GenBank-Updates@genbank.bio.net (05/15/91)
LOCUS HUMMCM 2798 bp ss-mRNA PRI 15-MAY-1991
DEFINITION Human methylmalonyl-CoA mutase (MCM) mRNA, complete cds.
ACCESSION M65131 M22990 M65022
KEYWORDS L-methylmalonyl-CoA mutase; adenosylcobalamin cofactor;
methymalonyl CoA mutase.
SOURCE Human liver, cDNA to mRNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2798)
AUTHORS Jansen,R., Kalousek,F., Fenton,W.A., Rosenberg,L.E. and Ledley,F.D.
TITLE Cloning of full-length methylmalonyl-CoA mutase from a cDNA library
using the polymerase chain reaction
JOURNAL Genomics 4, 198-205 (1989)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 2798)
AUTHORS Andrews,E., Crane,A.M., Jansen,R. and Ledley,F.D.
TITLE Biochemical characteristics of recombinant human methylmalonyl CoA
mutase expressed in S. cerevisiae
JOURNAL Unpublished (1991)
STANDARD full staff_entry
COMMENT Draft entry and computer-readable sequence for [Genomics 4, 198-205
(1989)] kindly submitted
by F.D.Ledley, 17-MAR-1989.
FEATURES Location/Qualifiers
mRNA 1..2770
/gene="MCM"
sig_peptide 77..172
/note="mitochondrial leader"
/gene="MCM"
/codon_start=77
CDS 77..2329
/EC_number="5.4.99.2"
/product="methylmalonyl-CoA mutase"
/gene="MCM"
/codon_start=77
mat_peptide 173..2326
/EC_number="5.4.99.2"
/product="methylmalonyl-CoA mutase"
/gene="MCM"
/codon_start=173
BASE COUNT 886 a 526 c 591 g 795 t
ORIGIN 374 bp upstream of AccI site.
1 gccctctccc acagcggagt ccaaaacagg cctaccagtc agttcttatt tctattgggt
61 gtttccatgc tccaccatgt taagagctaa gaatcagctt tttttacttt cacctcatta
121 cctgaggcag gtaaaagaat catcaggctc caggctcata cagcaacgac ttctacacca
181 gcaacagccc cttcacccag aatgggctgc cctggctaaa aagcagctga aaggcaaaaa
241 cccagaagac ctaatatggc acaccccgga agggatctct ataaaaccct tgtattccaa
301 gagagatact atggacttac ctgaagaact tccaggagtg aagccattca cacgtggacc
361 atatcctacc atgtatacct ttaggccctg gaccatccgc cagtatgctg gttttagtac
421 tgtggaagaa agcaataagt tctataagga caacattaag gctggtcagc agggattatc
481 agttgccttt gatctggcga cacatcgtgg ctatgattca gacaaccctc gagttcgtgg
541 tgatgttgga atggctggag ttgctattga cactgtggaa gataccaaaa ttctttttga
601 tggaattcct ttagaaaaaa tgtcagtttc catgactatg aatggagcag ttattccagt
661 tcttgcaaat tttatagtaa ctggagaaga acaaggtgta cctaaagaga aacttactgg
721 taccatccaa aatgatatac taaaggaatt tatggttcga aatacataca tttttcctcc
781 agaaccatcc atgaaaatta ttgctgacat atttgaatat acagcaaagc acatgccaaa
841 atttaattca atttcaatta gtggatacca tatgcaggaa gcaggggctg atgccattct
901 ggagctggcc tatactttag cagatggatt ggagtactct agaactggac tccaggctgg
961 cctgacaatt gatgaatttg caccaaggtt gtctttcttc tggggaattg gaatgaattt
1021 ctatatggaa atagcaaaga tgagagctgg tagaagactc tgggctcact taatagagaa
1081 aatgtttcag cctaaaaact caaaatctct tcttctaaga gcacactgtc agacatctgg
1141 atggtcactt actgagcagg atccctacaa taatattgtc cgtactgcaa tagaagcaat
1201 ggcagcagta tttggaggga ctcagtcttt gcacacaaat tcttttgatg aagctttggg
1261 tttgccaact gtgaaaagtg ctcgaattgc caggaacaca caaatcatca ttcaagaaga
1321 atctgggatt cccaaagtgg ctgatccttg gggaggttct tacatgatgg aatgtctcac
1381 aaatgatgtt tatgatgctg ctttaaagct cattaatgaa attgaagaaa tgggtggaat
1441 ggccaaagct gtagctgagg gaatacctaa acttcgaatt gaagaatgtg ctgcccgaag
1501 acaagctaga atagattctg gttctgaagt aattgttgga gtaaataagt accagttgga
1561 aaaagaagac gctgtagaag ttctggcaat tgataatact tcagtgcgaa acaggcagat
1621 tgaaaaactt aagaagatca aatccagcag ggatcaagct ttggctgaac attgtcttgc
1681 tgcactaacc gaatgtgctg ctagcggaga tggaaatatc ctggctcttg cagtggatgc
1741 atctcgggca agatgtacag tgggagaaat cacagatgcc ctgaaaaagg tatttggtga
1801 acataaagcg aatgatcgaa tggtgagtgg agcatatcgc caggaatttg gagaaagtaa
1861 agagataaca tctgctatca agagggttca taaattcatg gaacgtgaag gtcgcagacc
1921 tcgtcttctt gtagcaaaaa tgggacaaga tggccatgac agaggagcaa aagttattgc
1981 tacaggattt gctgatcttg gttttgatgt ggacataggc cctcttttcc agactcctcg
2041 tgaagtggcc cagcaggctg tggatgcgga tgtgcatgct gtgggcgtaa gcaccctcgc
2101 tgctggtcat aaaaccctag ttcctgaact catcaaagaa cttaactccc ttggacggcc
2161 agatattctt gtcatgtgtg gaggggtgat accacctcag gattatgaat ttctgtttga
2221 agttggtgtt tccaatgtat ttggtcctgg gactcgaatt ccaaaggctg ccgttcaggt
2281 gcttgatgat attgagaagt gtttggaaaa gaagcagcaa tctgtataat atcctctttt
2341 tgttttagct tttgtctaaa atattatttt agttatgatc aaagaagaga gtaaagctat
2401 gtcttcaatt taatttcaat acctgatttg tactttcctt gaaagcttta ctttaaaata
2461 ccttacttat aggcctggtg tcatgctata agtatgtaca tacagtttca cttcaaaaat
2521 aaaaaaaaat ccctaaaaac tctctatact ctctataaca atactttatc aagaactctg
2581 gacaatggta ttatttttaa aaatcatggt gatgtattta ttagaatgtt tcttataaat
2641 ctctttcatt tttatattaa gaattaaact gtacctaaaa aaactctgac tattcccatt
2701 tctcagttta gcattacatt gtcttgagca ccagaaaata aaatccatat attaattaaa
2761 acctatcttg aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//