GenBank-Updates@genbank.bio.net (05/10/91)
LOCUS HUMDBLPRO 3652 bp ss-mRNA PRI 10-MAY-1991
DEFINITION Human mRNA for dbl proto-oncogene.
ACCESSION X12556
KEYWORDS dbl oncogene; glycoprotein; phosphoprotein; proto-oncogene.
SOURCE human (Homo sapiens).
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 3652)
AUTHORS Ron,D., Tronick,S.R., Aaronson,S.A. and Eva,A.
TITLE Molecular clonimg and characterization of the human dbl
proto-oncogene: evidence that its overexpression is sufficient to
transform NIH/3T3 cells
JOURNAL EMBO J. 7, 2465-2473 (1988)
STANDARD simple staff_entry
COMMENT *source: tissue=brain stem; library=lambda gt11; clone=p18-nd-3.6.
EMBL features not translated to GenBank features:
key from to description
MSG <1 3652 dbl proto-oncogene mRNA
SITE 1201 1212 pot. palmitylation site
SITE 1558 1566 pot. N-linked glycosylation site
SITE 2191 2199 pot. N-linked glycosylation site
SITE 2386 2403 pot. serine phosphorylation site
SITE 3630 3635 polyA signal
POLYA 3652 3652 polyA site
FEATURES Location/Qualifiers
CDS 175..2952
/note="dbl protein (AA1 - 925)"
/codon_start=175
BASE COUNT 1198 a 614 c 771 g 1069 t
ORIGIN
1 tttttttttt ttcctcccaa cattgctgcc actgtgctaa tggaagcacc acggcagctt
61 tgtttgatag agatttttgg ctgccgtttt taaatactac ccaagaagca gctcgtattt
121 catcaatgtt gcgttgacaa ttggaaaaga aaagtgtaat tgcgtacagg cgaaatggca
181 gaagcaaatc cccggagagg caagatgagg ttcagaagga atgcggcttc cttccctggg
241 aacttgcact tggttttggt tttacgtcct accagctttc ttcaacgaac gttcacagac
301 attggatttt ggtttagtca ggaggatttt atgcctaaat taccagttgt tatgctgagc
361 tcagttagtg atttgctgac atacattgat gacaagcaat taacccctga gttaggcggc
421 accttgcagt actgccacag tgaatggatc atcttcagaa atgctataga aaattttgcc
481 ctcacagtga aagaaatggc tcagatgtta cagtcctttg gaactgaact ggctgagaca
541 gaactaccag atgatattcc ctcaatagaa gaaattctgg caattcgtgc tgaaaggtat
601 catctgttga agaatgatat tacagctgta accaaagaag gaaaaattct gctaacaaat
661 ctggaagtgc ctgacactga aggagctgtc agttcaagac tagaatgtca tcggcaaata
721 agtggtgact ggcaaactat taataagttg ctgactcaag tacatgatat ggaaacagct
781 tttgatggat tttgggaaaa acatcaatta aaaatggagc agtatctgca actatggaag
841 tttgagcagg attttcaaca gcttgtgact gaagttgaat ttctattaaa ccaacaagca
901 gaactggctg atgtaacagg gactatagct caagtaaaac aaaaaataaa aaaattggaa
961 aacttagatg aaaattctca ggagctatta tcaaaggccc agtttgtgat attacatgga
1021 cacaagcttg cagcaaatca ccattatgca cttgatttaa tctgccagag gtgcaatgag
1081 ctacgttacc tttctgatat tttggttaat gagataaaag caaaacggat acaactcagc
1141 aggaccttca aaatgcataa actcctacag caggctcgtc aatgctgtga tgaaggggaa
1201 tgtcttctag ctaatcagga aatagataag tttcagtcta aagaagatgc tcagaaagct
1261 ctccaagaca ttgaaaattt tcttgaaatg gctctaccct ttataaatta tgaacctgaa
1321 acactgcagt atgaatttga tgtaatatta tctcctgagc ttaaggttca aatgaagact
1381 atacaactca agcttgaaaa cattcgaagt atatttgaga accagcaggc tggtttcagg
1441 aacctggcag ataagcatgt gaggccaatc caatttgtgg tacccacacc tgaaaatttg
1501 gtcacatctg ggacaccatt tttttcatct aaacaaggga agaagacttg gagacaaaat
1561 cagagcaact taaaaattga agtggtgcct gattgtcagg agaagagaag ttctggtcca
1621 tcctccagtt tggacaatgg caatagcttg gatgttttaa agaaccacgt actaaatgaa
1681 ctgatacaga ctgagagagt ttatgttcga gaactgtata ctgttttgtt gggttataga
1741 gcggagatgg ataatccaga gatgtttgat cttatgccac ctcccctgag aaataaaaag
1801 gacattctct ttggaaacat ggcagaaata tatgaattcc ataacgacat tttcttgagc
1861 agcctggaaa attgtgctca tgctccagaa agagtgggac cttgtttcct ggaaaggaag
1921 gatgattttc agatgtatgc aaaatattgt cagaataagc ccagatcaga aacaatttgg
1981 aggaagtatt cagaatgcgc atttttccag gaatgtcaaa gaaagttaaa acacagactt
2041 agactggatt cctatttact caaaccagtg caacgaatca ctaaatatca gttattgttg
2101 aaggagctat taaaatatag caaagactgt gaaggttctg ctctgttgaa gaaggcactc
2161 gatgcaatgc tggatttact gaagtcagtt aatgattcta tgcatcagat tgcaataaat
2221 ggctatattg gaaacttaaa tgaactgggc aagatgataa tgcaaggtgg attcagcgtt
2281 tggatagggc acaagaaagg tgctacaaaa atgaaggatt tggctagatt caaaccaatg
2341 cagcgacacc ttttcttgta tgaaaaagcc attgtttttt gcaaaaggcg tgttgaaagt
2401 ggagaaggct ctgacagata cccgtcatac agttttaaac actgttggaa aatggatgaa
2461 gttggaatca ctgaatatgt aaaaggtgat aaccgcaagt ttgaaatctg gtatggtgaa
2521 aaggaagaag tttatattgt ccaggcttct aatgtagatg tgaagatgac gtggctaaaa
2581 gaaataagaa atattttgtt gaagcagcag gaacttttga cagttaaaaa aagaaagcaa
2641 caggatcaat taacagaacg ggataagttt cagatttctc ttcagcagaa tgatgaaaag
2701 caacagggag cttttataag tactgaggaa actgaattgg aacacaccag cactgtggtg
2761 gaggtctgtg aggcaattgc gtcagttcag gcagaagcaa atacagtttg gactgaggca
2821 tcacaatctg cagaaatctc tgaagaacct gcggaatggt caagcaacta tttctaccct
2881 acttatgatg aaaatgaaga agaaaatagg cccctcatga gacctgtgtc ggagatggct
2941 ctcctatatt gatgaagcta ctatgtcaaa tggcaagtag ctctttcctg cctgcttctc
3001 agctcatttg gaaaaatact gcgcaaaaga cattgagctc aaatgatgca gatgttgttt
3061 tcaggttaat ggacacgcaa agaaaccaca gcacatactt cttttctttc atttaataaa
3121 gcttttaatt atggtacgct gtctttttaa aatcatgtat ttaatgtgtc agatattgtg
3181 cttgaaagat tctcatctca gaatactttt ggacttgaaa attatttctt ctctactttg
3241 taaccaaatg caatcggtgt gccttggatt atttagttta ttaatgaatt aagtcaaaat
3301 tacggctgca aaatggctaa ggtcaagtaa agcacaacat tatgatttaa tatgcttttg
3361 ttgaaaccac agcttttgtg cccattgttt taacttgtgt gaaacaatac aaagcccaga
3421 aattcttttc ggggcatgag taaattttgt tcagggctac tgtctgtatg tgcccagata
3481 aaattttcat gagagtagtt tacaaaagcc gtatttaaaa gttaatattt tcacactttt
3541 tttctggatt tctgcttata attaatgtaa cttaaattag ttgtgctctg ctattttctg
3601 tatatttcat gttgtaattc tttttttcaa ataaaaatta attcttcagg tt
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