GenBank-Updates@genbank.bio.net (05/08/91)
LOCUS HUMCOLA1A2 2372 bp ss-mRNA PRI 08-MAY-1991
DEFINITION Human collagen type I alpha-2 chain mRNA, 5' end.
ACCESSION Y00724
KEYWORDS alpha-2 type 1 collagen; collagen type 1.
SOURCE human (Homo sapiens).
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2372)
AUTHORS Prockop,D.J.
JOURNAL Unpublished (1988) Jefferson Med C.,1020 Locust,Philadel.,PA 19107
STANDARD simple automatic
REFERENCE 2 (bases 1 to 2372)
AUTHORS Kuivaniemi,H., Tromp,G., Chu,M.-L. and Prockop,D.J.
TITLE Structure of a full-length cDNA clone for the prepro-alpha-2 (I)
chain of human type I procollagen. Comparison with the chicken gene
confirms unusual patterns of gene conservation
JOURNAL Biochem. J. 252, 633-640 (1988)
STANDARD simple automatic
COMMENT *source: strain = N/A; tissue = placenta; *source: library = cDNA
of placental RNA in lambda gt11; *source: clone = Hp2010;
FEATURES Location/Qualifiers
CDS 77..>2372
/note="prepro-collagen type I alpha-2 chain
/nomgen='COL1A2' /map='7q21.3-q22.1'
/hgml_locus_uid='LP0002V'"
/codon_start=77
sig_peptide 77..142
/note="collagen type I alpha-2 chain signal peptide"
/codon_start=77
mat_peptide 314..>2372
/note="collagen type I alpha-2 chain"
/codon_start=314
BASE COUNT 420 a 637 c 821 g 494 t
ORIGIN Chromosome 7q21.3-q22.1.
1 ggcgggccag gtgatacctc cgccggtgac ccaggggctc tgcgacacaa ggagtctgca
61 tgtctaagtg ctagacatgc tcagctttgt ggatacgcgg actttgttgc tgcttgcagt
121 aaccttatgc ctagcaacat gccaatcttt acaagaggaa actgtaagaa agggcccagc
181 cggagataga ggaccacgtg gagaaagggg tccaccaggc cccccaggca gagatggtga
241 agatggtccc acaggccctc ctggtccacc tggtcctcct ggcccccctg gtctcggtgg
301 gaactttgct gctcagtatg atggaaaagg agttggactt ggccctggac caatgggctt
361 aatgggacct agaggcccac ctggtgcagc tggagcccca ggccctcaag gtttccaagg
421 acctgctggt gagcctggtg aacctggtca aactggtcct gcaggtgctc gtggtccagc
481 tggccctcct ggcaaggctg gtgaagatgg tcaccctgga aaacccggac gacctggtga
541 gagaggagtt gttggaccac agggtgctcg tggtttccct ggaactcctg gacttcctgg
601 cttcaaaggc attaggggac acaatggtct ggatggattg aagggacagc ccggtgctcc
661 tggtgtgaag ggtgaacctg gtgcccctgg tgaaaatgga actccaggtc aaacaggagc
721 ccgtgggctt cctggtgaga gaggacgtgt tggtgcccct ggcccagctg gtgcccgtgg
781 cagtgatgga agtgtgggtc ccgtgggtcc tgctggtccc attgggtctg ctggccctcc
841 aggcttccca ggtgcccctg gccccaaggg tgaaattgga gctgttggta acgctggtcc
901 tgctggtccc gccggtcccc gtggtgaagt gggtcttcca ggcctctccg gccccgttgg
961 acctcctggt aatcctggag caaacggcct tactggtgcc aagggtgctg ctggccttcc
1021 cggcgttgct ggggctcccg gcctccctgg accccgcggt attcctggcc ctgttggtgc
1081 tgccggtgct actggtgcca gaggacttgt tggtgagcct ggtccagctg gctccaaagg
1141 agagagcggt aacaagggtg agcccggctc tgctgggccc caaggtcctc ctggtcccag
1201 tggtgaagaa ggaaagagag gccctaatgg ggaagctgga tctgccggcc ctccaggacc
1261 tcctgggctg agaggtagtc ctggttctcg tggtcttcct ggagctgatg gcagagctgg
1321 cgtcatgggc cctcctggta gtcgtggtgc aagtggccct gctggagtcc gaggacctaa
1381 tggagatgct ggtcgccctg gggagcctgg tctcatggga cccagaggtc ttcctggttc
1441 ccctggaaat atcggccccg ctggaaaaga aggtcctgtc ggcctccctg gcatcgacgg
1501 caggcctggc ccaattggcc cagctggagc aagaggagag cctggcaaca ttggattccc
1561 tggacccaaa ggccccactg gtgatcctgg caaaaacggt gataaaggtc atgctggtct
1621 tgctggtgct cggggtgctc caggtcctga tggaaacaat ggtgctcagg gacctcctgg
1681 accacagggt gttcaaggtg gaaaaggtga acagggtccc gatggtcctc caggcttcca
1741 gggtctgcct ggcccctcag gtcccgctgg tgaagttggc aaaccaggag aaaggggtct
1801 ccatggtgag tttggtctcc ctggtcctgc tggtccaaga ggggaacgcg gtcccccagg
1861 tgagagtggt gctgccggtc ctactggtcc tattggaagc cgaggtcctt ctggaccccc
1921 agggcctgat ggaaacaagg gtgaacctgg tgtggttggt gctgtgggca ctgctggtcc
1981 atctggtcct agtggactcc caggagagag gggtgctgct ggcatacctg gaggcaaggg
2041 agaaaagggt gaacctggtc tcagaggtga aattggtaac cctggcagag atggtgctcg
2101 tggtgctcat ggtgctgtag gtgcccctgg tcctgctgga gccacaggtg accggggcga
2161 agctggggct gctggtcctg ctggtcctgc tggtcctcgg ggaagccctg gtgaacgtgg
2221 cgaggtcggt cctgctggcc ccaacggatt tgctggtccg gctggtgctg ctggtcaacc
2281 gggtgctaaa ggagaaagag gaggcaaagg gcctaagggt gaaaacggtg ttgttggtcc
2341 cacaggcccc gttggagctg ctggcccagc tg
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