GenBank-Updates@genbank.bio.net (11/28/90)
LOCUS HUMSIS5DEL 1200 bp ds-DNA PRI 28-NOV-1990
DEFINITION Human c-sis proto-oncogene intron 5 with Alu repeat deletion.
ACCESSION M55987 M38065
KEYWORDS c-sis proto-oncogene; Alu repetitive sequence.
SOURCE Human (meningioma patient) Epstein-Barr virus immortalized
lymphocyte DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1200)
AUTHORS Smidt,M., Kirsch,I. and Ratner,L.
TITLE Deletion of Alu sequences in the fifth c-sis intron in individuals
with meningiomas
JOURNAL J. Clin. Invest. 86, 1151-1157 (1990)
STANDARD simple staff_entry
FEATURES from to/span description
rpt 405 835 Alu repeat
mut 555 689 deletion in meningioma patients
IVS < 1 > 1200 c-sis intron 5
BASE COUNT 314 a 293 c 336 g 257 t
ORIGIN
1 gagctcaaaa ggctcccagg aaatggctgg ccttgagctc cgcagacaca gctgtccctg
61 ccagggtggc cacctggaaa tccaggacgg agagaagtgt ataagagctc cccttgactg
121 aggctcacag gcactgtcgt ttgtgctgag tggttggagg tgtgcactct agaggcagat
181 ccctgagttc aaatcccagt ctctctgctt cagtttcctc atctgtaaag tgtgggtaac
241 agcatctgcc ggtaacagca cctgccgtga agggaaatga gcatagaaca gcaccaggta
301 catggtaaac actagctggg gggtttctgg ccatttccat gtattgtctc ctaacgctag
361 gaggccaggg ctgctgtctt ctctgcttta aagatgtgga aatcggctgg gcgtggtggc
421 tcacgcctgt aatcccagca ctttgggagg ccaaggcagg tggatcactt gaggtcagga
481 gttcaagacc agcctggcca acatggtgaa accccatctc tactaaaaat acaaaaatta
541 accaggtgtc atggcgtatg cctgtaatcc cagcactttg ggaggccaag gcaggtggat
601 cacttgaggt caggagttca agaccagcct ggccaacatg gtgaaacccc atctctacta
661 aaaatacaaa aattaaccag gtgtcatggt gcatgcctgt aatcccagct actcgggagg
721 ctgaggcagg agaatcactt gaacctgcga ggtggaggtt gcagtgagct gagatcgcgc
781 cactgcactc caacctgggc aacagagtga gcctccgtct taaaaacaaa taaataaaga
841 tgcggaaatc gaggcacagg gcggttaagt gacttgctcc aatgtccacg atacgtggag
901 agcccagatt tgagcccagg tgggtcagat cctcagcctg agttgtggcc catcccactc
961 taccatttct cagagtggca aggggcaggt aggtgacagg cacaactgac ccgaagccca
1021 gcttcatggt gggagtatga ttctggccca gagcccagtg gcctccacac cacgtgatcg
1081 gacggggctg agaggttggg aggaaacctc aatagtaggt caagctaagg aaaataagaa
1141 aaaaaagtga gtcgtagcag ctgccatgtg ctgaccactt catacttgag ctttttatta
//GenBank-Updates@genbank.bio.net (01/31/91)
LOCUS HUMSIS5DEL 1200 bp ds-DNA PRI 31-JAN-1991
DEFINITION Human c-sis proto-oncogene intron 5 with Alu repeat deletion.
ACCESSION M55987 M38065
KEYWORDS Alu repetitive element; c-sis proto-oncogene.
SOURCE Human (meningioma patient) Epstein-Barr virus immortalized
lymphocyte DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1200)
AUTHORS Smidt,M., Kirsch,I. and Ratner,L.
TITLE Deletion of Alu sequences in the fifth c-sis intron in individuals
with meningiomas
JOURNAL J. Clin. Invest. 86, 1151-1157 (1990)
STANDARD unannotated staff_entry
FEATURES Location/Qualifiers
intron <1..>1200
/number=5
/gene="c-sis proto-oncogene"
repeat_unit 405..835
/rpt_family="Alu"
/gene="c-sis proto-oncogene"
mutation 555..689
/=deletion
/note="found in meningioma patients"
BASE COUNT 314 a 293 c 336 g 257 t
ORIGIN
1 gagctcaaaa ggctcccagg aaatggctgg ccttgagctc cgcagacaca gctgtccctg
61 ccagggtggc cacctggaaa tccaggacgg agagaagtgt ataagagctc cccttgactg
121 aggctcacag gcactgtcgt ttgtgctgag tggttggagg tgtgcactct agaggcagat
181 ccctgagttc aaatcccagt ctctctgctt cagtttcctc atctgtaaag tgtgggtaac
241 agcatctgcc ggtaacagca cctgccgtga agggaaatga gcatagaaca gcaccaggta
301 catggtaaac actagctggg gggtttctgg ccatttccat gtattgtctc ctaacgctag
361 gaggccaggg ctgctgtctt ctctgcttta aagatgtgga aatcggctgg gcgtggtggc
421 tcacgcctgt aatcccagca ctttgggagg ccaaggcagg tggatcactt gaggtcagga
481 gttcaagacc agcctggcca acatggtgaa accccatctc tactaaaaat acaaaaatta
541 accaggtgtc atggcgtatg cctgtaatcc cagcactttg ggaggccaag gcaggtggat
601 cacttgaggt caggagttca agaccagcct ggccaacatg gtgaaacccc atctctacta
661 aaaatacaaa aattaaccag gtgtcatggt gcatgcctgt aatcccagct actcgggagg
721 ctgaggcagg agaatcactt gaacctgcga ggtggaggtt gcagtgagct gagatcgcgc
781 cactgcactc caacctgggc aacagagtga gcctccgtct taaaaacaaa taaataaaga
841 tgcggaaatc gaggcacagg gcggttaagt gacttgctcc aatgtccacg atacgtggag
901 agcccagatt tgagcccagg tgggtcagat cctcagcctg agttgtggcc catcccactc
961 taccatttct cagagtggca aggggcaggt aggtgacagg cacaactgac ccgaagccca
1021 gcttcatggt gggagtatga ttctggccca gagcccagtg gcctccacac cacgtgatcg
1081 gacggggctg agaggttggg aggaaacctc aatagtaggt caagctaagg aaaataagaa
1141 aaaaaagtga gtcgtagcag ctgccatgtg ctgaccactt catacttgag ctttttatta
//GenBank-Updates@genbank.bio.net (05/07/91)
LOCUS HUMSIS5DEL 1200 bp ds-DNA PRI 07-MAY-1991
DEFINITION Human c-sis proto-oncogene intron 5 with Alu repeat deletion.
ACCESSION M55987 M38065
KEYWORDS Alu repetitive element; c-sis proto-oncogene.
SOURCE Human (meningioma patient) Epstein-Barr virus immortalized
lymphocyte DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1200)
AUTHORS Smidt,M., Kirsch,I. and Ratner,L.
TITLE Deletion of Alu sequences in the fifth c-sis intron in individuals
with meningiomas
JOURNAL J. Clin. Invest. 86, 1151-1157 (1990)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
intron <1..>1200
/number=5
/gene="c-sis"
repeat_region 405..835
/rpt_family="Alu"
/gene="c-sis"
mutation 555..689
/note="deletion found in meningioma patients"
/note="replace(555..689,' ')"
BASE COUNT 314 a 293 c 336 g 257 t
ORIGIN
1 gagctcaaaa ggctcccagg aaatggctgg ccttgagctc cgcagacaca gctgtccctg
61 ccagggtggc cacctggaaa tccaggacgg agagaagtgt ataagagctc cccttgactg
121 aggctcacag gcactgtcgt ttgtgctgag tggttggagg tgtgcactct agaggcagat
181 ccctgagttc aaatcccagt ctctctgctt cagtttcctc atctgtaaag tgtgggtaac
241 agcatctgcc ggtaacagca cctgccgtga agggaaatga gcatagaaca gcaccaggta
301 catggtaaac actagctggg gggtttctgg ccatttccat gtattgtctc ctaacgctag
361 gaggccaggg ctgctgtctt ctctgcttta aagatgtgga aatcggctgg gcgtggtggc
421 tcacgcctgt aatcccagca ctttgggagg ccaaggcagg tggatcactt gaggtcagga
481 gttcaagacc agcctggcca acatggtgaa accccatctc tactaaaaat acaaaaatta
541 accaggtgtc atggcgtatg cctgtaatcc cagcactttg ggaggccaag gcaggtggat
601 cacttgaggt caggagttca agaccagcct ggccaacatg gtgaaacccc atctctacta
661 aaaatacaaa aattaaccag gtgtcatggt gcatgcctgt aatcccagct actcgggagg
721 ctgaggcagg agaatcactt gaacctgcga ggtggaggtt gcagtgagct gagatcgcgc
781 cactgcactc caacctgggc aacagagtga gcctccgtct taaaaacaaa taaataaaga
841 tgcggaaatc gaggcacagg gcggttaagt gacttgctcc aatgtccacg atacgtggag
901 agcccagatt tgagcccagg tgggtcagat cctcagcctg agttgtggcc catcccactc
961 taccatttct cagagtggca aggggcaggt aggtgacagg cacaactgac ccgaagccca
1021 gcttcatggt gggagtatga ttctggccca gagcccagtg gcctccacac cacgtgatcg
1081 gacggggctg agaggttggg aggaaacctc aatagtaggt caagctaagg aaaataagaa
1141 aaaaaagtga gtcgtagcag ctgccatgtg ctgaccactt catacttgag ctttttatta
//