GenBank-Updates@genbank.bio.net (03/28/91)
LOCUS HUMDES 11990 bp ds-DNA PRI 28-MAR-1991 DEFINITION Human desmin gene, complete cds. ACCESSION M63391 M58168 M59379 KEYWORDS Alu repetitive sequence; desmin. SOURCE Human DNA, clone pHuDes14, pHuDes1, pHuDes3, pHuDes10. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 3112 to 11990) AUTHORS Li,Z., Lilienbaum,A., Butler-Browne,G. and Paulin,D. TITLE Human desmin-coding gene: Complete nucleotide sequence, characterization and regulation of expression during myogenesis and development JOURNAL Gene 78, 243-254 (1989) STANDARD full staff_review REFERENCE 2 (bases 1 to 3280) AUTHORS Li,Z. and Paulin,D. TITLE High-level expression of desmin gene depends on a muscle-specific enhancer JOURNAL Unpublished (1990) STANDARD simple staff_entry COMMENT Draft entry and computer readable copy of sequence [Gene 78, 243-254 (1989)] kindly submitted by D.Paulin, 05-SEP-1989. FEATURES Location/Qualifiers CDS join(3278..3852,4905..4965,5062..5157,5306..5467, 5646..5771,6157..6377,8555..8598,10425..10507, 10692..10733) /note="desmin" /codon_start=3278 misc_signal 51..56 /note="TATA promoter (put.)" prim_transcript 86..>8351 /note="desmin mRNA and introns" exon 3278..3852 /note="desmin, exon 1 /nomgen='DES' /map='2' /hgml_locus_uid='LS0146T'" intron 3853..4904 /note="desmin, intron A" exon 4905..4965 /note="desmin, exon 2" intron 4966..5061 /note="desmin, intron B" exon 5062..5157 /note="desmin, exon 3" intron 5158..5305 /note="desmin, intron C" exon 5306..5467 /note="desmin, exon 4" intron 5468..5645 /note="desmin, intron D" exon 5646..5771 /note="desmin, exon 5" intron 5772..6156 /note="desmin, intron E" exon 6157..6377 /note="desmin, exon 6" intron 6378..8554 /note="desmin, intron F" repeat_region 6486..6780 /note="AluI repetitive sequence 1" repeat_region 7258..7751 /note="AluI repetitive sequence 2" repeat_region 8225..8515 /note="AluI repetitive sequence 3" exon 8555..8598 /note="desmin, exon 7" intron 8599..10424 /note="desmin, intron G" repeat_region 9683..9968 /note="AluI repetitive sequence 4" exon 10425..10507 /note="desmin, exon 8" intron 10508..10691 /note="desmin, intron H" exon 10692..10733 /note="desmin, exon 9" misc_signal 11458..11463 /note="poly-A signal" BASE COUNT 2734 a 3160 c 3331 g 2765 t ORIGIN 1 ctgcagatgg atggtgggga tagttgtaca acaatgtgaa tgtacttgac gccactgaac 61 tgtatactaa aaaatggctc aaatggtgaa ttttatttta tgtatatttt atcacaatgt 121 aaaagtgact cagctgtcaa tgtactaaaa tggaaccatc tctaacgtgt atgtcattga 181 aaaaagattg attcagaagt agggggctca cataagaaaa tgtggttgtg tgtacatgaa 241 tgtactctga aggaaccagt aacaaccaaa acctggttgt ctctgaagca gtgtttgggg 301 tggctgggtg tcaaaggggg aaggagactt acttttcatt ttatgccttt ttgcacatct 361 tgaattttgt accatataca ctacccatcc aaatcccttg tcggtatttt tagtgtgtcc 421 catccgagtg gtcctctcgg aggctgaact ctccctccag cggtgctgcc cagctcacag 481 catgttttgg agtgctcctc tttcacctgc cttccaagcc tcgggtgtga tttgcagccc 541 tccatggtag caaatcctca ggggcgaact gaattttgaa aacctcccaa gtggttcggg 601 ccaagtctgg tggttgttga ttttgactag agattagatg gcatgatatt tgtcttctgc 661 ctcttttcac caaggaactg aggacttggg ctggtccaaa ggccatttcc ttatgtggtc 721 tggagactat tcacagagaa gagctccaga aatgttgtcc cagtagcatc atagaaatag 781 gtgtagagtc cccttcagga agattaatct ggttctttgg gctgtaagtg atcaaagcaa 841 taccaaatgc cttaaattaa aaaaaaaaaa aaaaaaaaac ggaaagtttg ttgccaaggc 901 caggaaggac agtgtgggag ctcaactcac aaagttgagg gaagcactgc aggaaccaag 961 gggctggcct gctcctcctc tccagcctcc tctgcttctt acatattgac ctctctttct 1021 tcctactccc ccagggggca ggaaacatgg cttccacagg ttccagttga agaatcccag 1081 ttccgtctat aaattccagg gaaggtctct gattggccct actcattccc aggcccattc 1141 cttgacccag tcactgaagt cagggagatg cagtaataag actggctgga atcagggtct 1201 ttaggggtgg agggatgggg aggaggcaca gcatgtcatc aaaataagga aattgcaaaa 1261 gaaagcttgc aggctacttt gaatgacaat gagaaagacg gtgctgcctg agtgtgttaa 1321 ggatccacat ggtctccaaa atcctccagg agcatacagt ctagtctggg agatgagaca 1381 caaaaataac cagaacacaa cagcttgcac tgactcgagg gctggataag aatatctgga 1441 actcccccat ctatttcaga agcttgtctc ttggatgaaa attagacact taatgggaaa 1501 gggctttgaa aagagtgcag taacaaagcc ccctttacaa tttacccggc acattcacac 1561 ccatcctgag gccaaagcca caggctgtga ggtctcactg tctcagcttc ctgagctata 1621 aaatgggaat gatgctagtc tctacctcct agggttggag aattgggggt catgggtgtg 1681 aagtgctcag cagcttggcc cacactaggt ggtcagtaca tgtaaggtat tattgttgct 1741 acatacatta gtagggcctg ggcctcttta aacctttata gggtagcatg gcaaggctaa 1801 ccatcctcac tttatatctg acaagctggg gctcagagag gacgtgcctg agctggggct 1861 cagacaagga cacacctact agtaacccct ccagctggtg atggcaggtc tagggtagga 1921 ccagtgactg gctcctaatc gagcactcta ttttcaggtt tgcattgcaa aagggtcagt 1981 ccaagaggga cctggagagc caagtggagg tgtagagcac ggccagtacc catggagaat 2041 ggtggatgtc cttaggggtt agcaagtgcc gtgtgctaag gagggggctt tggaggttgg 2101 caggccctct gtggggctcc atttttgtgg gggtgggggc tggagcatta tagggggtgg 2161 gaagtgattg gggctgtcac cctagccttc cttatctgac gcccacccat gcctcctcag 2221 gtacccccct gcccccacag ctcctctcct gtgccttgtt tcccagccat gcgttctcct 2281 ctataaatac ccgctctggt atttggggtt ggcagctgtt gctgccaggg agatggttgg 2341 gttgacatgc ggctcctgac aaaacacaaa cccctggtgt gtgtgggcgt gggtggtgtg 2401 agtaggggga tgaatcaggg agggggcggg ggacccaggg ggcaggagcc acacaaagtc 2461 tgtgcggggg tgggagcgca catagcaatt ggaaactgaa agcttatcag accctttctg 2521 gaaatcagcc cactgtttat aaacttgagg ccccaccctc gacagtaccg gggaggaaga 2581 gggcctgcac tagtccagag ggaaactgag gctcagggcc agctcgccca tagacataca 2641 tggcagcttt ggccaggatc cctccgcctg ccaggctctc cctgccctcc cttcctgcct 2701 agagaccccc accctcaagc ctggctggtc tttgcctgag acccaaacct cttcgacttc 2761 aagagaatat ttaggaacaa ggtggtttag ggcctttcct gggaacaggc cttgaccctt 2821 taagaaatga cccaaagtct ctccttgacc aaaaagggga ccctcaaact aaagggaagc 2881 ctctcttctg ctgtctcccc tgaccccact cccccccacc ccaggacgag gagataacca 2941 gggctgaaag aggccgctgg gggctgcaga catgcttgct gcctgccctg gcgaaggatt 3001 ggtaggcttg ccgtcacagg acccccgctg gctgactcag gggcgcaggc tcttgcgggg 3061 gagctggcct cccgccccca cggccacggg ccctttcctg gcaggacagc gggatcttgc 3121 agctgtcagg ggaggggagg cgggggctga tgtcaggagg gatacaaata gtgccgacgg 3181 ctgggggccc tgtctcccct cgccgcatcc actctccggc cggccgcctg cccgccgcct 3241 cctccgtgcg cccgccagcc tcgcccgcgc cgtcaccatg agccaggcct actcgtccag 3301 ccagcgcgtg tcctcctacc gccgcacctt cggcggcgcc ccggtcttct cgctcggctc 3361 cccgctgagc tcgcccgtgt tcccgcgggc gcctttcggc tctaagggct cctccagctc 3421 ggtgacgtcc cgcgtgtacc aggtgtcgcg cacgtcggga ggggccgggg gcctggggtc 3481 gctgcgggcc agccggctgg ggaccacccg cacgccctcc tcctacggcg caggcgagct 3541 gctggacttc tcactggccg acgcggtgaa ccaggagttt ctgaccacgc gcaccaacga 3601 gaaggtggag ctgcaggagc tcaatgaccg ttcgccaatc tacatggaga aggtgcgctt 3661 cctggagcag cagaacgcgc tcgccgccga agtgaaccgg ctcaagggcc gcgagccgac 3721 gcgagtggcc gagctctacg aggaggagct gcgggagctg cggcgccagg tggaggtgct 3781 cactaaccag cgcgcgcgcg tcgacgtcga gcgcgacaac ctgctcgacg acctgcagcg 3841 gctcaaggcc aagtgagggc ccggcacccc agactcctct ttctgcgggc agggcacagg 3901 aggctaggcc tgggggctgg ggtcccgctg tcaccacctg ccttctcccg gggcccgacc 3961 gctcctcccc catgtggaga aagggtcctc cacctgtgtg tttcaagggg ccgtgacctc 4021 caggtctctc cccctgcgat cccatcttgc cacaggagtt ttcttgggga catagatcag 4081 ggggtggata tgggagaatt taggggaccc ggtgccctgt ggacagcccc gttaaaaagc 4141 attttaagat gctggggcga tatttatggg gtcaggtagt tgatgggcag aggaagggct 4201 gcaggaggcc cagagcgagt gtagccagag ggagaaggga ggctgatagg agacagggaa 4261 agcagggcaa gggccagagt ccaagcaaca gctctcagtc tcagcgttga tgaggccctg 4321 ggggaggtgg ggggaggggg gagcttggcc ctggggcttg ccgagactgt gtctttttac 4381 aaggtgaatg gacaggctgg agaaaaaggg agtaggtggg ggtcacagct ctcagagagc 4441 ttgggaggac ctgactgtag acttcaccag gctccaagaa cgaaaagggc agcaagtgta 4501 gcatatttcg ctctggtccc acttctgaca ggccaagtga gcacagtcac cctcctgcca 4561 ccaaagtcat aaatattaat tgagcagcta tatggccagg ctggagctgg gaaccagaaa 4621 cacagaggtg gataaaatag acacagtttc tagagaccca gggaggtcac acagtctggt 4681 ggggacatag acttcaaggg tgtggctcct gggcagagat tgggccactt cctctgccct 4741 ctctgggtgg gtggggcctc tccactccct gtctctcctg cctctaccca gcagccaggc 4801 cctccccctc tgtcctggac ccaccccctg gtcagccccg ccagtcgttt ccactgccag 4861 ctttatcacc cgcaactgtc tgtctttctg tctgtcccac ccaggctgca ggaggagatt 4921 cagttgaagg aagaagcaga gaacaatttg gctgccttcc gagcggtgag tgcccttctt 4981 ttccccttgc atggcctctc gcgtttgctc tgccccacct gggtcgcgga gaccatgtcc 5041 ttctcgcttg gcctctccca ggacgtggat gcagctactc tagctcgcat tgacctggag 5101 cgcagaattg aatctctcaa cgaggagatc gcgttcctta agaaagtgca tgaagaggta 5161 tacttggccc ctcttcctgg ggtcactggg ccattgggga aagcagccgg aaagtggggt 5221 ttggggtgag gctctggctg ggaatagggg tgtgagggtc gtgtgtgggc cctgagaggg 5281 actgaagccc agtcatgccc tacaggagat ccgtgagttg caggctcagc ttcaggaaca 5341 gcaggtccag gtggagatgg acatgtctaa gccagacctc actgccgccc tcagggatat 5401 ccgggctcag tatgagacca tcgcggctaa gaacatttct gaagctgagg agtggtacaa 5461 gtcgaaggtg ggtggcctcg cccggggact gggatctccg tccccctgga atcccaaggc 5521 ctttggattg ttgcttgcct gtggtaccat ccatgggagg agagcccaga ggttcatgct 5581 cccaagctca tccctacccg tgccctgcat ccttctcatt tttgggcccc tttctctgcc 5641 cttaggtgtc agacctgacc caggcagcca acaagaacaa cgacgccctg cgccaggcca 5701 agcaggagat gatggaatac cgacaccaga tccagtccta cacctgcgag attgacgccc 5761 tcaagggcac tgtgagtccc tgcccacctg ggccaggccc tgccccttct ctgtctgcag 5821 ttcacaccct cactttgtga ccttggccat catagatcct ctctggcctt catctactta 5881 aatctacaat agggtaaaac cagacaagtg gattccagtt ggatgctaag gaatcagggg 5941 ttcctgggca tctacctatg tggggacttg tgaggctgat gcaatgttcc tttgtatcta 6001 ttttattctg agtgttccac atatagctta atttgagttc agggttcaac atggccagga 6061 cctgaccatt ctggggttgc ctgccagccc caaagctttc tttgggctgc tagtgtcctc 6121 ttcccttcct tgacctgggt tccccctctc ctgcagaacg attccctgat gaggcagatg 6181 cgggaattgg aggaccgatt tgccagtgag gccagtggct accaggacaa cattgcacgc 6241 ctggaggagg aaatccggca cctcaaggat gagatggccc gccatctgcg cgagtaccag 6301 gacctgctca acgtgaagat ggccctggat gtggagattg ccacctaccg gaagctgctg 6361 gagggagagg agagccggtg aggggccagg caggagccga gtgggaggtg cggggtgctg 6421 ggtggtccat ttctgtcccc aggaggctcg agattactga ttacctcaac aagacctgga 6481 aacaattttt tttttttttg agatggagtt tcgctcttgt cgcccagtct ggagtgcaat 6541 ggcaccatct tggctcactg caacctccgc ctcctgggtt caagcaattc tcctgcctca 6601 gcttcccgag cagctgggat tacaggcgcc taccaccaca cctggctaat ttttgtattt 6661 ttagtagaga ggggtttcac tatgttgggc agctggtctc gaactcctga cctcaggtga 6721 tctgcctacc tcagcctcca aagtactggg attacaggcg tgcgccgcgc ccggcgtgga 6781 aacaatttta tacaagaggc cactgctcta taaccgcaga gaattaacca aggccacctg 6841 ggtaaaaagc aatttaatta acagcattta taaaaagaga aatataagta ttcccttatc 6901 caccttcaga attaagaacc agcagcaaaa aaaaccatat tcagcaacca ataataaaat 6961 attactgcca gtcaagggag agatgaaagc agaatgggga gtatgaggag ggaaacggag 7021 ggagcagata gaggcaaata gagagaggga gggagagacc ttcacaggga taggctaaga 7081 gaaggtaaag agatgcatac agaaggcatg agtttgcaca cacatgcaca catgtcagca 7141 tatcacatgt cggaggaaaa gacacagacg atatgctcag agcaacccac tctagacaca 7201 gaaacacata cactggaagg gacaccaggg aactgtcgga tacagaatgt ctatatcttt 7261 tttttttttt tttgagcaga gtctgctctg tacagccgct aggtagcgtg tgtatctccc 7321 tacactgcaa cctgctcctc ccaggctcaa gcgctctcct gtctcagcct ccctgtagct 7381 ggatacagga tcgacagtgc caacacactc agactcgatt ttttgtattt ttagtagaga 7441 tgaggtttca ccatgttggt caggctggac tctaactcct gacctcaagt aattcgcctg 7501 cctcagcctc ccaaagtgct gggattatag gcatgagcca ctgtgcctgg cctagaaatg 7561 ttctatatct tgatttggac tggtagttac acagacgtgg acattgatca aaactcattg 7621 aattgtacat taaagatctg tgcatttcac tgtatgtaaa tttaacctca atttaaaaca 7681 gatcagttac tccaaaaact ggtacccctt gatactcata aaaataacta tctgaaattt 7741 ttaaaaagga gcagacatgt ttagatacag gtacaaacat aaagagaaac ttcagatttt 7801 gtaaaatcac gtctacatat gatggccttt gaaggtagct aaaggcatgt tgcattttcc 7861 cagcattagg cctaaatagt aagctctcag aactggctgg ctggagggtg ggcatgagca 7921 atggatatca cccacagctg ctactagtac caacttcagt gccaggagca agaaggaaat 7981 cctggtgctc ttgagggtgc ggtggggttg cacatcctta gtgtcgcgca acgcagttca 8041 cagttgaaat aatgatcctt ccagaagaga ctatccctgg ggacagctct agctggcttc 8101 gaccccattc cttagcagta tgggtggtgg gagtgctggg gtcgtgggac tgggacagct 8161 gaggatggtg tttagaaagg accaggtgag ccttgatggg cgtgcaggga aagatcggga 8221 ggtctttttt ttttttttta gacagggctt gttctgtacc ccaggctgga gtgcagtggt 8281 gcaactccgc tcactgcaag ctccacctcc tgggttcgca ccattctcct gcctcaccct 8341 cctgagtatc tggaactaca ggtgcccgcc accatgcccg gctaattttt gtatttttag 8401 tagagacggg gtttcactgt gttagccagg atggtctcga tctcctgacc tggtgatccg 8461 cccgcctcgg ccttccaaag tgctgggatt acagctgggc ccggccgatg ggagggttct 8521 taactcttag gaggttttgt ctcttccctt ttaggatcaa tctccccatc cagacctact 8581 ctgccctcaa cttccgaggt gagtgtctgc tggaggcgga ggctggagtt gcaggggcca 8641 ggagtccagc atgggcactg cccaaggcca gccaggaggg aggatgggac cctggggcta 8701 gggacagacc tgagctaggg aagaaaaggg accactgcgg gtaggtcggg gagtttaggt 8761 agaggtggat gaggcaactt atgacagaga gagcttttta tgtgattata ttgtattgta 8821 tttaccatgt cccctgcacc ttcttggagt attgggcctc agaagcagcc tctgttctga 8881 atcccaaact catcccaaac tctgaaagca ggagtgtcct tggggccctg gcttcaggag 8941 catctcatac cacctgccct ctaagacacc cacagcccat tgtctgtttg gcacattgcc 9001 aagccccacc ttggctgctt gtcgaacacc tccagtttgt tggagcaaga tgttggatgc 9061 acgtttggaa aaaaatgcca aatcttagca aagccaaaca atgaaaagaa agagctctta 9121 gggcactctg ccattttgac attagtaata cgcagatcgg gtggctttcc aaccccagag 9181 agcagagaaa cacaggataa tgatgcatta ggaaagcaag tcggagtcct tggcagcttc 9241 tcctttccta gatcaaacct tttctatctt cgatgtacat ttccatcagg aaaaaaaacg 9301 cgctgcgtcc agcgagtcac aacattcatc acaggctggt tgctagctaa ggaaattcgt 9361 aagcaccaaa ctcataatac caaggacctc catttgacct ttcctacaca actcagagcc 9421 tctcttttca gttagttgtt tatacagaca ccaagtatga gtcttgcatt taaaacttca 9481 tagtacaaaa aactccaccc acattgcaca gtgcttttcc aaatcaatag ctttgtggcc 9541 atgataaggt tggtaccact tcactccgtg tcctcagtga ggaaactgag gcacagaatg 9601 gcaagtgact gagcatcagc acaatgagtc agtgccttat tcctgctctg tctcacttaa 9661 gacatcaagt tgctcatctg aatttttttt ttcttttgaa acggagtctc gctctgtcgc 9721 ccaggctgga gtgcagtggt gcaatctcgg ctcaccgcaa cctccgtcct cccaggttca 9781 agcaattctc ctgcctcagc ctcctgagta gctgggatta caggcatgtg caccagtccc 9841 cctaattttg tatttttagt agagacgggt tcacatgttg gtcagggtgg tctggaactc 9901 ctggtactca tgatccactg ccttggtcca aactactggc attacagatg tgaccaaccg 9961 cacctggccc tgaaatctta aagggagata ggtactgtaa ggtcctctaa agagtgtctt 10021 gagactgggc tttggggttc tatcttgaag aaggggagtc ccaggagaca aatgtgtgca 10081 gggctctcct ggggcctggg ggtggagagg aactaggagg gatggggaat gtcagtgctg 10141 tgcagcctgg gcctcaggtg tcccctaccc tcctgcacca tcctgcacat ggagcaaatc 10201 tgttggctcc tgagaccatc taaactatgg gacaggcgct gggggctgca gctgggtgct 10261 gggctgaagg aaaggtgtta aagtcttgaa gaagtaacaa gcctgtcttg agggggttgg 10321 ggtctgctag ggctctgcca atgtggcccc agatggactc ccagcccctg gtatagccca 10381 gcctggactt ggtcaggctg agtgtgcgat ggaccctgtt acagaaacca gccctgagca 10441 aaggggttct gaggtccata ccaagaagac ggtgatgatc aagaccatcg agacacggga 10501 tggggaggta agtggtctgt ctgggctcct tacccttggt tggggctatg gatgtgtctg 10561 gggggactgt cttccaccag ctgtgcaggt ctaggtcctg gctagtgggc aagagagatc 10621 ctgcgatcct gggtgggatg cctaggctga cgtcatcctg ctagcacatg tgactggact 10681 cctctcccca ggtcgtcagt gaggccacac agcagcagca tgaagtgctc taaagacgag 10741 agaccctctg ccaccagaga ccgtcctcac ccctgtcctc actgctccct gaagcccagc 10801 cttcttccga tcccaggaca ccacacccag cctcagtcct ccaaatcaca gcctctgacc 10861 cctcctcact ggccatccct cgtggtcccc aacagcgaca tagcccatcc ctgcctggtc 10921 acaggcatgc cccggccacc tctgcggacc ccagctgtga gccttggctg ttggcagtga 10981 gtgagcctgg ctcttgtgct ggatggagcc caggcgggag cggtggccct gtccctccca 11041 cctctgtgac ctcaggccta cgctttggct ctggagatag ccccagagca gggtgttggg 11101 atactgcagg gccaggactg agccccgcag acctccccag cccctagccc aggagagaga 11161 aagccaggca ggtagcctgg gggactagcc ctgtggagac tggggggctt gaaattgtcc 11221 ccgtggtctc ttactttcct ttccccagcc cagggtggac ttagaaagca ggggctacaa 11281 gagggaatcc ccgaaggtgc tggaggtggg agcaggagat tgagaaggag agaaagtggg 11341 tgagatgctg gagaagagag gagaggagag aggcagagag cggtctcagg ctggtgggag 11401 gggcgcccac ctccccacgc cctccccccc cctgctgcag gggctctgga gagaaacaat 11461 aaagagattc acacacaagc caagctggcc cctgttgtct tgactgccag gtctcctgtg 11521 ggtcccctgg ccggtgtgat acaacctgtc accctgagat ggactatact gaccttctac 11581 ccagccagac ttttcccagg gcctcgcgcc acttctgttc ccagagccac ctggccttga 11641 tgtctgtatg cagtgtatgg gggtggaggg gctggacagg gcttttgttg gggaaccaca 11701 aatacctctg cttaggcccc agttccagga ctgcacccct tgtgctctct actacacctt 11761 caggtcagcc aggctggggg acaccacctg ctattccttt tgaaggatgt acctgctccc 11821 cactgactgg ctctgaagta gggctccccc agtcccttct tcaaagatgc caagagcccc 11881 tttttttctc tctctctttt tttctttttg agatggagtc ttgctgtgtc acccaggctg 11941 gagtgcagca gtgtgatcac cgcttactgc agcctggact tcctgagctc //
GenBank-Updates@genbank.bio.net (05/15/91)
LOCUS HUMDES 11990 bp ds-DNA PRI 15-MAY-1991 DEFINITION Human desmin gene, complete cds. ACCESSION M63391 M26935 M58168 M59379 M65071 X53154 KEYWORDS Alu repetitive sequence; desmin. SOURCE Human DNA. ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 3112 to 11990) AUTHORS Li,Z., Lilienbaum,A., Butler-Browne,G. and Paulin,D. TITLE Human desmin-coding gene: Complete nucleotide sequence, characterization and regulation of expression during myogenesis and development JOURNAL Gene 78, 243-254 (1989) STANDARD full staff_review REFERENCE 2 (bases 1 to 3280) AUTHORS Li,Z. and Paulin,D. TITLE High level desmin expression depends on a muscle-specific enhancer JOURNAL J. Biol. Chem. 266, 6562-6570 (1991) STANDARD full staff_review COMMENT Draft entry and computer readable copy of sequence [Gene 78, 243-254 (1989)] kindly submitted by D.Paulin, 05-SEP-1989. The accession number M58186 is cited in reference J. Biol. Chem. 266, 6562- 6570 (1991). The correct accession number is M58168. FEATURES Location/Qualifiers mRNA join(3198..3852,4905..4965,5062..5157,5306..5467, 5646..5771,6157..6377,8555..8598,10425..10507, 10692..>11463) /product="desmin" CDS join(3278..3852,4905..4965,5062..5157,5306..5467, 5646..5771,6157..6377,8555..8598,10425..10507, 10692..10733) /product="desmin" /codon_start=3278 enhancer 2224..2500 misc_binding 3116..3129 /note="MEF1 binding site" TATA_signal 3163..3168 /note="putative" exon 3198..3852 /number=1 /product="desmin" intron 3853..4904 /number=1 /product="desmin" exon 4905..4965 /number=2 /product="desmin" intron 4966..5061 /number=2 /product="desmin" exon 5062..5157 /number=3 /product="desmin" intron 5158..5305 /number=3 /product="desmin" exon 5306..5467 /number=4 /product="desmin" intron 5468..5645 /number=4 /product="desmin" exon 5646..5771 /number=5 /product="desmin" intron 5772..6156 /number=5 /product="desmin" exon 6157..6377 /number=6 /product="desmin" intron 6378..8554 /number=6 /product="desmin" repeat_unit 6486..6780 /rpt_family="AluI" repeat_unit 7258..7751 /rpt_family="AluI" repeat_unit 8225..8515 /rpt_family="AluI" exon 8555..8598 /number=7 /product="desmin" intron 8599..10424 /number=7 /product="desmin" repeat_unit 9683..9968 /rpt_family="AluI" exon 10425..10507 /number=8 /product="desmin" intron 10508..10691 /number=8 /product="desmin" exon 10692..>11463 /number=9 /product="desmin" polyA_signal 11458..11463 BASE COUNT 2734 a 3160 c 3331 g 2765 t ORIGIN 1 ctgcagatgg atggtgggga tagttgtaca acaatgtgaa tgtacttgac gccactgaac 61 tgtatactaa aaaatggctc aaatggtgaa ttttatttta tgtatatttt atcacaatgt 121 aaaagtgact cagctgtcaa tgtactaaaa tggaaccatc tctaacgtgt atgtcattga 181 aaaaagattg attcagaagt agggggctca cataagaaaa tgtggttgtg tgtacatgaa 241 tgtactctga aggaaccagt aacaaccaaa acctggttgt ctctgaagca gtgtttgggg 301 tggctgggtg tcaaaggggg aaggagactt acttttcatt ttatgccttt ttgcacatct 361 tgaattttgt accatataca ctacccatcc aaatcccttg tcggtatttt tagtgtgtcc 421 catccgagtg gtcctctcgg aggctgaact ctccctccag cggtgctgcc cagctcacag 481 catgttttgg agtgctcctc tttcacctgc cttccaagcc tcgggtgtga tttgcagccc 541 tccatggtag caaatcctca ggggcgaact gaattttgaa aacctcccaa gtggttcggg 601 ccaagtctgg tggttgttga ttttgactag agattagatg gcatgatatt tgtcttctgc 661 ctcttttcac caaggaactg aggacttggg ctggtccaaa ggccatttcc ttatgtggtc 721 tggagactat tcacagagaa gagctccaga aatgttgtcc cagtagcatc atagaaatag 781 gtgtagagtc cccttcagga agattaatct ggttctttgg gctgtaagtg atcaaagcaa 841 taccaaatgc cttaaattaa aaaaaaaaaa aaaaaaaaac ggaaagtttg ttgccaaggc 901 caggaaggac agtgtgggag ctcaactcac aaagttgagg gaagcactgc aggaaccaag 961 gggctggcct gctcctcctc tccagcctcc tctgcttctt acatattgac ctctctttct 1021 tcctactccc ccagggggca ggaaacatgg cttccacagg ttccagttga agaatcccag 1081 ttccgtctat aaattccagg gaaggtctct gattggccct actcattccc aggcccattc 1141 cttgacccag tcactgaagt cagggagatg cagtaataag actggctgga atcagggtct 1201 ttaggggtgg agggatgggg aggaggcaca gcatgtcatc aaaataagga aattgcaaaa 1261 gaaagcttgc aggctacttt gaatgacaat gagaaagacg gtgctgcctg agtgtgttaa 1321 ggatccacat ggtctccaaa atcctccagg agcatacagt ctagtctggg agatgagaca 1381 caaaaataac cagaacacaa cagcttgcac tgactcgagg gctggataag aatatctgga 1441 actcccccat ctatttcaga agcttgtctc ttggatgaaa attagacact taatgggaaa 1501 gggctttgaa aagagtgcag taacaaagcc ccctttacaa tttacccggc acattcacac 1561 ccatcctgag gccaaagcca caggctgtga ggtctcactg tctcagcttc ctgagctata 1621 aaatgggaat gatgctagtc tctacctcct agggttggag aattgggggt catgggtgtg 1681 aagtgctcag cagcttggcc cacactaggt ggtcagtaca tgtaaggtat tattgttgct 1741 acatacatta gtagggcctg ggcctcttta aacctttata gggtagcatg gcaaggctaa 1801 ccatcctcac tttatatctg acaagctggg gctcagagag gacgtgcctg agctggggct 1861 cagacaagga cacacctact agtaacccct ccagctggtg atggcaggtc tagggtagga 1921 ccagtgactg gctcctaatc gagcactcta ttttcaggtt tgcattgcaa aagggtcagt 1981 ccaagaggga cctggagagc caagtggagg tgtagagcac ggccagtacc catggagaat 2041 ggtggatgtc cttaggggtt agcaagtgcc gtgtgctaag gagggggctt tggaggttgg 2101 caggccctct gtggggctcc atttttgtgg gggtgggggc tggagcatta tagggggtgg 2161 gaagtgattg gggctgtcac cctagccttc cttatctgac gcccacccat gcctcctcag 2221 gtacccccct gcccccacag ctcctctcct gtgccttgtt tcccagccat gcgttctcct 2281 ctataaatac ccgctctggt atttggggtt ggcagctgtt gctgccaggg agatggttgg 2341 gttgacatgc ggctcctgac aaaacacaaa cccctggtgt gtgtgggcgt gggtggtgtg 2401 agtaggggga tgaatcaggg agggggcggg ggacccaggg ggcaggagcc acacaaagtc 2461 tgtgcggggg tgggagcgca catagcaatt ggaaactgaa agcttatcag accctttctg 2521 gaaatcagcc cactgtttat aaacttgagg ccccaccctc gacagtaccg gggaggaaga 2581 gggcctgcac tagtccagag ggaaactgag gctcagggcc agctcgccca tagacataca 2641 tggcagcttt ggccaggatc cctccgcctg ccaggctctc cctgccctcc cttcctgcct 2701 agagaccccc accctcaagc ctggctggtc tttgcctgag acccaaacct cttcgacttc 2761 aagagaatat ttaggaacaa ggtggtttag ggcctttcct gggaacaggc cttgaccctt 2821 taagaaatga cccaaagtct ctccttgacc aaaaagggga ccctcaaact aaagggaagc 2881 ctctcttctg ctgtctcccc tgaccccact cccccccacc ccaggacgag gagataacca 2941 gggctgaaag aggccgctgg gggctgcaga catgcttgct gcctgccctg gcgaaggatt 3001 ggtaggcttg ccgtcacagg acccccgctg gctgactcag gggcgcaggc tcttgcgggg 3061 gagctggcct cccgccccca cggccacggg ccctttcctg gcaggacagc gggatcttgc 3121 agctgtcagg ggaggggagg cgggggctga tgtcaggagg gatacaaata gtgccgacgg 3181 ctgggggccc tgtctcccct cgccgcatcc actctccggc cggccgcctg cccgccgcct 3241 cctccgtgcg cccgccagcc tcgcccgcgc cgtcaccatg agccaggcct actcgtccag 3301 ccagcgcgtg tcctcctacc gccgcacctt cggcggcgcc ccggtcttct cgctcggctc 3361 cccgctgagc tcgcccgtgt tcccgcgggc gcctttcggc tctaagggct cctccagctc 3421 ggtgacgtcc cgcgtgtacc aggtgtcgcg cacgtcggga ggggccgggg gcctggggtc 3481 gctgcgggcc agccggctgg ggaccacccg cacgccctcc tcctacggcg caggcgagct 3541 gctggacttc tcactggccg acgcggtgaa ccaggagttt ctgaccacgc gcaccaacga 3601 gaaggtggag ctgcaggagc tcaatgaccg ttcgccaatc tacatggaga aggtgcgctt 3661 cctggagcag cagaacgcgc tcgccgccga agtgaaccgg ctcaagggcc gcgagccgac 3721 gcgagtggcc gagctctacg aggaggagct gcgggagctg cggcgccagg tggaggtgct 3781 cactaaccag cgcgcgcgcg tcgacgtcga gcgcgacaac ctgctcgacg acctgcagcg 3841 gctcaaggcc aagtgagggc ccggcacccc agactcctct ttctgcgggc agggcacagg 3901 aggctaggcc tgggggctgg ggtcccgctg tcaccacctg ccttctcccg gggcccgacc 3961 gctcctcccc catgtggaga aagggtcctc cacctgtgtg tttcaagggg ccgtgacctc 4021 caggtctctc cccctgcgat cccatcttgc cacaggagtt ttcttgggga catagatcag 4081 ggggtggata tgggagaatt taggggaccc ggtgccctgt ggacagcccc gttaaaaagc 4141 attttaagat gctggggcga tatttatggg gtcaggtagt tgatgggcag aggaagggct 4201 gcaggaggcc cagagcgagt gtagccagag ggagaaggga ggctgatagg agacagggaa 4261 agcagggcaa gggccagagt ccaagcaaca gctctcagtc tcagcgttga tgaggccctg 4321 ggggaggtgg ggggaggggg gagcttggcc ctggggcttg ccgagactgt gtctttttac 4381 aaggtgaatg gacaggctgg agaaaaaggg agtaggtggg ggtcacagct ctcagagagc 4441 ttgggaggac ctgactgtag acttcaccag gctccaagaa cgaaaagggc agcaagtgta 4501 gcatatttcg ctctggtccc acttctgaca ggccaagtga gcacagtcac cctcctgcca 4561 ccaaagtcat aaatattaat tgagcagcta tatggccagg ctggagctgg gaaccagaaa 4621 cacagaggtg gataaaatag acacagtttc tagagaccca gggaggtcac acagtctggt 4681 ggggacatag acttcaaggg tgtggctcct gggcagagat tgggccactt cctctgccct 4741 ctctgggtgg gtggggcctc tccactccct gtctctcctg cctctaccca gcagccaggc 4801 cctccccctc tgtcctggac ccaccccctg gtcagccccg ccagtcgttt ccactgccag 4861 ctttatcacc cgcaactgtc tgtctttctg tctgtcccac ccaggctgca ggaggagatt 4921 cagttgaagg aagaagcaga gaacaatttg gctgccttcc gagcggtgag tgcccttctt 4981 ttccccttgc atggcctctc gcgtttgctc tgccccacct gggtcgcgga gaccatgtcc 5041 ttctcgcttg gcctctccca ggacgtggat gcagctactc tagctcgcat tgacctggag 5101 cgcagaattg aatctctcaa cgaggagatc gcgttcctta agaaagtgca tgaagaggta 5161 tacttggccc ctcttcctgg ggtcactggg ccattgggga aagcagccgg aaagtggggt 5221 ttggggtgag gctctggctg ggaatagggg tgtgagggtc gtgtgtgggc cctgagaggg 5281 actgaagccc agtcatgccc tacaggagat ccgtgagttg caggctcagc ttcaggaaca 5341 gcaggtccag gtggagatgg acatgtctaa gccagacctc actgccgccc tcagggatat 5401 ccgggctcag tatgagacca tcgcggctaa gaacatttct gaagctgagg agtggtacaa 5461 gtcgaaggtg ggtggcctcg cccggggact gggatctccg tccccctgga atcccaaggc 5521 ctttggattg ttgcttgcct gtggtaccat ccatgggagg agagcccaga ggttcatgct 5581 cccaagctca tccctacccg tgccctgcat ccttctcatt tttgggcccc tttctctgcc 5641 cttaggtgtc agacctgacc caggcagcca acaagaacaa cgacgccctg cgccaggcca 5701 agcaggagat gatggaatac cgacaccaga tccagtccta cacctgcgag attgacgccc 5761 tcaagggcac tgtgagtccc tgcccacctg ggccaggccc tgccccttct ctgtctgcag 5821 ttcacaccct cactttgtga ccttggccat catagatcct ctctggcctt catctactta 5881 aatctacaat agggtaaaac cagacaagtg gattccagtt ggatgctaag gaatcagggg 5941 ttcctgggca tctacctatg tggggacttg tgaggctgat gcaatgttcc tttgtatcta 6001 ttttattctg agtgttccac atatagctta atttgagttc agggttcaac atggccagga 6061 cctgaccatt ctggggttgc ctgccagccc caaagctttc tttgggctgc tagtgtcctc 6121 ttcccttcct tgacctgggt tccccctctc ctgcagaacg attccctgat gaggcagatg 6181 cgggaattgg aggaccgatt tgccagtgag gccagtggct accaggacaa cattgcacgc 6241 ctggaggagg aaatccggca cctcaaggat gagatggccc gccatctgcg cgagtaccag 6301 gacctgctca acgtgaagat ggccctggat gtggagattg ccacctaccg gaagctgctg 6361 gagggagagg agagccggtg aggggccagg caggagccga gtgggaggtg cggggtgctg 6421 ggtggtccat ttctgtcccc aggaggctcg agattactga ttacctcaac aagacctgga 6481 aacaattttt tttttttttg agatggagtt tcgctcttgt cgcccagtct ggagtgcaat 6541 ggcaccatct tggctcactg caacctccgc ctcctgggtt caagcaattc tcctgcctca 6601 gcttcccgag cagctgggat tacaggcgcc taccaccaca cctggctaat ttttgtattt 6661 ttagtagaga ggggtttcac tatgttgggc agctggtctc gaactcctga cctcaggtga 6721 tctgcctacc tcagcctcca aagtactggg attacaggcg tgcgccgcgc ccggcgtgga 6781 aacaatttta tacaagaggc cactgctcta taaccgcaga gaattaacca aggccacctg 6841 ggtaaaaagc aatttaatta acagcattta taaaaagaga aatataagta ttcccttatc 6901 caccttcaga attaagaacc agcagcaaaa aaaaccatat tcagcaacca ataataaaat 6961 attactgcca gtcaagggag agatgaaagc agaatgggga gtatgaggag ggaaacggag 7021 ggagcagata gaggcaaata gagagaggga gggagagacc ttcacaggga taggctaaga 7081 gaaggtaaag agatgcatac agaaggcatg agtttgcaca cacatgcaca catgtcagca 7141 tatcacatgt cggaggaaaa gacacagacg atatgctcag agcaacccac tctagacaca 7201 gaaacacata cactggaagg gacaccaggg aactgtcgga tacagaatgt ctatatcttt 7261 tttttttttt tttgagcaga gtctgctctg tacagccgct aggtagcgtg tgtatctccc 7321 tacactgcaa cctgctcctc ccaggctcaa gcgctctcct gtctcagcct ccctgtagct 7381 ggatacagga tcgacagtgc caacacactc agactcgatt ttttgtattt ttagtagaga 7441 tgaggtttca ccatgttggt caggctggac tctaactcct gacctcaagt aattcgcctg 7501 cctcagcctc ccaaagtgct gggattatag gcatgagcca ctgtgcctgg cctagaaatg 7561 ttctatatct tgatttggac tggtagttac acagacgtgg acattgatca aaactcattg 7621 aattgtacat taaagatctg tgcatttcac tgtatgtaaa tttaacctca atttaaaaca 7681 gatcagttac tccaaaaact ggtacccctt gatactcata aaaataacta tctgaaattt 7741 ttaaaaagga gcagacatgt ttagatacag gtacaaacat aaagagaaac ttcagatttt 7801 gtaaaatcac gtctacatat gatggccttt gaaggtagct aaaggcatgt tgcattttcc 7861 cagcattagg cctaaatagt aagctctcag aactggctgg ctggagggtg ggcatgagca 7921 atggatatca cccacagctg ctactagtac caacttcagt gccaggagca agaaggaaat 7981 cctggtgctc ttgagggtgc ggtggggttg cacatcctta gtgtcgcgca acgcagttca 8041 cagttgaaat aatgatcctt ccagaagaga ctatccctgg ggacagctct agctggcttc 8101 gaccccattc cttagcagta tgggtggtgg gagtgctggg gtcgtgggac tgggacagct 8161 gaggatggtg tttagaaagg accaggtgag ccttgatggg cgtgcaggga aagatcggga 8221 ggtctttttt ttttttttta gacagggctt gttctgtacc ccaggctgga gtgcagtggt 8281 gcaactccgc tcactgcaag ctccacctcc tgggttcgca ccattctcct gcctcaccct 8341 cctgagtatc tggaactaca ggtgcccgcc accatgcccg gctaattttt gtatttttag 8401 tagagacggg gtttcactgt gttagccagg atggtctcga tctcctgacc tggtgatccg 8461 cccgcctcgg ccttccaaag tgctgggatt acagctgggc ccggccgatg ggagggttct 8521 taactcttag gaggttttgt ctcttccctt ttaggatcaa tctccccatc cagacctact 8581 ctgccctcaa cttccgaggt gagtgtctgc tggaggcgga ggctggagtt gcaggggcca 8641 ggagtccagc atgggcactg cccaaggcca gccaggaggg aggatgggac cctggggcta 8701 gggacagacc tgagctaggg aagaaaaggg accactgcgg gtaggtcggg gagtttaggt 8761 agaggtggat gaggcaactt atgacagaga gagcttttta tgtgattata ttgtattgta 8821 tttaccatgt cccctgcacc ttcttggagt attgggcctc agaagcagcc tctgttctga 8881 atcccaaact catcccaaac tctgaaagca ggagtgtcct tggggccctg gcttcaggag 8941 catctcatac cacctgccct ctaagacacc cacagcccat tgtctgtttg gcacattgcc 9001 aagccccacc ttggctgctt gtcgaacacc tccagtttgt tggagcaaga tgttggatgc 9061 acgtttggaa aaaaatgcca aatcttagca aagccaaaca atgaaaagaa agagctctta 9121 gggcactctg ccattttgac attagtaata cgcagatcgg gtggctttcc aaccccagag 9181 agcagagaaa cacaggataa tgatgcatta ggaaagcaag tcggagtcct tggcagcttc 9241 tcctttccta gatcaaacct tttctatctt cgatgtacat ttccatcagg aaaaaaaacg 9301 cgctgcgtcc agcgagtcac aacattcatc acaggctggt tgctagctaa ggaaattcgt 9361 aagcaccaaa ctcataatac caaggacctc catttgacct ttcctacaca actcagagcc 9421 tctcttttca gttagttgtt tatacagaca ccaagtatga gtcttgcatt taaaacttca 9481 tagtacaaaa aactccaccc acattgcaca gtgcttttcc aaatcaatag ctttgtggcc 9541 atgataaggt tggtaccact tcactccgtg tcctcagtga ggaaactgag gcacagaatg 9601 gcaagtgact gagcatcagc acaatgagtc agtgccttat tcctgctctg tctcacttaa 9661 gacatcaagt tgctcatctg aatttttttt ttcttttgaa acggagtctc gctctgtcgc 9721 ccaggctgga gtgcagtggt gcaatctcgg ctcaccgcaa cctccgtcct cccaggttca 9781 agcaattctc ctgcctcagc ctcctgagta gctgggatta caggcatgtg caccagtccc 9841 cctaattttg tatttttagt agagacgggt tcacatgttg gtcagggtgg tctggaactc 9901 ctggtactca tgatccactg ccttggtcca aactactggc attacagatg tgaccaaccg 9961 cacctggccc tgaaatctta aagggagata ggtactgtaa ggtcctctaa agagtgtctt 10021 gagactgggc tttggggttc tatcttgaag aaggggagtc ccaggagaca aatgtgtgca 10081 gggctctcct ggggcctggg ggtggagagg aactaggagg gatggggaat gtcagtgctg 10141 tgcagcctgg gcctcaggtg tcccctaccc tcctgcacca tcctgcacat ggagcaaatc 10201 tgttggctcc tgagaccatc taaactatgg gacaggcgct gggggctgca gctgggtgct 10261 gggctgaagg aaaggtgtta aagtcttgaa gaagtaacaa gcctgtcttg agggggttgg 10321 ggtctgctag ggctctgcca atgtggcccc agatggactc ccagcccctg gtatagccca 10381 gcctggactt ggtcaggctg agtgtgcgat ggaccctgtt acagaaacca gccctgagca 10441 aaggggttct gaggtccata ccaagaagac ggtgatgatc aagaccatcg agacacggga 10501 tggggaggta agtggtctgt ctgggctcct tacccttggt tggggctatg gatgtgtctg 10561 gggggactgt cttccaccag ctgtgcaggt ctaggtcctg gctagtgggc aagagagatc 10621 ctgcgatcct gggtgggatg cctaggctga cgtcatcctg ctagcacatg tgactggact 10681 cctctcccca ggtcgtcagt gaggccacac agcagcagca tgaagtgctc taaagacgag 10741 agaccctctg ccaccagaga ccgtcctcac ccctgtcctc actgctccct gaagcccagc 10801 cttcttccga tcccaggaca ccacacccag cctcagtcct ccaaatcaca gcctctgacc 10861 cctcctcact ggccatccct cgtggtcccc aacagcgaca tagcccatcc ctgcctggtc 10921 acaggcatgc cccggccacc tctgcggacc ccagctgtga gccttggctg ttggcagtga 10981 gtgagcctgg ctcttgtgct ggatggagcc caggcgggag cggtggccct gtccctccca 11041 cctctgtgac ctcaggccta cgctttggct ctggagatag ccccagagca gggtgttggg 11101 atactgcagg gccaggactg agccccgcag acctccccag cccctagccc aggagagaga 11161 aagccaggca ggtagcctgg gggactagcc ctgtggagac tggggggctt gaaattgtcc 11221 ccgtggtctc ttactttcct ttccccagcc cagggtggac ttagaaagca ggggctacaa 11281 gagggaatcc ccgaaggtgc tggaggtggg agcaggagat tgagaaggag agaaagtggg 11341 tgagatgctg gagaagagag gagaggagag aggcagagag cggtctcagg ctggtgggag 11401 gggcgcccac ctccccacgc cctccccccc cctgctgcag gggctctgga gagaaacaat 11461 aaagagattc acacacaagc caagctggcc cctgttgtct tgactgccag gtctcctgtg 11521 ggtcccctgg ccggtgtgat acaacctgtc accctgagat ggactatact gaccttctac 11581 ccagccagac ttttcccagg gcctcgcgcc acttctgttc ccagagccac ctggccttga 11641 tgtctgtatg cagtgtatgg gggtggaggg gctggacagg gcttttgttg gggaaccaca 11701 aatacctctg cttaggcccc agttccagga ctgcacccct tgtgctctct actacacctt 11761 caggtcagcc aggctggggg acaccacctg ctattccttt tgaaggatgt acctgctccc 11821 cactgactgg ctctgaagta gggctccccc agtcccttct tcaaagatgc caagagcccc 11881 tttttttctc tctctctttt tttctttttg agatggagtc ttgctgtgtc acccaggctg 11941 gagtgcagca gtgtgatcac cgcttactgc agcctggact tcctgagctc //