GenBank-Updates@genbank.bio.net (05/09/91)
LOCUS RABHBBA1A1 1827 bp ds-DNA MAM 09-MAY-1991
DEFINITION rabbit beta1-globin with 2 ivs, type 1 allele.
ACCESSION J00659
KEYWORDS beta-1-globin; beta-globin; globin.
SOURCE rabbit.
ORGANISM Oryctolagus cuniculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Lagomorpha; Leporidae.
REFERENCE 1 (bases 431 to 490)
AUTHORS Baralle,F.E.
TITLE Complete nucleotide sequence of the 5' noncoding region of human
alpha- and beta-globin mRNA
JOURNAL Cell 10, 549-558 (1977)
STANDARD full staff_review
REFERENCE 2 (bases 432 to 490; 1504 to 1719)
AUTHORS Proudfoot,N.J.
TITLE Complete 3' noncoding region sequences of rabbit and human
beta-globin messenger RNA's
JOURNAL Cell 10, 559-570 (1977)
STANDARD full staff_review
REFERENCE 3 (bases 431 to 576; 703 to 924; 1498 to 1719)
AUTHORS Efstratiadis,A., Kafatos,F.C. and Maniatis,T.
TITLE the primary structure of rabbit beta-globin mrna as determined from
cloned dna
JOURNAL Cell 10, 571-585 (1977)
STANDARD full staff_review
REFERENCE 4 (bases 208 to 1827)
AUTHORS van Ooyen,A., Van Den Berg,J., Mantei,N. and Weissman,C.
TITLE comparison of total sequence of a cloned rabbit beta-globin gene
and its flanking regions with a homologous mouse sequence
JOURNAL Science 206, 337-344 (1979)
STANDARD full staff_review
REFERENCE 5 (bases 1 to 480)
AUTHORS Dierks,P., van Ooyen,A., Mantei,N. and Weissmann,C.
TITLE dna sequences preceding the rabbit beta-globin gene are required
for formation in mouse l cells of beta-globin rna with the correct
5' terminus
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 78, 1411-1415 (1981)
STANDARD full staff_review
COMMENT on chromosome: 5'-beta4-(8kb)-beta3-(5kb)-beta2-(7kb)-beta1;
[Cell 10, 571-585 (1977)],[Cell 10, 559-570 (1977)] are mrna
sequences of beta globin; also sequenced were
rabbit alpha-globin and human alpha- and beta-globin; also compared
with mouse immunoglobulin and chicken ovalbumin.
FEATURES Location/Qualifiers
CDS join(484..575,702..924,1498..1626)
/note="beta1-globin"
/codon_start=484
prim_transcript 431..1719
/note="beta1-globin mRNA and intron"
exon 484..575
/note="beta1-globin, exon 1"
intron 576..701
/note="beta1-globin intron A"
exon 702..924
/note="beta1-globin, exon 2"
allele 766..766
/note="c in type 2"
allele 779..779
/note="g in type 2"
allele 839..839
/note="a in type 2"
intron 925..1497
/note="beta1-globin intron B"
unsure 1309..1309
/note="t"
allele 1367..1367
/note="c in type 2"
allele 1487..1487
/note="c in type 2"
exon 1498..1626
/note="beta1-globin, exon 3"
allele 1519..1519
/note="g in type 2"
unsure 1819..1819
/note="a"
BASE COUNT 457 a 381 c 398 g 591 t
ORIGIN -128 bp from PstI site.
1 agaggatctc tctctctctc tctctctctc tctctaccta tctatttatc tatttaagtg
61 gatttcaaca cacaaatctt ctcccttttc tgtgccttaa atcctcattt gtatgataaa
121 taattgcaga gaaaattttt cataggctta accaggctct aataacaaaa attatataaa
181 taaatttggc aagaaaggtg ttttcagtag caattagtac tgctggtatg ggtctgggag
241 atacatagaa ggaaggctga gtctgtcaga ctcctaagcc attgccataa ctgccaagga
301 caggggtgct gtcatcaccc agacctcacc ctgcagagcc acaccctggt gttggccaat
361 ctacacacgg ggtagggatt acatagttca ggacttgggc ataaaaggca gagcagggca
421 gctgctgctt acacttgctt ttgacacaac tgtgtttact tgcaatcccc caaaacagac
481 agaatggtgc atctgtccag tgaggagaag tctgcggtca ctgccctgtg gggcaaggtg
541 aatgtggaag aagttggtgg tgaggccctg ggcaggttgg tatccttttt acagcacaac
601 ttaatgagac agatagaaac tggtcttgta gaaacagagt agtcgcctgc ttttctgcca
661 ggtgctgact tctctcccct gggctgtttt cattttctca ggctgctggt tgtctaccca
721 tggacccaga ggttcttcga gtcctttggg gacctgtcct ctgcaaatgc tgttatgaac
781 aatcctaagg tgaaggctca tggcaagaag gtgctggctg ccttcagtga gggtctgagt
841 cacctggaca acctcaaagg cacctttgct aagctgagtg aactgcactg tgacaagctg
901 cacgtggatc ctgagaactt cagggtgagt ttggggaccc ttgattgttc tttctttttc
961 gctattgtaa aattcatgtt atatggaggg ggcaaagttt tcagggtgtt gtttagaatg
1021 ggaagatgtc ccttgtatca ccatggaccc tcatgataat tttgtttctt tcactttcta
1081 ctctgttgac aaccattgtc tcctcttatt ttcttttcat tttctgtaac tttttcgtta
1141 aactttagct tgcatttgta acgaattttt aaattcactt ttgtttattt gtcagattgt
1201 aagtactttc tctaatcact tttttttcaa ggcaatcagg gtatattata ttgtacttca
1261 gcacagtttt agagaacaat tgttataatt aaatgataag gtagaatatt tctgcatata
1321 aattctggct ggcgtggaaa tattcttatt ggtagaaaca actacatcct ggtcatcatc
1381 ctgcctttct ctttatggtt acaatgatat acactgtttg agatgaggat aaaatactct
1441 gagtccaaac cgggcccctc tgctaaccat gttcatgcct tcttcttttt cctacagctc
1501 ctgggcaacg tgctggttat tgtgctgtct catcattttg gcaaagaatt cactcctcag
1561 gtgcaggctg cctatcagaa ggtggtggct ggtgtggcca atgccctggc tcacaaatac
1621 cactgagatc tttttccctc tgccaaaaat tatggggaca tcatgaagcc ccttgagcat
1681 ctgacttctg gctaataaag gaaatttatt ttcattgcaa tagtgtgttg gaattttttg
1741 tgtctctcac tcggaaggac atatgggagg gcaaatcatt taaaacatca gaatgagtat
1801 ttggtttaga gtttggcaac atatgcc
//