GenBank-Updates@genbank.bio.net (05/10/91)
LOCUS HS4RSIRZ2T 6011 bp ds-DNA VRL 10-MAY-1991
DEFINITION Epstein-Barr virus (wild type B95-8) DL and DR segments containing
IR2 repeats.
ACCESSION J02070
KEYWORDS repetitive sequence; tandem repeat.
SOURCE Epstein-Barr virus (strain B95-8) DNA.
ORGANISM Epstein-Barr virus
Viridae; ds-DNA enveloped viruses; Herpesviridae;
Gammaherpesviridae.
REFERENCE 1 (bases 1894 to 2018)
AUTHORS Dambaugh,T.R. and Kieff,E.
TITLE Identification and nucleotide sequences of two similar tandem
direct repeats in Epstein-Barr virus DNA
JOURNAL J. Virol. 44, 823-833 (1982)
STANDARD full staff_review
REFERENCE 2 (bases 1533 to 2018; 2922 to 4098)
AUTHORS Jeang,K.-T. and Hayward,S.D.
TITLE Organisation of the Epstein-Barr virus molecule: III. The location
of the P3HR-1 deletion junction and characterization of the NotI
repeat units that form part of the template for an abundant
12-O-tetradecanoylphorbol-13-acetate-induced mRNA transcri
JOURNAL J. Virol. 48, 135-148 (1983)
STANDARD full staff_review
REFERENCE 3 (bases 1533 to 2018; 2922 to 4098)
AUTHORS Jeang,K.-T. and Hayward,S.D.
JOURNAL Unpublished (1984) Dr. Hayward, Johns Hopkins Univ. S. of Medicine
STANDARD full staff_review
REFERENCE 4 (bases 1 to 6011)
AUTHORS Jones,M.D., Foster,L., Sheedy,T. and Griffin,B.E.
TITLE The EB virus genome in Daudi Burkitt's lymphoma cells has a
deletion similar to that observed in a non-transforming strain
(P3HR-1) of the virus
JOURNAL EMBO J. 3, 813-821 (1984)
STANDARD full staff_review
COMMENT There are 12 and 1/3 (125 bp) tandem repeats found in the BamHI-H
fragment of the EBV B95-8 genome. It is thought that they play a
regulatory role. A 2.5 kb open reading frame, overlapping the
repeats is also found in this fragment. It is thought to code for
the early antigen (EA-R). The precise start and end of this coding
region has not yet been determined. [Unpublished (1984) Dr.
Hayward, Johns Hopkins Univ. S. of Medicine] resolved the conflicts
between [J. Virol. 48, 135-148 (1983)] and [EMBO J. 3, 813-821
(1984)] in favor of [EMBO J. 3, 813-821 (1984)].
FEATURES Location/Qualifiers
repeat_region 1731..1768
/note="repeat copy A (last 38 bp)"
repeat_region 1769..1893
/note="repeat copy B"
repeat_region 1894..2018
/note="repeat copy C"
conflict (1956.1957)..(1956.1957)
/location=J. Virol. 44, 823-833 (1982) | 63..63
repeat_region 2019..2143
/note="repeat copy D"
repeat_region 2144..2268
/note="repeat copy E"
repeat_region 2269..2393
/note="repeat copy F"
repeat_region 2394..2518
/note="repeat copy G"
repeat_region 2519..2643
/note="repeat copy H"
repeat_region 2644..2768
/note="repeat copy I"
repeat_region 2769..2893
/note="repeat copy J"
repeat_region 2894..3018
/note="repeat copy K"
repeat_region 3019..3143
/note="repeat copy L"
repeat_region 3144..3168
/note="repeat copy M"
BASE COUNT 972 a 1897 c 1919 g 1223 t
ORIGIN 1 bp upstream of BamHI site.
1 ggatccgcta ggatatgacg tcgggcatgg acctctagca tctgctatgc gaatgctttg
61 gatggctaat tatattgtaa gacaatcacg gggtgaccgg ggccttattt tgccacaagg
121 cccacaaaca gcccctcagg ccaggttggt ccagccacat gtcccccctc tacgcccgac
181 agcacccacc attttgtcac ctctgtcaca accgaggctt acccctccac aaccactcat
241 gatgccacca aggcctaccc ctcctacccc tctgccacct gcaacactaa cggtgccacc
301 aaggcctacc cgtcctacca ctctgccacc cacaccacta ctcacggtac tacaaaggcc
361 taccgaactt caacccacac catcaccacc acgcatgcat ctccctgtct tgcatgtgcc
421 agaccaatca atgcaccctc ttactcatca aagcacccca aatgatccag atagtccaga
481 accacggtcc ccgactgtat tttataacat tccacctatg ccattacccc cctcacaatt
541 gccaccacca gcagcaccag cacagccacc tccaggggtc atcaacgacc aacaattaca
601 tcatctaccc tcggggccac catggtggcc acccatctgc gaccccccgc aaccctctaa
661 gactcaaggc cagagccggg gacagagcag ggggaggggc aggggcaggg gcaggggcag
721 gggcaagggc aagtccaggg acaagcaacg caagcccggt ggaccttgga gaccagagcc
781 aaacacctcc agtcctagca tgcctgaact aagtccagtc ctcggtcttc atcagggaca
841 aggggctggg gactcaccaa ctcctggccc atccaatgcc gcccccgttt gtagaaattc
901 acacacggca acccctaacg tttcaccaat acatgaaccg gagtcccata atagcccaga
961 ggctcccatt ctcttccccg atgattggta tcctccatct atagaccccg cagacttaga
1021 cgaaagttgg gattacattt ttgagacaac agaatctcct agctcagatg aagattatgt
1081 ggagggaccc agtaaaagac ctcgcccctc catccagtaa aaacccttgc cctctccagc
1141 aaccaatgta tcccaaataa atgttacttc ttttgctctt aaccattgac acgcctgtca
1201 ttctatcaat taaacaaggg aaaaaggttt agctattcca ccaacacgac cccaaggaag
1261 gcttgccaaa attggtgcct tgctctcagc actttgccag caacttatag catggtaggc
1321 agctcaactc ggcccgtctt actgcccagc ctactctcca ctcccagtcc atgttcgcac
1381 tcctatgcat ttcctgccct cccactttta ccccagtccc aacccaaaac cacacacaac
1441 acatagaatt gttagtttaa acagtttatt gataggtggc tgcttttagc ctaattgtgt
1501 attgctctcg ttgccaaaac ctgttgtaag ggccggcacc cgcaacatgg ggaaaacata
1561 accgccgcca tcccatgggg agggtagagg cggttgacat gtaggtgagt agtgtaagaa
1621 gcatggcgaa gtagacaggt tacttttaga gtgtagtgta cagggccggg cgcaacagtg
1681 ccaccaaccc ggggtctgag cattccatgg gcagcaggga cactgcacta ccgccaggtc
1741 ctggggcagc cggggttcct ggcgctccgg gggcagccgg gcggccgccg gtgggtccgc
1801 tgggccgctg ccccgctccg ggtgcggggt ggccccgctg ggcaccgctg cgccgccgcc
1861 aggtcctggg gcagccgggg ttcctggcgc tccgggggca gccgggcggc cgccggtggg
1921 tccgctgggc cgctgccccg ctccgggtgg ggggtggccc cgctgggcac cgctgcgccg
1981 ccgccaggtc ctggggcagc cggggttcct ggcgctccgg gggcagccgg gcggccgccg
2041 gtgggtccgc tgggccgctg ccccgctccg ggtggggggt ggccccgctg ggcaccgctg
2101 cgccgccgcc aggtcctggg gcagccgggg ttcctggcgc tccgggggca gccgggcggc
2161 cgccggtggg tccgctgggc cgctgccccg ctccgggtgg ggggtggccc cgctgggcac
2221 cgctgcgccg ccgccaggtc ctggggcagc cggggttcct ggcgctccgg gggcagccgg
2281 gcggccgccg gtgggtccgc tgggccgctg ccccgctccg ggtggggggt ggccccgctg
2341 ggcaccgctg cgccgccgcc aggtcctggg gcagccgggg ttcctggcgc tccgggggca
2401 gccgggcggc cgccggtggg tccgctgggc cgctgccccg ctccgggtgg ggggtggccc
2461 cgctgggcac cgctgcgccg ccgccaggtc ctggggcagc cggggttcct ggcgctccgg
2521 gggcagccgg gcggccgccg gtgggtccgc tgggccgctg ccccgctccg ggtggggggt
2581 ggccccgctg ggcaccgctg cgccgccgcc aggtcctggg gcagccgggg ttcctggcgc
2641 tccgggggca gccgggcggc cgccggtggg tccgctgggc cgctgccccg ctccgggtgg
2701 ggggtggccc cgctgggcac cgctgcgccg ccgccaggtc ctggggcagc cggggttcct
2761 ggcgctccgg gggcagccgg gcggccgccg gtgggtccgc tgggccgctg ccccgctccg
2821 ggtggggggt ggccccgctg ggcaccgctg cgccgccgcc aggtcctggg gcagccgggg
2881 ttcctggcgc tccgggggca gccgggcggc cgccggtggg tccgctgggc cgctgccccg
2941 ctccgggtgg ggggtggccc cgctgggcac cgctgcgccg ccgccaggtc ctggggcagc
3001 cggggttcct ggcgctccgg gggcagccgg gcggccgccg gtgggtccgc tgggccgctg
3061 ccccgctccg ggtggggggt ggccccgctg ggcaccgctg cgccgccgcc aggtcctggg
3121 gcagccgggg ttcctggcgc tccgggggca gccgggcggc cgccggtggg tccgctgggc
3181 cgctgccccg ctccgggtgg ggggtggccc cgctgggcac cgctgcgccg ccgccaggtc
3241 ctggggcagc cggggttcct ggcgctccac tgcacctgga atgcagggtg ggggcgtggt
3301 cccctggacc ccagccccgc cgatccctcc cccagggcgt acccggcttg cctggttctg
3361 gggctcctct gggggtcgct gcatccgccg gtagggttcg aatgggcgtg gtccgcttgc
3421 tctgctggcc cggtacgcct ggattgccgg ctgggggctg gggtcccggg acgccccctc
3481 cctgctccca cccggttccc tcccccaggg cgtgccccgc ttgcctggtc ctggagctca
3541 tccggggatg ctgcatccgc tagtccgacc tgggtgggtg cggtccgctg gccccaccct
3601 gggggtagcc gccgggtctg ctggtccggt gcacctggaa ggcagggggg ggggcagtga
3661 gggaggggcg tggtcctggg accccgcgcc gactggcagg gggtccccat ggcacaggcc
3721 taggggtcca gggggcagcc gcggcccagc gcgccccgtt cacgggggag gaccgcggcc
3781 gagccaccag gggcccggcg ggggtggggg gtgcgctccc aggccggacc ctggtgccag
3841 gcagggaccc cgcgccaccc gcttcatggg gggggaggcc gccgcaagga cgccgggccg
3901 gctgggaggt gtgcaccccc cgagcgtctg gacgacgctg gcgagccggg ccggctcgcc
3961 ttcttttatc ctctttttgg ggtctctgtg taatacttta aggtttgctc aggagtgggg
4021 gcttcttatt ggttaattca ggtgtgtcat tttagcccgt tgggtttcat taaggtgtgt
4081 caccaggtgg gtggtacctg gaggttattc tattgggata acgagaggag gaggggctag
4141 aggtccgcga gatttggggt aggcggagcc tcaggagggt cccctccata gggttgaacc
4201 aggaggggga ggattgggct ccgccccgat atacctagtg ggtggagcct agaggtaggt
4261 atccataggg ttccattatc ctggaggtat cctaagctcc gcccctatat accaggtggg
4321 tggagctagg taggattcag ctaggttcct actggggtac ccccctaccc taccttaagg
4381 tgcgccaccc ttcctccttc cgttttaatg gtagaataac ctataggtta ttaacctagt
4441 ggtggaatag ggtattgcag ctgggtatat acctataggt atatagaacc tagaggaagg
4501 gaaccctata gtgtaatccc tcccccccct acccccccct cccttacggt tgcctgagcc
4561 catcccccac cccagcaccc cggggtgacg tggcaccccg cgtgccttac tgacttgtca
4621 cctttgcaca tttggtcagc tgaccgatgc tcgccacttc ctgggtcatg acctggcctg
4681 tgccttgtcc cgtggacaat gtccctccag cgtggtggct gcctttggga tgcatcactt
4741 tgagccacta agcccccgtt gctcgccttg cctgcctcac catgacacac taagcccctg
4801 ctaatccatg agccccgcct ttaggaagca ccacgtcccg gggacggaag gggacttggg
4861 gtgattttct atgtgggggt ggaaatatga gcaagaataa ggacggctcc ttattaacct
4921 gatcagcccc ggagttgcct gtttcatcac taaccccggg cctgaagagg ttgacaagaa
4981 gggtcaaggt ttcgtctgtg tgttgaaggg caggggctgt tgggtgcatc tggaacggct
5041 tacctcgggt aactgtttgc cattaaaagg ttggggatta ggtttagccc ctttagctgc
5101 catttcgaac cggggtgtgc agatgcaggt ctccgggtgg gcaggcagta cgagatgtca
5161 cgttgtgttg tctttcctcc cacccctgtc ctggctgtgg caaatgcgac cctcatagag
5221 ttgtgtttca ggtctgtgtc ctgttttgcg gtgggttatt tcttccctca gtgtttgcca
5281 gcttatttcc ccagttttca cgtactgggg cctgtggaca cctgagggag cggccgttgg
5341 tgggtatgtg ttggaattgc tcccaccctc aattttcgct tgccttcttc ccttgttaac
5401 ctgatagcat agcctctagg tttccttgta ggtctgtttg ggtttgttgg ttcacgtggt
5461 gctaacttga attttttggt tttctagttc cctcttaatt acatttgtgc cagatcttgt
5521 agagcaagat ggcctattca acaagggaga tactgttagc cctgtgtata cgggacagtc
5581 gtgtgcatgg aaatggtacc ctgcatcctg tgttggagct agcagcaaga gaaacacctc
5641 tccgcctttc gccagaggac actgtagttc tgcgttatca tgtgttgctt gaggagataa
5701 ttgaacgaaa ttcagagaca tttacagaaa cttggaacag atttataaca cacaccgaac
5761 atgtggatct ggattttaac tcagtatttt tagagatatt tcaccgtgga gacccaagcc
5821 ttgggcgcgc gttggcctgg atggcctggt gcatgcatgc ctgcaggaca ttgtgttgta
5881 accagtctac tccttactat gttgtggacc tgtcagttcg tgggatgtta gaagccagcg
5941 aaggcctgga tggttggatt catcaacagg gcggctggtc tacattaatt gaagacaaca
6001 ttcctggatc c
//