GenBank-Updates@genbank.bio.net (05/16/91)
LOCUS MUSTIMPA 1011 bp ds-DNA ROD 16-MAY-1991
DEFINITION Mouse tissue inhibitor of metalloproteinases (TIMP) gene, exon 2
partial cds.
ACCESSION M21162 M65031
KEYWORDS tissue inhibitor of metalloproteinases.
SOURCE Mouse (strain DBA-2) DNA (lambda-G3/10C-21b library), clone
pG3/10-H4.3.
ORGANISM Mus musculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Rodentia; Myomorpha; Muridae; Murinae.
REFERENCE 1 (bases 1 to 1011)
AUTHORS Coulombe,B., Ponton,A., Daigneault,L., Williams,B.R.G. and Skup,D.
TITLE Presence of transcription regulatory elements within an intron of
the virus-inducible murine TIMP gene
JOURNAL Mol. Cell. Biol. 8, 3227-3234 (1988)
STANDARD full staff_entry
REFERENCE 2 (sites)
AUTHORS Campbell,C.E., Flenniken,A.M., Skup,D. and Williams,B.R.G.
TITLE Identification of a serum- and phorbol ester-responsive element in
the murine tissue inhibitor of metalloproteinase gene
JOURNAL J. Biol. Chem. 266, 7199-7206 (1991)
STANDARD full staff_review
COMMENT Draft entry and computer-readable sequence [1] kindly submitted by
B.Coulombe (10-28-88).
FEATURES Location/Qualifiers
prim_transcript 276..>1011
/note="TIMP mRNA and introns"
intron 299..997
/note="TIMP, intron A"
/gene="TIMP"
CDS 1006..>1011
/product="metalloproteinase tissue inhibitor"
/gene="TIMP"
/codon_start=1006
BASE COUNT 230 a 306 c 211 g 264 t
ORIGIN 1 bp upstream of HindIII site.
1 aagctttagg cgctctctct cttctgccct tcaaggccgc caggaggact gtgcatgacg
61 tggagctggg ggaagggggc gcagtgggct ggctggcaga ggagggagta tctttgggtt
121 tatcctgggg cccgccccta ggctttgact ccagcggtgg gtggatgagt aatgcgtcca
181 ggaagcctgg aggcagtgat ttccccgcca actccgccct tcgcatggac atttattctc
241 cactgtgcag cccctgccgc catcatcgca gatcggggct cctagagaca caccagaggt
301 aagtgggagc cgggtgtccg gcagaactgg ggcttgcctg gagcctgtgt tggtgcggct
361 catgcagccc ttgccagact ttctgctcac gtggcttgca ggtatcagga tccctagtta
421 gctaaagagg aatataacgg gagagggcct ggaatgatcg tcccaagctg gactctccag
481 actccttcat gcctttgcta agtgctccaa acccacagcc tttaatacct tgaagacttc
541 ccaacttgcc tgccctcaat ccttatggtt cctggtaact cccctgttct ctttgccatg
601 tctggttcat ggaactcaac attcttctgc ctacaaattc ctaagcatta ccattgtcgt
661 aaacctccaa attcccaaga cccttaaccc ccattttctc cagctcccta aaacccaaac
721 ctttctaacc ccccaatatc tctgaaatcc tcagcccatt atattttaat agccctaatt
781 cctcattata tttctccagt ttcccaaact ccaaattcat cactacacaa attcctaatt
841 tcccaattct gttaaattcc tcaacgtttc cgctccctta ttcaccaact gccacaaact
901 ccaattctct aacctaaaga ggtcccaaat ctcccaagga ccaatggcca tggtaagccg
961 ttggtctggg aacctattaa cacctactct ttaccagcac ataccatgat g
//