GenBank-Updates@genbank.bio.net (05/08/91)
LOCUS HUMCOLA1A2 2372 bp ss-mRNA PRI 08-MAY-1991 DEFINITION Human collagen type I alpha-2 chain mRNA, 5' end. ACCESSION Y00724 KEYWORDS alpha-2 type 1 collagen; collagen type 1. SOURCE human (Homo sapiens). ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 2372) AUTHORS Prockop,D.J. JOURNAL Unpublished (1988) Jefferson Med C.,1020 Locust,Philadel.,PA 19107 STANDARD simple automatic REFERENCE 2 (bases 1 to 2372) AUTHORS Kuivaniemi,H., Tromp,G., Chu,M.-L. and Prockop,D.J. TITLE Structure of a full-length cDNA clone for the prepro-alpha-2 (I) chain of human type I procollagen. Comparison with the chicken gene confirms unusual patterns of gene conservation JOURNAL Biochem. J. 252, 633-640 (1988) STANDARD simple automatic COMMENT *source: strain = N/A; tissue = placenta; *source: library = cDNA of placental RNA in lambda gt11; *source: clone = Hp2010; FEATURES Location/Qualifiers CDS 77..>2372 /note="prepro-collagen type I alpha-2 chain /nomgen='COL1A2' /map='7q21.3-q22.1' /hgml_locus_uid='LP0002V'" /codon_start=77 sig_peptide 77..142 /note="collagen type I alpha-2 chain signal peptide" /codon_start=77 mat_peptide 314..>2372 /note="collagen type I alpha-2 chain" /codon_start=314 BASE COUNT 420 a 637 c 821 g 494 t ORIGIN Chromosome 7q21.3-q22.1. 1 ggcgggccag gtgatacctc cgccggtgac ccaggggctc tgcgacacaa ggagtctgca 61 tgtctaagtg ctagacatgc tcagctttgt ggatacgcgg actttgttgc tgcttgcagt 121 aaccttatgc ctagcaacat gccaatcttt acaagaggaa actgtaagaa agggcccagc 181 cggagataga ggaccacgtg gagaaagggg tccaccaggc cccccaggca gagatggtga 241 agatggtccc acaggccctc ctggtccacc tggtcctcct ggcccccctg gtctcggtgg 301 gaactttgct gctcagtatg atggaaaagg agttggactt ggccctggac caatgggctt 361 aatgggacct agaggcccac ctggtgcagc tggagcccca ggccctcaag gtttccaagg 421 acctgctggt gagcctggtg aacctggtca aactggtcct gcaggtgctc gtggtccagc 481 tggccctcct ggcaaggctg gtgaagatgg tcaccctgga aaacccggac gacctggtga 541 gagaggagtt gttggaccac agggtgctcg tggtttccct ggaactcctg gacttcctgg 601 cttcaaaggc attaggggac acaatggtct ggatggattg aagggacagc ccggtgctcc 661 tggtgtgaag ggtgaacctg gtgcccctgg tgaaaatgga actccaggtc aaacaggagc 721 ccgtgggctt cctggtgaga gaggacgtgt tggtgcccct ggcccagctg gtgcccgtgg 781 cagtgatgga agtgtgggtc ccgtgggtcc tgctggtccc attgggtctg ctggccctcc 841 aggcttccca ggtgcccctg gccccaaggg tgaaattgga gctgttggta acgctggtcc 901 tgctggtccc gccggtcccc gtggtgaagt gggtcttcca ggcctctccg gccccgttgg 961 acctcctggt aatcctggag caaacggcct tactggtgcc aagggtgctg ctggccttcc 1021 cggcgttgct ggggctcccg gcctccctgg accccgcggt attcctggcc ctgttggtgc 1081 tgccggtgct actggtgcca gaggacttgt tggtgagcct ggtccagctg gctccaaagg 1141 agagagcggt aacaagggtg agcccggctc tgctgggccc caaggtcctc ctggtcccag 1201 tggtgaagaa ggaaagagag gccctaatgg ggaagctgga tctgccggcc ctccaggacc 1261 tcctgggctg agaggtagtc ctggttctcg tggtcttcct ggagctgatg gcagagctgg 1321 cgtcatgggc cctcctggta gtcgtggtgc aagtggccct gctggagtcc gaggacctaa 1381 tggagatgct ggtcgccctg gggagcctgg tctcatggga cccagaggtc ttcctggttc 1441 ccctggaaat atcggccccg ctggaaaaga aggtcctgtc ggcctccctg gcatcgacgg 1501 caggcctggc ccaattggcc cagctggagc aagaggagag cctggcaaca ttggattccc 1561 tggacccaaa ggccccactg gtgatcctgg caaaaacggt gataaaggtc atgctggtct 1621 tgctggtgct cggggtgctc caggtcctga tggaaacaat ggtgctcagg gacctcctgg 1681 accacagggt gttcaaggtg gaaaaggtga acagggtccc gatggtcctc caggcttcca 1741 gggtctgcct ggcccctcag gtcccgctgg tgaagttggc aaaccaggag aaaggggtct 1801 ccatggtgag tttggtctcc ctggtcctgc tggtccaaga ggggaacgcg gtcccccagg 1861 tgagagtggt gctgccggtc ctactggtcc tattggaagc cgaggtcctt ctggaccccc 1921 agggcctgat ggaaacaagg gtgaacctgg tgtggttggt gctgtgggca ctgctggtcc 1981 atctggtcct agtggactcc caggagagag gggtgctgct ggcatacctg gaggcaaggg 2041 agaaaagggt gaacctggtc tcagaggtga aattggtaac cctggcagag atggtgctcg 2101 tggtgctcat ggtgctgtag gtgcccctgg tcctgctgga gccacaggtg accggggcga 2161 agctggggct gctggtcctg ctggtcctgc tggtcctcgg ggaagccctg gtgaacgtgg 2221 cgaggtcggt cctgctggcc ccaacggatt tgctggtccg gctggtgctg ctggtcaacc 2281 gggtgctaaa ggagaaagag gaggcaaagg gcctaagggt gaaaacggtg ttgttggtcc 2341 cacaggcccc gttggagctg ctggcccagc tg //