GenBank-Updates@genbank.bio.net (05/08/91)
LOCUS HUMICAMA1A 3003 bp ss-mRNA PRI 08-MAY-1991
DEFINITION Human major group rhinovirus receptor (HRV) mRNA, complete cds.
ACCESSION M24283
KEYWORDS cell surface adhesion glycoprotein; cell surface glycoprotein;
cell surface receptor; intercellular adhesion molecule;
major group rhinovirus receptor.
SOURCE Human HeLa R19 cell line, cDNA to mRNA, clone pHRVr1.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3003)
AUTHORS Tomassini,J.E., Graham,D., DeWitt,C.M., Lineberger,D.W.,
Rodkey,J.A. and Colonno,R.J.
TITLE cDNA cloning reveals that the major group rhinovirus receptor on
HeLa cells is ICAM-1
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86, 4907-4911 (1989)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Proc. Natl. Acad.
Sci. U.S.A. 86, 4907-4911 (1989)] kindly provided
by R.J.Colonno, 25-APR-1989.
Molecular characterization indicates that the 90-kDal major group
rhinovirus receptor is synonomous with the intercellular adhesion
molecule-1 (ICAM-1).
FEATURES Location/Qualifiers
mRNA <1..3003
/note="ICAM-1 mRNA"
CDS 72..1670
/note="major group rhinovirus receptor precusor"
sig_peptide 72..152
/note="major group rhinovirus receptor signal peptide"
mat_peptide 153..1667
/note="major group rhinovirus receptor"
BASE COUNT 690 a 879 c 805 g 629 t
ORIGIN 656 bp upstream of BglI site.
1 gctataagga tcacgcgccc cagtcgacgc tgagctcctc tgctactcag agttgcaacc
61 tcagcctcgc tatggctccc agcagccccc ggcccgcgct gcccgcactc ctggtcctgc
121 tcggggctct gttcccagga cctggcaatg cccagacatc tgtgtccccc tcaaaagtca
181 tcctgccccg gggaggctcc gtgctggtga catgcagcac ctcctgtgac cagcccaagt
241 tgttgggcat agagaccccg ttgcctaaaa aggagttgct cctgcctggg aacaaccgga
301 aggtgtatga actgagcaat gtgcaagaag atagccaacc aatgtgctat tcaaactgcc
361 ctgatgggca gtcaacagct aaaaccttcc tcaccgtgta ctggactcca gaacgggtgg
421 aactggcacc cctcccctct tggcagccag tgggcaagaa ccttacccta cgctgccagg
481 tggagggtgg ggcaccccgg gccaacctca ccgtggtgct gctccgtggg gagaaggagc
541 tgaaacggga gccagctgtg ggggagcccg ctgaggtcac gaccacggtg ctggtgagga
601 gagatcacca tggagccaat ttctcgtgcc gcactgaact ggacctgcgg ccccaagggc
661 tggagctgtt tgagaacacc tcggccccct accagctcca gacctttgtc ctgccagcga
721 ctcccccaca acttgtcagc ccccgggtcc tagaggtgga cacgcagggg accgtggtct
781 gttccctgga cgggctgttc ccagtctcgg aggcccaggt ccacctggca ctgggggacc
841 agaggttgaa ccccacagtc acctatggca acgactcctt ctcggccaag gcctcagtca
901 gtgtgaccgc agaggacgag ggcacccagc ggctgacgtg tgcagtaata ctggggaacc
961 agagccagga gacactgcag acagtgacca tctacagctt tccggcgccc aacgtgattc
1021 tgacgaagcc agaggtctca gaagggaccg aggtgacagt gaagtgtgag gcccacccta
1081 gagccaaggt gacgctgaat ggggttccag cccagccact gggcccgagg gcccagctcc
1141 tgctgaaggc caccccagag gacaacgggc gcagcttctc ctgctctgca accctggagg
1201 tggccggcca gcttatacac aagaaccaga cccgggagct tcgtgtcctg tatggccccc
1261 gactggacga gagggattgt ccgggaaact ggacgtggcc agaaaattcc cagcagactc
1321 caatgtgcca ggcttggggg aacccattgc ccgagctcaa gtgtctaaag gatggcactt
1381 tcccactgcc catcggggaa tcagtgactg tcactcgaga tcttgagggc acctacctct
1441 gtcgggccag gagcactcaa ggggaggtca cccgcaaggt gaccgtgaat gtgctctccc
1501 cccggtatga gattgtcatc atcactgtgg tagcagccgc agtcataatg ggcactgcag
1561 gcctcagcac gtacctctat aaccgccagc ggaagatcaa gaaatacaga ctacaacagg
1621 cccaaaaagg gacccccatg aaaccgaaca cacaagccac gcctccctga acctatcccg
1681 ggacagggcc tcttcctcgg ccttcccata ttggtggcag tggtgccaca ctgaacagag
1741 tggaagacat atgccatgca gctacaccta ccggccctgg gacgccggag gacagggcat
1801 tgtcctcagt cagatacaac agcatttggg gccatggtac ctgcacacct aaaacactag
1861 gccacgcatc tgatctgtag tcacatgact aagccaagag gaaggagcaa gactcaagac
1921 atgattgatg gatgttaaag tctagcctga tgagagggga agtggtgggg gagacatagc
1981 cccaccatga ggacatacaa ctgggaaata ctgaaacttg ctgcctattg ggtatgctga
2041 ggccccacag acttacagaa gaagtggccc tccatagaca tgtgtagcat caaaacacaa
2101 aggcccacac ttcctgacgg atgccagctt gggcactgct gtctactgac cccaaccctt
2161 gatgatatgt atttattcat ttgttatttt accagctatt tattgagtgt cttttatgta
2221 ggctaaatga acataggtct ctggcctcac ggagctccca gtccatgtca cattcaaggt
2281 caccaggtac agttgtacag gttgtacact gcaggagagt gcctggcaaa aagatcaaat
2341 ggggctggga cttctcattg gccaacctgc ctttccccag aaggagtgat ttttctatcg
2401 gcacaaaagc actatatgga ctggtaatgg ttcacaggtt cagagattac ccagtgaggc
2461 cttattcctc ccttcccccc aaaactgaca cctttgttag ccacctcccc acccacatac
2521 atttctgcca gtgttcacaa tgacactcag cggtcatgtc tggacatgag tgcccaggga
2581 atatgcccaa gctatgcctt gtcctcttgt cctgtttgca tttcactggg agcttgcact
2641 attgcagctc cagtttcctg cagtgatcag ggtcctgcaa gcagtgggga agggggccaa
2701 ggtattggag gactccctcc cagctttgga agcctcatcc gcgtgtgtgt gtgtgtgtgt
2761 atgtgtagac aagctctcgc tctgtcaccc aggctggagt gcagtggtgc aatcatggtt
2821 cactgcagtc ttgacctttt gggctcaagt gatcctccca cctcagcctc ctgagtagct
2881 gggaccatag gctcacaaca ccacacctgg caaatttgat tttttttttt tttttcagag
2941 acggggtctc gcaacattgc ccagacttcc tttgtgttag ttaataaagc tttctcaact
3001 gcc
//