GenBank-Updates@genbank.bio.net (03/14/91)
LOCUS RATCYP7S6 2400 bp ds-DNA ROD 14-MAR-1991
DEFINITION Rat cholesterol 7-alpha-hydroxylase gene, exon 6.
ACCESSION M59189
KEYWORDS cholesterol 7-alpha-hydroxylase; membrane-bound enzyme;
monooxygenase.
SEGMENT 6 of 6
SOURCE Rat DNA.
ORGANISM Rattus norvegicus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 2400)
AUTHORS Nishimoto,M., Gotoh,O., Okuda,K. and Noshiro,M.
TITLE Structural analysis of the gene encoding rat cholesterol
7-alpha-hydroxylase
JOURNAL Unpublished (1990)
STANDARD simple staff_review
FEATURES Location/Qualifiers
CDS join(M59184:659..738,M59185:33..273,M59186:39..625,
M59187:35..165,M59188:35..210,34..330)
/EC_number="1.14.13.17"
/product="cholesterol 7-alpha-hydroxylase"
/gene="CYP7"
/codon_start=659
mRNA join(M59185:33..273,M59184:598..738,M59186:39..625,
M59187:35..165,M59188:35..210,34..2328)
/EC_number="1.14.13.17"
/product="cholesterol 7-alpha-hydroxylase"
/gene="CYP7"
exon 34..2328
/number=6
/gene="CYP7"
BASE COUNT 705 a 444 c 443 g 808 t
ORIGIN About 0.5 kb from segment 5.
1 aacatctcat tggctgttgt attcttattg cagactttca aatatgaccg gtaccttgat
61 gaaagcggga aagcaaagac caccttctac agtaatggaa acaagctgaa gtgtttctac
121 atgcccttcg gatcaggcgc gacaatatgt cctggaagac tctttgccgt ccaagaaatc
181 aagcagtttt tgatcctgat gctctcctgc tttgaactgg agtttgtgga gagccaagtc
241 aagtgtcccc ctctagacca gtcccgggca ggcttgggaa ttttgccacc actacatgat
301 attgagttta aatataaact gaaacactga tacgtggttg gaagaagcga acactggatg
361 atgtcacttg gcggctgaga gtcatcacta aacaggcctt cgggaccaat gctcactgat
421 gcgccctagc gactggatta gtgggaagaa ctttgttctc gctgcccaca ttcctgggtg
481 ttcacatagc tggggccaga gcttcatcac tttcagaaag caatgtcttt tgtatttatt
541 ttcaaaatga agatattcca attggcagga tatttttcct aaggaaattg ctttatattt
601 ttatgaaaac taccaattaa ttatgaaagg gcttgaaatt cacgttttag tgaaattact
661 gatttttcac tagtaaggtt cttcaggtgt gaaactgtat tataaaaatg ttgtaatggg
721 tcacactgtg ctttgcataa aggtaaagga aactatgttt cagccttttc tgtgtctatg
781 agcttcgaaa ataatcttac tgttctagaa acactgggga ggtttcgaca tgctctcgct
841 atattttatt ttactgttgc tagaaatttt cattccagtt ttcaactacc ttatctttcc
901 cccattttga catgcatgcc aatgagaaga gtatttttta ggaattaaca aggcacctcc
961 cagaacccta ccctgagact tttaagcctt taatcccagc actcgagaag tagagccagg
1021 cagatctctg agtctgaggt tattctggtc tacatcagct ccagacaagc caggactaca
1081 gaatgggatc ttgtctaaaa aatacagcta atctttatgt cataactgat tatgaatcaa
1141 cctaaaagat aaattttcaa tcaggactca gagaaaatga gcaattaaaa aacttagctc
1201 tgaggtatgt ggaattcatt aagtacaagt tgacattaca tgttctttaa aaatagttta
1261 tgttttatct ctaaatgccc tgcagatgaa gaataataat gaaaagttga ataatactgt
1321 ttaaacacta agtgcaataa tgctttggta atgtacttta agagaatcat tagccgtgcc
1381 agttttacta aaatatattt atatgtaaat tatatttatc tttttcttat accataaata
1441 taaaaatatt gcaacattta gtaattttaa aattatatac ctttcagaaa atgatgtatg
1501 aatgtttgta tgttttttaa ctttgaacag aacatttaaa ttattcatct acggtgattt
1561 ttatcttatt tatttctttt tgtctcattc atatcttgaa gaaatccaaa aatatctgaa
1621 ggaatcgctc actcaaatgt ctccctatgg ttacagaaaa attcaatacc atgtttttgt
1681 cctcggggac tgaagcaggg tgtcgtgggt gccgagcaga ggctcctgct gcagcgagct
1741 ttatccacgg gactccttaa acttttaaaa tcttatcact attatcatgc atttattacc
1801 taagtaggat atttcccttt cctttttcat ttcagcagag tcccttagca acccaggctg
1861 actgggaccc tccatgtagc ttaagctgtg aactcactgt acttcctgtt ttcacttatt
1921 ttaggaagta attttcccta tcagaaattt taattgttta gatgatgtat aagagtaaca
1981 caattctgtt atatactaat ctgtagtaaa ctaaatttgt tcttagaaca agtttgatga
2041 ctctcaaatt gaatgtatcc atacatcttt ccatggcttc ttgaatgccc atttctcata
2101 cacagaatga tgggtttcac ggtgatgtct tcctttcatg tctttattct tgtgcggtga
2161 tggttggcaa atgataccca tggagcaagg ttactcttcc tatttctgtg cagcctaagt
2221 gttaagaata atttttaaat acttggaggg aaggcacatt ttgtgtcata tgtgaagtga
2281 catgtgacac acagactagc aaatccatga gtaaaatttt attgggatac cagacgccct
2341 cattcttttc attatgtcta cattccagtt ttttgagtgt acatggtgtg tgtggatgca
//GenBank-Updates@genbank.bio.net (05/08/91)
LOCUS RATCYP7S6 2400 bp ds-DNA ROD 08-MAY-1991
DEFINITION Rat cholesterol 7-alpha-hydroxylase gene, exon 6.
ACCESSION M59189
KEYWORDS cholesterol 7-alpha-hydroxylase; membrane-bound enzyme;
monooxygenase.
SEGMENT 6 of 6
SOURCE Rat DNA.
ORGANISM Rattus norvegicus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 2400)
AUTHORS Nishimoto,M., Gotoh,O., Okuda,K. and Noshiro,M.
TITLE Structural analysis of the gene encoding rat cholesterol
alpha-hydroxylase, the key enzyme for bile acid biosynthesis
JOURNAL J. Biol. Chem. 266, 6467-6471 (1991)
STANDARD simple staff_review
FEATURES Location/Qualifiers
CDS join(M59184:659..738,M59185:33..273,M59186:39..625,
M59187:35..165,M59188:35..210,34..330)
/EC_number="1.14.13.17"
/product="cholesterol 7-alpha-hydroxylase"
/gene="CYP7"
/codon_start=659
mRNA join(M59185:33..273,M59184:598..738,M59186:39..625,
M59187:35..165,M59188:35..210,34..2328)
/EC_number="1.14.13.17"
/product="cholesterol 7-alpha-hydroxylase"
/gene="CYP7"
exon 34..2328
/number=6
/gene="CYP7"
BASE COUNT 705 a 444 c 443 g 808 t
ORIGIN About 0.5 kb from segment 5.
1 aacatctcat tggctgttgt attcttattg cagactttca aatatgaccg gtaccttgat
61 gaaagcggga aagcaaagac caccttctac agtaatggaa acaagctgaa gtgtttctac
121 atgcccttcg gatcaggcgc gacaatatgt cctggaagac tctttgccgt ccaagaaatc
181 aagcagtttt tgatcctgat gctctcctgc tttgaactgg agtttgtgga gagccaagtc
241 aagtgtcccc ctctagacca gtcccgggca ggcttgggaa ttttgccacc actacatgat
301 attgagttta aatataaact gaaacactga tacgtggttg gaagaagcga acactggatg
361 atgtcacttg gcggctgaga gtcatcacta aacaggcctt cgggaccaat gctcactgat
421 gcgccctagc gactggatta gtgggaagaa ctttgttctc gctgcccaca ttcctgggtg
481 ttcacatagc tggggccaga gcttcatcac tttcagaaag caatgtcttt tgtatttatt
541 ttcaaaatga agatattcca attggcagga tatttttcct aaggaaattg ctttatattt
601 ttatgaaaac taccaattaa ttatgaaagg gcttgaaatt cacgttttag tgaaattact
661 gatttttcac tagtaaggtt cttcaggtgt gaaactgtat tataaaaatg ttgtaatggg
721 tcacactgtg ctttgcataa aggtaaagga aactatgttt cagccttttc tgtgtctatg
781 agcttcgaaa ataatcttac tgttctagaa acactgggga ggtttcgaca tgctctcgct
841 atattttatt ttactgttgc tagaaatttt cattccagtt ttcaactacc ttatctttcc
901 cccattttga catgcatgcc aatgagaaga gtatttttta ggaattaaca aggcacctcc
961 cagaacccta ccctgagact tttaagcctt taatcccagc actcgagaag tagagccagg
1021 cagatctctg agtctgaggt tattctggtc tacatcagct ccagacaagc caggactaca
1081 gaatgggatc ttgtctaaaa aatacagcta atctttatgt cataactgat tatgaatcaa
1141 cctaaaagat aaattttcaa tcaggactca gagaaaatga gcaattaaaa aacttagctc
1201 tgaggtatgt ggaattcatt aagtacaagt tgacattaca tgttctttaa aaatagttta
1261 tgttttatct ctaaatgccc tgcagatgaa gaataataat gaaaagttga ataatactgt
1321 ttaaacacta agtgcaataa tgctttggta atgtacttta agagaatcat tagccgtgcc
1381 agttttacta aaatatattt atatgtaaat tatatttatc tttttcttat accataaata
1441 taaaaatatt gcaacattta gtaattttaa aattatatac ctttcagaaa atgatgtatg
1501 aatgtttgta tgttttttaa ctttgaacag aacatttaaa ttattcatct acggtgattt
1561 ttatcttatt tatttctttt tgtctcattc atatcttgaa gaaatccaaa aatatctgaa
1621 ggaatcgctc actcaaatgt ctccctatgg ttacagaaaa attcaatacc atgtttttgt
1681 cctcggggac tgaagcaggg tgtcgtgggt gccgagcaga ggctcctgct gcagcgagct
1741 ttatccacgg gactccttaa acttttaaaa tcttatcact attatcatgc atttattacc
1801 taagtaggat atttcccttt cctttttcat ttcagcagag tcccttagca acccaggctg
1861 actgggaccc tccatgtagc ttaagctgtg aactcactgt acttcctgtt ttcacttatt
1921 ttaggaagta attttcccta tcagaaattt taattgttta gatgatgtat aagagtaaca
1981 caattctgtt atatactaat ctgtagtaaa ctaaatttgt tcttagaaca agtttgatga
2041 ctctcaaatt gaatgtatcc atacatcttt ccatggcttc ttgaatgccc atttctcata
2101 cacagaatga tgggtttcac ggtgatgtct tcctttcatg tctttattct tgtgcggtga
2161 tggttggcaa atgataccca tggagcaagg ttactcttcc tatttctgtg cagcctaagt
2221 gttaagaata atttttaaat acttggaggg aaggcacatt ttgtgtcata tgtgaagtga
2281 catgtgacac acagactagc aaatccatga gtaaaatttt attgggatac cagacgccct
2341 cattcttttc attatgtcta cattccagtt ttttgagtgt acatggtgtg tgtggatgca
//