GenBank-Updates@genbank.bio.net (05/08/91)
LOCUS HUMROSA 7375 bp ss-mRNA PRI 08-MAY-1991 DEFINITION Human transmembrane tyrosine-specific protein kinase (ROS1) mRNA, complete cds. ACCESSION M34353 KEYWORDS c-myc oncogene; transmembrane tyrosine-specific protein kinase. SOURCE Human glioblastoma cell line SW-1088, cDNA to mRNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 7375) AUTHORS Wigler,M., Riggs,M., O'Neil,K. and Birchmeier,C. TITLE Characterization of ROS1 cDNA from a human glioblastoma cell line JOURNAL Proc. Natl. Acad. Sci. U.S.A. 87, 4799-4803 (1990) STANDARD full staff_review COMMENT Draft entry and computer-readable sequence for [Proc. Natl. Acad. Sci. U.S.A. 87, 4799-4803 (1990)] kindly submitted by M.H.Wigler, 15-MAY-1990. FEATURES Location/Qualifiers CDS 207..7250 /note="transmembrane tyrosine-specific protein kinase precursor /hgml_locus_uid='LN0124W' /nomgen='ROS1' /map='6q21-q22'" /codon_start=207 sig_peptide 207..314 /note="transmembrane tyrosine-specific protein kinase signal peptide" /codon_start=207 mat_peptide 208..7247 /note="transmembrane tyrosine-specific protein kinase" /codon_start=208 BASE COUNT 2203 a 1496 c 1605 g 2071 t ORIGIN 1 ccgcattcaa gctttcaagc attcaaaggt ctaaatgaaa aaggctaagt attatttcaa 61 aaggcaagta tatcctaata tagcaaaaca aacaaagcaa aatccatcag ctactcctcc 121 aattgaagtg atgaagccca aataattcat atagcaaaat ggagaaaatt agaccggcca 181 tctaaaaatc tgccattggt gaagtgatga agaacattta ctgtcttatt ccgaagcttg 241 tcaattttgc aactcttggc tgcctatgga tttctgtggt gcagtgtaca gttttaaata 301 gctgcctaaa gtcgtgtgta actaatctgg gccagcagct tgaccttggc acaccacata 361 atctgagtga accgtgtatc caaggatgtc acttttggaa ctctgtagat cagaaaaact 421 gtgctttaaa gtgtcgggag tcgtgtgagg ttggctgtag cagcgcggaa ggtgcatatg 481 aagaggaagt actggaaaat gcagacctac caactgctcc ctttgcttct tccattggaa 541 gccacaatat gacattacga tggaaatctg caaacttctc tggagtaaaa tacatcattc 601 agtggaaata tgcacaactt ctgggaagct ggacttatac taagactgtg tccagaccgt 661 cctatgtggt caagcccctg caccccttca ctgagtacat tttccgagtg gtttggatct 721 tcacagcgca gctgcagctc tactcccctc caagtcccag ttacaggact catcctcatg 781 gagttcctga aactgcacct ttgattagga atattgagag ctcaagtccc gacactgtgg 841 aagtcagctg ggatccacct caattcccag gtggacctat tttgggttat aacttaaggc 901 tgatcagcaa aaatcaaaaa ttagatgcag ggacacagag aaccagtttc cagttttact 961 ccactttacc aaatactatc tacaggtttt ctattgcagc agtaaatgaa gttggtgagg 1021 gtccagaagc agaatctagt attaccactt catcttcagc agttcaacaa gaggaacagt 1081 ggctcttttt atccagaaaa acttctctaa gaaagagatc tttaaaacat ttagtagatg 1141 aagcacattg ccttcggttg gatgctatat accataatat tacaggaata tctgttgatg 1201 tccaccagca aattgtttat ttctctgaag gaactctcat atgggcgaag aaggctgcca 1261 acatgtctga tgtatctgac ctgagaattt tttacagagg ttcaggatta atttcttcta 1321 tctccataga ttggctttat caaagaatgt atttcatcat ggatgaactg gtatgtgtct 1381 gtgatttaga gaactgctca aacatcgagg aaattactcc accctctatt agtgcacctc 1441 aaaaaattgt ggctgattca tacaatgggt atgtctttta cctcctgaga gatggcattt 1501 atagagcaga ccttcctgta ccatctggcc ggtgtgcaga agctgtgcgt attgtggaga 1561 gttgcacgtt aaaggacttt gcaatcaagc cacaagccaa gcgaatcatt tacttcaatg 1621 acactgccca agtcttcatg tcaacatttc tggatggctc tgcttcccat ctcatcctac 1681 ctcgcatccc ctttgctgat gtgaaaagtt ttgcttgtga aaacaatgac tttcttgtca 1741 cagatggcaa ggtcattttc caacaggatg ctttgtcttt taatgaattc atcgtgggat 1801 gtgacctgag tcacatagaa gaatttgggt ttggtaactt ggtcatcttt ggctcatcct 1861 cccagctgca ccctctgcca ggccgcccgc aggagctttc ggtgctgttt ggctctcacc 1921 aggctcttgt tcaatggaag cctcctgccc ttgccatagg agccaatgtc atcctgatca 1981 gtgatattat tgaactcttt gaattaggcc cttctgcctg gcagaactgg acctatgagg 2041 tgaaagtatc cacccaagac cctcctgaag tcactcatat tttcttgaac ataagtggaa 2101 ccatgctgaa tgtacctgag ctgcagagtg ctatgaaata caaggtttct gtgagagcaa 2161 gttctccaaa gaggccaggc ccctggtcag agccctcagt gggtactacc ctggtgccag 2221 ctagtgaacc accatttatc atggctgtga aagaagatgg gctttggagt aaaccattaa 2281 atagctttgg cccaggagag ttcttatcct ctgatatagg aaatgtgtca gacatggatt 2341 ggtataacaa cagcctctac tacagtgaca cgaaaggcga cgtttttgtg tggctgctga 2401 atgggacgga tatctcagag aattatcacc tacccagcat tgcaggagca ggggctttag 2461 cttttgagtg gctgggtcac tttctctact gggctggaaa gacatatgtg atacaaaggc 2521 agtctgtgtt gacgggacac acagacattg ttacccacgt gaagctattg gtgaatgaca 2581 tggtggtgga ttcagttggt ggatatctct actggaccac actctattca gtggaaagca 2641 ccagactaaa tggggaaagt tcccttgtac tacagacaca gccttggttt tctgggaaaa 2701 aggtaattgc tctaacttta gacctcagtg atgggctcct gtattggttg gttcaagaca 2761 gtcaatgtat tcacctgtac acagctgttc ttcggggaca gagcactggg gataccacca 2821 tcacagaatt tgcagcctgg agtacttctg aaatttccca gaatgcactg atgtactata 2881 gtggtcggct gttctggatc aatggcttta ggattatcac aactcaagaa ataggtcaga 2941 aaaccagtgt ctctgttttg gaaccagcca gatttaatca gttcacaatt attcagacat 3001 cccttaagcc cctgccaggg aacttttcct ttacccctaa ggttattcca gattctgttc 3061 aagagtcttc atttaggatt gaaggaaatg cttcaagttt tcaaatcctg tggaatggtc 3121 cccctgcggt agactggggt gtagttttct acagtgtaga atttagtgct cattctaagt 3181 tcttggctag tgaacaacac tctttacctg tatttactgt ggaaggactg gaaccttatg 3241 ccttatttaa tctttctgtc actccttata cctactgggg aaagggcccc aaaacatctc 3301 tgtcacttcg agcacctgaa acagttccat cagcaccaga gaaccccaga atatttatat 3361 taccaagtgg aaaatgctgc aacaagaatg aagttgtggt ggaatttagg tggaacaaac 3421 ctaagcatga aaatggggtg ttaacaaaat ttgaaatttt ctacaatata tccaatcaaa 3481 gtattacaaa caaaacatgt gaagactgga ttgctgtcaa tgtcactccc tcagtgatgt 3541 cttttcaact tgaaggcatg agtcccagat gctttattgc cttccaggtt agggccttta 3601 catctaaggg gccaggacca tatgctgacg ttgtaaagtc tacaacatca gaaatcaacc 3661 catttcctca cctcataact cttcttggta acaagatagt ttttttagat atggatcaaa 3721 atcaagttgt gtggacgttt tcagcagaaa gagttatcag tgccgtttgc tacacagctg 3781 ataatgagat gggatattat gctgaagggg actcactctt tcttctgcac ttgcacaatc 3841 gctctagctc tgagcttttc caagattcac tggtttttga tatcacagtt attacaattg 3901 actggatttc aaggcacctc tactttgcac tgaaagaatc acaaaatgga atgcaagtat 3961 ttgatgttga tcttgaacac aaggtgaaat atcccagaga ggtgaagatt cacaatagga 4021 attcaacaat aatttctttt tctgtatatc ctcttttaag tcgcttgtat tggacagaag 4081 tttccaattt tggctaccag atgttctact acagtattat cagtcacacc ttgcaccgaa 4141 ttctgcaacc cacagctaca aaccaacaaa acaaaaggaa tcaatgttct tgtaatgtga 4201 ctgaatttga gttaagtgga gcaatggcta ttgatacctc taacctagag aaaccattga 4261 tatactttgc caaagcacaa gagatctggg caatggatct ggaaggctgt cagtgttgga 4321 gagttatcac agtacctgct atgctcgcag gaaaaaccct tgttagctta actgtggatg 4381 gagatcttat atactggatc atcacagcaa aggacagcac acagatttat caggcaaaga 4441 aaggaaatgg ggccatcgtt tcccaggtga aggccctaag gagtaggcat atcttggctt 4501 acagttcagt tatgcagcct tttccagata aagcgtttct gtctctagct tcagacactg 4561 tggaaccaac tatacttaat gccactaaca ctagcctcac aatcagatta cctctggcca 4621 agacaaacct cacatggtat ggcatcacca gccctactcc aacatacctg gtttattatg 4681 cagaagttaa tgacaggaaa aacagctctg acttgaaata tagaattctg gaatttcagg 4741 acagtatagc tcttattgaa gatttacaac cattttcaac atacatgata cagatagctg 4801 taaaaaatta ttattcagat cctttggaac atttaccacc aggaaaagag atttggggaa 4861 aaactaaaaa tggagtacca gaggcagtgc agctcattaa tacaactgtg cggtcagaca 4921 ccagcctcat tatatcttgg agagaatctc acaagccaaa tggacctaaa gaatcagtcc 4981 gttatcagtt ggcaatctca cacctggccc taattcctga aactcctcta agacaaagtg 5041 aatttccaaa tggaaggctc actctccttg ttactagact gtctggtgga aatatttatg 5101 tgttaaaggt tcttgcctgc cactctgagg aaatgtggtg tacagagagt catcctgtca 5161 ctgtggaaat gtttaacaca ccagagaaac cttattcctt ggttccagag aacactagtt 5221 tgcaatttaa ttggaaggct ccattgaatg ttaacctcat cagattttgg gttgagctac 5281 agaagtggaa atacaatgag ttttaccatg ttaaaacttc atgcagccaa ggtcctgctt 5341 atgtctgtaa tatcacaaat ctacaacctt atacttcata taatgtcaga gtagtggtgg 5401 tttataagac gggagaaaat agcacctcac ttccagaaag ctttaagaca aaagctggag 5461 tcccaaataa accaggcatt cccaaattac tagaagggag taaaaattca atacagtggg 5521 agaaagctga agataatgga tgtagaatta catactatat ccttgagata agaaagagca 5581 cttcaaataa tttacagaac cagaatttaa ggtggaagat gacatttaat ggatcctgca 5641 gtagtgtttg cacatggaag tccaaaaacc tgaaaggaat atttcagttc agagtagtag 5701 ctgcaaataa tctagggttt ggtgaatata gtggaatcag tgagaatatt atattagttg 5761 gagatgattt ttggatacca gaaacaagtt tcatacttac tattatagtt ggaatatttc 5821 tggttgttac aatcccactg acctttgtct ggcatagaag attaaagaat caaaaaagtg 5881 ccaaggaagg ggtgacagtg cttataaacg aagacaaaga gttggctgag ctgcgaggtc 5941 tggcagccgg agtaggcctg gctaatgcct gctatgcaat acatactctt ccaacccaag 6001 aggagattga aaatcttcct gccttccctc gggaaaaact gactctgcgt ctcttgctgg 6061 gaagtggagc ctttggagaa gtgtatgaag gaacagcagt ggacatctta ggagttggaa 6121 gtggagaaat caaagtagca gtgaagactt tgaagaaggg ttccacagac caggagaaga 6181 ttgaattcct gaaggaggca catctgatga gcaaatttaa tcatcccaac attctgaagc 6241 agcttggagt ttgtctgctg aatgaacccc aatacattat cctggaactg atggagggag 6301 gagaccttct tacttatttg cgtaaagccc ggatggcaac gttttatggt cctttactca 6361 ccttggttga ccttgtagac ctgtgtgtag atatttcaaa aggctgtgtc tacttggaac 6421 ggatgcattt cattcacagg gatctggcag ctcgaaattg ccttgtttcc gtgaaagact 6481 ataccagtcc acggatagtg aagattggag actttggact cgccagagac atctataaaa 6541 atgattacta tagaaagaga ggggaaggcc tgctcccagt tcggtggatg gctccagaaa 6601 gtttgatgga tggaatcttc actactcaat ctgatgtatg gtcttttgga attctgattt 6661 gggagatttt aactcttggt catcagcctt atccagctca ttccaacctt gatgtgttaa 6721 actatgtgca aacaggaggg agactggagc caccaagaaa ttgtcctgat gatctgtgga 6781 atttaatgac ccagtgctgg gctcaagaac ccgaccaaag acctactttt catagaattc 6841 agaaccaact tcagttattc agaaattttt tcttaaatag catttatcag tgcagagatg 6901 aagcaaacaa cagtggagtc ataaatgaaa gctttgaagg tgaagatggc gatgtgattt 6961 gtttgaattc agatgacatt atgccagttg ttttaatgga aacgaagaac cgagaagggt 7021 taaactatat ggtacttgct acagaatgtg gccaaggtga agaaaagtct gagggtcctc 7081 taggctccca ggaatctgaa tcttgtggtc tgaggaaaga agagaaggaa ccacatgcag 7141 acaaagattt ctgccaagaa aaacaagtgg cttactgccc ttctggcaag cctgaaggcc 7201 tgaactatgc ctgtctcact cacagtggat atggagatgg gtctgattaa tagcgttgtt 7261 tgggaaatag agagttgaga taaacactct cattcagtag ttactgaaag aaaactctgc 7321 tagaatgata aatgtcatgg tggtctataa ctccaaataa acaatgcaac gttcc //