GenBank-Updates@genbank.bio.net (05/17/91)
LOCUS PECACVAG 12425 bp ds-DNA PLN 17-MAY-1991
DEFINITION Penicillium acvA gene for ACV synthetase
ACCESSION X54296
KEYWORDS ACV synthetase; acvA gene; peptide synthetase.
SOURCE Penicillium chrysogenum DNA.
ORGANISM Penicillium chrysogenum
Eukaryota; Plantae; Thallobionta; Eumycota; Ascomycotina;
Plectomycetes; Eurotiales; Trichocomaceae.
REFERENCE 1 (bases 1 to 12425)
AUTHORS Turner,G.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (sites)
AUTHORS Smith,D.J., Earl,A.J. and Turner,G.
TITLE The multifunctional peptide synthetase performing the first step of
penicillin biosynthesis in Penicillium chrysogenum is a 421073
dalton protein similar to Bacillus brevis peptide antibiotic
synthetases
JOURNAL EMBO J. 9, 2743-2750 (1990)
STANDARD full staff_review
COMMENT *source: strain=CMI 314652; library=cosmid PEN1/pCAP2; clone=pCX3.2
From EMBL 26 entry PCACVAG; dated 31-OCT-1990.
FEATURES Location/Qualifiers
CDS complement(<1..3)
/note="pbC protein (AA 1)"
/codon_start=3
CDS 1110..12347
/note="ACV synthetase (AA 1 - 3746)"
/codon_start=1110
misc_feature 2028..3758
/note="domain A"
misc_feature 5307..7010
/note="domain B"
misc_feature 8556..10271
/note="domain C"
BASE COUNT 2951 a 3414 c 3330 g 2730 t
ORIGIN
1 catggtgtct agaaaaataa tggtgaaaac ttgaaggcgt ggacaacgac gaagagaggg
61 cttggcaaag ggacagggga agttctcctg cagatgacaa tgagtgaaga gtatggacgc
121 aatggaaacg acctgagctc tcttcctgtg tgcctgagcg ggggcggggt gtttatgctg
181 agacaacctg gagacattat acgcttgcag cccagatgct tactggatgg ggccgctgga
241 gccagtgtaa aattagtaac cgtatctcga agtcggaggg tctttggtgg tctgagattt
301 cagtcggtcc gcaccgtggc atttgcagac ggtgcgatca ggccaatcgt tgatgctcgg
361 gcagagcaac actcccccgc tcgaagacta gtaagtactt atcattaccg tgccagaaaa
421 cggggccata gatacccaag taacaccgtc gagtcaatcg ggctcgtggg cccagccaag
481 ccacgagaga gtaggcaacg tgcactcaac gacggcgatg ttccaaggta aaccggcacg
541 tagaaaatgt ccggaccacc ttggctctcg ttgcagcgcg ttgaatcttc agccaccgta
601 agtcgatagc atccggttag agtgcaacgt gggtctgtct cattcttctc ggttcttggc
661 accagaatcg ggcgtagttt gcccactgcc aagtcgcggg gccgcttggc tgtccctgtg
721 gtgggatttc ccgatgcaac atgcagatac atgtagtcga cagttgacag agccaatggc
781 atcggatctg ccctagaccg tgctagacga aagtctccat cttgtctgcg ggcagtgctt
841 cagtcgccca gattctcgat ggagattggc caggtcagcc atatataccc tgcaatggca
901 gaccaatgca gcaggcccag tataaggaat tcccctcgag cttgtctgtg attgcgtttt
961 ttctaacact tgttgttgca tccgatccgt ccctaccaat tattggtcat tgacagacat
1021 gactcaactg aagccaccga acggaaccac gccgataggc ttctcggcca ctacatccct
1081 gaacgccagt gggagctcga gtgtgaaaaa tgggaccatc aaacccagca atggcatact
1141 tcaagcccag cactagggac accatggacc cttgcagtgg gaatgcggcc gatggcagta
1201 tccgcgtccg tttccgtgga ggaatcgaac ggtggaagga gtgcgtcaac caggtccccg
1261 agcgctgcga cctgagtggt ctgacaaccg actccacgcg atatcagctc gcatcgactg
1321 ggttcggtga cgcgagcgct gcctaccagg agcgcttgat gacggtccct gttgacgtac
1381 atgccgcgct ccaagagctg tgcctagaac gccgtgtgag cgtgggatcc gtcattaatt
1441 tctccgtgca ccagatgctg aaagggtttg gaaatggcac acacactatc accgcctctc
1501 tgcaccgtga gcagaatttg cagaattctt cgccatcctg ggtagtctcc cccacaatcg
1561 tcacccatga gaacagagac ggatggtccg tcgcgcaggc ggtcgagagt atcgaagcgg
1621 ggcgcggttc cgagaaggag tcagtgactg cgattgactc cgggtcaagt ctcgtgaaaa
1681 tggggttatt tgacttactc gtcagctttg tcgatgcaga cgatgctcgt attccatgtt
1741 tcgactttcc cctcgcagtg atagtgcgtg agtgtgatgc caacctctcg ctgactctgc
1801 gtttctccga ctgtctcttc aacgaggaga cgatatgcaa ttttaccgat gccctaaaca
1861 tcttgctcgc cgaagcagtg ataggaagag tgaccccggt tgccgatatc gaactactat
1921 ccgcggagca gaagcagcag ctggaagagt ggaacaacac ggatggcgag tacccttcat
1981 caaagcgact gcaccatctc attgaagagg tggttgaacg gcatgaagac aaaatagccg
2041 ttgtctgcga cgagcgagag ctcacttacg gcgagctcaa tgcccaaggc aacagcctcg
2101 cacgctatct ccgttccatt ggtatcctgc ccgagcagct agtcgcattg tttctagata
2161 agagcgagaa gctcattgtt accatcctcg gcgtgtggaa atccggcgcc gcctacgtgc
2221 ccatcgaccc gacttatccg gatgagcgag tgcgcttcgt gctggatgac accaaggcac
2281 gggccatcat cgccagtaat caacatgtgg agaggctcca gcgagaggtc atcggcgata
2341 gaaacctatg cattatccgt ctggagccct tgttggcctc ccttgctcag gattcctcaa
2401 aattccccgc gcataacttg gacgacctac ccctcacaag ccagcagctc gcctatgtga
2461 cttacacctc tgggaccact ggcttcccaa agggcatatt taaacaacac accaatgtgg
2521 tgaacagtat caccgacctg tctgcaaggt acggggtggc cgggcagcac cacgaagcca
2581 ttctgctttt ctcggcctgc gtgttcgagc cgttcgttcg acagacgctc atggcactcg
2641 tgaatggcca tctcctcgca gttatcaatg acgtggaaaa atatgatgcc gatacgctcc
2701 tgccgttcat acgcagacac agcatcacct acctcaatgg tactgcctct gtcctgcaag
2761 agtacgactt ttccgactgc ccatcactga atcggataat cctggtgggt gagaacctga
2821 cagaagcccg gtatctggcg ctgcgccagc ggttcaagaa tcgcatcctc aacgagtatg
2881 gttttaccga gtcagccttt gtaacggccc tcaagatttt cgacccggag tcgacccgta
2941 aggacacgag tctggggaga ccggtgcgca acgtcaagtg ctacatcctc aatccatccc
3001 ttaaacgtgt cccgattgga gctacgggtg agttgcatat cggagggttg ggcatttcca
3061 agggatacct caaccgcccc gaactcacgc cgcaccgctt cattcccaac cccttccaaa
3121 cggattgcga gaagcagctc gggatcaaca gcttgatgta caagaccggt gacctggccc
3181 gctggcttcc gaacggcgag gttgagtatc tcggacgcgc agatttccag atcaaactgc
3241 gaggtattcg aattgaacct ggtgaaattg agacgatgct ggctatgtac cctagggtcc
3301 ggaccagttt agtggtgtcc aaaaagctcc gcaacggtcc agaggaaact accaacgagc
3361 acctcgtggg ttattatgtt tgtgatagcg cctcagtgtc cgaggcagac ctgctgtcat
3421 ttttagagaa gaaactgcct cgatacatga ttcccacgcg gttggtacag ctgtcgcaga
3481 tcccagtgaa tgtgaacggg aaggcggacc tacgcgcctt gccggccgtc gatatctcca
3541 attccacgga ggtccgttcc gaccttcgag gcgatacgga aatcgccctc ggggaaatct
3601 gggccgacgt gttgggagcc cgccagagat ccgtctctcg caacgacaac ttcttccgcc
3661 taggagggca cagcatcacc tgcatccaac tgatcgctcg catccgacaa cgactctcgg
3721 tcagcatctc cgtcgaagat gtttttgcaa caaggacact tgagcgcatg gcagaccttc
3781 tacagaacaa gcagcaggag aaatgcgaca aaccccatga ggcgccgaca gagctgcttg
3841 aggagaatgc agcaacggac aatatctatc tggcaaacag tcttcagcag ggcttcgtct
3901 accattacct caagagcatg gaacaatccg acgcctatgt aatgcagtcc gttcttcggt
3961 acaacaccac attgtctcca gatctgtttc agagagcctg gaagcatgca cagcagtcct
4021 ttccagcgct gcggctgcgg ttctcatggg aaaaggaggt tttccaactg ctcgatcagg
4081 atccaccatt ggactggcgt ttcctctact tcaccgacgt tgccgcgggt gctgtcgagg
4141 accggaaatt ggaagacttg cggcgccaag accttacgga gagattcaag ctggatgttg
4201 gcagactgtt ccgcgtctat ctgattaaac acagcgagaa tcgcttcacg tgtcttttca
4261 gctgccacca tgcaatcctc gatggttgga gtctgccact cttgttcgaa aaggttcacg
4321 agacctacct gcaactgctg catggggaca atctcacttc gtccatggat gacccttaca
4381 ctcgcaccca gcggtatctc cacgctcacc gtgaggatca cctcgacttt tgggccggtg
4441 tggttcaaaa gatcaacgaa cggtgtgata tgaacgcctt gttgaacgag cgcagtcgtt
4501 acaaagtcca gctggcagac tatgaccagg tgcaggagca gcgacagctg acaattgctc
4561 tctctggaga cgcatggcta gcagaccttc gtcagacctg ctccgcccag ggtattacct
4621 tacattcgat tctccaattt gtttggcacg ccgtgctgca cgcttatggc ggtggcaccc
4681 acaccataac cggcacgacc atttctggaa ggaacctgcc catcttggga attgaacgag
4741 cagttggtcc gtatatcaac actctaccgc tggtactcga tcattcgacg ttcaaggata
4801 agacaatcat ggaggccatc gaggatgtgc aggccaaggt aaacgtcatg aacagccggg
4861 gcaatgtgga actgggccgt ttgcacaaaa ccgacttaaa gcacggatta ttcgattctt
4921 tattcgtgct tgaaaactac ccgaatttgg acaaatcgcg aacacttgag caccagactg
4981 aactggggta ttcgattgaa ggcggcactg agaagctgaa ttatccactg gctgtcatcg
5041 cgcgcgaagt cgagacgact ggcggattca cagtatccat ctgctacgcc agtgagctat
5101 ttgaggaggt tatgatctcc gagcttcttc atatggtcca ggacacactg atgcaggttg
5161 cccgaggttt gaatgaaccc gtcggcagcc tggagtatct ctcatctatc caattggagc
5221 aactcgccgc gtggaatgcc acggaagctg agtttcccga taccacgctt catgagatgt
5281 ttgaaaacga agcgagccag aagccggaca agatagcagt ggtctatgag gagacgtcct
5341 tgacttaccg cgagttgaat gagcgggcga accgtatggc acatcagcta aggtccgacg
5401 tcagccccaa ccccaacgag gtcattgcgc tggtgatgga caagagcgag catatgatcg
5461 tcaacattct ggccgtatgg aagagcggcg gtgcctatgt ccccattgac cctggatatc
5521 ctaacgaccg cattcaatac atcctagagg acacacaagc cctcgcagtc atcgcggact
5581 cctgctatct gcctcgcatc aagggaatgg ctgcctccgg cacgcttctt tatccctctg
5641 tcttgcctgc caatccggat tccaagtgga gcgtatcgaa cccttcaccg ttgagtcgga
5701 gcacggactt agcttatatc atctatacct ctggaacgac aggtcggccc aagggcgtca
5761 cggtagagca tcatggagtg gtcaacctgc aggtgtcgct atccaaagta ttcggactac
5821 gggatactga cgacgaggta attctctcct tttccaacta tgtgttcgac catttcgtgg
5881 agcagatgac cgacgccatt ctcaatggcc aaaccctcct ggtcctcaac gatggaatgc
5941 gcggggacaa agagcgactc tacagataca ttgagaagaa ccgagtgacc tacttgtctg
6001 gcaccccatc cgtggtctcc atgtacgaat ttagccggtt caaggaccat ctacgccgtg
6061 tggactgcgt gggggaggcg ttcagcgaac cggtcttcga caagatccgc gaaacgttcc
6121 atggcctcgt tatcaacggc tacggcccaa ctgaagtttc catcaccacc cacaagcggc
6181 tctatccatt cccagagcgg cgaatggaca aaagtattgg ccaacaggtc cacaatagca
6241 cgagctatgt gctgaacgag gacatgaagc gcacccccat aggttctgtc ggcgagctct
6301 acctgggtgg tgaaggagtg gtacggggat atcacaatcg cgcagatgtg accgcggagc
6361 gttttattcc taatccattc cagtcggaag aagataagcg agaaggtcgt aactcccgtt
6421 tgtacaagac cggtgacctg gtacgctgga ttcctggaag cagcggggag gtcgagtatc
6481 taggtcgtaa tgacttccag gtcaagattc gcggactgcg catcgaacta ggcgagattg
6541 aggccatcct atcgtcttat cacggaatca aacagtctgt ggtgattgcc aaggattgca
6601 gagaaggggc ccagaaattc ctggttggtt actatgtcgc cgatgcagcg ctgccgtccg
6661 ctgccattcg gcgcttcatg cagtctcggc tccctggcta catggtgccc tctcgtctca
6721 ttctcgtcag caagttcccc gtcactccta gtggaaaatt agacaccaag gctttgcccc
6781 cagccgagga agagagcgag attgacgtgg tgccgccgcg tagtgaaatc gaacgctcct
6841 tgtgtgacat ctgggcggaa ctactcgaga tgcacccaga ggagatcggc atttacagcg
6901 atttcttcag cctgggaggt gacagcctaa agagcacaaa gctttccttc atgattcacg
6961 agtcctttaa ccgcgccgtc tcagtcagcg cccttttctg tcaccggaca gttgaagccc
7021 agacgcactt gatcctgaac gatgctgcag atgtgcacga aattactccc atagattgca
7081 atgatacgca gatgattccc gtgtcccgtg cccaggagcg actcctcttc atccacgaat
7141 ttgagaatgg cagcaatgca tacaatatcg acgctgcatt tgaactgcct ggctcggttg
7201 acgcgtcgct tctcgagcag gcgctgcgtg gaaaccttgc tcgacatgag gcgttgagaa
7261 ctttactggt caaggatcac gcaaccggca tctatcttca gaaggtattg agtcccgatg
7321 aagcccaggg catgttctcc gtcaacgtgg acacagccaa gcaggtggag cggctggacc
7381 aggagatagc cagtctatcc cagcatgttt tccgcctcga tgatgaactg ccttgggagg
7441 cccgcatcct taaactcgaa tccggcggcc tgtatctcat tctggcgttc caccatacct
7501 gcttcgatgc atggtcattg aaagtcttcg agcaagagct tcgggccttg tacgcagcgc
7561 tccagaaaac caaaagtgca gcgaacttac cagccctcaa agcgcagtac aaggaatacg
7621 cgctctacca tcgccggcag ctgtctggcg atcgcatgcg caacctgtca gacttttggc
7681 tgcggaaact cattggcttg gaaccattgc agctgatcac ggaccgccca cgtcctgtgc
7741 aattcaaata cgacggtgac gacctcagta tcgaactgag caagaaggaa acggagaacc
7801 tgaggggggt ggccaaacgt tgcaagtcga gtctgtacgt cgtgttggtt tccgtttatt
7861 gcgttatgct agcctcgtac gcgaaccagt ccgatgtttc cgtgggtatc ccagtcagcc
7921 accgaacgca tcctcagttc caatcggtca ttggattctt cgtcaacctt gtggtgctaa
7981 gggtggatat ttctcagtca gccatttgcg ggctcatcag aagggtaatg aaagagctcg
8041 tggacgccca actgcaccaa gacatgccgt tccaggaagt gacgaagctg ctgcaggtgg
8101 ataatgaccc cagccggcat ccgctggtac agaacgtgtt caacttcgaa tcccgtgcga
8161 acggagaaca cgatgccagg tcggaggatg aaggatcgct tgcattcaat caataccggc
8221 cggttcagcc cgtggattcc gttgcgaagt ttgatctgaa cgcaacggtc acggaattgg
8281 agtcgggatt gagagtcaac ttcaactatg cgaccagcct attcaacaaa agcacgatcc
8341 agggtttttt gcatacctat gagtatctcc tgcgccagct gtccgaactg agtgcagaag
8401 ggatcaatga ggatacgcag ctgtcgttag ttcgcccgac agagaatggc gatctgcact
8461 tgccattggc acagtccccg cttgcgacga ctgctgagga gcagaaagta gcgtcgttga
8521 accaggcctt tgagcgcgaa gctttccttg ccgcagagaa gattgccgtc gtgcagggag
8581 atagagcact tagttatgct gatcttaacg ggcaggctaa ccagctcgcc cggtacatac
8641 agtccgtgtc ctgtattggg gcagacgacg gaatagcttt gatgctggaa aagagtatcg
8701 acacgattat ttgcattctc gcgatttgga aggctggtgc agcatacgtg cccttggatc
8761 cgacttaccc acccggacgc gtccagctga ttctggagga gattaaagcg aaggctgtcc
8821 ttgtgcactc cagtcatgct tcgaaatgtg aacgccatgg cgcgaaggtg attgcagtcg
8881 actcgcccgc catcgagacg gcggtcagcc aacagtcagc tgctgacctg cccacaattg
8941 ctagcctcgg caatctagcg tatataatct ttacttcagg cacttccggt aagccaaagg
9001 gagtcctagt tgagcaaaag gcagttcttc ttctacgcga tgccctccgg gagcggtatt
9061 tcggtcgaga ctgtaccaag catcatggcg tcctgttcct gtccaactac gtcttcgact
9121 tctccgtcga acaacttgtg ttgtcggtg
c tcagcggaca caagctgatc gttcccccag
9181 ctgagttcgt cgcagatgat gaattttaca gaatggccag cacgcacggt ctctcctatc
9241 tcagcggcac accatcctta ctgcagaaga tcgatctggc acgactggac catctgcagg
9301 ttgttaccgc cgcgggcgaa gagcttcacg ccacccagta cgagaagatg cgccgccgat
9361 tcaacggtcc catctacaat gcctatggtg tcaccgagac cacggtgtac aacattatcg
9421 cggaattcac aacgaattcg atatttgaga atgctcttcg ggaagtgctc cctggtaccc
9481 gagcgtatgt gctgaacgcg gcacttcagc ccgtcccctt cgatgctgtc ggagaactct
9541 atct
tgccgg cgacagcgtt acgcgtggtt atctcaacca acctcttcta acggatcagc
9601 gattcattcc caaccctttc tgcaaagagg aggacatcgc tatggggcgc ttcgcgcggc
9661 tctacaagac cggcgacctg gttcgatcgc gtttcaaccg tcagcagcag ccgcagctgg
9721 aatacctagg aagaggcgat ctgcagatca agatgagggg ataccggatc gagatttctg
9781 aagttcagaa cgtgctcact tcaagtcccg gtgtccggga gggtgcagtc gttgccaagt
9841 atgagaacaa cgatacctat tcccggaccg ctcactctct ggtcggttac tataccacgg
9901 acaatgaaac agtatcggaa gccgatattc tcactttcat gaaagcaagg cttccaacgt
9961 acatggtgcc aagccacctc tgctgtctgg aaggcgcact gcctgtgacg attaacggaa
10021 agctcgacgt ccggagattg ccggagatta tcaacgactc cgcgcagtcc tcgtacagcc
10081 caccaaggaa cataatcgag gccaagatgt gcagactgtg ggaatccgcc ttgggaatgg
10141 agcgatgcgg tatcgacgac gacctgttca aactgggtgg cgacagcatc acatctttgc
10201 atctcgtggc ccagattcac aaccaggtgg gctgcaagat caccgttcgg gatatatttg
10261 aacatcgtac cgcccgagcc ctccatgatc acgtcttcat gaaggactcc gaccggagta
10321 atgtgactca gttccgaacc gaacaagggc cggtcatcgg cgaggcgccc ctactgccga
10381 ttcaagactg gtttttgtca aaggctctgc agcatccgat gtattggaat cacactttct
10441 acgtccgaac gccagagctg gatgttgatt ccttaagcgc tgctgtcagg gacttgcaac
10501 agtatcacga tgttttccgc atgcgactca agcgcgagga agtcggattc gtgcagtcct
10561 ttgctgagga cttctctcct gcccagcttc gggtgctgaa cgtaaaagat gttgacgggt
10621 ccgcggccgt caacgagata ttggatgggt ggcagtctgg cttcaacctt gagaacggac
10681 ccattggttc cattggctac ctacatgggt atgaagaccg atccgcgcga gtctggttct
10741 ccgttcacca tatggccatt gacaccgtca gctggcagat ccttgtccgt gacctgcaga
10801 cgctgtaccg aaatggaagc ctcggaagca agggcagcag tttccggcag tgggctgaag
10861 ccatccaaaa ttacaaggcg tcagactctg agaggaacca ttggaataag ctcgtcatgg
10921 aaacagcttc cagcatatcc gcattgccta cgtcaaccgg ttcgcgcgtg cgcctgagca
10981 gaagtttgag ccctgagaag acagcctcac tgatccaagg aggaatcgat cgacaggatg
11041 tctccgtgta cgactccctc ctgacttcag ttggattggc gctccaacat atcgctccaa
11101 ccggcccaag tatggttacg atcgagggac atggccgtga agaagtggat cagacactgg
11161 atgtgagccg caccatgggt tggttcacca ccatgtatcc atttgaaatt ccccgtctca
11221 gcaccgagaa cattgttcaa ggagtcgtcg ctgtgagcga acggttcaga caggtgcctg
11281 cccgtggcgt cgggtatgga accttgtacg gctatactca acacccgctg ccccaggtga
11341 ccgtcaacta cctgggccag ctcgcccgca agcaatcgaa gccaaaggaa tgggtcctcg
11401 cggtgggcga caacgaattt gaatacggac tcatgactag cccagaggac aaagaccgga
11461 gctcttctgc cgtcgacgtc acggccgtgt gtattgacgg cactatgatc atcgatgtgg
11521 acagtgcttg gagccttgag gagagcgagc aattcatctc gagcatcgag gaaggactga
11581 acaagatcct cgacggcagg gcaagtcagc aaacctcgcg attcccggat gttcctcaac
11641 cggcggagac atatacgccg tatttcgagt atctggaacc tccacgacag ggaccgacgc
11701 tgttcctgct gccgccgggc gaaggaggcg ccgagagtta cttcaacaac atcgtcaagc
11761 gcctgcgtca gacaaatatg gtggtcttca acaactacta cttgcacagc aaacgcctgc
11821 gcacgttcga ggagctggcg gaaatgtatc tcgaccaagt acgcggcatc caaccacacg
11881 gaccgtacca cttcatcgga tggagcttcg gaggaattct cgcaatggaa atgtcgcggc
11941 gactggtagc ctcggacgag aagattggct tcctcggtat tatcgacacc tatttcaacg
12001 tgcggggagc gacacgcacc attggcttgg gggacactga gattctggac ccgatccatc
12061 acatctacaa tcccgatccg gccaacttcc aacgcctgcc ctctgcaaca gatcgcattg
12121 tgctgttcaa ggccatgagg ccgaacaaca agtacgaatc cgagaaccag cgtcgcctgt
12181 acgagtacta tgacggcact cgactcaacg gactggacag cttgttacca agcgattccg
12241 acgtccagct ggtcccgctt acggacgata cacacttttc ctgggtcgga aatccacaac
12301 aggtggagca gatgtgtgcg actatcaagg aacacctcgc tcgctattga tccgtcacta
12361 gcagcacagt atatcggacg atggaagtga tggagtgggg gggataggat acgatcaaac
12421 caggg
//