GenBank-Updates@genbank.bio.net (05/15/91)
LOCUS HUMFIBRA 5943 bp ds-DNA PRI 15-MAY-1991
DEFINITION Human fibrinogen alpha chain gene, complete mRNA.
ACCESSION M64982
KEYWORDS fibrinogen; fibrinogen alpha chain.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 5943)
AUTHORS Chung,D.W., Harris,J.E. and Davie,E.W.
TITLE Nucleotide sequences of the three genes coding for human fibrinogen
JOURNAL (in) ;
Fibrinogen, Thrombosis, Coagulation and Fibrinolysis: 39-48,
Unknown name, Unknown city (1991)
STANDARD full automatic
FEATURES Location/Qualifiers
mRNA join(1..84,1154..1279,1739..1922,3055..3202,3788..5210)
/product="fibrinogen alpha chain"
exon 1..84
/number=1
intron 85..1153
/number=1
exon 1154..1279
/number=2
intron 1280..1738
/number=2
exon 1739..1922
/number=3
intron 1923..3054
/number=3
exon 3055..3202
/number=4
intron 3203..3787
/number=4
exon 3788..5210
/number=5
3'UTR 5211..5427
misc_RNA 5428..5943
/function="3'flanking sequence"
BASE COUNT 1772 a 1193 c 1218 g 1760 t
ORIGIN
1 gtctaggagc cagccccacc cttagaaaag atgttttcca tgaggatcgt ctgcctagtt
61 ctaagtgtgg tgggcacagc atgggtatgg cccttttcat tttttcttct tgctttctct
121 ctggtgttta ttccacaaag agcctggagg tcagagtcta cctgctctat gtcctgacac
181 actcttagct ttatgacccc aggcctggga ggaaatttcc tgggtgggct tgacacctca
241 agaatacagg gtaatatgac accaagagga agatcttaga tggatgagag tgtacaacta
301 caagggaaac tttagcatct gtcattcagt cttaccacat tttgttttgt tttgttttaa
361 aaagggcaag aattatttgc catccttgta cctataaagc cttggtgcat tataatgcta
421 gttaatggaa taaaacattt tatggtaaga tttgttttct ttagttatta atttcttgct
481 acttgtccat aataagcaga acttttagtg ttagtacagt tttgctgaaa ggttattgtt
541 gtgtttgtca agacagaaga aaaagcaaac gaattatctt tggaaatatc tttgcagtat
601 cagaagagat tagttagtaa ggcaatacgc ttttccgcag taatggtatt cttttaaatt
661 atgaatccat ctctaaaggt tacatagaaa cttgaaggag agaggaacat tcagttaaga
721 tagtctaggt ttttctactg aagcagcaat tacaggagaa agagctctac agtagttttc
781 aactttctgt ctgcagtcat tagtaaaaat gaaaaggtaa aatttaactg attttataga
841 ttcaaataat tttcctttta ggatggattc tttaaaactc ctaatattta tcaaatgctt
901 atttaagtgt cacacacagt taagaaattt gtacaccttg tctcctttaa ttctcataac
961 aactccataa aatgggtcct aggatttcca tttgaagata agaaacctga agcttgccga
1021 agccctgtgt ctgctctcct taatctctgt gagagtgcca tctcttcctg gggacttgta
1081 ggcatgccac tgtctcctct tctggctaac attgctgttg ctctcttttg tgtatgtgaa
1141 tgaatcttta aagactgcag atagtggtga aggtgacttt ctagctgaag gaggaggcgt
1201 gcgtggccca agggttgtgg aaagacatca atctgcctgc aaagattcag actggccctt
1261 ctgctctgat gaagactggg taagcagtca gcgggggaag caggagattc cttccctctg
1321 atgctagagg ggctcacagg ctgacctgat tggtcccaga aactttttta aatagaaaat
1381 aattgaatag ttacctacat agcaaataaa gaaaaggaac ctactcccaa gagcactgtt
1441 tatttacctc cccaactctg gatcattagt gggtgaacag acaggatttc agttgcatgc
1501 tcaggcaaaa ccaggctcct gagtattgtg gcctcaattt cctggcacct atttatggct
1561 aagtggaccc tcattccaga gtttctctgc gacctctaac tagtcctctt acctactttt
1621 aagccaactt atctggaaga gaaagggtag gaagaaatgg gggctgcatg gaaacatgca
1681 aaattattct gaatctgaga gatagatcct tactgtaatt ttctcccttc actttcagaa
1741 ctacaaatgc ccttctggct gcaggatgaa agggttgatt gatgaagtca atcaagattt
1801 tacaaacaga ataaataagc tcaaaaattc actatttgaa tatcagaaga acaataagga
1861 ttctcattcg ttgaccacta atataatgga aattttgaga ggcgattttt cctcagccaa
1921 tagtaagtat tacatattta cttctttgac tttataacag aaacaacaaa aatcctaaat
1981 aaatatgata tccgcttata tctatgacaa tttcatccca aagtacttag tgtagaaaca
2041 cataccttca taatatccct gaaaatttta agagggagct tttgttttcg ttattttttc
2101 aaagtaaaag atgttaactg agattgttta aggtcacaaa ataagtcaga attttggatt
2161 aaaacaagaa tttaaatgtg ttcttttcaa cagtatatac tgaaagtagg atgggtcaga
2221 ctctttgagt tgatattttt gtttctgctt tgtaaaggtg aaaactgaga ggtcaaggaa
2281 cttgttcaaa gacacagagc tgggaattca actcccagac tccactgagc tgattaggta
2341 gatttttaaa tttaaaatat agggtcaagc tacgtcattc tcacagtcta ctcattaggg
2401 ttaggaaaca ttgcattcac tctgggcatg gacagcgagt ctagggagtc ctcagtttct
2461 caagttttgc tttgcctttt tacaccttca caaacacttg acatttaaaa tcagtgatgc
2521 caacactagc tggcaagtga gtgatcctgt tgacccaaaa cagcttagga accatttcaa
2581 atctatagag ttaaaaagaa aagctcatca gtaagaaaat ccaatatgtt caagtccctt
2641 gattaaggat gttataaaat aattgaaatg caatcaaacc aactatttta actccaaatt
2701 acacctttaa aattccaaag aaagttcttc ttctatattt ctttgggatt actaattgct
2761 attaggacat cttaactggc attcatggaa ggctgcaggg cataacatta tccaaaagtc
2821 aaatgcccca taggttttga actcacagat taaactgtaa ccaaaataaa attaggcata
2881 tttacaagct agtttctttc tttctttttt ctctttcttt ctttctttct ttctttcttt
2941 ctttctttct ttctttcttt ctttctcctt ccttcctttc ttcctttctt ttttgctggc
3001 aattacagac aaatcactca gcagctactt caataaccat attttcgatt tcagaccgtg
3061 ataataccta caaccgagtg tcagaggatc tgagaagcag aattgaagtc ctgaagcgca
3121 aagtcataga aaaagtacag catatccagc ttctgcagaa aaatgttaga gctcagttgg
3181 ttgatatgaa acgactggag gtaagtatgt ggctgtggtc ccgagtgtcc ttgtttttga
3241 gtagagggaa aaggaaggcg atagttatgc actgagtgtc tactatatgc agagaaaagt
3301 gttatatcca tcatctacct aaaagtaggt attattttcc tcactccaca gttgaagaaa
3361 aaaaaattca gagatattaa gtaaattttc caacgtacat agatagtaat tcaaagcaat
3421 gttcagtccc tgtctattcc aagccattac atcaccacac ctctgagccc tcagcctgag
3481 ttcaccaagg atcatttaat tagcgtttcc tttgagaggg aatagcacct tactcttgat
3541 ccattctgag gctaagatga attaaacagc atccattgct tatcctggct agccctgcaa
3601 tacccaacat ctcttccact gagggtgctc gataggcaga aaacagagaa tattaagtgg
3661 taggtctccg agtcaaaaaa aatgaaacca gtttccagaa ggaaaattaa ctaccaggaa
3721 ctcaatagac gtagtttatg tatttgtatc tacattttct ctttattttt ctcccctctc
3781 tctaggtgga cattgatatt aagatccgat cttgtcgagg gtcatgcagt agggctttag
3841 ctcgtgaagt agatctgaag gactatgaag atcagcagaa gcaacttgaa caggtcattg
3901 ccaaagactt acttccctct agagataggc aacacttacc actgataaaa atgaaaccag
3961 ttccagactt ggttcccgga aattttaaga gccagcttca gaaggtaccc ccagagtgga
4021 aggcattaac agacatgccg cagatgagaa tggagttaga gagacctggt ggaaatgaga
4081 ttactcgagg aggctccacc tcttatggaa ccggatcaga gacggaaagc cccaggaacc
4141 ctagcagtgc tggaagctgg aactctggga gctctggacc tggaagtact ggaaaccgaa
4201 accctgggag ctctgggact ggagggactg caacctggaa acctgggagc tctggacctg
4261 gaagtgctgg aagctggaac tctgggagct ctggaactgg aagtactgga aaccaaaacc
4321 ctgggagccc tagacctggt agtaccggaa cctggaatcc tggcagctct gaacgcggaa
4381 gtgctgggca ctggacctct gagagctctg tatctggtag tactggacaa tggcactctg
4441 aatctggaag ttttaggcca gatagcccag gctctgggaa cgcgaggcct aacaacccag
4501 actggggcac atttgaagag gtgtcaggaa atgtaagtcc agggacaagg agagagtacc
4561 acacagaaaa actggtcact tctaaaggag ataaagagct caggactggt aaagagaagg
4621 tcacctctgg tagcacaacc accacgcgtc gttcatgctc taaaaccgtt actaagactg
4681 ttattggtcc tgatggtcac aaagaagtta ccaaagaagt ggtgacctcc gaagatggtt
4741 ctgactgtcc cgaggcaatg gatttaggca cattgtctgg cataggtact ctggatgggt
4801 tccgccatag gcaccctgat gaagctgcct tcttcgacac tgcctcaact ggaaaaacat
4861 tcccaggttt cttctcacct atgttaggag agtttgtcag tgagactgag tctaggggct
4921 cagaatctgg catcttcaca aatacaaagg aatccagttc tcatcaccct gggatagctg
4981 aattcccttc ccgtggtaaa tcttcaagtt acagcaaaca atttactagt agcacgagtt
5041 acaacagagg agactccaca tttgaaagca agagctataa aatggcagat gaggccggaa
5101 gtgaagccga tcatgaagga acacatagca ccaagagagg ccatgctaaa tctcgccctg
5161 tcagaggtat ccacacttct cctttgggga agccttccct gtccccctag actaagttaa
5221 atatttctgc acagtgttcc catggcccct tgcatttcct tcttaactct ctgttacacg
5281 tcattgaaac tacacttttt tggtctgttt ttgtgctaga ctgtaagttc cttgggggca
5341 gggcctttgt ctgtctcatc tctgtattcc caaatgccta acagtacaga gccatgactc
5401 aataaataca tgttaaatgg atgaatgaat tcctctgaaa ctctatttga gcttatttag
5461 tcaaattctt tcactattca aagtgtgtgc tattagaatt gtcacccaac tgattaatca
5521 catttttagt atgtgtctca gttgacattt aggtcaggct aaatacaagt tgtgttagta
5581 ttaagtgagc ttagctacct gtactggtta cttgctatta gtttgtgcaa gtaaaattcc
5641 aaatacattt gaggaaaatc ccctttgcaa tttgtaggta taaataaccg cttatttgca
5701 taagttctat cccactgtaa gtgcatcctt tccctatgga gggaaggaaa ggaggaagaa
5761 agaaaggaag ggaaagaaac agtatttgcc ttatttaatc tgagccgtgc ctatctttgt
5821 aaagttaaat gagaataact tcttccaacc agcttaattt tttttttaga ctgtgatgat
5881 gtcctccaaa cacatccttc aggtacccaa agtggcattt tcaatatcaa gctatccgga
5941 tcc
//GenBank-Updates@genbank.bio.net (05/18/91)
LOCUS HUMFIBRA 5943 bp ds-DNA PRI 18-MAY-1991
DEFINITION Human fibrinogen alpha chain gene, complete mRNA.
ACCESSION M64982
KEYWORDS fibrinogen; fibrinogen alpha chain.
SOURCE Human DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 5943)
AUTHORS Chung,D.W., Harris,J.E. and Davie,E.W.
TITLE Nucleotide sequences of the three genes coding for human fibrinogen
JOURNAL (in) Liu,C.Y. and Chien,S. (Eds.);
Fibrinogen, Thrombosis, Coagulation and Fibrinolysis: 39-48,
Plenum Press, New York (1991)
STANDARD full automatic
FEATURES Location/Qualifiers
mRNA join(1..84,1154..1279,1739..1922,3055..3202,3788..5210)
/product="fibrinogen alpha chain"
exon 1..84
/number=1
intron 85..1153
/number=1
exon 1154..1279
/number=2
intron 1280..1738
/number=2
exon 1739..1922
/number=3
intron 1923..3054
/number=3
exon 3055..3202
/number=4
intron 3203..3787
/number=4
exon 3788..5210
/number=5
3'UTR 5211..5427
misc_RNA 5428..5943
/function="3'flanking sequence"
BASE COUNT 1772 a 1193 c 1218 g 1760 t
ORIGIN
1 gtctaggagc cagccccacc cttagaaaag atgttttcca tgaggatcgt ctgcctagtt
61 ctaagtgtgg tgggcacagc atgggtatgg cccttttcat tttttcttct tgctttctct
121 ctggtgttta ttccacaaag agcctggagg tcagagtcta cctgctctat gtcctgacac
181 actcttagct ttatgacccc aggcctggga ggaaatttcc tgggtgggct tgacacctca
241 agaatacagg gtaatatgac accaagagga agatcttaga tggatgagag tgtacaacta
301 caagggaaac tttagcatct gtcattcagt cttaccacat tttgttttgt tttgttttaa
361 aaagggcaag aattatttgc catccttgta cctataaagc cttggtgcat tataatgcta
421 gttaatggaa taaaacattt tatggtaaga tttgttttct ttagttatta atttcttgct
481 acttgtccat aataagcaga acttttagtg ttagtacagt tttgctgaaa ggttattgtt
541 gtgtttgtca agacagaaga aaaagcaaac gaattatctt tggaaatatc tttgcagtat
601 cagaagagat tagttagtaa ggcaatacgc ttttccgcag taatggtatt cttttaaatt
661 atgaatccat ctctaaaggt tacatagaaa cttgaaggag agaggaacat tcagttaaga
721 tagtctaggt ttttctactg aagcagcaat tacaggagaa agagctctac agtagttttc
781 aactttctgt ctgcagtcat tagtaaaaat gaaaaggtaa aatttaactg attttataga
841 ttcaaataat tttcctttta ggatggattc tttaaaactc ctaatattta tcaaatgctt
901 atttaagtgt cacacacagt taagaaattt gtacaccttg tctcctttaa ttctcataac
961 aactccataa aatgggtcct aggatttcca tttgaagata agaaacctga agcttgccga
1021 agccctgtgt ctgctctcct taatctctgt gagagtgcca tctcttcctg gggacttgta
1081 ggcatgccac tgtctcctct tctggctaac attgctgttg ctctcttttg tgtatgtgaa
1141 tgaatcttta aagactgcag atagtggtga aggtgacttt ctagctgaag gaggaggcgt
1201 gcgtggccca agggttgtgg aaagacatca atctgcctgc aaagattcag actggccctt
1261 ctgctctgat gaagactggg taagcagtca gcgggggaag caggagattc cttccctctg
1321 atgctagagg ggctcacagg ctgacctgat tggtcccaga aactttttta aatagaaaat
1381 aattgaatag ttacctacat agcaaataaa gaaaaggaac ctactcccaa gagcactgtt
1441 tatttacctc cccaactctg gatcattagt gggtgaacag acaggatttc agttgcatgc
1501 tcaggcaaaa ccaggctcct gagtattgtg gcctcaattt cctggcacct atttatggct
1561 aagtggaccc tcattccaga gtttctctgc gacctctaac tagtcctctt acctactttt
1621 aagccaactt atctggaaga gaaagggtag gaagaaatgg gggctgcatg gaaacatgca
1681 aaattattct gaatctgaga gatagatcct tactgtaatt ttctcccttc actttcagaa
1741 ctacaaatgc ccttctggct gcaggatgaa agggttgatt gatgaagtca atcaagattt
1801 tacaaacaga ataaataagc tcaaaaattc actatttgaa tatcagaaga acaataagga
1861 ttctcattcg ttgaccacta atataatgga aattttgaga ggcgattttt cctcagccaa
1921 tagtaagtat tacatattta cttctttgac tttataacag aaacaacaaa aatcctaaat
1981 aaatatgata tccgcttata tctatgacaa tttcatccca aagtacttag tgtagaaaca
2041 cataccttca taatatccct gaaaatttta agagggagct tttgttttcg ttattttttc
2101 aaagtaaaag atgttaactg agattgttta aggtcacaaa ataagtcaga attttggatt
2161 aaaacaagaa tttaaatgtg ttcttttcaa cagtatatac tgaaagtagg atgggtcaga
2221 ctctttgagt tgatattttt gtttctgctt tgtaaaggtg aaaactgaga ggtcaaggaa
2281 cttgttcaaa gacacagagc tgggaattca actcccagac tccactgagc tgattaggta
2341 gatttttaaa tttaaaatat agggtcaagc tacgtcattc tcacagtcta ctcattaggg
2401 ttaggaaaca ttgcattcac tctgggcatg gacagcgagt ctagggagtc ctcagtttct
2461 caagttttgc tttgcctttt tacaccttca caaacacttg acatttaaaa tcagtgatgc
2521 caacactagc tggcaagtga gtgatcctgt tgacccaaaa cagcttagga accatttcaa
2581 atctatagag ttaaaaagaa aagctcatca gtaagaaaat ccaatatgtt caagtccctt
2641 gattaaggat gttataaaat aattgaaatg caatcaaacc aactatttta actccaaatt
2701 acacctttaa aattccaaag aaagttcttc ttctatattt ctttgggatt actaattgct
2761 attaggacat cttaactggc attcatggaa ggctgcaggg cataacatta tccaaaagtc
2821 aaatgcccca taggttttga actcacagat taaactgtaa ccaaaataaa attaggcata
2881 tttacaagct agtttctttc tttctttttt ctctttcttt ctttctttct ttctttcttt
2941 ctttctttct ttctttcttt ctttctcctt ccttcctttc ttcctttctt ttttgctggc
3001 aattacagac aaatcactca gcagctactt caataaccat attttcgatt tcagaccgtg
3061 ataataccta caaccgagtg tcagaggatc tgagaagcag aattgaagtc ctgaagcgca
3121 aagtcataga aaaagtacag catatccagc ttctgcagaa aaatgttaga gctcagttgg
3181 ttgatatgaa acgactggag gtaagtatgt ggctgtggtc ccgagtgtcc ttgtttttga
3241 gtagagggaa aaggaaggcg atagttatgc actgagtgtc tactatatgc agagaaaagt
3301 gttatatcca tcatctacct aaaagtaggt attattttcc tcactccaca gttgaagaaa
3361 aaaaaattca gagatattaa gtaaattttc caacgtacat agatagtaat tcaaagcaat
3421 gttcagtccc tgtctattcc aagccattac atcaccacac ctctgagccc tcagcctgag
3481 ttcaccaagg atcatttaat tagcgtttcc tttgagaggg aatagcacct tactcttgat
3541 ccattctgag gctaagatga attaaacagc atccattgct tatcctggct agccctgcaa
3601 tacccaacat ctcttccact gagggtgctc gataggcaga aaacagagaa tattaagtgg
3661 taggtctccg agtcaaaaaa aatgaaacca gtttccagaa ggaaaattaa ctaccaggaa
3721 ctcaatagac gtagtttatg tatttgtatc tacattttct ctttattttt ctcccctctc
3781 tctaggtgga cattgatatt aagatccgat cttgtcgagg gtcatgcagt agggctttag
3841 ctcgtgaagt agatctgaag gactatgaag atcagcagaa gcaacttgaa caggtcattg
3901 ccaaagactt acttccctct agagataggc aacacttacc actgataaaa atgaaaccag
3961 ttccagactt ggttcccgga aattttaaga gccagcttca gaaggtaccc ccagagtgga
4021 aggcattaac agacatgccg cagatgagaa tggagttaga gagacctggt ggaaatgaga
4081 ttactcgagg aggctccacc tcttatggaa ccggatcaga gacggaaagc cccaggaacc
4141 ctagcagtgc tggaagctgg aactctggga gctctggacc tggaagtact ggaaaccgaa
4201 accctgggag ctctgggact ggagggactg caacctggaa acctgggagc tctggacctg
4261 gaagtgctgg aagctggaac tctgggagct ctggaactgg aagtactgga aaccaaaacc
4321 ctgggagccc tagacctggt agtaccggaa cctggaatcc tggcagctct gaacgcggaa
4381 gtgctgggca ctggacctct gagagctctg tatctggtag tactggacaa tggcactctg
4441 aatctggaag ttttaggcca gatagcccag gctctgggaa cgcgaggcct aacaacccag
4501 actggggcac atttgaagag gtgtcaggaa atgtaagtcc agggacaagg agagagtacc
4561 acacagaaaa actggtcact tctaaaggag ataaagagct caggactggt aaagagaagg
4621 tcacctctgg tagcacaacc accacgcgtc gttcatgctc taaaaccgtt actaagactg
4681 ttattggtcc tgatggtcac aaagaagtta ccaaagaagt ggtgacctcc gaagatggtt
4741 ctgactgtcc cgaggcaatg gatttaggca cattgtctgg cataggtact ctggatgggt
4801 tccgccatag gcaccctgat gaagctgcct tcttcgacac tgcctcaact ggaaaaacat
4861 tcccaggttt cttctcacct atgttaggag agtttgtcag tgagactgag tctaggggct
4921 cagaatctgg catcttcaca aatacaaagg aatccagttc tcatcaccct gggatagctg
4981 aattcccttc ccgtggtaaa tcttcaagtt acagcaaaca atttactagt agcacgagtt
5041 acaacagagg agactccaca tttgaaagca agagctataa aatggcagat gaggccggaa
5101 gtgaagccga tcatgaagga acacatagca ccaagagagg ccatgctaaa tctcgccctg
5161 tcagaggtat ccacacttct cctttgggga agccttccct gtccccctag actaagttaa
5221 atatttctgc acagtgttcc catggcccct tgcatttcct tcttaactct ctgttacacg
5281 tcattgaaac tacacttttt tggtctgttt ttgtgctaga ctgtaagttc cttgggggca
5341 gggcctttgt ctgtctcatc tctgtattcc caaatgccta acagtacaga gccatgactc
5401 aataaataca tgttaaatgg atgaatgaat tcctctgaaa ctctatttga gcttatttag
5461 tcaaattctt tcactattca aagtgtgtgc tattagaatt gtcacccaac tgattaatca
5521 catttttagt atgtgtctca gttgacattt aggtcaggct aaatacaagt tgtgttagta
5581 ttaagtgagc ttagctacct gtactggtta cttgctatta gtttgtgcaa gtaaaattcc
5641 aaatacattt gaggaaaatc ccctttgcaa tttgtaggta taaataaccg cttatttgca
5701 taagttctat cccactgtaa gtgcatcctt tccctatgga gggaaggaaa ggaggaagaa
5761 agaaaggaag ggaaagaaac agtatttgcc ttatttaatc tgagccgtgc ctatctttgt
5821 aaagttaaat gagaataact tcttccaacc agcttaattt tttttttaga ctgtgatgat
5881 gtcctccaaa cacatccttc aggtacccaa agtggcattt tcaatatcaa gctatccgga
5941 tcc
//