GenBank-Updates@genbank.bio.net (05/08/91)
LOCUS HS4NA3ABC 10089 bp ds-DNA VRL 08-MAY-1991
DEFINITION Epstein-Barr virus nuclear antigen EBNA-3A, EBNA-3B, and EBNA-3C
genes, complete cds.
ACCESSION M34440
KEYWORDS nuclear antigen.
SOURCE Epstein-Barr virus type 2 (isolate AG876) DNA.
ORGANISM Epstein-Barr virus
Viridae; ds-DNA enveloped viruses; Herpesviridae;
Gammaherpesviridae.
REFERENCE 1 (bases 1 to 10089)
AUTHORS Sample,J., Young,L., Martin,B., Chatman,T., Kieff,E., Rickinson,A.
and Kieff,E.
TITLE Epstein-barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B
and EBNA-3C genes
JOURNAL J. Virol. 64, 4084-4092 (1990)
STANDARD full staff_entry
COMMENT Draft entry and computer-readable sequence for [Unpublished (1990)]
kindly submitted
by J.T.Sample, 23-MAY-1990.
Kieff Laboratory
Harvard Medical School
75 Francis Street
Boston, MA 02115
FEATURES Location/Qualifiers
CDS join(189..524,610..3051)
/note="nuclear antigen EBNA-3A"
/codon_start=189
CDS join(3237..3593,3672..6155)
/note="nuclear antigen EBNA-3B"
/codon_start=3237
CDS join(6277..6636,6711..9560)
/note="nuclear antigen EBNA-3C"
/codon_start=6277
exon 189..524
/note="nuclear antigen EBNA-3A, exon 1"
intron 525..609
/note="EBNA-3A intron"
exon 610..3051
/note="nuclear antigen EBNA-3A, exon 2"
exon 3237..3593
/note="nuclear antigen EBNA-3B, exon 1"
intron 3594..3671
/note="EBNA-3B intron"
exon 3672..6155
/note="nuclear antigen EBNA-3B, exon 2"
exon 6277..6636
/note="nuclear antigen EBNA-3C, exon 1"
intron 6637..6710
/note="EBNA-3C intron"
exon 6711..9560
/note="nuclear antigen EBNA-3C, exon 2"
BASE COUNT 2495 a 2837 c 2619 g 2138 t
ORIGIN
1 gaattccaga atctcaacat tgaaaaaacc aggatcatca cgcgtgagtt ggataaggct
61 ctggatggtg tactgacaca caagcaaggc tgcctccatt gtctcagcac cgatttctag
121 gcagcaccct ctttaatagg tgcaaggggg gtgcggtgtt ggtgagtcac actttcgttg
181 cagacaaaat ggacaaggac aggccgggtc tcccggcccc ggatgacaac atagaagaag
241 taccatctac ctcgggtgtt caggaacggg cgtctgaggg agattgggaa aatgtcctca
301 tagagatatc agatagcagc tcagaagagg aagcagaaga tgcccacctg gagccatccc
361 agaggggtaa aaagagaaaa cgggtcgatg atgatgccgg tggttcagct ccagcacaac
421 acgtgccccc ccctcagctg gatcaccctg gtcgagaagc cattctctac aggtttccgc
481 tagatttaag aaggtttatt caagcaattg gagccgcagc tacggtgagc ttccctatgg
541 cccaggtgtg tgatgtgtgt ttttgcccat cgcacaacaa ggtaagtgat ttgttgccgt
601 tggtttcagc accccgacac gcgagccata gaccagtttt tcggatccca gatttcaaat
661 accgacctgt acgtaatgta tgccatggcc attcgacagg ccattagaga tcgtcggagg
721 aatccagctt ctcgtagaag tcaggtcaaa tggagaatga ccaccctggc cgctggttgg
781 cctatgggtt accaggcata cagtagctgg atgtacagct acaccgatcc ccaggtgact
841 gccacgatca tacatctgca ggcgactctt gggtgcgcaa gtggccgtag gtgtcatgtg
901 accttttctg ccggcacctt taggccgccg cgatgtagtc ccggggatcg ccagtggttg
961 tatgttcaga gccgcgtggg tgaccttgtg cagagttcta atccatgcta cagtattttc
1021 tttgactaca tggccataca taggagcctc acgaaaatct gggatgaagt ggtaacacct
1081 gatcagcgtg ttacatttat ggaattcctg ggctttttgc aacgcacgga gttggtctac
1141 atcaagagct ttgtcagcta tgccttgggc accactagta tcgaaacacc gtggatggat
1201 gagaatccta gcacagagac ggcacaggct tggaatgccg gcttgctccg ggggcgtgcg
1261 tacgggcaag acttgcttag aactgaagga gaacatggcg aaggtgctac ctgtgaaaca
1321 cgggaagaaa gtgaggacac agagagcgat ggggatgatg aagaacttcc tcgtgtagtg
1381 tccagggatg gaactaagca cagacgaccc cctatatttt taagacgcct gcacaggttg
1441 ctgttgatga gagcgggcaa aggaaaggaa cgggccaggg agacactggc gaaggcccct
1501 aggcgcactt atggcacacc taggccgcca gttcagaaac caagaccaga ggtcccgcaa
1561 agctatgaga cagctaccag tcacgggtcg gcgcaagtcc cagaaccccc acccacccac
1621 ccattacatc agcaacacag catggccccg tgtatggtag ctcagaaccc acgtgcaccc
1681 ttaggggacc aactcccagg tgttcctaaa gatggacgag gggcgtgtgc accggtaccc
1741 gccctggccg ggcctattgt ccggccctgg gagtcatccc tgttacagtc tccgggaagg
1801 gcctttgcac ccgttagccc acaacccatg ccagtagaac ccgtccctgt ccctactgtg
1861 gcacttgagc gaccagtttg tcccgcacct cctgagattg ctatgcaggg cccgggggaa
1921 ccttctggca ttaaacgcac acgggagcgt tggaggcccg caccgtggac gccaaaccca
1981 ccccgctctc ccagtcagat gtccgtgcgt gaccgtctgg ctcgtttgcg tgctgaggca
2041 caggcccgtc aggctagtgt tgaggtgcag cccacccagt tgacccaagt atcccctcag
2101 caaccaatgg agaggccgtt ggaaccagag cagcagatgt tccctggttc cccctttagc
2161 caggtcgctg atgttgcccg ggaatctggg gtacctgcaa tgcagcctca gtactttgac
2221 ctccccttaa ctcaacccat tagccagggg gcacccgcgg ccccgttgag ggctagtatg
2281 ggcccggtac ctccggtacc ggcaacacag ccacagtatt ttgacatccc cttaactgaa
2341 cccattaacc agggggcatc cgcggcccat tttctccctc agcaaccaat ggaggggccg
2401 ttggtacccg agcggtggat gttccaaggt gccaccctga gccagagtgt taggccaggg
2461 gtagcgcagt cacaatattt tgacctcccc ttaactcaac ccattaacca tggggcaccc
2521 gcagcccatt tcctccatca gccaccaatg gaggggccgt gggtacccga gcagtggatg
2581 ttccaaggtg ccccccctag ccaaggcact gacgtggtcc aacatcagct ggatgatttg
2641 gggtatccac tccatgatct caaccatccc ggggttcccg tgtctcctgc cgttaaccaa
2701 tatcatttca gccaggctgc ctttgggtta cctattgatg aggatgagag tggcgagagg
2761 tccgatacct ccgagccgta tgaagctctt gatttgtcaa tccatggcag gccctgccct
2821 caggcccccg aatggcctgt tcaaggggag ggtggccagg atgccaccga ggttcttgat
2881 ttgtcaatcc atggcaggcc ccgccctcgg acccccgagt ggcctgttca aggggagagt
2941 ggccagaatg tcacagacca tgaacctaga agggtggtgg tgtcagctat tgttcacatg
3001 tgtcaggatg acgagtttcc ggatctacaa gatcctccag atgaggccta agcaaaggtg
3061 tagaagtgtg tccccctcca ttccacccac tgatatacgc ccgacaataa agttgatgat
3121 attgaattcc acacctactc gtgtttgtga ttttatttca tattccatga gagagacctc
3181 gcatatttgc agagggtcac tgaaacattt tatcttaaaa cagttacacc tgaaaaatga
3241 agaaagcgtg gctcagcaga gcacagcaag ccgatgccgg gggggcatct ggctccgagg
3301 acccaccaga ttatggagat caaggtaatg tgcaacaggt gggatctgat cctatttcac
3361 ctgcgattgg cccctttgaa ctctctgcgg ccagtgagga tgatcctcaa tctgggccag
3421 tggaagagaa tttagatgcc gctgcaagag aggaagagga acctgatgag caggagcaca
3481 atggtggtga tgatcccttg gaagtccata ctcggcagcc tagatttgtg gatgtgaacc
3541 caacgcaggc tccagtgatc caactagtcc atgctgttta tgattccatg ttggtaagag
3601 gcacctagaa catttccaga tgtttagctt ggatattttg gccagtctta atttattgtc
3661 attggtttca gcaatcggac ctccggtctc taggcagttt attccttgag caaaacctga
3721 acatcgaaga gtttatatgg atgtgcatga cagtgcgtca cagatgtcag gccatcagac
3781 aaaaaccatt accgattgat aagcagaggc ggtggaagct cctgtcacct tacagaacct
3841 ggcgtatggg ttaccgtacg caaaccctca atgtaaacag ttttgagaca gggggagata
3901 aagtccaccc actccttgtg actgctacgc taggatgtga agagggcctg cggcatgcaa
3961 taacttacag tgctggcatt gtacagctac cacgaatgtc agaccaaaac caaaagatag
4021 aaacagcctt cttgatggca cgtcgtgcta ggtcactttc ggcagaaaga tatactttgt
4081 tctttgattt agtatcctct ggaaacaccc tgtatgccat atggattggg ctgggcacga
4141 gaaaccgagt tgcatttgtc gagtttgtag gatggctatg taagaaggac cacactcata
4201 tacgtgaatg gttccgccag tgcaccggga gaccctcacc atccaagcca tggatgagag
4261 cgcatcccgt cgccgttcct tatgacgatc cattaacaag tgaggagact gacctggcct
4321 atgcccgtgg actggccatg agtatcgagg ctgctagact gccagatgat ccaataattg
4381 ttgaggatga cgatgaaagt gaggaaattg aagataaatg tgataaggat gaagaggaaa
4441 gtggaacgga agatgttaca agcataccgc aaacactgcc gcacagtcca acagtatacg
4501 gcaggccctc ggtgttttac cgaaagccag atactaaatc aaccaaaaaa tgcagggcca
4561 tagtgactga ccttagtata atcaaggtca ttgaagatga acacagaaag aagaagacag
4621 ccagaacaga gcaaccaaga gccaagcctg attcccctgc ccccacagtg gtccttcggc
4681 gaccacccac gcaaaaggtg actggccctg ccggttcact gagtgtccag gctcagctgg
4741 agccatggca acctttgtcc tggccacatg agacaagagt tatacttcac ggaccaccca
4801 cgcagggtga ccaagcacac ggttccatgc tagaccttct tgaaaaggac gaccagcaca
4861 tggagcagca ggttatggca accctactgc caccagaacc acaccagccc cggtctggga
4921 gaagagcccc ttgtgtctac accgctgacc tagacataga aagtgatgag cccgccacgt
4981 cagagccggt tcttgatcag ctactgcccg ccccaggact tggacctctt gcaattcaac
5041 cattaacgtc ccccaccacg tctcaactcc gcagttcagc accgagccac gcacaaactc
5101 catggccggt tacccaccca agtcagactc caggtggccc aacgacacag tccctggcac
5161 cggaaacaga agccccgcgc cagtggccaa tgccactgcg acctatccct ctgcacccct
5221 tgcggatgca gccaatatca tttaatcctg cagtgagacc cactccccat cagccacctc
5281 aggtggagcc cactttctat cagtccactt gggtgaaacc ccctcaacaa taccagcctc
5341 agatggggca cattccatat cagccccgac caacgggtca ctctactatg ctccggcccc
5401 agtgggcacc caccaccatg cagccaccac caagggcgcc cactcccatg ccgccacctc
5461 aggggccacc caccgctatg cagaggcctc agggggcgcc cactcccatg ccgccacctc
5521 aggggccacc caccgccatg cagaggcctc ggggggcgcc cactcccatg ccgccacctc
5581 aggggccacc caccgccatg cagctgtcac caagggcact taccggccag aaggggccag
5641 caaagcacat tctgcgccag ttgttaacgg ggggcgtcaa gagtgggaga ccatcactta
5701 agtttaaggc tgcccttgag cgtcaagccg ctgcgggctt gcgaccttca ccagggtctg
5761 gaacgggtgc caagattgtg caggcacctg ttttctatcc acccgtccta cagcccatac
5821 aagttatgtg gcaagtgggt tcctcaaagg ccgtggccgc ctcaacggtg acacaggcac
5881 ccacggaata taccggggaa aggaggttag gggggcctat gtctcccact gatattccgc
5941 cgtctaaacg ggtgaagaaa aaggcctatc cagagcgcaa gacgccgcat ggggggccct
6001 cacactcttc caccgttatg tgggagaatg tcagccaggg acaacagcag actctggagt
6061 gcggaggaac tgataaacag gaaaggaaca tgttggggat gggggacatt gcagtttctt
6121 ccccttcctc ttctgaaaca tcgaatgatg agtgatttca accacgtaac aagaactggg
6181 atgaaccctc gggcagtatc agactgcggg gaggggcagt gataagtcat gacaatttta
6241 gatgaggtag acattttgca tattttcaga cccaccatgg aatcatttga aggagagggg
6301 gactctatac agtcacctga caatgcgcgg ggagatgatg tacagaatac tggtgagcat
6361 attcaggacc ccgggccggg gccttcaacc ggcggggctt ctgagggatt ggtgcagaac
6421 gagccggact caagagatca acagtcccgg gggcagagaa ggggtgatga aaacagaggc
6481 tggatgcagc gcatcaggcg aaggcggaga agacgggccg cattgtccgg ccatctttta
6541 gacatggaag acaatgtgcc gccgtggttt cctccacacg atatcacacc atatgtcgca
6601 aggaatatca gggacgctgc ctgccaggct gtcaaggtga gcatgcctct aactgggttc
6661 atgggggcca tctaaggccc acgtgtgacc catgtttcca ttaattttag cactcgcacc
6721 tgcaagcgct atcaaacctg atactcgata gtggtttaga cacacaacac ctcttgtgct
6781 tcgtgatggc agccaggcag cgtcttcagg acattcgacg tggacccttg gttgtagagg
6841 gaggtgttgg ttggcgacat tggcttctga catctcccag ccgatcctgg tccatgggat
6901 atcgcacagc aacactacgc acattaactc ccgtgcctaa cagggttggg gctgacagca
6961 tcatgttaac tgccacgttt ggatgccaaa atggggcact agctataaac accttctccg
7021 ccaccgtgtg gataccaccc cctgctggac caagagagca agaaagatac gctcgggaag
7081 ccgaggtgcg cttccttcgt ggtaaatggc agaggcggtt ccgaagaatc tttgatttga
7141 tagaactgtg tggctctctg caccacgtct ggcaaaacat gctgcagacc gaggagaacc
7201 ttttagattt cgtgcgtttc atgggtgtca tgtccagctg caatagttca tctgtgaatt
7261 actggtttca caagacaatc ggaaacttta agccatatta cccgtggaat gcaccaccta
7321 atgaaaatcc atatcacgca cggagaggca taaaagaaca agtaatccag aaagcatttc
7381 taaaggcaca aagacagggt ttatcaatgt tagcaacggg aggtggaccc agaggtgatg
7441 ctactagtga aacgagcagc gatgaggata ccggtagaca gggttcggat gtggagctag
7501 agtcatcgga cgatgagctg ccatatatcg atcccaacat ggagccagtt cagcagaggc
7561 ccgtcatgtt tgtgagccgt gtgcctgtaa ggaaaccgag gacactgccg tggcctacac
7621 ccaagacgca cccagtgaag cgcacaattg ttaagacctc ctatagatct gatgaggcag
7681 aagaagcaca gagcacccct gaaaggccgg gcccttccaa acaaccatca gagcccgtgg
7741 agcccgccca cacaacccca gcggggaggt caacggtgat tctccacgaa ccacctcgag
7801 agcccgaagc tgtttccttc aagcctccgc caccaccttc ccggaggaga aggggagcgt
7861 gtgttgtata tgacgatgat atcatagagg tgattgatgt tgaaaccacc gaagaggaga
7921 cgacgtcaat gcaaagacag cctccgctcg ggcaacaacc gccccccccc gtgatttcta
7981 ccgggagtgc catgtcttcc agtcacacgg atccatcagt aacacagcca agtaagccac
8041 atcggaaacc tcaagacgga tttcaacgtt caggccgacg tcaaaaacga gccatgcctc
8101 ccccagtgag tccttctgac gctgggcctc cttccaccag gcctcgtgtc atggcgcctc
8161 cttccaccgg gcctcgtgtc atggcgactc cttccaccgg gcctcgtgac atggcgcctc
8221 cttccaccgg gcctcgtgac atggcgcctc cttccaccgg gcctcgtgac atggcgcctc
8281 cttccaccgg gcctcgtgac atggcgccta ccgtcgtaca tatgtttacg agggagcgcc
8341 tgctcaccca gtccaccggc cctgcacctc ggagcttctg ggaaatgcgg gccggccgtg
8401 atgctcccaa aattcaacaa gaaccaagtt cacaacagca gccagccact cagtctacac
8461 cgccttgcca atcatgggtc ccatctgtct atgtcctccc ggcagtggat gctggtaatg
8521 cccagcccct acaaatatca cacttgagct ccatgtcgcc cacgcagccg atatcgcatg
8581 aagaacaacc ccggtatgag gatcctgaca ctcctctgga tttgagttta catccagata
8641 ctgcaactct gccgcccacc caggatttat accctggacg cgaggatctg caggccaccc
8701 aggctccata cccgggatac gaggagccac ggccccccca ggctcctttt gtaggtgact
8761 atggttttgt tcaaattccc tcggctcaat gggagccaca cccctctcag ggcacatacc
8821 agggccacat tgatccccag cttccggctg ctctagattt agggccagag cagccccggt
8881 tcccacaaga tccatatgtg tattccgggg gccaattgtc ttcatgtcca ggttatgcag
8941 gtccctggcc ctcgaggcct caacatccaa gatataggca caccttggca ttgtggcctc
9001 gagaacccag gcatgggcac tctcagggcc catggaaacc ctggtcagca catctcccac
9061 ctcagtggga tggatctgca ggacatggcc aggatcaggt ctcccagttc ccacatctgc
9121 attcggagac aggcccacca cgtcttcaac tttcatcggt gccacaggtg ctgtacccgc
9181 agccactggt ctcatcctct gcaccatcgt ggtcatctcc ccagccccga gcccccatac
9241 gccccattcc aacaagattc ccccctcccc ctatgccgtt acaagatagc atggccgtgg
9301 ggtgcgactc atcaggtaca gcatgcccaa gcatgccctt tgccagtgat tacagtcaag
9361 gtgcatttac cccactggac attaatgccc ccacgccaaa aagtcctcga gtagaagaaa
9421 gttctcacgg acccgcccgg tgttcccaag ctacttctga agcacaggag attcttagtg
9481 acaattctga gatctccgtg ttcccaaaag atgcaaagca gactgactat gatgcatcca
9541 ctgaaagtga gctagattaa ggggatccaa ggtgacccct gttagctatt tgatctttga
9601 ctgacacata aacatggttt aaggaatgaa cactcatggt gtgagactgg aactgtacta
9661 aatttgctga catatgtaca atgagagcca aaaatttgat aaaccttaaa agtcccccca
9721 tctaatgatg tccagttccc ttctcccacc ctgtacaccc cgacccaaag ggactcaatg
9781 gcattcagat ttctagttac cacaggtaga atatcgggcg ttggcccata aaaataagtg
9841 catggatata gctctgcaca ggcttggaaa cacccattcc aggtgtgctt ctttttggtg
9901 aaataaaaac agcgttcttt atatgaaaat gtgtattctc ttgtgttgca gtatgtacag
9961 ttagctttgg tatagttttt gggtacctga aacgtgtgca gggtgggtgt ccaatgtggc
10021 agttttatct ctttgtcccc atactcctgc tcggccgtct tgttaaagtt aaccggcggt
10081 ggaggatcc
//