GenBank-Updates@genbank.bio.net (05/08/91)
LOCUS HUMRBA1RA 4600 bp ss-mRNA PRI 08-MAY-1991
DEFINITION Human retinoblastoma associated (RB1) mRNA.
ACCESSION M33647 J02994
KEYWORDS retinoblastoma protein.
SOURCE Human retinoblast cDNA to mRNA, clone p4.7R.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 4600)
AUTHORS Friend,S.H., Horowitz,J.M., Gerber,M.R., Wang,X.-F., Bogenmann,E.,
Li,F.P. and Weinberg,R.A.
TITLE Deletions of a DNA sequence in retinoblastomas and mesenchymal
tumors: Organization of the sequence and its encoded protein
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 84, 9059-9063 (1987)
STANDARD full staff_entry
COMMENT Draft entry and computer-readable copy of sequence for [Proc. Natl.
Acad. Sci. U.S.A. 84, 9059-9063 (1987)] kindly
provided by S.H.Friend, 10-FEB-1988.
FEATURES Location/Qualifiers
CDS 4..2790
/note="retinoblastoma-associated protein
/hgml_locus_uid='LE0159J' /map='13q14.2' /nomgen='RB1'"
/codon_start=4
BASE COUNT 1489 a 842 c 815 g 1454 t
ORIGIN
1 gtcatgccgc ccaaaacccc ccgaaaaacg gccgccaccg ccgccgctgc cgccgcggaa
61 cccccggcac cgccgccgcc gccccctcct gaggaggacc cagagcagga cagcggcccg
121 gaggacctgc ctctcgtcag gcttgagttt gaagaaacag aagaacctga ttttactgca
181 ttatgtcaga aattaaagat accagatcat gtcagagaga gagcttggtt aacttgggag
241 aaagtttcat ctgtggatgg agtattggga ggttatattc aaaagaaaaa ggaactgtgg
301 ggaatctgta tctttattgc agcagttgac ctagatgaga tgtcgttcac ttttactgag
361 ctacagaaaa acatagaaat cagtgtccat aaattcttta acttactaaa agaaattgat
421 accagtacca aagttgataa tgctatgtca agactgttga agaagtatga tgtattgttt
481 gcactcttca gcaaattgga aaggacatgt gaacttatat atttgacaca acccagcagt
541 tcgatatcta ctgaaataaa ttctgcattg gtgctaaaag tttcttggat cacattttta
601 ttagctaaag gggaagtatt acaaatggaa gatgatctgg tgatttcatt tcagttaatg
661 ctatgtgtcc ttgactattt tattaaactc tcacctccca tgttgctcaa agaaccatat
721 aaaacagctg ttatacccat taatggttca cctcgaacac ccaggcgagg tcagaacagg
781 agtgcacgga tagcaaaaca actagaaaat gatacaagaa ttattgaagt tctctgtaaa
841 gaacatgaat gtaatataga tgaggtgaaa aatgtttatt tcaaaaattt tatacctttt
901 atgaattctc ttggacttgt aacatctaat ggacttccag aggttgaaaa tctttctaaa
961 cgatacgaag aaatttatct taaaaataaa gatctagatg caagattatt tttggatcat
1021 gataaaactc ttcagactga ttctatagac agttttgaaa cacagagaac accacgaaaa
1081 agtaaccttg atgaagaggt gaatgtaatt cctccacaca ctccagttag gactgttatg
1141 aacactatcc aacaattaat gatgatttta aattcagcaa gtgatcaacc ttcagaaaat
1201 ctgatttcct attttaacaa ctgcacagtg aatccaaaag aaagtatact gaaaagagtg
1261 aaggatatag gatacatctt taaagagaaa tttgctaaag ctgtgggaca gggttgtgtc
1321 gaaattggat cacagcgata caaacttgga gttcgcttgt attaccgagt aatggaatcc
1381 atgcttaaat cagaagaaga acgattatcc attcaaaatt ttagcaaact tctgaatgac
1441 aacatttttc atatgtcttt attggcgtgc gctcttgagg ttgtaatggc cacatatagc
1501 agaagtacat ctcagaatct tgattctgga acagatttgt ctttcccatg gattctgaat
1561 gtgcttaatt taaaagcctt tgatttttac aaagtgatcg aaagttttat caaagcagaa
1621 ggcaacttga caagagaaat gataaaacat ttagaacgat gtgaacatcg aatcatggaa
1681 tcccttgcat ggctctcaga ttcaccttta tttgatctta ttaaacaatc aaaggaccga
1741 gaaggaccaa ctgatcacct tgaatctgct tgtcctctta atcttcctct ccagaataat
1801 cacactgcag cagatatgta tctttctcct gtaagatctc caaagaaaaa aggttcaact
1861 acgcgtgtaa attctactgc aaatgcagag acacaagcaa cctcagcctt ccagacccag
1921 aagccattga aatctacctc tctttcactg ttttataaaa aagtgtatcg gctagcctat
1981 ctccggctaa atacactttg tgaacgcctt ctgtctgagc acccagaatt agaacatatc
2041 atctggaccc ttttccagca caccctgcag aatgagtatg aactcatgag agacaggcat
2101 ttggaccaaa ttatgatgtg ttccatgtat ggcatatgca aagtgaagaa tatagacctt
2161 aaattcaaaa tcattgtaac agcatacaag gatcttcctc atgctgttca ggagacattc
2221 aaacgtgttt tgatcaaaga agaggagtat gattctatta tagtattcta taactcggtc
2281 ttcatgcaga gactgaaaac aaatattttg cagtatgctt ccaccaggcc ccctaccttg
2341 tcaccaatac ctcacattcc tcgaagccct tacaagtttc ctagttcacc cttacggatt
2401 cctggaggga acatctatat ttcacccctg aagagtccat ataaaatttc agaaggtctg
2461 ccaacaccaa caaaaatgac tccaagatca agaatcttag tatcaattgg tgaatcattc
2521 gggacttctg agaagttcca gaaaataaat cagatggtat gtaacagcga ccgtgtgctc
2581 aaaagaagtg ctgaaggaag caaccctcct aaaccactga aaaaactacg ctttgatatt
2641 gaaggatcag atgaagcaga tggaagtaaa catctcccag gagagtccaa atttcagcag
2701 aaactggcag aaatgacttc tactcgaaca cgaatgcaaa agcagaaaat gaatgatagc
2761 atggatacct caaacaagga agagaaatga ggatctcagg accttggtgg acactgtgta
2821 cacctctgga ttcattgtct ctcacagatg tgactgtata actttcccag gttctgttta
2881 tggccacatt taatatcttc agctcttttt gtggatataa aatgtgcaga tgcaattgtt
2941 tgggtgattc ctaagccact tgaaatgtta gtcattgtta tttatacaag attgaaaatc
3001 ttgtgtaaat cctgccattt aaaaagttgt agcagattgt ttcctcttcc aaagtaaaat
3061 tgctgtgctt tatggatagt aagaatggcc ctagagtggg agtcctgata acccaggcct
3121 gtctgactac tttgccttct tttgtagcat ataggtgatg tttgctcttg tttttattaa
3181 tttatatgta tattttttta atttaacatg aacaccctta gaaaatgtgt cctatctatc
3241 ttccaaatgc aatttgattg actgcccatt caccaaaatt atcctgaact cttctgcaaa
3301 aatggatatt attagaaatt agaaaaaaat tactaatttt acacattaga ttttatttta
3361 ctattggaat ctgatatact gtgtgcttgt tttataaaat tttgctttta attaaataaa
3421 agctggaagc aaagtataac catatgatac tatcatacta ctgaaacaga tttcatacct
3481 cagaatgtaa aagaacttac tgattatttt cttcatccaa cttatgtttt taaatgagga
3541 ttattgatag tactcttggt ttttatacca ttcagatcac tgaatttata aagtacccat
3601 ctagtacttg aaaaagtaaa gtgttctgcc agatcttagg tatagaggac cctaacacag
3661 tatatcccaa gtgcactttc taatgtttct gggtcctgaa gaattaagat acaaattaat
3721 tttactccat aaacagactg ttaattatag gagccttaat ttttttttca tagagatttg
3781 tctaattgca tctcaaaatt attctgccct ccttaatttg ggaaggtttg tgttttctct
3841 ggaatggtac atgtcttcca tgtatctttt gaactggcaa ttgtctattt atcttttatt
3901 tttttaagtc agtatggtct aacactggca tgttcaaagc cacattattt ctagtccaaa
3961 attacaagta atcaagggtc attatgggtt aggcattaat gtttctatct gattttgtgc
4021 aaaagcttca aattaaaaca gctgcattag aaaaagaggc gcttctcccc tcccctacac
4081 ctaaaggtgt atttaaacta tcttgtgtga ttaacttatt tagagatgct gtaacttaaa
4141 ataggggata tttaaggtag cttcagctag cttttaggaa aatcactttg tctaactcag
4201 aattattttt aaaaagaaat ctggtcttgt tagaaaacaa aattttattt tgtgctcatt
4261 taagtttcaa acttactatt ttgacagtta ttttgataac aatgacacta gaaaacttga
4321 ctccatttca tcattgtttc tgcatgaata tcatacaaat cagttagttt ttaggtcaag
4381 ggcttactat ttctgggtct tttgctacta agttcacatt agaattagtg ccagaatttt
4441 aggaacttca gagatcgtgt attgagattt cttaaataat gcttcagata ttattgcttt
4501 attgcttttt tgtattggtt aaaactgtac atttaaaatt gctatgttac tattttctac
4561 aattaatagt ttgtctattt taaaataaat tagttgttag
//