GenBank-Updates@genbank.bio.net (05/10/91)
LOCUS RATTSHBA2 1044 bp ds-DNA ROD 10-MAY-1991
DEFINITION Rat thyrotropin (TSH) beta-subunit gene, exons 2 and 3.
ACCESSION M14450 J02648
KEYWORDS thyrotropin.
SEGMENT 2 of 2
SOURCE Rat liver (library Sprague-Dawley) DNA, clone TSH-beta.
ORGANISM Rattus sp.
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 1044)
AUTHORS Carr,F.E., Need,L.R. and Chin,W.W.
TITLE Isolation and characterization of the rat thyrotropin beta-subunit
gene: Differential regulation of two transcriptional start sites by
thyroid hormone
JOURNAL J. Biol. Chem. 262, 981-987 (1987)
STANDARD simple staff_review
FEATURES Location/Qualifiers
prim_transcript <1..920
/note="thyrotropin mRNA and introns"
CDS join(34..195,591..845)
/note="thyrotropin beta-subunit precursor"
/codon_start=34
mat_peptide join(94..195,591..845)
/note="thyrotropin beta-subunit"
/codon_start=94
exon 34..195
/note="thyrotropin beta-subunit precursor, exon 2 (first
expressed exon)"
sig_peptide 34..93
/note="thyrotropin beta-subunit signal peptide"
/codon_start=34
mat_peptide 94..195
/note="thyrotropin beta-subunit, exon 2"
exon 591..845
/note="thyrotropin beta-subunit precursor, exon 3"
mat_peptide 591..845
/note="thyrotropin beta-subunit, exon 3"
BASE COUNT 280 a 213 c 239 g 312 t
ORIGIN About 4 kb after segment 1.
1 tatgagctct gtggttcttc ctcagatttt agcatgaatg ctgtcgttct cttttccgtg
61 cttttcgctc ttgcttgtgg gcaagtgtca tcgttttgta ttcccactga gtatatgatg
121 tacgtggaca ggagagagtg tgcctactgc ctgaccatca acaccaccat ctgcgctggg
181 tattgtatga cacgggtatg ttggtcactg cgtttctttt gctgtaaatt gtacaggtct
241 aaagttgtct gttaatattt tagaaaggga agtggataaa tcatagtctc ctctttggga
301 agccaagcac actgctttac gaattataat tatgtgattc tacacagaaa aagagtacag
361 atacattgta acagtttacc ctaaaggtgt tgtgttctgc tcaatggtag atgagaagaa
421 aggtgtccgt ttttgtctct gaggggttaa gatgtagagt gtagtgaggt aacagagctc
481 aggagtcctt taagatcatc aggaaacaaa gggatattag tattctatta cgacgtacgc
541 ttgcattgca ggtttatcac ctgttaacga tctccttttc gttccacaag gatatcaatg
601 gcaaactgtt tcttcccaag tacgcactct ctcaggatgt ctgtacatac agagacttca
661 cctacagaac ggtggaaata ccgggatgcc cacaccatgt tgctccttat ttctcctacc
721 ccgttgccct gagctgcaag tgtggcaagt gtaacactga ctacagcgac tgtacacacg
781 aggctgtcaa aaccaactac tgcaccaagc cacagacatt ctatctgggg ggattttctg
841 gttaactgta atggcaatgc aatctggtta aatgtgttta cctggaatag aatagaacta
901 ataaaatatc attcattgat atgttgcctg ccatttaatc cataggcaca tccacaaggc
961 cgattagaga gcttacacac ttcagacgag aggcgttatg agctgtgtgg tttcatcaga
1021 gtagagcaga gcagaggtca aagg
//