GenBank-Updates@genbank.bio.net (05/10/91)
LOCUS HUMALRED2 12277 bp ds-DNA PRI 10-MAY-1991 DEFINITION Human aldose reductase (AR) gene, segment 2. ACCESSION M59783 KEYWORDS aldose reductase. SEGMENT 2 of 2 SOURCE Human DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 12277) AUTHORS Graham,A., Brown,L., Hedge,P.J., Gammack,A.J. and Markham,A.F. TITLE Structure of the Human aldose reductase gene JOURNAL J. Biol. Chem. 266, 6872-6877 (1991) STANDARD simple staff_entry FEATURES Location/Qualifiers intron order(M59856:567..>2585,<1..2846) /note="2.3 kb gap" CDS join(M59856:501..566,2847..3014,3698..3814,4801..4878, 5481..5603,6106..6212,6538..6619,7218..7301,9254..9336, 11797..11839) /EC_number="1.1.1.21" /product="aldose reductase" /gene="AR" /codon_start=501 mRNA join(M59856:470..566,2847..3014,3698..3814,4801..4878, 5481..5603,6106..6212,6538..6619,7218..7301,9254..9336, 11797..12209) /product="aldose reductase" /gene="AR" exon 2847..3014 /number=2 /product="aldose reductase" /gene="AR" intron 3015..3697 /number=2 /gene="AR" exon 3698..3814 /number=3 /product="aldose reductase" /gene="AR" intron 3815..4800 /number=3 /gene="AR" exon 4801..4878 /number=4 /product="aldose reductase" /gene="AR" intron 4879..5480 /number=4 repeat_region 4999..5293 /note="Alu 'C'" exon 5481..5603 /number=5 /product="aldose reductase" /gene="AR" intron 5604..6105 /number=5 /gene="AR" exon 6106..6212 /number=6 /product="aldose reductase" /gene="AR" intron 6213..6537 /number=6 /gene="AR" exon 6538..6619 /number=7 /product="aldose reductase" /gene="AR" intron 6620..7217 /number=7 /gene="AR" exon 7218..7301 /number=8 /product="aldose reductase" /gene="AR" intron 7302..9253 /number=8 /gene="AR" exon 9254..9336 /number=9 /product="aldose reductase" /gene="AR" intron 9337..11796 /number=9 /gene="AR" repeat_region 11146..11437 /note="Alu 'D'" exon 11797..12209 /number=10 /product="aldose reductase" /gene="AR" BASE COUNT 2696 a 3098 c 3046 g 3437 t ORIGIN Map position: 7q35. 1 ccaatctctg agatactttg gttttaccat aaacactgtc ctgtgaccgt cttcctgttt 61 agcactgtgg cttgcttttt gacttgcaga gggaagagag ggaggggtat cttgaagtaa 121 ctagcaagac ctgtaagcaa aagggaagaa gactaggttt taaaaggagt gttgtatctg 181 tgtaggaggg agacactgat tttagttatc agtgtctcag agttggtatt agccagccgg 241 tgttatcaaa ggaggaacta ggaccgctgt cttgaaggag gtggtggagg actcaaggca 301 gaggcttctc actgccatca cttggtgcca tcagcccaga gcatttcaag tcactgccca 361 acgtagagct ttgcagagcc agaagttctg ggaggaatgg gcatgcatgg ttttgcccat 421 caagggcaca cagattagtg gcaggatcgg gttagaaaca tgtaggattt gtatgattga 481 gctgtaattg gagtgtttca tatactgcat ttctacagct ctcatcagta atggctgtgc 541 ctggatgcca cccagcatgt tttcatagtt taccttcttt ttagaagtca atctggaccc 601 ctccttctgt ttgcattttc tctttgttga catggaatgg ggagatgttg tcatcctgtg 661 ttggcattcc caagtttagt gaatggtttc tcaccatagc ttaagttggc tgcttcattt 721 ttcataaggc aaattagttt ctctcaggga agggctgtac attgagatca ttaacataga 781 atgtggttgt ggatcctcgt acattttcat tgcagaggtg actttttccc tccagcacct 841 ttgatcagcc tcccagcaca catgtctcca gcgaatggca catatccaag gaatgatcag 901 cagcttcttc gtgacctctt gcagtcattg ctgtctttta cttttctaga aaaacctctc 961 acaacttttt tttcatgtcg tgccaacgca agcttgatta tcctagtctg tgctcttttt 1021 ggttccaaag aactgaaaaa ccactttaat cttaagcagg aaaaaaaaaa gtgtgtttgg 1081 ggtggggatt gattgacttc cccaaacaac agccgctgac attaggtgtt tgagattcag 1141 ggttgtaaat gttgtcacca ggatttggcc tccctccact ttcctgcagc agctccaggc 1201 tgacattctc ccagctcagt gaccccagca gaaccggggc tggactcagg ggttccaatt 1261 caagtgcaaa gattgagtct tatggcctgg attgagtcat gttcctgtcc ccgcaccagt 1321 tgcatggcag gcagtgcgtg gctaggctga gctgcggagt gtgccctcag cagctcctca 1381 gagaaaaatc aatcaaggcg ccatcaagcc tggagaaagt tcagtgtgtc ctgggcagtt 1441 tcctgcctgg gccccagttg ttctttctgg ggtagggtgt cctctgctct ccctgctgtc 1501 atcagtggtg gttgtgcccg gacaccactc agggcctgtg gtaaggcatt ctttctggaa 1561 attgagattc tctgttcctt caaccgtgca gagtggggaa ggctgcaaga gcacgttctg 1621 aggtcctcca gtcaaataag aggtcgccag gtcctctgag ggtcgtcccc tcttaaccca 1681 caccttcgat gagcatcccc accctgcctc gctgctccct ctgaggtgga gagtgagctc 1741 catgctaaca ggctctggta acgggcttgt tcaactgggc ccctttcttc cccaaagcct 1801 gttgaaaata gctgatgtca aaacacagat gtctgcagct gctatggccc tgggggtttt 1861 tcttttcatt tgtttctacc ccagctctcc aaaggaatgt gctctgttca ttcaacagcc 1921 cgctgcacat gtttattgct cagctctgtg atcatagcag gatagtgaaa gttgggggat 1981 acgtgtccat gcagcctacc tgggtgccag tgaagcgcga tgccatgtag gcactcctcc 2041 tcctcttcag tagccaggct ccccacagcc gttctggtta ctcagatggt caggtggctt 2101 ggccatggac acccattcag tcattttgcc aggtcagcca ctaaccgttt ggtgatcttc 2161 catgatccac attccccctc gtttcccttt aacttatttc tctctgctga tacctctgag 2221 gggccatctc ccgtgtctcc accccttgaa gcagatcctc atacagtgag aattgacaca 2281 tgggcctttg aataaacatc agtgatgtgc ttaacttcat gataatctcc cagaacgctt 2341 gaaacaagcg actgccggta tcagaagcca tgcatgaaaa gagagcgtaa ggggcaggca 2401 ttcactggct gaactgggga gccacatggg aattggggtc cataggacat ctatttttga 2461 aatattttga gatatttgaa ggaaatggtt tcccttacta tctcagcatt cagagtgtgg 2521 ggaaatgttt ttaatacagt ggtttgcaaa tcagtggatg tgaagaagca agaaaatgag 2581 atggcttcag catatctttt aaaagtgatc tcacctacac ttaagtggct gtcagattct 2641 cctacagggc aatgctgtgt ggcctttcac ttccatcccc cgcgtctgag gctgatagtc 2701 cagaatgctg ctgaggaagt gcacgtggtc tgtctttgct gaacaaagtg gcaggctggt 2761 cagcagggat cggtggctgc cactgcccct cctccttgct gtgcagactc tgcattctgc 2821 ggggctcacg ttctttctcc tttcagtccc ctccagggca ggtgactgag gccgtgaagg 2881 tggccattga cgtcgggtac cgccacatcg actgtgccca tgtgtaccag aatgagaatg 2941 aggtgggggt ggccattcag gagaagctca gggagcaggt ggtgaagcgt gaggagctct 3001 tcatcgtcag caaggtatcg ttccgcggtg gggctggaag gggctctcgg tcccatcatc 3061 tgttggtgca tcagcccaaa gccaagtcca cactcaatac agctacactt ttcactgatg 3121 ggcgattctt cccggggaaa cgtatcaccc acggccatac agggctccag agctcgccca 3181 tccttggctc tctgttgaat ggtcattcca tctgggccca ttgcttagag tcccgtgctg 3241 atgaggctga ggttgtggat tggccctccc tttccaggga gtcgctttca aggatggaac 3301 ttggttccat ctgcaaactg aatctccagt gctagccacc tgtctttgac ctgagatact 3361 gatgcacaaa ggacatgagg caggaggatg gggctggctc cacaaacacc agcccggggg 3421 gaaagtttcg agagttcttg cttaggccta gggcaggcta gccaatctgt ccattccatt 3481 ttgtgtcctc tggtccttgt aagaggtctc tgtgacctgg tcatcctgcc tgcctttgga 3541 aagttaggat ccagtacgca gtggaaatgc cctcacaacc attcacagca tcatggtaaa 3601 gcaaatgggt tttggggaga ggagactgct ctgtctttcc agccaggaag ctgccttgtg 3661 gctggcaatg atgacatgtg ccctctcgct ggcttagctg tggtgcacgt accatgagaa 3721 gggcctggtg aaaggagcct gccagaagac actcagcgac ctgaagctgg actacctgga 3781 cctctacctt attcactggc cgactggctt taaggtatgg gatgcctggt gcagaccagt 3841 cccttggggc tcaggtgcaa cctgtggtgt gttttgagct cccttagcag attacgtgtg 3901 ggtgactttc tgttcttgct gctcaaggta tagccagtgg accatcagca ctggcatcac 3961 ctgggagcgc ttagaaatca cagtctcggg ccccacgcag gccatttgaa tccgcaccag 4021 catgtgactc atacgcacac ttcttcaaag tttgaggagc actgctcttt gccagttggt 4081 agatgtgcaa tttaaaactg tcagcaaaca cagctgctgt ctgtagtgca cacagccatg 4141 aggcacggtc agccctggcc ctcccctcca ggcacgtgca cacaccaacc cccatacaca 4201 tgagtcccta cccacgttct acatgcatac cctgtcctgt ggaggcccgg taactatttg 4261 cagtctagtt gttggcacaa gaagaacttg agagttactt tgtcttttgc cttttttcta 4321 gccactgcct cagttttctg ctgtgagcca ggttcaaagt gtgggtttag ctttatcccg 4381 tagccctgtt ttattgcacc acagcatatc agggctgaag ggacttgact tttatctttt 4441 gattttaggg gtaagctggg gaggctgggc caggtggtag ttttataggc cagtgacccg 4501 ccagccttgg gccctgtgag tcctggtctt gagtccttcc tgtatccaca cattgcagtc 4561 agtggcgggg ctagtctctg tgaccaagta gtgtccatgt ctccgtctga cagtctcagc 4621 tccagcccgt ttgataaaga agtgttggct atctgcctat ttccttttca tagtggcaca 4681 cagattatcc ctagccagct gtggtggttt agaattgttt tagatgccag cttcccccag 4741 caggtctgtg aaggactatt actgattgtt ttgtttgttt gttttttatt gtaatgacag 4801 cctgggaagg aatttttccc attggatgag tcgggcaatg tggttcccag tgacaccaac 4861 attctggaca cgtgggcggt aagacagccc ctggttggac cttgttttcg tgactggttc 4921 cctcttcttc ttagaagcaa tctgcctgcc atttctcaca ttgcattttg ttattctgtc 4981 cctgttgttt gctctctctt tttttttttt tgagttgggg tctccctctg ttgcccaggc 5041 tggagtgcag tggcacaatc tcggctcact gcaagctcca cctcctgggt tcacgccatt 5101 ctcctgcctc agcctcaaaa gtagctggca ctacaggggc ccgccaccac gcccggctaa 5161 tttttttgta tttttagtag agacggggtt tcaccgtgtt agccaggatg gtcttgatct 5221 cctgacctcg tgattcgccc gcctcagcct cccaaagtgc tgggatttta caggtgtgag 5281 ccaccgcgcc cggcctgttt gctcttctta tctcattaaa gccagcctgg ctttcgtctc 5341 actgtctctt agcttctgaa aggtctaatt cactggcact gaagagtgag ggcaggaccc 5401 gttaaactgg tgcaaacgac acttctgatc ctgtcctttc tgggttcgtt tctgcaccac 5461 acagacactt ttctctgtag gccatggaag agctggtgga tgaagggctg gtgaaagcta 5521 ttggcatctc caacttcaac catctccagg tggagatgat cttaaacaaa cctggcttga 5581 agtataagcc tgcagttaac caggtaaaca tcccccaacg acactggcat tgcaacgttg 5641 ctgttttact gtctgatgct ggtagggatt tctcgtccac ctcacccagc aagtggccag 5701 gaggcagctc ctgggtgttg gcagagtcct gagttatgat tcagcatgac acagcacatc 5761 tgggagagga aacttacagg aaagaaagag tttgagcctg gcttgtgacg atttggggtc 5821 tgacaaagag gcagccatga gatcctcaga actgtgatag ttgataagtg ctaaagccaa 5881 gaaaagcctc tagggcccat gagaacatct ataataagat aataataaca ccaaggatac 5941 tacctgggaa ctgtaggaag ttacagctta tctgggaaat agggtgtttg ttatacatag 6001 ttttctgtat ggggtaggga gggactttag cataggaagc ttcatctgtg tcccatcagc 6061 gtgtagccac agtgctccca tcagctcttg tttttgcatt tgcagattga gtgccaccca 6121 tatctcactc aggagaagtt aatccagtac tgccagtcca aaggcatcgt ggtgaccgcc 6181 tacagccccc tcggctctcc tgacaggccc tggtgagctt cccacaggct catgctcctg 6241 tgtcacttgg tgaagattag aaaagactaa aaagaacaat tcagcctcaa ggaagatgtt 6301 tctgggggtg atctgcaaaa cttcccctga gcctcttgct ggttttcctg gaagggttgg 6361 agtttctagt agcaagacac ctactctttt tccaaagggt tgggggttct taacccagct 6421 ctgaggagga gactggtggc tgccctctga ggtcgatggg aggattaggg ttggggtttc 6481 tggctgctgt gagtggtggc catgatggtg tgacctggac tgtctttcta tcctcagggc 6541 caagcccgag gacccttctc tcctggagga tcccaggatc aaggcgatcg cagccaagca 6601 caataaaact acagcccagg tacagccact tcaggtgttg ctgaccgtcc acaactgcct 6661 gcattcctga cagtcctgtt agccaagagg aggaagtgac tgagcctgtt acaccctcac 6721 aggaagtatg gttaggggtc ctcaagtaca gagtggaaag ggcacagatc ggggttttag 6781 aagactctgg catgggctct tagattaata gtgcctgccc ccactactgc aagggtgact 6841 gccacgaggg ccagcgcttg ttcattcatg tggaacctca tctgtacaaa tgtaagagct 6901 cttagccgtg cagggaatgt tctttctcct gagtggtagt gtgcatttct agccagtgga 6961 gggcctcatg tggtctcatg atatgcctga gacactgaag cgtgtggcac agtggctagc 7021 gcaggactct ggagtcagat ctggacctga atgcgtcgcc tacctgttgc tagctgtgac 7081 ctgacatctt ggagcccctc tctgatcacc tgtggagttc tagcacgtcc ttctgcaggt 7141 tgtgtgtgtg agagactgag atgatgggtg cgagtgcctg gcatgtatac acactcactg 7201 tctccttggg ctcacaggtc ctgatccggt tccccatgca gaggaacttg gtggtgatcc 7261 ccaagtctgt gacaccagaa cgcattgctg agaactttaa ggtaagatct tggctggtca 7321 ggcctggccc tcctccatgg agtgggggat gggggaggcc tctcatcctg tctctggagt 7381 gtcatctgtg ggatcaccac catcctctct tctgaggcca gggagctgtg gcgagcaagc 7441 caagactgag actgacacct caccagtgga gccgtgtgca ggggcaggcc ttgggctcca 7501 gggcccgtgc tgtgcacata cacctacacc tttgctcagg cccttcagcc acaccgagag 7561 gttacccggg gagaatctcg ctcttgagct tcactgcctg gacctgccct gcactggagc 7621 tctgtcagct accagctgca taaccctggg caagtcgctt aactgctcga tgcctcagct 7681 tccctatcta taaaataata tccattttga gggttgttac gaagattaag tgatgcatca 7741 gagcacttca catggtgctt aataccttag taagtgatcg agaaatgttg ctgtgctgat 7801 aagtccaggg actgcaaagg accctctggc catttagtcc actcaccagc tctgcaagga 7861 gttccgtgtg atgatgggca gagctagacc tgtgtcagga ctctggcgaa cgctcagtgt 7921 ggcagctgga gcagctcagg ctacttggcg ccacctccct ccctgcctgc ccttgcgcat 7981 tggtggcggg ggtgtggggg aggggggggc acgccaaagg agagcagctc aggggagtcc 8041 tgatggccca agagcctctg ttctcactga gcaaagtggc tctgcaggga tgctctgtct 8101 ttatccaaga tctgtgccga gcgcacgaca gccatgggcc tggggctctt gggcaggccc 8161 agcttaggtg agcagctgat tttgcccaat tccactgccc aaagactgtg gccatagtgc 8221 tgccacctgt cacatatgag acagggatgg agtgatccct gaagaggaag tggagctcat 8281 tgtttaggag aggagacgtt ttcttcttac gtgcaggtag atgttctaag tacacaagat 8341 aaaatggcaa aacagtggcc actgagggaa aggcatatcc accagagatg catcgtttgt 8401 ttcgtatttc attttttaag gaattaggaa agaaaaaata aatgactaat gtgaaaatgc 8461 taacctaatt attttatttt tgcatcttac tgtatagctt ttgcacattt ttctgtgatc 8521 ataaccacag agcctgtagc agactctctt tctgcacatt ctgtgatcat ctgaagctaa 8581 gagcccttcg ctgggagtgt gtgtcagcct cttgtgggtc tcaccagtgg tgcctgcctg 8641 cctcctcctc ccagcctcca tgccagctga gttgtgtacc gtctgctgcc ttcatgcagg 8701 tggttctctt ctcccagtat acctttgttg ccctctctgt caaaatctta tacttcttag 8761 gccatgtcaa ataccatctc ctcttcggct gtggttgttc agtttcccgg ctggaatccc 8821 tttggaatac ctctgccctt cctgtgctgt tgagtgtctt atacagtgtg tgattagtta 8881 tttgtattac agttgtagaa atacctctgc cctttgtttg cttcataaaa tagaggcaaa 8941 gacacatctt acccataatt atattcctca ctgcaactta tcacaataga agtgctcagt 9001 agtgtttttt gaaatgaaat aaatgtatca tttccctgga ggttctggaa accaaccact 9061 gtttccatcg ttccatatat tatctagccc aacatgcaca tttcctgaat actaatatat 9121 cagcttttcc taagttcagt ttatcttatc gctcctctct gctcaaagcc atccaagaca 9181 tctgggtcct gcacagtatt ttgtctttta tttttatttg cagagcttac tggatttttt 9241 gtttgttttt taggtctttg actttgaact gagcagccag gatatgacca ccttactcag 9301 ctacaacagg aactggaggg tctgtgcctt gttgaggtga gtgagcccca gtgtgaggag 9361 cagttcccag gagatattca gatgctgcac agcaagagag tgatccctgc aggcctcagc 9421 gccaatgtgc tctcgtcaca gctgttcttg ctttgcacat taccttgctt tctcagccac 9481 gtgacttgca tcagctgaac tgcatggagc caagatgcca agagatccgc tcttgatatc 9541 ttcttccacc ctggggcatt gttggcctgg cctgaagtaa ctacatattt tggctttcca 9601 ttcaattttt aaatcctagc atggcatctg aaactaggtg atcccaggtg accctggatc 9661 aaactcttga agaatttgcc tgtgactttt tgtcttaatg accctaatga aaggggtttg 9721 gtcgggacgc cctggggctg aggtttgaga cagtcccggc tctgacctgg taagccacat 9781 ggctccaaaa caggccctcc ctcttgagca gcaggcacca cagtcctcca gccacacatc 9841 ctctggttct gtttcctctg catggtagtt tggaaggagc tgcctaggaa ggttttctgt 9901 ggggttttct cttttcctac cattacaata actaggtgac gcatgtaact cactttctgg 9961 ctttcaagaa ggaacttctc attttgcagt ggagactgag actctgtttc tctctcacta 10021 cccttattct tgtctgagct cttggtttcc acactctctc ctttagtact tcctcttcta 10081 agcaaaatgt gaacattccc taagatgggg tgggctacca gctttccctt tccagcgtct 10141 gtcccatctc cctccccgga gtttgcactg cttggcttca gccaccgccc caggcagatg 10201 tttgcccagt ctgcgtcctg gacaataact ctggccctgc ttcaggcata tgcgtgcctg 10261 gcaagcctgc tgctcgacac tgtggcctca cactcaaaat aggccgcaaa cagagcatgt 10321 cacaggcagc cccaggccag tgccctttca gacatctctg ttaatgctac ttagccctag 10381 acattaaaat catttttgga tctagtggac aaggaggaga ggagtgaatc agtcaccaag 10441 ctacattcgt tctcctttca gaatctctcc cattcatccg tcttcctttt cccctcccac 10501 ttgagacaga gtggattgaa gctttcaggg ctgaggaaac acagtggttt tctcattgct 10561 ccctttacag ttaggctcct ctgccctgga gtattgtgct agaaacttct gttcgattat 10621 cctgttgcgt ggcggtgagt gggaggaaga ggctagccct gacatgctca ggtctcctag 10681 ggagttttcg ctaactacac acacaccacc cctctggcag ataatgcttt actgagcctg 10741 acctgctgat gtcagtgtca ctgtgggtat acaaaaaggc agaccatgga gaacttttga 10801 ataagagtta cagactgtaa gcacccagct cagattacat aactctggcc ttgcgtgagc 10861 tgcccagcta tctgtccagt gttcctgcct ttatgttcct agcacagcca ttggccctac 10921 tagatggaca gtgagtgagc cttgacaaac acgtctgcac ctgtgctccc tgccatgtgc 10981 tccctgccct gtgctccctg ccctgtttcc aatataaaat cgccgaccgt tgattgggct 11041 cacttcagcc cccactgata caagaggctc cctctgtcct aagagcactt gccgttgctt 11101 ctcttatcct ttgagattca gtcacataca gacttttaac atcccttttt tttttgaaat 11161 gggctggtac tctgtcaccc aggctggaat gtaatggcat gatcacagct cactgcagcc 11221 ttgacctcct gggctcaaat gatcctccca cctcagcctc ccaagtagct ggggccatgg 11281 gcatgcacca ccatgcctgg ttaatttaaa aagttttttt attaagatgg aaatcttgct 11341 atgttgccca ggctagtcgc aaacccctag cctcaagtga tcctctcgct tcagcctgga 11401 ttacaggcgt gagccactgt gtctggcctg ccttctcata ttattacaca agatgtttaa 11461 gaccacaaaa tacagtctgg tcctgccagc tagactgagt tactggaagg cagaaatcgt 11521 gttgccgtcc tgcacggccc aggcacagtg ctgggcacat ggggagggtg gtgtccctca 11581 cacatgtgct gcttgatgac agtagtggta gaggggtctg gagggtgagt tgcttccccc 11641 agctgcagaa ccatcatctg cacactcaga actagcttgt tgcctctgag gttctatttt 11701 atttcttcag tgagacacat catttctctg ttgggagttg ggtatagtca aaatcacctc 11761 ttcaaaaagc aactgttttc tcctttctcc tgacagctgt acctcccaca aggattaccc 11821 cttccatgaa gagttttgaa gctgtggttg cctgctcgtc cccaagtgac ctatacctgt 11881 gtttcttgcc tcattttttt ccttgcaaat gtagtatggc ctgtgtcact cagcagtggg 11941 acagcaacct gtagagtggc cagcgagggc gtgtctagct tgatgttgga tctcaagagc 12001 cctgtcagta gagtagaagt ctcttccagt ttgctttgcc cttctttcta ccctgctggg 12061 gaaagtacaa cctgaatacc cttttctgac caaagagaag caaaatctac caggtcaaaa 12121 tagtgccact aacggttgag ttttgactgc ttggaactgg aatcctttca gcaagacttc 12181 tctttgcctc aaataaaaag tgcttttgtg agcttggttt tgtgagcttt ggttttttaa 12241 aacaatagca accttctatc tcacttcaac cattcac //
GenBank-Updates@genbank.bio.net (05/10/91)
LOCUS HUMALRED1 2585 bp ds-DNA PRI 10-MAY-1991 DEFINITION Human aldose reductase (AR) gene, segment 1. ACCESSION M59856 KEYWORDS aldose reductase. SEGMENT 1 of 2 SOURCE Human DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 2585) AUTHORS Graham,A., Brown,L., Hedge,P.J., Gammack,A.J. and Markham,A.F. TITLE Structure of the Human aldose reductase gene JOURNAL J. Biol. Chem. 266, 6872-6877 (1991) STANDARD simple staff_entry FEATURES Location/Qualifiers exon 470..566 /number=1 /product="aldose reductase" /gene="AR" repeat_region 1557..1838 /note="Alu 'A'" repeat_region 2405..>2585 /note="Alu 'B'" BASE COUNT 617 a 653 c 698 g 617 t ORIGIN Map position: 7q35. 1 tggcatgcac ctttgtctaa gaacaaagtg cggtaaacta tatgtgtagt cagtatgatt 61 cacatagatt aaggacaagg tattcgtcag attcccaaag agcatcaaac tggggttgga 121 caacaaaggc attcttctgg gctcttaatg aaaccaaaac ttatttctag tctatgtatt 181 tatgggatgc ctgttatttt cgctaaagat tcgctttccc accagataca gcagctgagg 241 aactcctttc tgcagcgggg cgcgggcgag cgttgggggc ggaaagaatc cgctgccact 301 aggaccaggc ggaagaagca tccccgccga cccttgggga aggccgccgc ggcaccccag 361 cgcaaccaat cagaaggctc cttcgcgcac ggcgcgccaa ccgcaggcgc cctttctgcc 421 gacctcacgg gctatttaaa ggtacgcgcc gcggccaagg ccgcaccgta ctgggcgggg 481 gtctggggag cgcagcagcc atggcaagcc gtctcctgct caacaacggc gccaagatgc 541 ccatcctggg gttgggtacc tggaaggtag gtgctcgtgg gggcgcgggc ccggggctcg 601 cctcacactc tccgcgcggc ctgtattggc gagggacccc gagtgaccct gagcagctcg 661 ccccgcggac gccggcgtgc tgggagccac gcgcgggctt gcagggtccc cagcggctgg 721 gtcggccttg cagagaccgg gggccttggc tccccggttg gccctgggcg tcagggcagc 781 atcctgcgag tggggtttgg gagcagctca cgggagcccc cgccctaccg cggcaaccct 841 tgatgggcgg cccaccagtc cgcattttgg gtcctagcgg gcgccccaag cggcacaacg 901 cgagagggag gcggggaaag tgggcttcac agaccggtgg acctcgggcg cagacaggga 961 cgtggagccg tcggcaaggt gtgggagcgc agacccagcc tcctttccct cgaggcacct 1021 gtagcccggt tgcctcactt gtaaatagtt ggtctcaatc gtttcgattc ttgccctccc 1081 tgaggaataa gcatctcaag ccggtagagg gcagagaatt aggtggcgcg agtttgcccg 1141 gacccagctg ttaacaaggc gcagtgcgga cgtcctcggc caggcgccgc ctcggggtgc 1201 ctgggtctgg aactcgggag aaaaatctgg gcaccccgta gctagttgat aattcaggag 1261 gcgccaaggt tagcattttc cctgtaaaac ctcaacacca cacagcgtcc ccgagaagtg 1321 cctagccgga tgagaatgac aataggacac gaaacatcat aggatatgaa aaatgataat 1381 atgatatgaa aaaccaaaaa taatagcctg agcctgatta tctgaaaatt gagcaacaaa 1441 ggtggtggta tgggagctga ggcaaaacct agaattttta accttctaag tattgcatat 1501 tatattccac agccataacc tgggtttctc agtttctgtt tttgttgttt gcttgtttgt 1561 ttgtgacagg gtctcgttgc ccaagctggg gttgcagtgg caatcatggt tcattgcagc 1621 ctggaactcc tgggctcaag tgatcctcct gcctcagcac tgcgggtagc tgggactaca 1681 ggcgctcacc accacacctg gctaatcttt tttcttcccc gcagagacag tctccgcttg 1741 ttgcttaggg tgatctccaa ttcctgggct caaagcgctc ctcccacctc gcctcccaaa 1801 gctacaggtg tgaaccatct ggcaggccca cgtcccaggt ttttctctta aaatttgaat 1861 atgggcctgg gcgttggata tttacacaca gacaagggaa gaaaacaaca gaaagaactg 1921 agtgaactgt gagatgtttg aaataggaca gaagagttta catgtaccct aaaacctgct 1981 gttgaaaatt agtaaatata aggtaagaaa aaggtcattt gcatcaggga gagtgtttct 2041 tggccagaat gatcagggta cgtgatttgt ttcctccaaa aactccagtg gtgtctctaa 2101 ggttgtaatt gaattacaac catgacacca agctaatttc catctgttgg catgttatgc 2161 tcttggaatg gatgcagaag gatgctttct tggcaatagc aaatactttc taagcatgat 2221 gcaacgcaca gatatataca tgtaactgga ataaaaatta cttaacagta cttaacctat 2281 gtaggctgca tttcaatatt tttttctatt ccatttttcc aaaaattatt gtcatacctc 2341 cagaagctag ttttgtgacc catcatttga aaatcactac tctagggtaa ataaggagta 2401 aaagtttatt tttttttttt tgagacaggg gctcagtgtc acccaggctg gagtgcagtg 2461 gcatgatcat gattcactgt agccttaacc tcttgggctc aagtggtcct catacctcag 2521 cctcccaagt agctgggacc acaggtgtgt gccaccacac tcgggtagtt tgtttttaat 2581 ttttt //