GenBank-Updates@genbank.bio.net (05/10/91)
LOCUS MUSKAL07 9433 bp ds-DNA ROD 10-MAY-1991
DEFINITION mouse pseudo-kallikrein 2, exons 4 and 5, and kallikrein 1 gene,
complete cds.
ACCESSION J00390 J02754 M18580 M18600
KEYWORDS kallikrein; pseudogene.
SEGMENT 7 of 9
SOURCE Mouse (BALB/c) liver DNA, clones mGK-[1,2].
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 9433)
AUTHORS Mason,A.J., Evans,B.A., Cox,D.r., Shine,J. and Richards,R.I.
TITLE structure of mouse kallikrein gene family suggests a role in
specific processing of biologically active peptides
JOURNAL Nature 303, 300-307 (1983)
STANDARD simple staff_review
REFERENCE 2 (bases 6967 to 7090; 7948 to 8115)
AUTHORS Evans,B.A., Drinkwater,C.C. and Richards,R.I.
TITLE Mouse glandular kallikrein genes: Structure and partial sequence
analysis of the kallikrein gene locus
JOURNAL J. Biol. Chem. 262, 8027-8034 (1987)
STANDARD full staff_entry
COMMENT Draft entry and printed copy of sequence for [Nature 303, 300-307
(1983)] kindly provided by
B.A.Evans, 20-JUL-1987.
FEATURES Location/Qualifiers
prim_transcript <1..725
/note="ps-KAL mRNA and introns"
intron <1..10
/note="ps-KAL intron C"
CDS join(11..147,522..677)
/partial
/note="pseudo-kallikrein"
CDS join(4513..4558,6975..7134,7956..8242,8339..8475,
8848..9003)
/note="kallikrein precursor"
sig_peptide join(4513..4558,6975..6982)
/note="kallikrein signal pepptide"
mat_peptide join(7001..7134,7956..8242,8339..8475,8848..9000)
/note="kallikrein"
exon <11..147
/pseudo
/note="pseudo-kallikrein, exon 4"
intron 148..521
/note="ps-KAL intron D"
exon 522..>677
/pseudo
/note="pseudo-kallikrein, exon 5"
prim_transcript 4471..9048
/note="KAL mRNA and introns (alt.)"
prim_transcript 4477..9048
/note="KAL mRNA and introns (alt.)"
exon 4513..4558
/note="kallikrein precursor, exon 1"
sig_peptide 4513..4558
/note="kallikrein signal pepptide"
intron 4559..6974
/note="KAL intron A"
exon 6975..7134
/note="kallikrein precursor, exon 2"
sig_peptide 6975..6982
/note="kallikrein signal pepptide"
mat_peptide 7001..7134
/note="kallikrein"
intron 7135..7955
/note="KAL intron B"
exon 7956..8242
/note="kallikrein precursor, exon 3"
mat_peptide 7956..8242
/note="kallikrein"
intron 8243..8338
/note="KAL intron C"
exon 8339..8475
/note="kallikrein precursor, exon 4"
mat_peptide 8339..8475
/note="kallikrein"
intron 8476..8847
/note="KAL intron D"
exon 8848..9003
/note="kallikrein precursor, exon 5"
mat_peptide 8848..9000
/note="kallikrein"
BASE COUNT 2390 a 2421 c 2102 g 2520 t
ORIGIN About 2 kb after segment 6; chromosome 7.
1 ggatccacag tccaaaatgc aaaagatctc cagtgtgtga acctcaagct cctgcctaat
61 gagaattgtg acaaaaacca caataagaag gtgacagatg tcatggtgtg tgtaggagag
121 atggatggag gcaaagacac ttgtgtggtg agacagccac tttctgctgt gaggtgaagg
181 gctgaaagct ggaactgagg ttcttggttc ccacttcaac accctgacta ggcaggctct
241 ttttatcctt ccctatggaa gggatgtgca ctgggagggg aggatcctgt agctggcatg
301 atttctcacc ttagacttgt cttaggggac agtcttgtga gcccctcacc acaaaccaat
361 gttctcatac gatctgaggt cccaagagct agattccctc acctactgac tagagctgcc
421 tcttaagagt ccctgtgttc ctccctgggg tcagttccag gttgtcaagt aggactccaa
481 agtcaggtcc tccattactg ctgtcccttt ccttctttca gggagactca ggaggcccac
541 tgatatgtga tggtgttcta caaggtatca catcatgggg ctctatccca tgcagtaaac
601 ccaatgcgcc gggcatctac accaaactta ttaagtttaa ctcctggata aaagacacta
661 tgacgaaaaa tgcctaagtg tcacattatc ctctgttctc aataaaatcc actatgcaac
721 aaatgagtca aggtctgaca gtctctatcc tactggaata cagtacacaa ccaaggtccc
781 aactaaggtg agggcttcca aagtagatca gcaagggaca ggtgtacatg tactgttggt
841 taaggacatg gggttgagac aaatgcagac aaaaggctca gaccaactca aggattccac
901 ttgagtctcc tctggcaaag aaaatgttca tatcacagag gaaaagtcta aagagatcag
961 aatgggagac tccagctagg cctgatccta tactggaagc cgaagggatg ataaacagtc
1021 agacgctccg aattcagact gcctacctga gtttcttagg ttgggctggg gtgttttgtt
1081 aatacagcct tggctcgctg gagaagaatt tgtgcacaga agggcaggga ctgccaaagg
1141 ctaggtaggc tgcagtgtct ctgctcccag tggccactgg agggggtttc tttggtaggg
1201 ctggatcaaa ggatgaagag tgacttagaa ccatgtcctg tgggcagagt aatacccatc
1261 ttaggaaaag ggccacactg ctgctgcaca ggaccacaaa ccactgtctg ttttagaggg
1321 gacataacca cagctaagag tatcagagat ccgaagaagg gccagagaag gtcagaaaga
1381 tagacagaac tggaaatcta ccaacaactc tgggtaggag gaggcactgg ggttaaatgg
1441 aggatcccca gacacccttg tccttgccaa cacatattga ttccaatgct aaggaaactg
1501 aagatgaagt ctatcttctt caggcagcag cagactggtc gaaaggagaa gaacatggtg
1561 ggcaggagga tgaagcatag ttccagggcc agaattatga agcccttgct catgtgaatg
1621 tgaactgggg aggaaagttg gaaagataac tacagtcatt agtcattcaa acctctctct
1681 ctctctctct ttctctctct ctctctctct ctctctctct ctctctctct ctctctctct
1741 ctctcccccc ctctctctct ccctcccccc cagtctagct tcctctctcc ttcctctcac
1801 accattggag cacaacctaa gtactccagc acgctggaag ggagtggggg aatgtctttt
1861 catgttctga ctgtgaagtt agagacacat tgatcttttc ttgttctaaa tacaaggtaa
1921 aagcagtcga gggtcttgat gtatcttttt ttggcagaat atttgcatac gttgagcagc
1981 ctgcatttca ttctcaacac tgtgctgagc tgagtctgca gcacatgcct gtgatccctg
2041 caactgggag gaggatcaga aaatcatggt tgtccacaga tacacattga gttggaggtc
2101 agcctgggct aaacagacat gttacaaaga gtgcagaaga agggaatgta gctgtctaga
2161 atccatccca caatgagggt caggaaatgg ttctgagtac agcaagtcct agagtctcaa
2221 taggtggagt tctttggggg tgtgggcttc aagtagatag agaccctgtg gagtgtttgt
2281 gtggcgactg ggtgctgact tcagaaattc ccataaaaga ggtataagaa aaacaccacc
2341 ctccacttca cattaacaaa atcattccct agaaattcta aagtaactct actgcaactc
2401 attgaatgac ctaccatcga tgatgtcccc actgtgagcc caaacctaga cccccagaaa
2461 gagtcctggg agagtgggag tataccaccc acacagccac ctctagaata caatggaatg
2521 aacccccagt ctatatattc actgaccaga gatttgtccc acgttgtcat atttatgccc
2581 cctgcagcca atccagaggc tatgaatcca gtgtatgttc ggtgcgcata ggtattcaca
2641 catccattat actgaacacc aacaaggtta ccgagaggat gaacatgagg gaccagtttc
2701 gtaggacaag atttcagtcc tcctccccag gaatagagca ggacagcagg ggagggaaaa
2761 aattctggga cctggatctt ttctcccctc tctctcaatg catacaaacc tccatcttct
2821 tcctcattta catattcccc ctcatctaca acctgttccc tgtggatgct gtttggagct
2881 cgtctccagc accacttcat ctctttctat tctcatgcac tggactcttc cggtgcagta
2941 cacctatctc aaactccagc atgattatgt gtgcttgaag acatacaaaa agatcaagtg
3001 catggatgta ctcacaagtg gatgaatgca ggcttcctct cttgtccttt agagcaaaga
3061 acagtgcaat tttcagaaaa acttcagcac agaggcctag ggccagagga gaacttggtg
3121 gccagttgat caccaagtcc tcacttaccc tagattaggg ttagcctagc cttcttggag
3181 cttacagggc acacaggaat acacccaagt caaatgtgct aactgtcatg agagctgaaa
3241 tagtctagat gctcaacaag aggggatggg tctgaaacct gcaacagtaa gtaggtgtca
3301 aaggctgggt atttcccctt ctctgtacca gaacccatgc tgacttcttg atgttttaac
3361 gtttgagaca aagtcgtctc ctgtgtagtt tcactggcct aaatacacta tgtgcacagt
3421 ctaacctgga cctcaccaag atccaccagc ccctgactcc taagttctgg gatcaaggtg
3481 tgcaccaaaa tatgcagctg ccaagctgaa cccttaatga ggctcttgga gggaagtgac
3541 attttctggt tgctgtttct tgagaaaggg tctcacatga accttggctt ggctaacctc
3601 aaaatgtagc tcctgatcta ggagatgagg aagggaaaag tcatagtgac cccaacattg
3661 ttcaggacag gtgacactcc cctggaataa cctgaatttt catacttttg aataaaagac
3721 tgatcaggcc atggtaatgt gcaccataac ttttattcat tttattttat aggtttgttt
3781 tgagacagct ctatatataa ccttggctgt cttgaaagtc actatgtaga ctaggttggt
3841 ctacatcaca gaatactaga gcctagaatc acacagatcc acctggcttc aaagtactgg
3901 tattagagga gtgcactgct atacactgct cccaagcttc tcttagaaac aataaaatca
3961 gtgatccaga gttccaagtc caaaaaggaa gcattttggc attctccaag aaaggatttg
4021 tatctgcagg gagcttgcag ccctctaggc tatcacttgt gaaagactct gttctaactg
4081 caactttctg ggataatctt ggacttgagg tacaggacct tccttaaagt tgtgggttag
4141 gcagcacttg ctccactacc caccattcat accaagtcac catttccacg accttgccat
4201 ctggctccca gtacccggaa cactaacagt tccagaaaca gcaggaattg ccctcccaat
4261 ctcattcttg ggaatgtatc cagggtgacc tagagccttc tggacagtgg gtgcaacgag
4321 gtcatccctt accacagcca ggatggtgca agtagagaat cctaaccctg tcagcaaggg
4381 cagggctttg tcagcatctg ggtggcaaca ggacagagga ggggctgtgg ggagaatggg
4441 ggatttaaag tctccccagg gagcctcaat agctccaagc tcactgcctg ctgctcctga
4501 acacctgtta ccatgtggtt cctgatcctg ttcctagccc tgtccctagg agggattggt
4561 gagatgaggg aatgggaggg gacacagccc tcactcccct gcttacttag gccctggctg
4621 tccctttccc cttgcccctc tccccagcta catcatgagc accacctgct cctccttttc
4681 tggccctgta cactgccagg tccctcacat tccttgctcc cgggacaggc ccctgttccc
4741 tcccactttc cagtaatttc tcctcttcct tggacacata accatctctg gtcttctcca
4801 gtctttctaa ggaacccaac ctcttaccaa acttaggacc tcagatttcc ctacagttca
4861 ttatttttcc tagagcctca taacacaaac tctaagtcag aggcctgctt aaatcctcta
4921 actgccacgc ttcaactgtg tttgccacat cctgacaact ggtgctactc ttcttaaatt
4981 gcccagtttc taccaaaact ttcacttctc aaattggctt gtgatataag atgggttact
5041 cccctttgtg ctgtgggaaa aatgtgcata tacctatcca atgacttttt ggtttcgtct
5101 ggttttttag agaagggatc aggttggaga caccagacat ggacatcatg tatcttcatc
5161 aatcactcgc cacctgagac tgggtctctc actgtatgga gagttcctgt taggctaaga
5221 tgactgtgca gcaagcctcg ggggaatctt cctgtttcca cctcccctag atctggggtt
5281 acaggtgcac agcatcacac ctgacttttt gccttggggt ctggaaggtt tagctccagt
5341 cttaaggttt acatgagcaa tcttgtagca accaagccat ctccagtcca gcattttgga
5401 ataagatctg agttagtgtc tcatgatgta gcccaggctt ctcttccgtc catggcaatt
5461 cttttgcctc agcctgctgt ttactggggt tacagagaag tgcggcttat gcatggcttg
5521 ccaagatttc ctgtttccaa atgctgtggc ttggcctgct cttccctctc atgccttact
5581 gcctgagagt aaggctgcca tcccatctcc ctagagctcc actgcacagt tctagctccc
5641 actctgtgca ggacaccaca aagaccccaa tgcttaaccc tagtacctca catcagcttg
5701 gcttgcctct ctacctcaga gtggcctgac ttgctgtaac tatgtttcca gtcttgtcct
5761 gaggctgcct caaaaagaac tctgagcctc tccaatactc atattacttg ttccacatcc
5821 acaagaagca gatcctgtct gtcacagact ttccagattt tccacctcta actgctcgca
5881 ccatatcaaa ctcctttctt agggagatcc acacctctta gatgccatct ccaccacaga
5941 cacaaacagg agcccacgca ccttttatcg gatcccctca ctctctccat tccagctgcc
6001 acttcacacc caaccaaaga aaccaaaaat caaccccagc tccctttcct ggattcattt
6061 attcattgag atccagtttc ctgcgacctc accctttcca gaattcccaa aacccagcca
6121 aggcagtggt cttttctcaa gccttggaga ctctaaattc caaatcagag gattctcatt
6181 ggaataaaaa tgaacaggaa gtctctctct gtctctctct gtcagtgtct ttgtctcatg
6241 ctctctctgt ctctttttct cactgtctct ctctctctct gtctctctct ctgtccctct
6301 ctctttctct ctttctcatt gcccatctgt cctttagtca aaaactataa agtgatttcc
6361 acagtggttg tacaagcttg caatcccacc aacaatggag gagtgttcct ctttctccat
6421 atcctcgcca gcatctgctg tcacctgaat ttttgatctt agccattctg attggtgtga
6481 ggtggagtct cagggttgtt ttgatttgca attccctgat gattaaggat gctgaacatt
6541 ttatcaggtg cttctcagcc attcggtatt cctcaggtgg aaagagaggc ccataggtct
6601 tgcaaacttt atatgcctca gtacagggga acaccagggc caagaagtgt gagtgggtgg
6661 gtaggggaat gtggggggag ggtatggggg acttttggga tagcattgga aatttaaatg
6721 aagaaaatac ctaataaaaa ataataataa ttaaaaaaaa ctataaagtg gcctgatact
6781 atacccaatt cttgattcta gagttatttc tgtacccaca gcatagatct ccctatccaa
6841 gaccagccat atacgggtcc tttgcccaga tcacctgaca atgtcccctg aaccctgtcc
6901 tgcttaactt tgtcccccaa aagtgcacct ccctacatgt gccaactctc ccctccccca
6961 ttgccacttt gcagatgctg cacctcctgt ccagtctcga atagttggag gatttaaatg
7021 tgagaagaac tcccagccct ggcatgtggc tgtgtaccgc tacaaggaat atatatgcgg
7081 gggagtcctg ttggatgcca actgggttct cacagctgcc cactgctatt atgagtgagt
7141 aagggtggag acagaaaagc agggtggcag ccatagatca tgacgacggg acaagctggg
7201 tactgtaggg caggtggtta ggactggatg aaagtctatc catgatatcc tgggtctctc
7261 tttgctcctc caatccagcc ttgggttcag agtactgttt ctttcttttc tgtcttattt
7321 tttgtctgtc tgtctgtctg tctgtctgtc tgtctgtctg tctgtctact gtctgtatca
7381 catcagagtg tcttcctggc catctctact gtgtgtctct tccttggaac tctgacaaca
7441 tctgtctggg tctgggtctc atgtgttctc ttgtatcact actgcccata gtggggacaa
7501 atcctaacca gcccttgatg atagaaagtg ctgtccatga aggtaggctg tgagagaagt
7561 ccttactctc cttagaccag atctgcattt aggacctact gtcactctga ggacacacag
7621 agaagggctg gtcgtaactg gagctgggtg aggtaactga gttcagtgag agacctggat
7681 gctaggaagg taagagagag ctcagacctt gggctgcagg tcaggcctta cctgctgggg
7741 aagtacagac ccgtcctagc tgcacctgag cagctctcag gtctgccact cctccttact
7801 acctcttcca agtgtgtgtg tgtccgtccg ttcttgtgtt tttctctctc tgagtctttc
7861 tcttcctgct tccctctttc ccctcttctc ctatactttt taactctcct tggttgcctc
7921 ttctcaatct ctccatgtca tttcatgccc tctagaaaga acaacgtttg gctgggcaaa
7981 aacaacctat accaagatga accctctgct cagcaccgat tagtcagcaa aagcttcctt
8041 cacccttgct acaacatgag cctccatcgg aaccgcatcc aaaatcctca ggacgactac
8101 agctatgacc tgatgctgct ccgactcagc aagcctgctg acatcacaga tgttgtgaag
8161 cccatcgccc tgcccactga ggagcccaag ctggggagca catgccttgc ctcaggctgg
8221 ggcagcatta tacctgtcaa gtgtgagtct ggtccaagca acacagctgg gtgtggagga
8281 ggggcagaaa ggacttagct ggcacctgct caccaccctc ttgcctcctg atccacagtc
8341 caatatgcaa aagatctcca gtgtgtgaac ctcaagctcc tgcctaatga ggactgtgac
8401 aaagcctatg tacagaaagt cacagatgtc atgctgtgtg caggagtgaa gggtggaggc
8461 aaagacactt gtaaggtgag acagaccctc cctgcagtga ggtgaaggcc tgtaagaggg
8521 aactgaggtt cttggttccc acttcaacac cctgactaag caggctcttt gcatccttcc
8581 ctatggacgg gatgtgcact gggaggggag gatcctgtag ctggtactat ttctcctctg
8641 tgacatcgct taggggactg tctagtcaac ccctcacccc cgctccatgt ctctggaaga
8701 gatggccttc taagatctgt gttcttacct attgaacaga gctgcctctt agagtccctg
8761 tgtttatccc ctgggagtca gttccagctt gttgagtaga atccaactgc caggccctgc
8821 ttactcctgt ccctgtcctt ctttcaggga gactcaggag gcccactgat ctgtgatggt
8881 gttctccaag gtctcacatc atggggctat aacccatgtg gtgaacccaa aaagccgggc
8941 gtctacacca aacttattaa gttcacctcc tggatcaaag acactttggc ccaaaacccc
9001 tgagtgacac actgtctgtt ctcaataaaa tccaccatgc aacaaatgag ttcaaggtct
9061 gacattctct gtcctactag agtgtgacac ccaatcatga tttccctcag ctaagatcag
9121 gatttccaaa gtagatcagc aagggacagg tgtacatgta ctgttggcta aaggaacagg
9181 gttgaaacaa atgtagacaa aaggctcagg caaactcacg gatgccactt gagtctcctc
9241 tggcaaggaa aattctcaga tcacagagca aaaagttaga gacatcagaa agttcaactg
9301 tagctatgct catccacact ggaaagcaga agagatgata aacagtcaga cacagagaat
9361 ttagacagca aaccaagttg tactgtgttg gggaagccag gaaggaggca ggggtgttac
9421 gttaattaag ctt
//