
BASE COUNT 1194 a 822 c 944 g 1027 t
ORIGIN Map position 1q26.
1 cttgaagatg ggcagaaaga gtaaaaagga gaagaaagag aagaaaccag tggtcagtgt
61 gtttacaatg ctcaagtcaa tgcttcagac atctttggca aactggagga agaaatgacc
121 acgtacgcct attactacac agggattggt gctggtgtgc ttatagttgc ctacattcag
181 gtttcatttt ggtgcctggc agctggaaga caaatacaca aaattagaca gaagtttttt
241 catgctataa tgaatcagga gataggctgg tttgacgtgc acgacgttgg ggagctcaac
301 acccggctca cagatgatgt ctccaaaatt aacgaaggaa ttggtgacaa aattggaatg
361 ttctttcagg caatggcaac attttttggt ggttttataa taggatttac tcgaggctgg
421 aagctaaccc ttgtgatttt ggccatcagc cctgttcttg gactgtcagc tggtatttgg
481 gcaaagatat tatcttcatt tactgataaa gaacttcagg catatgcaaa agctggagca
541 gttgctgaag aagtcttagc agccatcaga actgtgattg catttggagg acaaaagaaa
601 gaacttgaaa ggtacaacaa caatttagaa gaagccaaaa gacttgggat aaagaaagcg
661 atcacagcca acatttccat gggcgcagct ttccttctta tctatgcatc atatgctctg
721 gccttctggt atggaacgtc cttggtcatc tcaaaagaat attctattgg acaagtgctc
781 actgtcttct ttgctgtatt aattgcgcca ttcagtattg gacaggcatc tccaaatatc
841 gaagcctttg ccaatgcaag aggagcagcc tatgaaatct tcaacataat tgataataag
901 cccagtattg acagcttctc aaagaatggg tacaaaccag acaacattaa aggaaatttg
961 gaattcaaaa atattcactt cagttaccca tctcgaaaag acgttcagat cttgaagggc
1021 ctcaacctga aggtgcagag cggacagaca gtggccctgg ttggcaacag tggctgtggg
1081 aaaagcacca ctgtccagct gctgcagagg ctctacgacc ccacagaggg cgtggtcagt
1141 atcgacggac aggacatcag gaccatcaat gtgaggtatc tgcgggaaat cattggggtc
1201 gtgagtcagg aacctgtgtt gtttgccacc actatcgctg aaaacattcg ctatggccga
1261 gaaaatgtca ctatggacga gatcgagaaa gctgtcaagg aagccaatgc ctatgacttc
1321 atcatgaaac tgccccataa atttgacact cttgttggtg agagaggagc acagctgagt
1381 ggaggacaga aacagagaat cgccattgct cgtgccctgg tccgcaaccc caagatcctt
1441 ttgttggatg aggcgacatc agccttggac acagaaagtg aagccgtggt tcaggctgct
1501 ctggataagg ctagagaagg ccggactacc attgtgatag cccaccgctt gtctacagtt
1561 cgaaatgctg acatcatagc tgggtttgat ggtggtgtca ttgtggagca aggaaatcat
1621 gaagagctca tgagagagaa gggcatttac ttcaaacttg tcatgacaca gacagcagga
1681 aatgaaattg aattaggaaa tgaagttggt gagtctaaaa atgaaattga taatttagac
1741 atgtcttcaa aagattcagc atccagtcta atcagaagga gatcaactcg cagaagtatc
1801 cgtggaccac atgaccaaga caggaagctt agtaccaaag aggccttgga tgaagatgta
1861 cctccaattt ccttttggcg tatcctaaag ttgaattcat ctgaatggcc atattttgtg
1921 gttggtatat tctgtgccat agtaaatgga gccttgcaac cagcattctc aataatattt
1981 tctaaggttg taggggtttt cacaagaaat actgatgatg aaaccaaacg acatgatagc
2041 aacttgtttt ccttattgtt tctgatcctt ggggtcattt cttttattac attttttctt
2101 cagggcttca catttggcaa agctggagag atcctcacca agcgactccg atacatggtt
2161 ttcaaatcca tgctgagaca ggatgtgagc tggtttgata accctaaaaa caccactgga
2221 gcattgacca ccaggctcgc caacgatgct ggtcaagtta aaggggctac aggagccaga
2281 cttgctgtca ttacccagaa tatagcaaat cttgggacag gaatcatcat atccctaatc
2341 tatggctggc agttgacact tctactctta gcaattgtcc ccatcattgc aatagcagga
2401 gtggttgaga tgaaaatgtt gtctggacaa gcactaaaag ataagaagga gctagaaggt
2461 tctgggaaga ttgctactga agcaatagag aacttccgca ctgtcgtctc tttgactcgg
2521 gagcagaagt ttgaaaatat gtatgcccag agcttgcaga taccatacag aaatgctctg
2581 aagaaagcac acgtctttgg gatcacattc tccttcaccc aggccatgat gtatttttcg
2641 tatgctgctt gtttccggtt tggtgcttac ttggtggcac gggaattaat gacatttgaa
2701 aatgttctat tagtattctc agctattgtc tttggtgcca tggcagttgg gcaggtcagt
2761 tcatttgctc ctgactatgc caaagccaaa gtgtcggcat cgcatatcat catgatcatt
2821 gaaaaagtcc cttccattga cagctacagc accggaggcc tgaagcctaa tacattggaa
2881 ggaaatgtga aatttaatga agtcgtgttc aactacccca cccggcctga catcccagtg
2941 cttcaggggc tgaacctgga ggtgaagaag ggccagacgc tggccctggt gggcagcagt
3001 ggctgcggga agagcacagt ggtccagctg ctcgagcggt tctacgaccc catggccgga
3061 acagtgtttc tagatggcaa agaagtaaac caactaaatg tccagtggct ccgagcacac
3121 ctaggcattg tgtcccaaga gcccatcctg tttgactgca gcatcgctga gaacatcgct
3181 tatggagaca acagccgggt cgtgtcccag gatgagatcg agagggcggc gaaggaagcc
3241 aacatccacc agttcattga gtcactgcct gacaaataca acaccagagt aggagacaaa
3301 gggactcagc tgtcgggtgg gcagaaacaa cgcatcgcca tagcacgcgc cctcgtcaga
3361 cagcctcaca ttttgctcct ggatgaagca acatcagccc tggatacaga gagtgaaaag
3421 gttgtccagg aagctctgga caaagccaga gaaggccgca cctgcattgt gatcgctcac
3481 cgcctgtcca ccatccagaa cgcagacttg atcgtggtga ttcagaatgg caaggtcaag
3541 gagcatggca cccaccagca gctgctggca cagaaaggca tctatttctc catggtcagt
3601 gtgcaggctg gagcaaagcg ctagtgaact gtgttaaata tttttttaat atttgtatta
3661 acacatagca tttaaccaaa gttaaaaaga aagtacgtac cagaataacc agttatctat
3721 ttcctgtcat tatgagaagc atttagtcca gtttagagtt ttcagagact ttgtaattaa
3781 agggacagaa atagatatat catcaaatgg aaaggaatca tttaaattgc actataaaat
3841 tatacaagaa ttaaaagtaa atgtttcata atatatactt ttatttatac tttctcattt
3901 gtaactataa ctgatttcct tgctaaacaa atcatgtgtg tatcaaaaat taatgaaatg
3961 tttgtataaa gtatatatag tgaaact
//