GenBank-Updates@genbank.bio.net (05/08/91)
LOCUS HUMROSA 7375 bp ss-mRNA PRI 08-MAY-1991
DEFINITION Human transmembrane tyrosine-specific protein kinase (ROS1) mRNA,
complete cds.
ACCESSION M34353
KEYWORDS c-myc oncogene; transmembrane tyrosine-specific protein kinase.
SOURCE Human glioblastoma cell line SW-1088, cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 7375)
AUTHORS Wigler,M., Riggs,M., O'Neil,K. and Birchmeier,C.
TITLE Characterization of ROS1 cDNA from a human glioblastoma cell line
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87, 4799-4803 (1990)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence for [Proc. Natl. Acad.
Sci. U.S.A. 87, 4799-4803 (1990)] kindly submitted
by M.H.Wigler, 15-MAY-1990.
FEATURES Location/Qualifiers
CDS 207..7250
/note="transmembrane tyrosine-specific protein kinase
precursor /hgml_locus_uid='LN0124W' /nomgen='ROS1'
/map='6q21-q22'"
/codon_start=207
sig_peptide 207..314
/note="transmembrane tyrosine-specific protein kinase
signal peptide"
/codon_start=207
mat_peptide 208..7247
/note="transmembrane tyrosine-specific protein kinase"
/codon_start=208
BASE COUNT 2203 a 1496 c 1605 g 2071 t
ORIGIN
1 ccgcattcaa gctttcaagc attcaaaggt ctaaatgaaa aaggctaagt attatttcaa
61 aaggcaagta tatcctaata tagcaaaaca aacaaagcaa aatccatcag ctactcctcc
121 aattgaagtg atgaagccca aataattcat atagcaaaat ggagaaaatt agaccggcca
181 tctaaaaatc tgccattggt gaagtgatga agaacattta ctgtcttatt ccgaagcttg
241 tcaattttgc aactcttggc tgcctatgga tttctgtggt gcagtgtaca gttttaaata
301 gctgcctaaa gtcgtgtgta actaatctgg gccagcagct tgaccttggc acaccacata
361 atctgagtga accgtgtatc caaggatgtc acttttggaa ctctgtagat cagaaaaact
421 gtgctttaaa gtgtcgggag tcgtgtgagg ttggctgtag cagcgcggaa ggtgcatatg
481 aagaggaagt actggaaaat gcagacctac caactgctcc ctttgcttct tccattggaa
541 gccacaatat gacattacga tggaaatctg caaacttctc tggagtaaaa tacatcattc
601 agtggaaata tgcacaactt ctgggaagct ggacttatac taagactgtg tccagaccgt
661 cctatgtggt caagcccctg caccccttca ctgagtacat tttccgagtg gtttggatct
721 tcacagcgca gctgcagctc tactcccctc caagtcccag ttacaggact catcctcatg
781 gagttcctga aactgcacct ttgattagga atattgagag ctcaagtccc gacactgtgg
841 aagtcagctg ggatccacct caattcccag gtggacctat tttgggttat aacttaaggc
901 tgatcagcaa aaatcaaaaa ttagatgcag ggacacagag aaccagtttc cagttttact
961 ccactttacc aaatactatc tacaggtttt ctattgcagc agtaaatgaa gttggtgagg
1021 gtccagaagc agaatctagt attaccactt catcttcagc agttcaacaa gaggaacagt
1081 ggctcttttt atccagaaaa acttctctaa gaaagagatc tttaaaacat ttagtagatg
1141 aagcacattg ccttcggttg gatgctatat accataatat tacaggaata tctgttgatg
1201 tccaccagca aattgtttat ttctctgaag gaactctcat atgggcgaag aaggctgcca
1261 acatgtctga tgtatctgac ctgagaattt tttacagagg ttcaggatta atttcttcta
1321 tctccataga ttggctttat caaagaatgt atttcatcat ggatgaactg gtatgtgtct
1381 gtgatttaga gaactgctca aacatcgagg aaattactcc accctctatt agtgcacctc
1441 aaaaaattgt ggctgattca tacaatgggt atgtctttta cctcctgaga gatggcattt
1501 atagagcaga ccttcctgta ccatctggcc ggtgtgcaga agctgtgcgt attgtggaga
1561 gttgcacgtt aaaggacttt gcaatcaagc cacaagccaa gcgaatcatt tacttcaatg
1621 acactgccca agtcttcatg tcaacatttc tggatggctc tgcttcccat ctcatcctac
1681 ctcgcatccc ctttgctgat gtgaaaagtt ttgcttgtga aaacaatgac tttcttgtca
1741 cagatggcaa ggtcattttc caacaggatg ctttgtcttt taatgaattc atcgtgggat
1801 gtgacctgag tcacatagaa gaatttgggt ttggtaactt ggtcatcttt ggctcatcct
1861 cccagctgca ccctctgcca ggccgcccgc aggagctttc ggtgctgttt ggctctcacc
1921 aggctcttgt tcaatggaag cctcctgccc ttgccatagg agccaatgtc atcctgatca
1981 gtgatattat tgaactcttt gaattaggcc cttctgcctg gcagaactgg acctatgagg
2041 tgaaagtatc cacccaagac cctcctgaag tcactcatat tttcttgaac ataagtggaa
2101 ccatgctgaa tgtacctgag ctgcagagtg ctatgaaata caaggtttct gtgagagcaa
2161 gttctccaaa gaggccaggc ccctggtcag agccctcagt gggtactacc ctggtgccag
2221 ctagtgaacc accatttatc atggctgtga aagaagatgg gctttggagt aaaccattaa
2281 atagctttgg cccaggagag ttcttatcct ctgatatagg aaatgtgtca gacatggatt
2341 ggtataacaa cagcctctac tacagtgaca cgaaaggcga cgtttttgtg tggctgctga
2401 atgggacgga tatctcagag aattatcacc tacccagcat tgcaggagca ggggctttag
2461 cttttgagtg gctgggtcac tttctctact gggctggaaa gacatatgtg atacaaaggc
2521 agtctgtgtt gacgggacac acagacattg ttacccacgt gaagctattg gtgaatgaca
2581 tggtggtgga ttcagttggt ggatatctct actggaccac actctattca gtggaaagca
2641 ccagactaaa tggggaaagt tcccttgtac tacagacaca gccttggttt tctgggaaaa
2701 aggtaattgc tctaacttta gacctcagtg atgggctcct gtattggttg gttcaagaca
2761 gtcaatgtat tcacctgtac acagctgttc ttcggggaca gagcactggg gataccacca
2821 tcacagaatt tgcagcctgg agtacttctg aaatttccca gaatgcactg atgtactata
2881 gtggtcggct gttctggatc aatggcttta ggattatcac aactcaagaa ataggtcaga
2941 aaaccagtgt ctctgttttg gaaccagcca gatttaatca gttcacaatt attcagacat
3001 cccttaagcc cctgccaggg aacttttcct ttacccctaa ggttattcca gattctgttc
3061 aagagtcttc atttaggatt gaaggaaatg cttcaagttt tcaaatcctg tggaatggtc
3121 cccctgcggt agactggggt gtagttttct acagtgtaga atttagtgct cattctaagt
3181 tcttggctag tgaacaacac tctttacctg tatttactgt ggaaggactg gaaccttatg
3241 ccttatttaa tctttctgtc actccttata cctactgggg aaagggcccc aaaacatctc
3301 tgtcacttcg agcacctgaa acagttccat cagcaccaga gaaccccaga atatttatat
3361 taccaagtgg aaaatgctgc aacaagaatg aagttgtggt ggaatttagg tggaacaaac
3421 ctaagcatga aaatggggtg ttaacaaaat ttgaaatttt ctacaatata tccaatcaaa
3481 gtattacaaa caaaacatgt gaagactgga ttgctgtcaa tgtcactccc tcagtgatgt
3541 cttttcaact tgaaggcatg agtcccagat gctttattgc cttccaggtt agggccttta
3601 catctaaggg gccaggacca tatgctgacg ttgtaaagtc tacaacatca gaaatcaacc
3661 catttcctca cctcataact cttcttggta acaagatagt ttttttagat atggatcaaa
3721 atcaagttgt gtggacgttt tcagcagaaa gagttatcag tgccgtttgc tacacagctg
3781 ataatgagat gggatattat gctgaagggg actcactctt tcttctgcac ttgcacaatc
3841 gctctagctc tgagcttttc caagattcac tggtttttga tatcacagtt attacaattg
3901 actggatttc aaggcacctc tactttgcac tgaaagaatc acaaaatgga atgcaagtat
3961 ttgatgttga tcttgaacac aaggtgaaat atcccagaga ggtgaagatt cacaatagga
4021 attcaacaat aatttctttt tctgtatatc ctcttttaag tcgcttgtat tggacagaag
4081 tttccaattt tggctaccag atgttctact acagtattat cagtcacacc ttgcaccgaa
4141 ttctgcaacc cacagctaca aaccaacaaa acaaaaggaa tcaatgttct tgtaatgtga
4201 ctgaatttga gttaagtgga gcaatggcta ttgatacctc taacctagag aaaccattga
4261 tatactttgc caaagcacaa gagatctggg caatggatct ggaaggctgt cagtgttgga
4321 gagttatcac agtacctgct atgctcgcag gaaaaaccct tgttagctta actgtggatg
4381 gagatcttat atactggatc atcacagcaa aggacagcac acagatttat caggcaaaga
4441 aaggaaatgg ggccatcgtt tcccaggtga aggccctaag gagtaggcat atcttggctt
4501 acagttcagt tatgcagcct tttccagata aagcgtttct gtctctagct tcagacactg
4561 tggaaccaac tatacttaat gccactaaca ctagcctcac aatcagatta cctctggcca
4621 agacaaacct cacatggtat ggcatcacca gccctactcc aacatacctg gtttattatg
4681 cagaagttaa tgacaggaaa aacagctctg acttgaaata tagaattctg gaatttcagg
4741 acagtatagc tcttattgaa gatttacaac cattttcaac atacatgata cagatagctg
4801 taaaaaatta ttattcagat cctttggaac atttaccacc aggaaaagag atttggggaa
4861 aaactaaaaa tggagtacca gaggcagtgc agctcattaa tacaactgtg cggtcagaca
4921 ccagcctcat tatatcttgg agagaatctc acaagccaaa tggacctaaa gaatcagtcc
4981 gttatcagtt ggcaatctca cacctggccc taattcctga aactcctcta agacaaagtg
5041 aatttccaaa tggaaggctc actctccttg ttactagact gtctggtgga aatatttatg
5101 tgttaaaggt tcttgcctgc cactctgagg aaatgtggtg tacagagagt catcctgtca
5161 ctgtggaaat gtttaacaca ccagagaaac cttattcctt ggttccagag aacactagtt
5221 tgcaatttaa ttggaaggct ccattgaatg ttaacctcat cagattttgg gttgagctac
5281 agaagtggaa atacaatgag ttttaccatg ttaaaacttc atgcagccaa ggtcctgctt
5341 atgtctgtaa tatcacaaat ctacaacctt atacttcata taatgtcaga gtagtggtgg
5401 tttataagac gggagaaaat agcacctcac ttccagaaag ctttaagaca aaagctggag
5461 tcccaaataa accaggcatt cccaaattac tagaagggag taaaaattca atacagtggg
5521 agaaagctga agataatgga tgtagaatta catactatat ccttgagata agaaagagca
5581 cttcaaataa tttacagaac cagaatttaa ggtggaagat gacatttaat ggatcctgca
5641 gtagtgtttg cacatggaag tccaaaaacc tgaaaggaat atttcagttc agagtagtag
5701 ctgcaaataa tctagggttt ggtgaatata gtggaatcag tgagaatatt atattagttg
5761 gagatgattt ttggatacca gaaacaagtt tcatacttac tattatagtt ggaatatttc
5821 tggttgttac aatcccactg acctttgtct ggcatagaag attaaagaat caaaaaagtg
5881 ccaaggaagg ggtgacagtg cttataaacg aagacaaaga gttggctgag ctgcgaggtc
5941 tggcagccgg agtaggcctg gctaatgcct gctatgcaat acatactctt ccaacccaag
6001 aggagattga aaatcttcct gccttccctc gggaaaaact gactctgcgt ctcttgctgg
6061 gaagtggagc ctttggagaa gtgtatgaag gaacagcagt ggacatctta ggagttggaa
6121 gtggagaaat caaagtagca gtgaagactt tgaagaaggg ttccacagac caggagaaga
6181 ttgaattcct gaaggaggca catctgatga gcaaatttaa tcatcccaac attctgaagc
6241 agcttggagt ttgtctgctg aatgaacccc aatacattat cctggaactg atggagggag
6301 gagaccttct tacttatttg cgtaaagccc ggatggcaac gttttatggt cctttactca
6361 ccttggttga ccttgtagac ctgtgtgtag atatttcaaa aggctgtgtc tacttggaac
6421 ggatgcattt cattcacagg gatctggcag ctcgaaattg ccttgtttcc gtgaaagact
6481 ataccagtcc acggatagtg aagattggag actttggact cgccagagac atctataaaa
6541 atgattacta tagaaagaga ggggaaggcc tgctcccagt tcggtggatg gctccagaaa
6601 gtttgatgga tggaatcttc actactcaat ctgatgtatg gtcttttgga attctgattt
6661 gggagatttt aactcttggt catcagcctt atccagctca ttccaacctt gatgtgttaa
6721 actatgtgca aacaggaggg agactggagc caccaagaaa ttgtcctgat gatctgtgga
6781 atttaatgac ccagtgctgg gctcaagaac ccgaccaaag acctactttt catagaattc
6841 agaaccaact tcagttattc agaaattttt tcttaaatag catttatcag tgcagagatg
6901 aagcaaacaa cagtggagtc ataaatgaaa gctttgaagg tgaagatggc gatgtgattt
6961 gtttgaattc agatgacatt atgccagttg ttttaatgga aacgaagaac cgagaagggt
7021 taaactatat ggtacttgct acagaatgtg gccaaggtga agaaaagtct gagggtcctc
7081 taggctccca ggaatctgaa tcttgtggtc tgaggaaaga agagaaggaa ccacatgcag
7141 acaaagattt ctgccaagaa aaacaagtgg cttactgccc ttctggcaag cctgaaggcc
7201 tgaactatgc ctgtctcact cacagtggat atggagatgg gtctgattaa tagcgttgtt
7261 tgggaaatag agagttgaga taaacactct cattcagtag ttactgaaag aaaactctgc
7321 tagaatgata aatgtcatgg tggtctataa ctccaaataa acaatgcaac gttcc
//