GenBank-Updates@genbank.bio.net (03/28/91)
LOCUS HUMDES 11990 bp ds-DNA PRI 28-MAR-1991
DEFINITION Human desmin gene, complete cds.
ACCESSION M63391 M58168 M59379
KEYWORDS Alu repetitive sequence; desmin.
SOURCE Human DNA, clone pHuDes14, pHuDes1, pHuDes3, pHuDes10.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 3112 to 11990)
AUTHORS Li,Z., Lilienbaum,A., Butler-Browne,G. and Paulin,D.
TITLE Human desmin-coding gene: Complete nucleotide sequence,
characterization and regulation of expression during myogenesis and
development
JOURNAL Gene 78, 243-254 (1989)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 3280)
AUTHORS Li,Z. and Paulin,D.
TITLE High-level expression of desmin gene depends on a muscle-specific
enhancer
JOURNAL Unpublished (1990)
STANDARD simple staff_entry
COMMENT Draft entry and computer readable copy of sequence [Gene 78,
243-254 (1989)] kindly
submitted by D.Paulin, 05-SEP-1989.
FEATURES Location/Qualifiers
CDS join(3278..3852,4905..4965,5062..5157,5306..5467,
5646..5771,6157..6377,8555..8598,10425..10507,
10692..10733)
/note="desmin"
/codon_start=3278
misc_signal 51..56
/note="TATA promoter (put.)"
prim_transcript 86..>8351
/note="desmin mRNA and introns"
exon 3278..3852
/note="desmin, exon 1 /nomgen='DES' /map='2'
/hgml_locus_uid='LS0146T'"
intron 3853..4904
/note="desmin, intron A"
exon 4905..4965
/note="desmin, exon 2"
intron 4966..5061
/note="desmin, intron B"
exon 5062..5157
/note="desmin, exon 3"
intron 5158..5305
/note="desmin, intron C"
exon 5306..5467
/note="desmin, exon 4"
intron 5468..5645
/note="desmin, intron D"
exon 5646..5771
/note="desmin, exon 5"
intron 5772..6156
/note="desmin, intron E"
exon 6157..6377
/note="desmin, exon 6"
intron 6378..8554
/note="desmin, intron F"
repeat_region 6486..6780
/note="AluI repetitive sequence 1"
repeat_region 7258..7751
/note="AluI repetitive sequence 2"
repeat_region 8225..8515
/note="AluI repetitive sequence 3"
exon 8555..8598
/note="desmin, exon 7"
intron 8599..10424
/note="desmin, intron G"
repeat_region 9683..9968
/note="AluI repetitive sequence 4"
exon 10425..10507
/note="desmin, exon 8"
intron 10508..10691
/note="desmin, intron H"
exon 10692..10733
/note="desmin, exon 9"
misc_signal 11458..11463
/note="poly-A signal"
BASE COUNT 2734 a 3160 c 3331 g 2765 t
ORIGIN
1 ctgcagatgg atggtgggga tagttgtaca acaatgtgaa tgtacttgac gccactgaac
61 tgtatactaa aaaatggctc aaatggtgaa ttttatttta tgtatatttt atcacaatgt
121 aaaagtgact cagctgtcaa tgtactaaaa tggaaccatc tctaacgtgt atgtcattga
181 aaaaagattg attcagaagt agggggctca cataagaaaa tgtggttgtg tgtacatgaa
241 tgtactctga aggaaccagt aacaaccaaa acctggttgt ctctgaagca gtgtttgggg
301 tggctgggtg tcaaaggggg aaggagactt acttttcatt ttatgccttt ttgcacatct
361 tgaattttgt accatataca ctacccatcc aaatcccttg tcggtatttt tagtgtgtcc
421 catccgagtg gtcctctcgg aggctgaact ctccctccag cggtgctgcc cagctcacag
481 catgttttgg agtgctcctc tttcacctgc cttccaagcc tcgggtgtga tttgcagccc
541 tccatggtag caaatcctca ggggcgaact gaattttgaa aacctcccaa gtggttcggg
601 ccaagtctgg tggttgttga ttttgactag agattagatg gcatgatatt tgtcttctgc
661 ctcttttcac caaggaactg aggacttggg ctggtccaaa ggccatttcc ttatgtggtc
721 tggagactat tcacagagaa gagctccaga aatgttgtcc cagtagcatc atagaaatag
781 gtgtagagtc cccttcagga agattaatct ggttctttgg gctgtaagtg atcaaagcaa
841 taccaaatgc cttaaattaa aaaaaaaaaa aaaaaaaaac ggaaagtttg ttgccaaggc
901 caggaaggac agtgtgggag ctcaactcac aaagttgagg gaagcactgc aggaaccaag
961 gggctggcct gctcctcctc tccagcctcc tctgcttctt acatattgac ctctctttct
1021 tcctactccc ccagggggca ggaaacatgg cttccacagg ttccagttga agaatcccag
1081 ttccgtctat aaattccagg gaaggtctct gattggccct actcattccc aggcccattc
1141 cttgacccag tcactgaagt cagggagatg cagtaataag actggctgga atcagggtct
1201 ttaggggtgg agggatgggg aggaggcaca gcatgtcatc aaaataagga aattgcaaaa
1261 gaaagcttgc aggctacttt gaatgacaat gagaaagacg gtgctgcctg agtgtgttaa
1321 ggatccacat ggtctccaaa atcctccagg agcatacagt ctagtctggg agatgagaca
1381 caaaaataac cagaacacaa cagcttgcac tgactcgagg gctggataag aatatctgga
1441 actcccccat ctatttcaga agcttgtctc ttggatgaaa attagacact taatgggaaa
1501 gggctttgaa aagagtgcag taacaaagcc ccctttacaa tttacccggc acattcacac
1561 ccatcctgag gccaaagcca caggctgtga ggtctcactg tctcagcttc ctgagctata
1621 aaatgggaat gatgctagtc tctacctcct agggttggag aattgggggt catgggtgtg
1681 aagtgctcag cagcttggcc cacactaggt ggtcagtaca tgtaaggtat tattgttgct
1741 acatacatta gtagggcctg ggcctcttta aacctttata gggtagcatg gcaaggctaa
1801 ccatcctcac tttatatctg acaagctggg gctcagagag gacgtgcctg agctggggct
1861 cagacaagga cacacctact agtaacccct ccagctggtg atggcaggtc tagggtagga
1921 ccagtgactg gctcctaatc gagcactcta ttttcaggtt tgcattgcaa aagggtcagt
1981 ccaagaggga cctggagagc caagtggagg tgtagagcac ggccagtacc catggagaat
2041 ggtggatgtc cttaggggtt agcaagtgcc gtgtgctaag gagggggctt tggaggttgg
2101 caggccctct gtggggctcc atttttgtgg gggtgggggc tggagcatta tagggggtgg
2161 gaagtgattg gggctgtcac cctagccttc cttatctgac gcccacccat gcctcctcag
2221 gtacccccct gcccccacag ctcctctcct gtgccttgtt tcccagccat gcgttctcct
2281 ctataaatac ccgctctggt atttggggtt ggcagctgtt gctgccaggg agatggttgg
2341 gttgacatgc ggctcctgac aaaacacaaa cccctggtgt gtgtgggcgt gggtggtgtg
2401 agtaggggga tgaatcaggg agggggcggg ggacccaggg ggcaggagcc acacaaagtc
2461 tgtgcggggg tgggagcgca catagcaatt ggaaactgaa agcttatcag accctttctg
2521 gaaatcagcc cactgtttat aaacttgagg ccccaccctc gacagtaccg gggaggaaga
2581 gggcctgcac tagtccagag ggaaactgag gctcagggcc agctcgccca tagacataca
2641 tggcagcttt ggccaggatc cctccgcctg ccaggctctc cctgccctcc cttcctgcct
2701 agagaccccc accctcaagc ctggctggtc tttgcctgag acccaaacct cttcgacttc
2761 aagagaatat ttaggaacaa ggtggtttag ggcctttcct gggaacaggc cttgaccctt
2821 taagaaatga cccaaagtct ctccttgacc aaaaagggga ccctcaaact aaagggaagc
2881 ctctcttctg ctgtctcccc tgaccccact cccccccacc ccaggacgag gagataacca
2941 gggctgaaag aggccgctgg gggctgcaga catgcttgct gcctgccctg gcgaaggatt
3001 ggtaggcttg ccgtcacagg acccccgctg gctgactcag gggcgcaggc tcttgcgggg
3061 gagctggcct cccgccccca cggccacggg ccctttcctg gcaggacagc gggatcttgc
3121 agctgtcagg ggaggggagg cgggggctga tgtcaggagg gatacaaata gtgccgacgg
3181 ctgggggccc tgtctcccct cgccgcatcc actctccggc cggccgcctg cccgccgcct
3241 cctccgtgcg cccgccagcc tcgcccgcgc cgtcaccatg agccaggcct actcgtccag
3301 ccagcgcgtg tcctcctacc gccgcacctt cggcggcgcc ccggtcttct cgctcggctc
3361 cccgctgagc tcgcccgtgt tcccgcgggc gcctttcggc tctaagggct cctccagctc
3421 ggtgacgtcc cgcgtgtacc aggtgtcgcg cacgtcggga ggggccgggg gcctggggtc
3481 gctgcgggcc agccggctgg ggaccacccg cacgccctcc tcctacggcg caggcgagct
3541 gctggacttc tcactggccg acgcggtgaa ccaggagttt ctgaccacgc gcaccaacga
3601 gaaggtggag ctgcaggagc tcaatgaccg ttcgccaatc tacatggaga aggtgcgctt
3661 cctggagcag cagaacgcgc tcgccgccga agtgaaccgg ctcaagggcc gcgagccgac
3721 gcgagtggcc gagctctacg aggaggagct gcgggagctg cggcgccagg tggaggtgct
3781 cactaaccag cgcgcgcgcg tcgacgtcga gcgcgacaac ctgctcgacg acctgcagcg
3841 gctcaaggcc aagtgagggc ccggcacccc agactcctct ttctgcgggc agggcacagg
3901 aggctaggcc tgggggctgg ggtcccgctg tcaccacctg ccttctcccg gggcccgacc
3961 gctcctcccc catgtggaga aagggtcctc cacctgtgtg tttcaagggg ccgtgacctc
4021 caggtctctc cccctgcgat cccatcttgc cacaggagtt ttcttgggga catagatcag
4081 ggggtggata tgggagaatt taggggaccc ggtgccctgt ggacagcccc gttaaaaagc
4141 attttaagat gctggggcga tatttatggg gtcaggtagt tgatgggcag aggaagggct
4201 gcaggaggcc cagagcgagt gtagccagag ggagaaggga ggctgatagg agacagggaa
4261 agcagggcaa gggccagagt ccaagcaaca gctctcagtc tcagcgttga tgaggccctg
4321 ggggaggtgg ggggaggggg gagcttggcc ctggggcttg ccgagactgt gtctttttac
4381 aaggtgaatg gacaggctgg agaaaaaggg agtaggtggg ggtcacagct ctcagagagc
4441 ttgggaggac ctgactgtag acttcaccag gctccaagaa cgaaaagggc agcaagtgta
4501 gcatatttcg ctctggtccc acttctgaca ggccaagtga gcacagtcac cctcctgcca
4561 ccaaagtcat aaatattaat tgagcagcta tatggccagg ctggagctgg gaaccagaaa
4621 cacagaggtg gataaaatag acacagtttc tagagaccca gggaggtcac acagtctggt
4681 ggggacatag acttcaaggg tgtggctcct gggcagagat tgggccactt cctctgccct
4741 ctctgggtgg gtggggcctc tccactccct gtctctcctg cctctaccca gcagccaggc
4801 cctccccctc tgtcctggac ccaccccctg gtcagccccg ccagtcgttt ccactgccag
4861 ctttatcacc cgcaactgtc tgtctttctg tctgtcccac ccaggctgca ggaggagatt
4921 cagttgaagg aagaagcaga gaacaatttg gctgccttcc gagcggtgag tgcccttctt
4981 ttccccttgc atggcctctc gcgtttgctc tgccccacct gggtcgcgga gaccatgtcc
5041 ttctcgcttg gcctctccca ggacgtggat gcagctactc tagctcgcat tgacctggag
5101 cgcagaattg aatctctcaa cgaggagatc gcgttcctta agaaagtgca tgaagaggta
5161 tacttggccc ctcttcctgg ggtcactggg ccattgggga aagcagccgg aaagtggggt
5221 ttggggtgag gctctggctg ggaatagggg tgtgagggtc gtgtgtgggc cctgagaggg
5281 actgaagccc agtcatgccc tacaggagat ccgtgagttg caggctcagc ttcaggaaca
5341 gcaggtccag gtggagatgg acatgtctaa gccagacctc actgccgccc tcagggatat
5401 ccgggctcag tatgagacca tcgcggctaa gaacatttct gaagctgagg agtggtacaa
5461 gtcgaaggtg ggtggcctcg cccggggact gggatctccg tccccctgga atcccaaggc
5521 ctttggattg ttgcttgcct gtggtaccat ccatgggagg agagcccaga ggttcatgct
5581 cccaagctca tccctacccg tgccctgcat ccttctcatt tttgggcccc tttctctgcc
5641 cttaggtgtc agacctgacc caggcagcca acaagaacaa cgacgccctg cgccaggcca
5701 agcaggagat gatggaatac cgacaccaga tccagtccta cacctgcgag attgacgccc
5761 tcaagggcac tgtgagtccc tgcccacctg ggccaggccc tgccccttct ctgtctgcag
5821 ttcacaccct cactttgtga ccttggccat catagatcct ctctggcctt catctactta
5881 aatctacaat agggtaaaac cagacaagtg gattccagtt ggatgctaag gaatcagggg
5941 ttcctgggca tctacctatg tggggacttg tgaggctgat gcaatgttcc tttgtatcta
6001 ttttattctg agtgttccac atatagctta atttgagttc agggttcaac atggccagga
6061 cctgaccatt ctggggttgc ctgccagccc caaagctttc tttgggctgc tagtgtcctc
6121 ttcccttcct tgacctgggt tccccctctc ctgcagaacg attccctgat gaggcagatg
6181 cgggaattgg aggaccgatt tgccagtgag gccagtggct accaggacaa cattgcacgc
6241 ctggaggagg aaatccggca cctcaaggat gagatggccc gccatctgcg cgagtaccag
6301 gacctgctca acgtgaagat ggccctggat gtggagattg ccacctaccg gaagctgctg
6361 gagggagagg agagccggtg aggggccagg caggagccga gtgggaggtg cggggtgctg
6421 ggtggtccat ttctgtcccc aggaggctcg agattactga ttacctcaac aagacctgga
6481 aacaattttt tttttttttg agatggagtt tcgctcttgt cgcccagtct ggagtgcaat
6541 ggcaccatct tggctcactg caacctccgc ctcctgggtt caagcaattc tcctgcctca
6601 gcttcccgag cagctgggat tacaggcgcc taccaccaca cctggctaat ttttgtattt
6661 ttagtagaga ggggtttcac tatgttgggc agctggtctc gaactcctga cctcaggtga
6721 tctgcctacc tcagcctcca aagtactggg attacaggcg tgcgccgcgc ccggcgtgga
6781 aacaatttta tacaagaggc cactgctcta taaccgcaga gaattaacca aggccacctg
6841 ggtaaaaagc aatttaatta acagcattta taaaaagaga aatataagta ttcccttatc
6901 caccttcaga attaagaacc agcagcaaaa aaaaccatat tcagcaacca ataataaaat
6961 attactgcca gtcaagggag agatgaaagc agaatgggga gtatgaggag ggaaacggag
7021 ggagcagata gaggcaaata gagagaggga gggagagacc ttcacaggga taggctaaga
7081 gaaggtaaag agatgcatac agaaggcatg agtttgcaca cacatgcaca catgtcagca
7141 tatcacatgt cggaggaaaa gacacagacg atatgctcag agcaacccac tctagacaca
7201 gaaacacata cactggaagg gacaccaggg aactgtcgga tacagaatgt ctatatcttt
7261 tttttttttt tttgagcaga gtctgctctg tacagccgct aggtagcgtg tgtatctccc
7321 tacactgcaa cctgctcctc ccaggctcaa gcgctctcct gtctcagcct ccctgtagct
7381 ggatacagga tcgacagtgc caacacactc agactcgatt ttttgtattt ttagtagaga
7441 tgaggtttca ccatgttggt caggctggac tctaactcct gacctcaagt aattcgcctg
7501 cctcagcctc ccaaagtgct gggattatag gcatgagcca ctgtgcctgg cctagaaatg
7561 ttctatatct tgatttggac tggtagttac acagacgtgg acattgatca aaactcattg
7621 aattgtacat taaagatctg tgcatttcac tgtatgtaaa tttaacctca atttaaaaca
7681 gatcagttac tccaaaaact ggtacccctt gatactcata aaaataacta tctgaaattt
7741 ttaaaaagga gcagacatgt ttagatacag gtacaaacat aaagagaaac ttcagatttt
7801 gtaaaatcac gtctacatat gatggccttt gaaggtagct aaaggcatgt tgcattttcc
7861 cagcattagg cctaaatagt aagctctcag aactggctgg ctggagggtg ggcatgagca
7921 atggatatca cccacagctg ctactagtac caacttcagt gccaggagca agaaggaaat
7981 cctggtgctc ttgagggtgc ggtggggttg cacatcctta gtgtcgcgca acgcagttca
8041 cagttgaaat aatgatcctt ccagaagaga ctatccctgg ggacagctct agctggcttc
8101 gaccccattc cttagcagta tgggtggtgg gagtgctggg gtcgtgggac tgggacagct
8161 gaggatggtg tttagaaagg accaggtgag ccttgatggg cgtgcaggga aagatcggga
8221 ggtctttttt ttttttttta gacagggctt gttctgtacc ccaggctgga gtgcagtggt
8281 gcaactccgc tcactgcaag ctccacctcc tgggttcgca ccattctcct gcctcaccct
8341 cctgagtatc tggaactaca ggtgcccgcc accatgcccg gctaattttt gtatttttag
8401 tagagacggg gtttcactgt gttagccagg atggtctcga tctcctgacc tggtgatccg
8461 cccgcctcgg ccttccaaag tgctgggatt acagctgggc ccggccgatg ggagggttct
8521 taactcttag gaggttttgt ctcttccctt ttaggatcaa tctccccatc cagacctact
8581 ctgccctcaa cttccgaggt gagtgtctgc tggaggcgga ggctggagtt gcaggggcca
8641 ggagtccagc atgggcactg cccaaggcca gccaggaggg aggatgggac cctggggcta
8701 gggacagacc tgagctaggg aagaaaaggg accactgcgg gtaggtcggg gagtttaggt
8761 agaggtggat gaggcaactt atgacagaga gagcttttta tgtgattata ttgtattgta
8821 tttaccatgt cccctgcacc ttcttggagt attgggcctc agaagcagcc tctgttctga
8881 atcccaaact catcccaaac tctgaaagca ggagtgtcct tggggccctg gcttcaggag
8941 catctcatac cacctgccct ctaagacacc cacagcccat tgtctgtttg gcacattgcc
9001 aagccccacc ttggctgctt gtcgaacacc tccagtttgt tggagcaaga tgttggatgc
9061 acgtttggaa aaaaatgcca aatcttagca aagccaaaca atgaaaagaa agagctctta
9121 gggcactctg ccattttgac attagtaata cgcagatcgg gtggctttcc aaccccagag
9181 agcagagaaa cacaggataa tgatgcatta ggaaagcaag tcggagtcct tggcagcttc
9241 tcctttccta gatcaaacct tttctatctt cgatgtacat ttccatcagg aaaaaaaacg
9301 cgctgcgtcc agcgagtcac aacattcatc acaggctggt tgctagctaa ggaaattcgt
9361 aagcaccaaa ctcataatac caaggacctc catttgacct ttcctacaca actcagagcc
9421 tctcttttca gttagttgtt tatacagaca ccaagtatga gtcttgcatt taaaacttca
9481 tagtacaaaa aactccaccc acattgcaca gtgcttttcc aaatcaatag ctttgtggcc
9541 atgataaggt tggtaccact tcactccgtg tcctcagtga ggaaactgag gcacagaatg
9601 gcaagtgact gagcatcagc acaatgagtc agtgccttat tcctgctctg tctcacttaa
9661 gacatcaagt tgctcatctg aatttttttt ttcttttgaa acggagtctc gctctgtcgc
9721 ccaggctgga gtgcagtggt gcaatctcgg ctcaccgcaa cctccgtcct cccaggttca
9781 agcaattctc ctgcctcagc ctcctgagta gctgggatta caggcatgtg caccagtccc
9841 cctaattttg tatttttagt agagacgggt tcacatgttg gtcagggtgg tctggaactc
9901 ctggtactca tgatccactg ccttggtcca aactactggc attacagatg tgaccaaccg
9961 cacctggccc tgaaatctta aagggagata ggtactgtaa ggtcctctaa agagtgtctt
10021 gagactgggc tttggggttc tatcttgaag aaggggagtc ccaggagaca aatgtgtgca
10081 gggctctcct ggggcctggg ggtggagagg aactaggagg gatggggaat gtcagtgctg
10141 tgcagcctgg gcctcaggtg tcccctaccc tcctgcacca tcctgcacat ggagcaaatc
10201 tgttggctcc tgagaccatc taaactatgg gacaggcgct gggggctgca gctgggtgct
10261 gggctgaagg aaaggtgtta aagtcttgaa gaagtaacaa gcctgtcttg agggggttgg
10321 ggtctgctag ggctctgcca atgtggcccc agatggactc ccagcccctg gtatagccca
10381 gcctggactt ggtcaggctg agtgtgcgat ggaccctgtt acagaaacca gccctgagca
10441 aaggggttct gaggtccata ccaagaagac ggtgatgatc aagaccatcg agacacggga
10501 tggggaggta agtggtctgt ctgggctcct tacccttggt tggggctatg gatgtgtctg
10561 gggggactgt cttccaccag ctgtgcaggt ctaggtcctg gctagtgggc aagagagatc
10621 ctgcgatcct gggtgggatg cctaggctga cgtcatcctg ctagcacatg tgactggact
10681 cctctcccca ggtcgtcagt gaggccacac agcagcagca tgaagtgctc taaagacgag
10741 agaccctctg ccaccagaga ccgtcctcac ccctgtcctc actgctccct gaagcccagc
10801 cttcttccga tcccaggaca ccacacccag cctcagtcct ccaaatcaca gcctctgacc
10861 cctcctcact ggccatccct cgtggtcccc aacagcgaca tagcccatcc ctgcctggtc
10921 acaggcatgc cccggccacc tctgcggacc ccagctgtga gccttggctg ttggcagtga
10981 gtgagcctgg ctcttgtgct ggatggagcc caggcgggag cggtggccct gtccctccca
11041 cctctgtgac ctcaggccta cgctttggct ctggagatag ccccagagca gggtgttggg
11101 atactgcagg gccaggactg agccccgcag acctccccag cccctagccc aggagagaga
11161 aagccaggca ggtagcctgg gggactagcc ctgtggagac tggggggctt gaaattgtcc
11221 ccgtggtctc ttactttcct ttccccagcc cagggtggac ttagaaagca ggggctacaa
11281 gagggaatcc ccgaaggtgc tggaggtggg agcaggagat tgagaaggag agaaagtggg
11341 tgagatgctg gagaagagag gagaggagag aggcagagag cggtctcagg ctggtgggag
11401 gggcgcccac ctccccacgc cctccccccc cctgctgcag gggctctgga gagaaacaat
11461 aaagagattc acacacaagc caagctggcc cctgttgtct tgactgccag gtctcctgtg
11521 ggtcccctgg ccggtgtgat acaacctgtc accctgagat ggactatact gaccttctac
11581 ccagccagac ttttcccagg gcctcgcgcc acttctgttc ccagagccac ctggccttga
11641 tgtctgtatg cagtgtatgg gggtggaggg gctggacagg gcttttgttg gggaaccaca
11701 aatacctctg cttaggcccc agttccagga ctgcacccct tgtgctctct actacacctt
11761 caggtcagcc aggctggggg acaccacctg ctattccttt tgaaggatgt acctgctccc
11821 cactgactgg ctctgaagta gggctccccc agtcccttct tcaaagatgc caagagcccc
11881 tttttttctc tctctctttt tttctttttg agatggagtc ttgctgtgtc acccaggctg
11941 gagtgcagca gtgtgatcac cgcttactgc agcctggact tcctgagctc
//GenBank-Updates@genbank.bio.net (05/15/91)
LOCUS HUMDES 11990 bp ds-DNA PRI 15-MAY-1991
DEFINITION Human desmin gene, complete cds.
ACCESSION M63391 M26935 M58168 M59379 M65071 X53154
KEYWORDS Alu repetitive sequence; desmin.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 3112 to 11990)
AUTHORS Li,Z., Lilienbaum,A., Butler-Browne,G. and Paulin,D.
TITLE Human desmin-coding gene: Complete nucleotide sequence,
characterization and regulation of expression during myogenesis and
development
JOURNAL Gene 78, 243-254 (1989)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 3280)
AUTHORS Li,Z. and Paulin,D.
TITLE High level desmin expression depends on a muscle-specific enhancer
JOURNAL J. Biol. Chem. 266, 6562-6570 (1991)
STANDARD full staff_review
COMMENT Draft entry and computer readable copy of sequence [Gene 78,
243-254 (1989)] kindly
submitted by D.Paulin, 05-SEP-1989.
The accession number M58186 is cited in reference J. Biol. Chem.
266, 6562- 6570 (1991). The correct accession number is M58168.
FEATURES Location/Qualifiers
mRNA join(3198..3852,4905..4965,5062..5157,5306..5467,
5646..5771,6157..6377,8555..8598,10425..10507,
10692..>11463)
/product="desmin"
CDS join(3278..3852,4905..4965,5062..5157,5306..5467,
5646..5771,6157..6377,8555..8598,10425..10507,
10692..10733)
/product="desmin"
/codon_start=3278
enhancer 2224..2500
misc_binding 3116..3129
/note="MEF1 binding site"
TATA_signal 3163..3168
/note="putative"
exon 3198..3852
/number=1
/product="desmin"
intron 3853..4904
/number=1
/product="desmin"
exon 4905..4965
/number=2
/product="desmin"
intron 4966..5061
/number=2
/product="desmin"
exon 5062..5157
/number=3
/product="desmin"
intron 5158..5305
/number=3
/product="desmin"
exon 5306..5467
/number=4
/product="desmin"
intron 5468..5645
/number=4
/product="desmin"
exon 5646..5771
/number=5
/product="desmin"
intron 5772..6156
/number=5
/product="desmin"
exon 6157..6377
/number=6
/product="desmin"
intron 6378..8554
/number=6
/product="desmin"
repeat_unit 6486..6780
/rpt_family="AluI"
repeat_unit 7258..7751
/rpt_family="AluI"
repeat_unit 8225..8515
/rpt_family="AluI"
exon 8555..8598
/number=7
/product="desmin"
intron 8599..10424
/number=7
/product="desmin"
repeat_unit 9683..9968
/rpt_family="AluI"
exon 10425..10507
/number=8
/product="desmin"
intron 10508..10691
/number=8
/product="desmin"
exon 10692..>11463
/number=9
/product="desmin"
polyA_signal 11458..11463
BASE COUNT 2734 a 3160 c 3331 g 2765 t
ORIGIN
1 ctgcagatgg atggtgggga tagttgtaca acaatgtgaa tgtacttgac gccactgaac
61 tgtatactaa aaaatggctc aaatggtgaa ttttatttta tgtatatttt atcacaatgt
121 aaaagtgact cagctgtcaa tgtactaaaa tggaaccatc tctaacgtgt atgtcattga
181 aaaaagattg attcagaagt agggggctca cataagaaaa tgtggttgtg tgtacatgaa
241 tgtactctga aggaaccagt aacaaccaaa acctggttgt ctctgaagca gtgtttgggg
301 tggctgggtg tcaaaggggg aaggagactt acttttcatt ttatgccttt ttgcacatct
361 tgaattttgt accatataca ctacccatcc aaatcccttg tcggtatttt tagtgtgtcc
421 catccgagtg gtcctctcgg aggctgaact ctccctccag cggtgctgcc cagctcacag
481 catgttttgg agtgctcctc tttcacctgc cttccaagcc tcgggtgtga tttgcagccc
541 tccatggtag caaatcctca ggggcgaact gaattttgaa aacctcccaa gtggttcggg
601 ccaagtctgg tggttgttga ttttgactag agattagatg gcatgatatt tgtcttctgc
661 ctcttttcac caaggaactg aggacttggg ctggtccaaa ggccatttcc ttatgtggtc
721 tggagactat tcacagagaa gagctccaga aatgttgtcc cagtagcatc atagaaatag
781 gtgtagagtc cccttcagga agattaatct ggttctttgg gctgtaagtg atcaaagcaa
841 taccaaatgc cttaaattaa aaaaaaaaaa aaaaaaaaac ggaaagtttg ttgccaaggc
901 caggaaggac agtgtgggag ctcaactcac aaagttgagg gaagcactgc aggaaccaag
961 gggctggcct gctcctcctc tccagcctcc tctgcttctt acatattgac ctctctttct
1021 tcctactccc ccagggggca ggaaacatgg cttccacagg ttccagttga agaatcccag
1081 ttccgtctat aaattccagg gaaggtctct gattggccct actcattccc aggcccattc
1141 cttgacccag tcactgaagt cagggagatg cagtaataag actggctgga atcagggtct
1201 ttaggggtgg agggatgggg aggaggcaca gcatgtcatc aaaataagga aattgcaaaa
1261 gaaagcttgc aggctacttt gaatgacaat gagaaagacg gtgctgcctg agtgtgttaa
1321 ggatccacat ggtctccaaa atcctccagg agcatacagt ctagtctggg agatgagaca
1381 caaaaataac cagaacacaa cagcttgcac tgactcgagg gctggataag aatatctgga
1441 actcccccat ctatttcaga agcttgtctc ttggatgaaa attagacact taatgggaaa
1501 gggctttgaa aagagtgcag taacaaagcc ccctttacaa tttacccggc acattcacac
1561 ccatcctgag gccaaagcca caggctgtga ggtctcactg tctcagcttc ctgagctata
1621 aaatgggaat gatgctagtc tctacctcct agggttggag aattgggggt catgggtgtg
1681 aagtgctcag cagcttggcc cacactaggt ggtcagtaca tgtaaggtat tattgttgct
1741 acatacatta gtagggcctg ggcctcttta aacctttata gggtagcatg gcaaggctaa
1801 ccatcctcac tttatatctg acaagctggg gctcagagag gacgtgcctg agctggggct
1861 cagacaagga cacacctact agtaacccct ccagctggtg atggcaggtc tagggtagga
1921 ccagtgactg gctcctaatc gagcactcta ttttcaggtt tgcattgcaa aagggtcagt
1981 ccaagaggga cctggagagc caagtggagg tgtagagcac ggccagtacc catggagaat
2041 ggtggatgtc cttaggggtt agcaagtgcc gtgtgctaag gagggggctt tggaggttgg
2101 caggccctct gtggggctcc atttttgtgg gggtgggggc tggagcatta tagggggtgg
2161 gaagtgattg gggctgtcac cctagccttc cttatctgac gcccacccat gcctcctcag
2221 gtacccccct gcccccacag ctcctctcct gtgccttgtt tcccagccat gcgttctcct
2281 ctataaatac ccgctctggt atttggggtt ggcagctgtt gctgccaggg agatggttgg
2341 gttgacatgc ggctcctgac aaaacacaaa cccctggtgt gtgtgggcgt gggtggtgtg
2401 agtaggggga tgaatcaggg agggggcggg ggacccaggg ggcaggagcc acacaaagtc
2461 tgtgcggggg tgggagcgca catagcaatt ggaaactgaa agcttatcag accctttctg
2521 gaaatcagcc cactgtttat aaacttgagg ccccaccctc gacagtaccg gggaggaaga
2581 gggcctgcac tagtccagag ggaaactgag gctcagggcc agctcgccca tagacataca
2641 tggcagcttt ggccaggatc cctccgcctg ccaggctctc cctgccctcc cttcctgcct
2701 agagaccccc accctcaagc ctggctggtc tttgcctgag acccaaacct cttcgacttc
2761 aagagaatat ttaggaacaa ggtggtttag ggcctttcct gggaacaggc cttgaccctt
2821 taagaaatga cccaaagtct ctccttgacc aaaaagggga ccctcaaact aaagggaagc
2881 ctctcttctg ctgtctcccc tgaccccact cccccccacc ccaggacgag gagataacca
2941 gggctgaaag aggccgctgg gggctgcaga catgcttgct gcctgccctg gcgaaggatt
3001 ggtaggcttg ccgtcacagg acccccgctg gctgactcag gggcgcaggc tcttgcgggg
3061 gagctggcct cccgccccca cggccacggg ccctttcctg gcaggacagc gggatcttgc
3121 agctgtcagg ggaggggagg cgggggctga tgtcaggagg gatacaaata gtgccgacgg
3181 ctgggggccc tgtctcccct cgccgcatcc actctccggc cggccgcctg cccgccgcct
3241 cctccgtgcg cccgccagcc tcgcccgcgc cgtcaccatg agccaggcct actcgtccag
3301 ccagcgcgtg tcctcctacc gccgcacctt cggcggcgcc ccggtcttct cgctcggctc
3361 cccgctgagc tcgcccgtgt tcccgcgggc gcctttcggc tctaagggct cctccagctc
3421 ggtgacgtcc cgcgtgtacc aggtgtcgcg cacgtcggga ggggccgggg gcctggggtc
3481 gctgcgggcc agccggctgg ggaccacccg cacgccctcc tcctacggcg caggcgagct
3541 gctggacttc tcactggccg acgcggtgaa ccaggagttt ctgaccacgc gcaccaacga
3601 gaaggtggag ctgcaggagc tcaatgaccg ttcgccaatc tacatggaga aggtgcgctt
3661 cctggagcag cagaacgcgc tcgccgccga agtgaaccgg ctcaagggcc gcgagccgac
3721 gcgagtggcc gagctctacg aggaggagct gcgggagctg cggcgccagg tggaggtgct
3781 cactaaccag cgcgcgcgcg tcgacgtcga gcgcgacaac ctgctcgacg acctgcagcg
3841 gctcaaggcc aagtgagggc ccggcacccc agactcctct ttctgcgggc agggcacagg
3901 aggctaggcc tgggggctgg ggtcccgctg tcaccacctg ccttctcccg gggcccgacc
3961 gctcctcccc catgtggaga aagggtcctc cacctgtgtg tttcaagggg ccgtgacctc
4021 caggtctctc cccctgcgat cccatcttgc cacaggagtt ttcttgggga catagatcag
4081 ggggtggata tgggagaatt taggggaccc ggtgccctgt ggacagcccc gttaaaaagc
4141 attttaagat gctggggcga tatttatggg gtcaggtagt tgatgggcag aggaagggct
4201 gcaggaggcc cagagcgagt gtagccagag ggagaaggga ggctgatagg agacagggaa
4261 agcagggcaa gggccagagt ccaagcaaca gctctcagtc tcagcgttga tgaggccctg
4321 ggggaggtgg ggggaggggg gagcttggcc ctggggcttg ccgagactgt gtctttttac
4381 aaggtgaatg gacaggctgg agaaaaaggg agtaggtggg ggtcacagct ctcagagagc
4441 ttgggaggac ctgactgtag acttcaccag gctccaagaa cgaaaagggc agcaagtgta
4501 gcatatttcg ctctggtccc acttctgaca ggccaagtga gcacagtcac cctcctgcca
4561 ccaaagtcat aaatattaat tgagcagcta tatggccagg ctggagctgg gaaccagaaa
4621 cacagaggtg gataaaatag acacagtttc tagagaccca gggaggtcac acagtctggt
4681 ggggacatag acttcaaggg tgtggctcct gggcagagat tgggccactt cctctgccct
4741 ctctgggtgg gtggggcctc tccactccct gtctctcctg cctctaccca gcagccaggc
4801 cctccccctc tgtcctggac ccaccccctg gtcagccccg ccagtcgttt ccactgccag
4861 ctttatcacc cgcaactgtc tgtctttctg tctgtcccac ccaggctgca ggaggagatt
4921 cagttgaagg aagaagcaga gaacaatttg gctgccttcc gagcggtgag tgcccttctt
4981 ttccccttgc atggcctctc gcgtttgctc tgccccacct gggtcgcgga gaccatgtcc
5041 ttctcgcttg gcctctccca ggacgtggat gcagctactc tagctcgcat tgacctggag
5101 cgcagaattg aatctctcaa cgaggagatc gcgttcctta agaaagtgca tgaagaggta
5161 tacttggccc ctcttcctgg ggtcactggg ccattgggga aagcagccgg aaagtggggt
5221 ttggggtgag gctctggctg ggaatagggg tgtgagggtc gtgtgtgggc cctgagaggg
5281 actgaagccc agtcatgccc tacaggagat ccgtgagttg caggctcagc ttcaggaaca
5341 gcaggtccag gtggagatgg acatgtctaa gccagacctc actgccgccc tcagggatat
5401 ccgggctcag tatgagacca tcgcggctaa gaacatttct gaagctgagg agtggtacaa
5461 gtcgaaggtg ggtggcctcg cccggggact gggatctccg tccccctgga atcccaaggc
5521 ctttggattg ttgcttgcct gtggtaccat ccatgggagg agagcccaga ggttcatgct
5581 cccaagctca tccctacccg tgccctgcat ccttctcatt tttgggcccc tttctctgcc
5641 cttaggtgtc agacctgacc caggcagcca acaagaacaa cgacgccctg cgccaggcca
5701 agcaggagat gatggaatac cgacaccaga tccagtccta cacctgcgag attgacgccc
5761 tcaagggcac tgtgagtccc tgcccacctg ggccaggccc tgccccttct ctgtctgcag
5821 ttcacaccct cactttgtga ccttggccat catagatcct ctctggcctt catctactta
5881 aatctacaat agggtaaaac cagacaagtg gattccagtt ggatgctaag gaatcagggg
5941 ttcctgggca tctacctatg tggggacttg tgaggctgat gcaatgttcc tttgtatcta
6001 ttttattctg agtgttccac atatagctta atttgagttc agggttcaac atggccagga
6061 cctgaccatt ctggggttgc ctgccagccc caaagctttc tttgggctgc tagtgtcctc
6121 ttcccttcct tgacctgggt tccccctctc ctgcagaacg attccctgat gaggcagatg
6181 cgggaattgg aggaccgatt tgccagtgag gccagtggct accaggacaa cattgcacgc
6241 ctggaggagg aaatccggca cctcaaggat gagatggccc gccatctgcg cgagtaccag
6301 gacctgctca acgtgaagat ggccctggat gtggagattg ccacctaccg gaagctgctg
6361 gagggagagg agagccggtg aggggccagg caggagccga gtgggaggtg cggggtgctg
6421 ggtggtccat ttctgtcccc aggaggctcg agattactga ttacctcaac aagacctgga
6481 aacaattttt tttttttttg agatggagtt tcgctcttgt cgcccagtct ggagtgcaat
6541 ggcaccatct tggctcactg caacctccgc ctcctgggtt caagcaattc tcctgcctca
6601 gcttcccgag cagctgggat tacaggcgcc taccaccaca cctggctaat ttttgtattt
6661 ttagtagaga ggggtttcac tatgttgggc agctggtctc gaactcctga cctcaggtga
6721 tctgcctacc tcagcctcca aagtactggg attacaggcg tgcgccgcgc ccggcgtgga
6781 aacaatttta tacaagaggc cactgctcta taaccgcaga gaattaacca aggccacctg
6841 ggtaaaaagc aatttaatta acagcattta taaaaagaga aatataagta ttcccttatc
6901 caccttcaga attaagaacc agcagcaaaa aaaaccatat tcagcaacca ataataaaat
6961 attactgcca gtcaagggag agatgaaagc agaatgggga gtatgaggag ggaaacggag
7021 ggagcagata gaggcaaata gagagaggga gggagagacc ttcacaggga taggctaaga
7081 gaaggtaaag agatgcatac agaaggcatg agtttgcaca cacatgcaca catgtcagca
7141 tatcacatgt cggaggaaaa gacacagacg atatgctcag agcaacccac tctagacaca
7201 gaaacacata cactggaagg gacaccaggg aactgtcgga tacagaatgt ctatatcttt
7261 tttttttttt tttgagcaga gtctgctctg tacagccgct aggtagcgtg tgtatctccc
7321 tacactgcaa cctgctcctc ccaggctcaa gcgctctcct gtctcagcct ccctgtagct
7381 ggatacagga tcgacagtgc caacacactc agactcgatt ttttgtattt ttagtagaga
7441 tgaggtttca ccatgttggt caggctggac tctaactcct gacctcaagt aattcgcctg
7501 cctcagcctc ccaaagtgct gggattatag gcatgagcca ctgtgcctgg cctagaaatg
7561 ttctatatct tgatttggac tggtagttac acagacgtgg acattgatca aaactcattg
7621 aattgtacat taaagatctg tgcatttcac tgtatgtaaa tttaacctca atttaaaaca
7681 gatcagttac tccaaaaact ggtacccctt gatactcata aaaataacta tctgaaattt
7741 ttaaaaagga gcagacatgt ttagatacag gtacaaacat aaagagaaac ttcagatttt
7801 gtaaaatcac gtctacatat gatggccttt gaaggtagct aaaggcatgt tgcattttcc
7861 cagcattagg cctaaatagt aagctctcag aactggctgg ctggagggtg ggcatgagca
7921 atggatatca cccacagctg ctactagtac caacttcagt gccaggagca agaaggaaat
7981 cctggtgctc ttgagggtgc ggtggggttg cacatcctta gtgtcgcgca acgcagttca
8041 cagttgaaat aatgatcctt ccagaagaga ctatccctgg ggacagctct agctggcttc
8101 gaccccattc cttagcagta tgggtggtgg gagtgctggg gtcgtgggac tgggacagct
8161 gaggatggtg tttagaaagg accaggtgag ccttgatggg cgtgcaggga aagatcggga
8221 ggtctttttt ttttttttta gacagggctt gttctgtacc ccaggctgga gtgcagtggt
8281 gcaactccgc tcactgcaag ctccacctcc tgggttcgca ccattctcct gcctcaccct
8341 cctgagtatc tggaactaca ggtgcccgcc accatgcccg gctaattttt gtatttttag
8401 tagagacggg gtttcactgt gttagccagg atggtctcga tctcctgacc tggtgatccg
8461 cccgcctcgg ccttccaaag tgctgggatt acagctgggc ccggccgatg ggagggttct
8521 taactcttag gaggttttgt ctcttccctt ttaggatcaa tctccccatc cagacctact
8581 ctgccctcaa cttccgaggt gagtgtctgc tggaggcgga ggctggagtt gcaggggcca
8641 ggagtccagc atgggcactg cccaaggcca gccaggaggg aggatgggac cctggggcta
8701 gggacagacc tgagctaggg aagaaaaggg accactgcgg gtaggtcggg gagtttaggt
8761 agaggtggat gaggcaactt atgacagaga gagcttttta tgtgattata ttgtattgta
8821 tttaccatgt cccctgcacc ttcttggagt attgggcctc agaagcagcc tctgttctga
8881 atcccaaact catcccaaac tctgaaagca ggagtgtcct tggggccctg gcttcaggag
8941 catctcatac cacctgccct ctaagacacc cacagcccat tgtctgtttg gcacattgcc
9001 aagccccacc ttggctgctt gtcgaacacc tccagtttgt tggagcaaga tgttggatgc
9061 acgtttggaa aaaaatgcca aatcttagca aagccaaaca atgaaaagaa agagctctta
9121 gggcactctg ccattttgac attagtaata cgcagatcgg gtggctttcc aaccccagag
9181 agcagagaaa cacaggataa tgatgcatta ggaaagcaag tcggagtcct tggcagcttc
9241 tcctttccta gatcaaacct tttctatctt cgatgtacat ttccatcagg aaaaaaaacg
9301 cgctgcgtcc agcgagtcac aacattcatc acaggctggt tgctagctaa ggaaattcgt
9361 aagcaccaaa ctcataatac caaggacctc catttgacct ttcctacaca actcagagcc
9421 tctcttttca gttagttgtt tatacagaca ccaagtatga gtcttgcatt taaaacttca
9481 tagtacaaaa aactccaccc acattgcaca gtgcttttcc aaatcaatag ctttgtggcc
9541 atgataaggt tggtaccact tcactccgtg tcctcagtga ggaaactgag gcacagaatg
9601 gcaagtgact gagcatcagc acaatgagtc agtgccttat tcctgctctg tctcacttaa
9661 gacatcaagt tgctcatctg aatttttttt ttcttttgaa acggagtctc gctctgtcgc
9721 ccaggctgga gtgcagtggt gcaatctcgg ctcaccgcaa cctccgtcct cccaggttca
9781 agcaattctc ctgcctcagc ctcctgagta gctgggatta caggcatgtg caccagtccc
9841 cctaattttg tatttttagt agagacgggt tcacatgttg gtcagggtgg tctggaactc
9901 ctggtactca tgatccactg ccttggtcca aactactggc attacagatg tgaccaaccg
9961 cacctggccc tgaaatctta aagggagata ggtactgtaa ggtcctctaa agagtgtctt
10021 gagactgggc tttggggttc tatcttgaag aaggggagtc ccaggagaca aatgtgtgca
10081 gggctctcct ggggcctggg ggtggagagg aactaggagg gatggggaat gtcagtgctg
10141 tgcagcctgg gcctcaggtg tcccctaccc tcctgcacca tcctgcacat ggagcaaatc
10201 tgttggctcc tgagaccatc taaactatgg gacaggcgct gggggctgca gctgggtgct
10261 gggctgaagg aaaggtgtta aagtcttgaa gaagtaacaa gcctgtcttg agggggttgg
10321 ggtctgctag ggctctgcca atgtggcccc agatggactc ccagcccctg gtatagccca
10381 gcctggactt ggtcaggctg agtgtgcgat ggaccctgtt acagaaacca gccctgagca
10441 aaggggttct gaggtccata ccaagaagac ggtgatgatc aagaccatcg agacacggga
10501 tggggaggta agtggtctgt ctgggctcct tacccttggt tggggctatg gatgtgtctg
10561 gggggactgt cttccaccag ctgtgcaggt ctaggtcctg gctagtgggc aagagagatc
10621 ctgcgatcct gggtgggatg cctaggctga cgtcatcctg ctagcacatg tgactggact
10681 cctctcccca ggtcgtcagt gaggccacac agcagcagca tgaagtgctc taaagacgag
10741 agaccctctg ccaccagaga ccgtcctcac ccctgtcctc actgctccct gaagcccagc
10801 cttcttccga tcccaggaca ccacacccag cctcagtcct ccaaatcaca gcctctgacc
10861 cctcctcact ggccatccct cgtggtcccc aacagcgaca tagcccatcc ctgcctggtc
10921 acaggcatgc cccggccacc tctgcggacc ccagctgtga gccttggctg ttggcagtga
10981 gtgagcctgg ctcttgtgct ggatggagcc caggcgggag cggtggccct gtccctccca
11041 cctctgtgac ctcaggccta cgctttggct ctggagatag ccccagagca gggtgttggg
11101 atactgcagg gccaggactg agccccgcag acctccccag cccctagccc aggagagaga
11161 aagccaggca ggtagcctgg gggactagcc ctgtggagac tggggggctt gaaattgtcc
11221 ccgtggtctc ttactttcct ttccccagcc cagggtggac ttagaaagca ggggctacaa
11281 gagggaatcc ccgaaggtgc tggaggtggg agcaggagat tgagaaggag agaaagtggg
11341 tgagatgctg gagaagagag gagaggagag aggcagagag cggtctcagg ctggtgggag
11401 gggcgcccac ctccccacgc cctccccccc cctgctgcag gggctctgga gagaaacaat
11461 aaagagattc acacacaagc caagctggcc cctgttgtct tgactgccag gtctcctgtg
11521 ggtcccctgg ccggtgtgat acaacctgtc accctgagat ggactatact gaccttctac
11581 ccagccagac ttttcccagg gcctcgcgcc acttctgttc ccagagccac ctggccttga
11641 tgtctgtatg cagtgtatgg gggtggaggg gctggacagg gcttttgttg gggaaccaca
11701 aatacctctg cttaggcccc agttccagga ctgcacccct tgtgctctct actacacctt
11761 caggtcagcc aggctggggg acaccacctg ctattccttt tgaaggatgt acctgctccc
11821 cactgactgg ctctgaagta gggctccccc agtcccttct tcaaagatgc caagagcccc
11881 tttttttctc tctctctttt tttctttttg agatggagtc ttgctgtgtc acccaggctg
11941 gagtgcagca gtgtgatcac cgcttactgc agcctggact tcctgagctc
//