GenBank-Updates@genbank.bio.net (05/18/91)
LOCUS HUMCGM6MR 1364 bp ss-mRNA PRI 18-MAY-1991
DEFINITION Human CGM6 mRNA for carcinoembryonic antigen NCA-95
ACCESSION X52378
KEYWORDS antigen; carcinoembryonic antigen.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 1364)
AUTHORS Zimmermann,W.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (bases 1 to 1364)
AUTHORS Berling,B., Kolbinger,F., Grunert,F., Thompson,J.A., Brombacher,F.,
Buchegger,F., vKleist,S. and Zimmermann,W.
TITLE Cloning of a carcinoembryonic antigen gene family member expressed
in leukocytes of chronic myeloid leukemia patients and bone marrow
JOURNAL Cancer Res. 50, 6534-6539 (1990)
STANDARD full automatic
COMMENT *source: strain=chronic myeloid leukamia patient; tissue=spleen;
*source: library=lambda gt11; clone=lambdaC6M6a and lambda C6M6b;
**map: chromosome=19;
From EMBL entry HSCGM6MR; dated 15-FEB-1991.
FEATURES Location/Qualifiers
CDS 33..1079
/note="precursor protein (AA -34 to 315)"
/codon_start=33
CDS 33..134
/note="signal peptide (AA -34 to -1)"
/codon_start=33
CDS 135..1079
/note="mature carcinoembryonic antigen NCA-95 (AA 1-315)"
/codon_start=135
BASE COUNT 388 a 391 c 280 g 305 t
ORIGIN
1 gcacagagga gaacacgcag gcagcagaga ccatggggcc catctcagcc ccttcctgca
61 gatggcgcat cccctggcag gggctcctgc tcacagcctc acttttcacc ttctggaacc
121 cgcccaccac tgctcagctc actattgaag ctgtgccatc caatgctgca gaggggaagg
181 aggttcttct acttgtccac aatctgcccc aggaccctcg tggctacaac tggtacaaag
241 gggaaacagt ggatgccaac cgtcgaatta taggatatgt aatatcaaat caacagatta
301 ccccagggcc tgcatacagc aatcgagaga caatataccc caatgcatcc ctgctgatgc
361 ggaacgtcac caaaaatgac acaggatcct acaccctaca agtcataaag ctaaatctta
421 tgagtgaaga agtaactggc cagttcagcg tacatccgga gactcccaag ccctccatct
481 ccagcaacaa ctccaacccc gtggaggaca aggatgctgt ggccttcacc tgtgaacctg
541 agactcagaa cacaacctac ctgtggtggg taaatggtca gagtctcccg gtcagtccca
601 ggctgcagct gtccaatggc aacaggaccc tcactctact cagtgtcaca aggaatgacg
661 taggacccta tgaatgtgaa atacagaacc cagcgagtgc aaacttcagt gacccagtca
721 ccctgaatgt cctctatggc ccagatgccc ccaccatttc cccttcagac acctattacc
781 atgcaggggt aaatctcaac ctctcctgcc atgcggcctc taatccaccc tcacagtatt
841 cttggtctgt caatggcaca ttccagcaat acacacaaaa gctctttatc cccaacatca
901 ctacaaagaa cagcggatcc tatgcctgcc acaccactaa ctcagccact ggccgcaaca
961 ggaccacagt caggatgatc acagtctctg atgctttagt acaaggaagt tctcctggcc
1021 tctcagctag agccactgtc agcatcatga ttggagtact ggccagggtg gctctgatat
1081 agtagctctg gtgtagtttc tgcatttcaa gaagactggc agacagttgt ttttattctt
1141 cctcaaagca tttgcaatca gctaccattc aaaattgctt cttcttcaag atttatggaa
1201 aatactctga cgagtactct tgaacacaag ttcctgataa ctttaagatc acgccactgg
1261 actgtctatg aacttgcaaa caggctgata cctttgtgaa gttgcccacc aaaacacaga
1321 aggaaaaaaa catgaatttc attgaactaa ataataatga ggcg
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