GenBank-Updates@genbank.bio.net (05/17/91)
LOCUS BOVPRP 795 bp ds-DNA MAM 17-MAY-1991
DEFINITION Bovine PrP gene for a prion-protein.
ACCESSION X55882
KEYWORDS prion protein.
SOURCE Bos taurus DNA.
ORGANISM Bos taurus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Artiodactyla; Ruminantia; Pecora; Bovidae.
REFERENCE 1 (bases 1 to 795)
AUTHORS Goldmann,W.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (sites)
AUTHORS Goldmann,W., Hunter,N., Martin,T.E., Dawson,M. and Hope,J.
TITLE Different forms of the bovine PrP gene have five or six copies of a
short, G-C-rich element within the protein-coding exon
JOURNAL J. Gen. Virol. 72, 201-204 (1991)
STANDARD full staff_review
COMMENT *source: strain=Holstein-Friesian; tissue=peripheral lymphocytes;
*source: developmental stage=adult,germline; PrP protein aggregates
are found in BSE which is a member of the scrapie-like diseases. A
second bovine PrP allele shows deletion of nucleotides 211 to 234.
Nucleotide 576 exhibits C to T transition, creating a HindII
polymorphism.
From EMBL 23 entry BTPRP; dated 25-FEB-1991.
FEATURES Location/Qualifiers
mat_peptide 1..792
/product="prion protein"
/gene="PrP gene"
CDS 1..795
/product="prion protein"
/gene="PrP gene"
/codon_start=1
BASE COUNT 197 a 193 c 244 g 161 t
ORIGIN
1 atggtgaaaa gccacatagg cagttggatc ctggttctct ttgtggccat gtggagtgac
61 gtgggcctct gcaagaagcg accaaaacct ggaggaggat ggaacactgg ggggagccga
121 tacccaggac agggcagtcc tggaggcaac cgttatccac ctcagggagg gggtggctgg
181 ggtcagcccc atggaggtgg ctggggccag cctcatggag gtggctgggg ccagcctcat
241 ggaggtggct ggggtcagcc ccatggtggt ggctggggac agccacatgg tggtggaggc
301 tggggtcaag gtggtaccca cggtcaatgg aacaaaccca gtaagccaaa aaccaacatg
361 aagcatgtgg caggagctgc tgcagctgga gcagtggtag ggggccttgg tggctacatg
421 ctgggaagtg ccatgagcag gcctcttata cattttggca gtgactatga ggaccgttac
481 tatcgtgaaa acatgcaccg ttaccccaac caagtgtact acaggccagt ggatcagtat
541 agtaaccaga acaactttgt gcatgactgt gtcaacatca cagtcaagga acacacagtc
601 accaccacca ccaaggggga gaacttcacc gaaactgaca tcaagatgat ggagcgagtg
661 gtggagcaaa tgtgcattac ccagtaccag agagaatccc aggcttatta ccaacgaggg
721 gcaagtgtga tcctcttctc ttcccctcct gtgatcctcc tcatctcttt cctcattttt
781 ctcatagtag gatag
//