GenBank-Updates@genbank.bio.net (05/10/91)
LOCUS HUMALRED2 12277 bp ds-DNA PRI 10-MAY-1991
DEFINITION Human aldose reductase (AR) gene, segment 2.
ACCESSION M59783
KEYWORDS aldose reductase.
SEGMENT 2 of 2
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 12277)
AUTHORS Graham,A., Brown,L., Hedge,P.J., Gammack,A.J. and Markham,A.F.
TITLE Structure of the Human aldose reductase gene
JOURNAL J. Biol. Chem. 266, 6872-6877 (1991)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
intron order(M59856:567..>2585,<1..2846)
/note="2.3 kb gap"
CDS join(M59856:501..566,2847..3014,3698..3814,4801..4878,
5481..5603,6106..6212,6538..6619,7218..7301,9254..9336,
11797..11839)
/EC_number="1.1.1.21"
/product="aldose reductase"
/gene="AR"
/codon_start=501
mRNA join(M59856:470..566,2847..3014,3698..3814,4801..4878,
5481..5603,6106..6212,6538..6619,7218..7301,9254..9336,
11797..12209)
/product="aldose reductase"
/gene="AR"
exon 2847..3014
/number=2
/product="aldose reductase"
/gene="AR"
intron 3015..3697
/number=2
/gene="AR"
exon 3698..3814
/number=3
/product="aldose reductase"
/gene="AR"
intron 3815..4800
/number=3
/gene="AR"
exon 4801..4878
/number=4
/product="aldose reductase"
/gene="AR"
intron 4879..5480
/number=4
repeat_region 4999..5293
/note="Alu 'C'"
exon 5481..5603
/number=5
/product="aldose reductase"
/gene="AR"
intron 5604..6105
/number=5
/gene="AR"
exon 6106..6212
/number=6
/product="aldose reductase"
/gene="AR"
intron 6213..6537
/number=6
/gene="AR"
exon 6538..6619
/number=7
/product="aldose reductase"
/gene="AR"
intron 6620..7217
/number=7
/gene="AR"
exon 7218..7301
/number=8
/product="aldose reductase"
/gene="AR"
intron 7302..9253
/number=8
/gene="AR"
exon 9254..9336
/number=9
/product="aldose reductase"
/gene="AR"
intron 9337..11796
/number=9
/gene="AR"
repeat_region 11146..11437
/note="Alu 'D'"
exon 11797..12209
/number=10
/product="aldose reductase"
/gene="AR"
BASE COUNT 2696 a 3098 c 3046 g 3437 t
ORIGIN Map position: 7q35.
1 ccaatctctg agatactttg gttttaccat aaacactgtc ctgtgaccgt cttcctgttt
61 agcactgtgg cttgcttttt gacttgcaga gggaagagag ggaggggtat cttgaagtaa
121 ctagcaagac ctgtaagcaa aagggaagaa gactaggttt taaaaggagt gttgtatctg
181 tgtaggaggg agacactgat tttagttatc agtgtctcag agttggtatt agccagccgg
241 tgttatcaaa ggaggaacta ggaccgctgt cttgaaggag gtggtggagg actcaaggca
301 gaggcttctc actgccatca cttggtgcca tcagcccaga gcatttcaag tcactgccca
361 acgtagagct ttgcagagcc agaagttctg ggaggaatgg gcatgcatgg ttttgcccat
421 caagggcaca cagattagtg gcaggatcgg gttagaaaca tgtaggattt gtatgattga
481 gctgtaattg gagtgtttca tatactgcat ttctacagct ctcatcagta atggctgtgc
541 ctggatgcca cccagcatgt tttcatagtt taccttcttt ttagaagtca atctggaccc
601 ctccttctgt ttgcattttc tctttgttga catggaatgg ggagatgttg tcatcctgtg
661 ttggcattcc caagtttagt gaatggtttc tcaccatagc ttaagttggc tgcttcattt
721 ttcataaggc aaattagttt ctctcaggga agggctgtac attgagatca ttaacataga
781 atgtggttgt ggatcctcgt acattttcat tgcagaggtg actttttccc tccagcacct
841 ttgatcagcc tcccagcaca catgtctcca gcgaatggca catatccaag gaatgatcag
901 cagcttcttc gtgacctctt gcagtcattg ctgtctttta cttttctaga aaaacctctc
961 acaacttttt tttcatgtcg tgccaacgca agcttgatta tcctagtctg tgctcttttt
1021 ggttccaaag aactgaaaaa ccactttaat cttaagcagg aaaaaaaaaa gtgtgtttgg
1081 ggtggggatt gattgacttc cccaaacaac agccgctgac attaggtgtt tgagattcag
1141 ggttgtaaat gttgtcacca ggatttggcc tccctccact ttcctgcagc agctccaggc
1201 tgacattctc ccagctcagt gaccccagca gaaccggggc tggactcagg ggttccaatt
1261 caagtgcaaa gattgagtct tatggcctgg attgagtcat gttcctgtcc ccgcaccagt
1321 tgcatggcag gcagtgcgtg gctaggctga gctgcggagt gtgccctcag cagctcctca
1381 gagaaaaatc aatcaaggcg ccatcaagcc tggagaaagt tcagtgtgtc ctgggcagtt
1441 tcctgcctgg gccccagttg ttctttctgg ggtagggtgt cctctgctct ccctgctgtc
1501 atcagtggtg gttgtgcccg gacaccactc agggcctgtg gtaaggcatt ctttctggaa
1561 attgagattc tctgttcctt caaccgtgca gagtggggaa ggctgcaaga gcacgttctg
1621 aggtcctcca gtcaaataag aggtcgccag gtcctctgag ggtcgtcccc tcttaaccca
1681 caccttcgat gagcatcccc accctgcctc gctgctccct ctgaggtgga gagtgagctc
1741 catgctaaca ggctctggta acgggcttgt tcaactgggc ccctttcttc cccaaagcct
1801 gttgaaaata gctgatgtca aaacacagat gtctgcagct gctatggccc tgggggtttt
1861 tcttttcatt tgtttctacc ccagctctcc aaaggaatgt gctctgttca ttcaacagcc
1921 cgctgcacat gtttattgct cagctctgtg atcatagcag gatagtgaaa gttgggggat
1981 acgtgtccat gcagcctacc tgggtgccag tgaagcgcga tgccatgtag gcactcctcc
2041 tcctcttcag tagccaggct ccccacagcc gttctggtta ctcagatggt caggtggctt
2101 ggccatggac acccattcag tcattttgcc aggtcagcca ctaaccgttt ggtgatcttc
2161 catgatccac attccccctc gtttcccttt aacttatttc tctctgctga tacctctgag
2221 gggccatctc ccgtgtctcc accccttgaa gcagatcctc atacagtgag aattgacaca
2281 tgggcctttg aataaacatc agtgatgtgc ttaacttcat gataatctcc cagaacgctt
2341 gaaacaagcg actgccggta tcagaagcca tgcatgaaaa gagagcgtaa ggggcaggca
2401 ttcactggct gaactgggga gccacatggg aattggggtc cataggacat ctatttttga
2461 aatattttga gatatttgaa ggaaatggtt tcccttacta tctcagcatt cagagtgtgg
2521 ggaaatgttt ttaatacagt ggtttgcaaa tcagtggatg tgaagaagca agaaaatgag
2581 atggcttcag catatctttt aaaagtgatc tcacctacac ttaagtggct gtcagattct
2641 cctacagggc aatgctgtgt ggcctttcac ttccatcccc cgcgtctgag gctgatagtc
2701 cagaatgctg ctgaggaagt gcacgtggtc tgtctttgct gaacaaagtg gcaggctggt
2761 cagcagggat cggtggctgc cactgcccct cctccttgct gtgcagactc tgcattctgc
2821 ggggctcacg ttctttctcc tttcagtccc ctccagggca ggtgactgag gccgtgaagg
2881 tggccattga cgtcgggtac cgccacatcg actgtgccca tgtgtaccag aatgagaatg
2941 aggtgggggt ggccattcag gagaagctca gggagcaggt ggtgaagcgt gaggagctct
3001 tcatcgtcag caaggtatcg ttccgcggtg gggctggaag gggctctcgg tcccatcatc
3061 tgttggtgca tcagcccaaa gccaagtcca cactcaatac agctacactt ttcactgatg
3121 ggcgattctt cccggggaaa cgtatcaccc acggccatac agggctccag agctcgccca
3181 tccttggctc tctgttgaat ggtcattcca tctgggccca ttgcttagag tcccgtgctg
3241 atgaggctga ggttgtggat tggccctccc tttccaggga gtcgctttca aggatggaac
3301 ttggttccat ctgcaaactg aatctccagt gctagccacc tgtctttgac ctgagatact
3361 gatgcacaaa ggacatgagg caggaggatg gggctggctc cacaaacacc agcccggggg
3421 gaaagtttcg agagttcttg cttaggccta gggcaggcta gccaatctgt ccattccatt
3481 ttgtgtcctc tggtccttgt aagaggtctc tgtgacctgg tcatcctgcc tgcctttgga
3541 aagttaggat ccagtacgca gtggaaatgc cctcacaacc attcacagca tcatggtaaa
3601 gcaaatgggt tttggggaga ggagactgct ctgtctttcc agccaggaag ctgccttgtg
3661 gctggcaatg atgacatgtg ccctctcgct ggcttagctg tggtgcacgt accatgagaa
3721 gggcctggtg aaaggagcct gccagaagac actcagcgac ctgaagctgg actacctgga
3781 cctctacctt attcactggc cgactggctt taaggtatgg gatgcctggt gcagaccagt
3841 cccttggggc tcaggtgcaa cctgtggtgt gttttgagct cccttagcag attacgtgtg
3901 ggtgactttc tgttcttgct gctcaaggta tagccagtgg accatcagca ctggcatcac
3961 ctgggagcgc ttagaaatca cagtctcggg ccccacgcag gccatttgaa tccgcaccag
4021 catgtgactc atacgcacac ttcttcaaag tttgaggagc actgctcttt gccagttggt
4081 agatgtgcaa tttaaaactg tcagcaaaca cagctgctgt ctgtagtgca cacagccatg
4141 aggcacggtc agccctggcc ctcccctcca ggcacgtgca cacaccaacc cccatacaca
4201 tgagtcccta cccacgttct acatgcatac cctgtcctgt ggaggcccgg taactatttg
4261 cagtctagtt gttggcacaa gaagaacttg agagttactt tgtcttttgc cttttttcta
4321 gccactgcct cagttttctg ctgtgagcca ggttcaaagt gtgggtttag ctttatcccg
4381 tagccctgtt ttattgcacc acagcatatc agggctgaag ggacttgact tttatctttt
4441 gattttaggg gtaagctggg gaggctgggc caggtggtag ttttataggc cagtgacccg
4501 ccagccttgg gccctgtgag tcctggtctt gagtccttcc tgtatccaca cattgcagtc
4561 agtggcgggg ctagtctctg tgaccaagta gtgtccatgt ctccgtctga cagtctcagc
4621 tccagcccgt ttgataaaga agtgttggct atctgcctat ttccttttca tagtggcaca
4681 cagattatcc ctagccagct gtggtggttt agaattgttt tagatgccag cttcccccag
4741 caggtctgtg aaggactatt actgattgtt ttgtttgttt gttttttatt gtaatgacag
4801 cctgggaagg aatttttccc attggatgag tcgggcaatg tggttcccag tgacaccaac
4861 attctggaca cgtgggcggt aagacagccc ctggttggac cttgttttcg tgactggttc
4921 cctcttcttc ttagaagcaa tctgcctgcc atttctcaca ttgcattttg ttattctgtc
4981 cctgttgttt gctctctctt tttttttttt tgagttgggg tctccctctg ttgcccaggc
5041 tggagtgcag tggcacaatc tcggctcact gcaagctcca cctcctgggt tcacgccatt
5101 ctcctgcctc agcctcaaaa gtagctggca ctacaggggc ccgccaccac gcccggctaa
5161 tttttttgta tttttagtag agacggggtt tcaccgtgtt agccaggatg gtcttgatct
5221 cctgacctcg tgattcgccc gcctcagcct cccaaagtgc tgggatttta caggtgtgag
5281 ccaccgcgcc cggcctgttt gctcttctta tctcattaaa gccagcctgg ctttcgtctc
5341 actgtctctt agcttctgaa aggtctaatt cactggcact gaagagtgag ggcaggaccc
5401 gttaaactgg tgcaaacgac acttctgatc ctgtcctttc tgggttcgtt tctgcaccac
5461 acagacactt ttctctgtag gccatggaag agctggtgga tgaagggctg gtgaaagcta
5521 ttggcatctc caacttcaac catctccagg tggagatgat cttaaacaaa cctggcttga
5581 agtataagcc tgcagttaac caggtaaaca tcccccaacg acactggcat tgcaacgttg
5641 ctgttttact gtctgatgct ggtagggatt tctcgtccac ctcacccagc aagtggccag
5701 gaggcagctc ctgggtgttg gcagagtcct gagttatgat tcagcatgac acagcacatc
5761 tgggagagga aacttacagg aaagaaagag tttgagcctg gcttgtgacg atttggggtc
5821 tgacaaagag gcagccatga gatcctcaga actgtgatag ttgataagtg ctaaagccaa
5881 gaaaagcctc tagggcccat gagaacatct ataataagat aataataaca ccaaggatac
5941 tacctgggaa ctgtaggaag ttacagctta tctgggaaat agggtgtttg ttatacatag
6001 ttttctgtat ggggtaggga gggactttag cataggaagc ttcatctgtg tcccatcagc
6061 gtgtagccac agtgctccca tcagctcttg tttttgcatt tgcagattga gtgccaccca
6121 tatctcactc aggagaagtt aatccagtac tgccagtcca aaggcatcgt ggtgaccgcc
6181 tacagccccc tcggctctcc tgacaggccc tggtgagctt cccacaggct catgctcctg
6241 tgtcacttgg tgaagattag aaaagactaa aaagaacaat tcagcctcaa ggaagatgtt
6301 tctgggggtg atctgcaaaa cttcccctga gcctcttgct ggttttcctg gaagggttgg
6361 agtttctagt agcaagacac ctactctttt tccaaagggt tgggggttct taacccagct
6421 ctgaggagga gactggtggc tgccctctga ggtcgatggg aggattaggg ttggggtttc
6481 tggctgctgt gagtggtggc catgatggtg tgacctggac tgtctttcta tcctcagggc
6541 caagcccgag gacccttctc tcctggagga tcccaggatc aaggcgatcg cagccaagca
6601 caataaaact acagcccagg tacagccact tcaggtgttg ctgaccgtcc acaactgcct
6661 gcattcctga cagtcctgtt agccaagagg aggaagtgac tgagcctgtt acaccctcac
6721 aggaagtatg gttaggggtc ctcaagtaca gagtggaaag ggcacagatc ggggttttag
6781 aagactctgg catgggctct tagattaata gtgcctgccc ccactactgc aagggtgact
6841 gccacgaggg ccagcgcttg ttcattcatg tggaacctca tctgtacaaa tgtaagagct
6901 cttagccgtg cagggaatgt tctttctcct gagtggtagt gtgcatttct agccagtgga
6961 gggcctcatg tggtctcatg atatgcctga gacactgaag cgtgtggcac agtggctagc
7021 gcaggactct ggagtcagat ctggacctga atgcgtcgcc tacctgttgc tagctgtgac
7081 ctgacatctt ggagcccctc tctgatcacc tgtggagttc tagcacgtcc ttctgcaggt
7141 tgtgtgtgtg agagactgag atgatgggtg cgagtgcctg gcatgtatac acactcactg
7201 tctccttggg ctcacaggtc ctgatccggt tccccatgca gaggaacttg gtggtgatcc
7261 ccaagtctgt gacaccagaa cgcattgctg agaactttaa ggtaagatct tggctggtca
7321 ggcctggccc tcctccatgg agtgggggat gggggaggcc tctcatcctg tctctggagt
7381 gtcatctgtg ggatcaccac catcctctct tctgaggcca gggagctgtg gcgagcaagc
7441 caagactgag actgacacct caccagtgga gccgtgtgca ggggcaggcc ttgggctcca
7501 gggcccgtgc tgtgcacata cacctacacc tttgctcagg cccttcagcc acaccgagag
7561 gttacccggg gagaatctcg ctcttgagct tcactgcctg gacctgccct gcactggagc
7621 tctgtcagct accagctgca taaccctggg caagtcgctt aactgctcga tgcctcagct
7681 tccctatcta taaaataata tccattttga gggttgttac gaagattaag tgatgcatca
7741 gagcacttca catggtgctt aataccttag taagtgatcg agaaatgttg ctgtgctgat
7801 aagtccaggg actgcaaagg accctctggc catttagtcc actcaccagc tctgcaagga
7861 gttccgtgtg atgatgggca gagctagacc tgtgtcagga ctctggcgaa cgctcagtgt
7921 ggcagctgga gcagctcagg ctacttggcg ccacctccct ccctgcctgc ccttgcgcat
7981 tggtggcggg ggtgtggggg aggggggggc acgccaaagg agagcagctc aggggagtcc
8041 tgatggccca agagcctctg ttctcactga gcaaagtggc tctgcaggga tgctctgtct
8101 ttatccaaga tctgtgccga gcgcacgaca gccatgggcc tggggctctt gggcaggccc
8161 agcttaggtg agcagctgat tttgcccaat tccactgccc aaagactgtg gccatagtgc
8221 tgccacctgt cacatatgag acagggatgg agtgatccct gaagaggaag tggagctcat
8281 tgtttaggag aggagacgtt ttcttcttac gtgcaggtag atgttctaag tacacaagat
8341 aaaatggcaa aacagtggcc actgagggaa aggcatatcc accagagatg catcgtttgt
8401 ttcgtatttc attttttaag gaattaggaa agaaaaaata aatgactaat gtgaaaatgc
8461 taacctaatt attttatttt tgcatcttac tgtatagctt ttgcacattt ttctgtgatc
8521 ataaccacag agcctgtagc agactctctt tctgcacatt ctgtgatcat ctgaagctaa
8581 gagcccttcg ctgggagtgt gtgtcagcct cttgtgggtc tcaccagtgg tgcctgcctg
8641 cctcctcctc ccagcctcca tgccagctga gttgtgtacc gtctgctgcc ttcatgcagg
8701 tggttctctt ctcccagtat acctttgttg ccctctctgt caaaatctta tacttcttag
8761 gccatgtcaa ataccatctc ctcttcggct gtggttgttc agtttcccgg ctggaatccc
8821 tttggaatac ctctgccctt cctgtgctgt tgagtgtctt atacagtgtg tgattagtta
8881 tttgtattac agttgtagaa atacctctgc cctttgtttg cttcataaaa tagaggcaaa
8941 gacacatctt acccataatt atattcctca ctgcaactta tcacaataga agtgctcagt
9001 agtgtttttt gaaatgaaat aaatgtatca tttccctgga ggttctggaa accaaccact
9061 gtttccatcg ttccatatat tatctagccc aacatgcaca tttcctgaat actaatatat
9121 cagcttttcc taagttcagt ttatcttatc gctcctctct gctcaaagcc atccaagaca
9181 tctgggtcct gcacagtatt ttgtctttta tttttatttg cagagcttac tggatttttt
9241 gtttgttttt taggtctttg actttgaact gagcagccag gatatgacca ccttactcag
9301 ctacaacagg aactggaggg tctgtgcctt gttgaggtga gtgagcccca gtgtgaggag
9361 cagttcccag gagatattca gatgctgcac agcaagagag tgatccctgc aggcctcagc
9421 gccaatgtgc tctcgtcaca gctgttcttg ctttgcacat taccttgctt tctcagccac
9481 gtgacttgca tcagctgaac tgcatggagc caagatgcca agagatccgc tcttgatatc
9541 ttcttccacc ctggggcatt gttggcctgg cctgaagtaa ctacatattt tggctttcca
9601 ttcaattttt aaatcctagc atggcatctg aaactaggtg atcccaggtg accctggatc
9661 aaactcttga agaatttgcc tgtgactttt tgtcttaatg accctaatga aaggggtttg
9721 gtcgggacgc cctggggctg aggtttgaga cagtcccggc tctgacctgg taagccacat
9781 ggctccaaaa caggccctcc ctcttgagca gcaggcacca cagtcctcca gccacacatc
9841 ctctggttct gtttcctctg catggtagtt tggaaggagc tgcctaggaa ggttttctgt
9901 ggggttttct cttttcctac cattacaata actaggtgac gcatgtaact cactttctgg
9961 ctttcaagaa ggaacttctc attttgcagt ggagactgag actctgtttc tctctcacta
10021 cccttattct tgtctgagct cttggtttcc acactctctc ctttagtact tcctcttcta
10081 agcaaaatgt gaacattccc taagatgggg tgggctacca gctttccctt tccagcgtct
10141 gtcccatctc cctccccgga gtttgcactg cttggcttca gccaccgccc caggcagatg
10201 tttgcccagt ctgcgtcctg gacaataact ctggccctgc ttcaggcata tgcgtgcctg
10261 gcaagcctgc tgctcgacac tgtggcctca cactcaaaat aggccgcaaa cagagcatgt
10321 cacaggcagc cccaggccag tgccctttca gacatctctg ttaatgctac ttagccctag
10381 acattaaaat catttttgga tctagtggac aaggaggaga ggagtgaatc agtcaccaag
10441 ctacattcgt tctcctttca gaatctctcc cattcatccg tcttcctttt cccctcccac
10501 ttgagacaga gtggattgaa gctttcaggg ctgaggaaac acagtggttt tctcattgct
10561 ccctttacag ttaggctcct ctgccctgga gtattgtgct agaaacttct gttcgattat
10621 cctgttgcgt ggcggtgagt gggaggaaga ggctagccct gacatgctca ggtctcctag
10681 ggagttttcg ctaactacac acacaccacc cctctggcag ataatgcttt actgagcctg
10741 acctgctgat gtcagtgtca ctgtgggtat acaaaaaggc agaccatgga gaacttttga
10801 ataagagtta cagactgtaa gcacccagct cagattacat aactctggcc ttgcgtgagc
10861 tgcccagcta tctgtccagt gttcctgcct ttatgttcct agcacagcca ttggccctac
10921 tagatggaca gtgagtgagc cttgacaaac acgtctgcac ctgtgctccc tgccatgtgc
10981 tccctgccct gtgctccctg ccctgtttcc aatataaaat cgccgaccgt tgattgggct
11041 cacttcagcc cccactgata caagaggctc cctctgtcct aagagcactt gccgttgctt
11101 ctcttatcct ttgagattca gtcacataca gacttttaac atcccttttt tttttgaaat
11161 gggctggtac tctgtcaccc aggctggaat gtaatggcat gatcacagct cactgcagcc
11221 ttgacctcct gggctcaaat gatcctccca cctcagcctc ccaagtagct ggggccatgg
11281 gcatgcacca ccatgcctgg ttaatttaaa aagttttttt attaagatgg aaatcttgct
11341 atgttgccca ggctagtcgc aaacccctag cctcaagtga tcctctcgct tcagcctgga
11401 ttacaggcgt gagccactgt gtctggcctg ccttctcata ttattacaca agatgtttaa
11461 gaccacaaaa tacagtctgg tcctgccagc tagactgagt tactggaagg cagaaatcgt
11521 gttgccgtcc tgcacggccc aggcacagtg ctgggcacat ggggagggtg gtgtccctca
11581 cacatgtgct gcttgatgac agtagtggta gaggggtctg gagggtgagt tgcttccccc
11641 agctgcagaa ccatcatctg cacactcaga actagcttgt tgcctctgag gttctatttt
11701 atttcttcag tgagacacat catttctctg ttgggagttg ggtatagtca aaatcacctc
11761 ttcaaaaagc aactgttttc tcctttctcc tgacagctgt acctcccaca aggattaccc
11821 cttccatgaa gagttttgaa gctgtggttg cctgctcgtc cccaagtgac ctatacctgt
11881 gtttcttgcc tcattttttt ccttgcaaat gtagtatggc ctgtgtcact cagcagtggg
11941 acagcaacct gtagagtggc cagcgagggc gtgtctagct tgatgttgga tctcaagagc
12001 cctgtcagta gagtagaagt ctcttccagt ttgctttgcc cttctttcta ccctgctggg
12061 gaaagtacaa cctgaatacc cttttctgac caaagagaag caaaatctac caggtcaaaa
12121 tagtgccact aacggttgag ttttgactgc ttggaactgg aatcctttca gcaagacttc
12181 tctttgcctc aaataaaaag tgcttttgtg agcttggttt tgtgagcttt ggttttttaa
12241 aacaatagca accttctatc tcacttcaac cattcac
//GenBank-Updates@genbank.bio.net (05/10/91)
LOCUS HUMALRED1 2585 bp ds-DNA PRI 10-MAY-1991
DEFINITION Human aldose reductase (AR) gene, segment 1.
ACCESSION M59856
KEYWORDS aldose reductase.
SEGMENT 1 of 2
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2585)
AUTHORS Graham,A., Brown,L., Hedge,P.J., Gammack,A.J. and Markham,A.F.
TITLE Structure of the Human aldose reductase gene
JOURNAL J. Biol. Chem. 266, 6872-6877 (1991)
STANDARD simple staff_entry
FEATURES Location/Qualifiers
exon 470..566
/number=1
/product="aldose reductase"
/gene="AR"
repeat_region 1557..1838
/note="Alu 'A'"
repeat_region 2405..>2585
/note="Alu 'B'"
BASE COUNT 617 a 653 c 698 g 617 t
ORIGIN Map position: 7q35.
1 tggcatgcac ctttgtctaa gaacaaagtg cggtaaacta tatgtgtagt cagtatgatt
61 cacatagatt aaggacaagg tattcgtcag attcccaaag agcatcaaac tggggttgga
121 caacaaaggc attcttctgg gctcttaatg aaaccaaaac ttatttctag tctatgtatt
181 tatgggatgc ctgttatttt cgctaaagat tcgctttccc accagataca gcagctgagg
241 aactcctttc tgcagcgggg cgcgggcgag cgttgggggc ggaaagaatc cgctgccact
301 aggaccaggc ggaagaagca tccccgccga cccttgggga aggccgccgc ggcaccccag
361 cgcaaccaat cagaaggctc cttcgcgcac ggcgcgccaa ccgcaggcgc cctttctgcc
421 gacctcacgg gctatttaaa ggtacgcgcc gcggccaagg ccgcaccgta ctgggcgggg
481 gtctggggag cgcagcagcc atggcaagcc gtctcctgct caacaacggc gccaagatgc
541 ccatcctggg gttgggtacc tggaaggtag gtgctcgtgg gggcgcgggc ccggggctcg
601 cctcacactc tccgcgcggc ctgtattggc gagggacccc gagtgaccct gagcagctcg
661 ccccgcggac gccggcgtgc tgggagccac gcgcgggctt gcagggtccc cagcggctgg
721 gtcggccttg cagagaccgg gggccttggc tccccggttg gccctgggcg tcagggcagc
781 atcctgcgag tggggtttgg gagcagctca cgggagcccc cgccctaccg cggcaaccct
841 tgatgggcgg cccaccagtc cgcattttgg gtcctagcgg gcgccccaag cggcacaacg
901 cgagagggag gcggggaaag tgggcttcac agaccggtgg acctcgggcg cagacaggga
961 cgtggagccg tcggcaaggt gtgggagcgc agacccagcc tcctttccct cgaggcacct
1021 gtagcccggt tgcctcactt gtaaatagtt ggtctcaatc gtttcgattc ttgccctccc
1081 tgaggaataa gcatctcaag ccggtagagg gcagagaatt aggtggcgcg agtttgcccg
1141 gacccagctg ttaacaaggc gcagtgcgga cgtcctcggc caggcgccgc ctcggggtgc
1201 ctgggtctgg aactcgggag aaaaatctgg gcaccccgta gctagttgat aattcaggag
1261 gcgccaaggt tagcattttc cctgtaaaac ctcaacacca cacagcgtcc ccgagaagtg
1321 cctagccgga tgagaatgac aataggacac gaaacatcat aggatatgaa aaatgataat
1381 atgatatgaa aaaccaaaaa taatagcctg agcctgatta tctgaaaatt gagcaacaaa
1441 ggtggtggta tgggagctga ggcaaaacct agaattttta accttctaag tattgcatat
1501 tatattccac agccataacc tgggtttctc agtttctgtt tttgttgttt gcttgtttgt
1561 ttgtgacagg gtctcgttgc ccaagctggg gttgcagtgg caatcatggt tcattgcagc
1621 ctggaactcc tgggctcaag tgatcctcct gcctcagcac tgcgggtagc tgggactaca
1681 ggcgctcacc accacacctg gctaatcttt tttcttcccc gcagagacag tctccgcttg
1741 ttgcttaggg tgatctccaa ttcctgggct caaagcgctc ctcccacctc gcctcccaaa
1801 gctacaggtg tgaaccatct ggcaggccca cgtcccaggt ttttctctta aaatttgaat
1861 atgggcctgg gcgttggata tttacacaca gacaagggaa gaaaacaaca gaaagaactg
1921 agtgaactgt gagatgtttg aaataggaca gaagagttta catgtaccct aaaacctgct
1981 gttgaaaatt agtaaatata aggtaagaaa aaggtcattt gcatcaggga gagtgtttct
2041 tggccagaat gatcagggta cgtgatttgt ttcctccaaa aactccagtg gtgtctctaa
2101 ggttgtaatt gaattacaac catgacacca agctaatttc catctgttgg catgttatgc
2161 tcttggaatg gatgcagaag gatgctttct tggcaatagc aaatactttc taagcatgat
2221 gcaacgcaca gatatataca tgtaactgga ataaaaatta cttaacagta cttaacctat
2281 gtaggctgca tttcaatatt tttttctatt ccatttttcc aaaaattatt gtcatacctc
2341 cagaagctag ttttgtgacc catcatttga aaatcactac tctagggtaa ataaggagta
2401 aaagtttatt tttttttttt tgagacaggg gctcagtgtc acccaggctg gagtgcagtg
2461 gcatgatcat gattcactgt agccttaacc tcttgggctc aagtggtcct catacctcag
2521 cctcccaagt agctgggacc acaggtgtgt gccaccacac tcgggtagtt tgtttttaat
2581 ttttt
//