GenBank-Updates@genbank.bio.net (05/18/91)
LOCUS DROMHCHIN 8400 bp ds-DNA INV 18-MAY-1991
DEFINITION D.melanogaster muscle myosin heavy chain gene (exon 12 to 19)
alternatively spliced products
ACCESSION X53155
KEYWORDS alternative splicing; myosin; myosin heavy chain.
SOURCE Drosophila melanogaster DNA.
ORGANISM Drosophila melanogaster
Eukaryota; Animalia; Metazoa; Arthropoda; Uniramia; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera;
Cyclorrhapha; Schizophora; Drosophiloidea; Drosophilidae.
REFERENCE 1 (bases 1 to 8400)
AUTHORS Bernstein,S.I.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (bases 1 to 8400)
AUTHORS Collier,V.L., Kronert,W.A., O'Donnell,P.T., Edwards,K.A. and
Bernstein,S.I.
TITLE Alternative myosin hinge regions are utilized in a tissue-specific
fashion that correlates with musle contraction speed
JOURNAL Genes Dev. 4, 885-895 (1990)
STANDARD full automatic
COMMENT *source: strain=Canton S; developmental stage=embryo; *source:
clone=lambda 9 MHC, lambda 10 MHC; See also <M13360> and <M12741>
for overlapping sequences. Alternative splicing gives rise to
alternative exons 15a and 15b and also to exons 18 and 19.
Data kindly reviewed (08-OCT-1990) by Bernstein S.
From EMBL 26 entry DMMHCHIN; dated 30-NOV-1990.
FEATURES Location/Qualifiers
intron <1..75
/note="intron XI"
mRNA 76..339
/note="exon 12"
CDS 76..339
/note="myosin heavy chain (88 AA)"
/codon_start=76
intron 340..1854
/note="intron XII"
mRNA 1855..2064
/note="exon 13"
CDS 1855..2064
/note="myosin heavy chain (70 AA)"
/codon_start=1855
intron 2065..2284
/note="intron XIII"
mRNA 2285..3171
/note="exon 14"
CDS 2285..3171
/note="myosin heavy chain (296 AA) (3171 is 2nd base in
codon)"
/codon_start=2285
intron 3172..3759
/note="intron XIVb"
intron 3172..3342
/note="intron XIVa"
mRNA 3343..3421
/note="alternatively spliced exon 15a"
CDS 3343..3421
/note="myosin heavy chain (26 AA) (3343 is 3rd base in
codon)"
/codon_start=3343
intron 3422..4175
/note="intron XVa"
mRNA 3760..3838
/note="alternatively spliced exon 15b"
CDS 3760..3838
/note="myosin heavy chain (26 AA) (3760 is 3rd base in
codon)"
/codon_start=3760
intron 3839..4175
/note="intron XVb"
mRNA 4176..5351
/note="exon 16"
CDS 4176..5351
/note="myosin heavy chain (302 AA)"
/codon_start=4176
intron 5352..5418
/note="intron XVI"
mRNA 5419..6324
/note="exon 17"
CDS 5419..6324
/note="myosin heavy chain (302 AA)"
/codon_start=5419
intron 6325..7530
/note="intron XVIIb"
intron 6325..6588
/note="intron XVIIa"
mRNA 6589..7090
/note="exon 18"
CDS 6589..6591
/note="myosin heavy chain (1 AA)"
/codon_start=6589
mRNA 7531..8277
/note="alternative exon 19"
CDS 7531..7611
/note="myosin heavy chain (27 AA)"
/codon_start=7531
misc_feature 8271..8277
/note="polyA signal"
BASE COUNT 2400 a 2198 c 1992 g 1810 t
ORIGIN
1 gatggaacca acagaaatct aacctatttt ctttcccccc acccaatcca aaatctcaat
61 acgaaaaaaa aacaggtgtt cttccgcgcc ggtgtcctgg gtcagatgga ggagttccgt
121 gatgagcgtc tgggcaagat catgtcctgg atgcaggcat gggcccgtgg ttacctgtcc
181 cgtaagggct tcaagaagct ccaggaacag cgcgtcgccc tcaaggttgt ccagcgcaat
241 ctgcgcaagt acctgcagct ccgtacctgg ccctggtaca aactgtggca gaaggtcaag
301 cccctcctca acgtcagccg catcgaggat gagattgccg tgagtattcc ccagaacgaa
361 tgagaacgag accagcctgg gtctggggac ttagtggtct ttggtgattc gatgcgatga
421 acttggacag tacagttgct ggtggcaatc atttggtgac cgcagcacgt tgatgtagcc
481 atagccctgg tgtgtccatt ccatttggtc actgtctggg gtaattggat gagctggggc
541 agctgcaagc agcaatcaaa tccccaactc aatcttattt tagccaatgg tcattatctt
601 gtttctgatg cgaaattctt gcgcttatta acacacatct tatacctgca gcaggggcca
661 atgagaggga gaaccaccac ccacccacta ccagctgccc gaaacatatc gatacgatct
721 gattccaatc gctgggctag ccaaaaatag acgctgtcat aatcttttcg cactttcggg
781 ccaaatgtgg ctctatgtgt gtgccccagg cgaatcattt cgctggaatc caacaactct
841 tcacctctca cattttcata cacccaaacc atccccccat acgtacattg tatgtatttg
901 ggtatgaata tttttcgaaa gttatgactt gtagtttggg atctattctt ggccctgcca
961 tatagctggg gattttttaa agagccacaa ttagtttgcc aattagcttg ctaattaaat
1021 aataaaaaat gacccgagga tgcccacgta tagttccgat ccccgatgag taatttacca
1081 tgcatatgta catccatacg cacgatattt ctaaccgatc tatataccta agatggtaca
1141 cctgctggtc ccgccgcaca agtgcacttg ataggcccca taccgacgca atatagcatt
1201 atagcaatgc cagcaattcg tgaattatga tggctacctc ctaaccaagg cgattacaca
1261 catgccaagt ggcagcagct gccatttcgc tgctctgctc tgctctgctc tggtgccgtt
1321 ctgctcgcat cggggcgttt ttgctaattt tatagccaaa gtggcccagt gcatttgcag
1381 cagccattcc agttgtattt gaccagtcgc cgtcgcggta acgcgtacca caaaaaatcg
1441 aacccctaac gaagaaccaa tcgatctgag caaaagagcc acattagcca cagagcatct
1501 tgactggcat caagataacg aattcaaatt gaaattgtat tgtagttgac aattgtgaaa
1561 agcccctttc caagagagtt tcacatttaa ttaggagtta ttgaaagtgc ttaatcatca
1621 acatggccga tgaaaagaaa gccaagaaaa cgaaaaagtc caccgaatcg accacaccca
1681 gtgccactga ggaagcagct ccagccgaag ctgctccacc agcagagact gcagaagctg
1741 ctccttcagc ccgaatcgac cgccgtcgaa ccaccacaaa atccccagcc agctgacgag
1801 ctcagctccg gcaacaaccc ttctaaccca tcaaatgcct ctaatgactt acagcgtctg
1861 gaggagaagg ccaagaaggc tgaggaactg catgccgctg aagtgaaggt gcgcaaggag
1921 ctcgaggccc tcaacgccaa gcttttggct gagaagaccg ctctgctgga ctccctgtcc
1981 ggcgagaagg gtgccctgca ggactaccag gagcgcaacg ccaagttgac cgcccagaag
2041 aacgacctcg agaaccagct gcgcgtaagt atcccattaa tcccatacac taaatcccat
2101 ttatgcgatg gcataaatcc aagtgccacg aaagcggaaa acgcgaaatt gatcagaggc
2161 aatcgagcat gaaagttgct cggctatttc tgggctctgg cgcacttggc taaatttagg
2221 agtgacccat cgctaacttc tcagccactt aacacgccca cacaattttg ttcaattcca
2281 ataggatatc caagagcgcc tgactcagga ggaggatgcc cgcaaccagc tgttccagca
2341 gaagaagaag gccgatcagg agatctctgg cctgaagaag gacatcgagg atctggaatt
2401 gaacgtccag aaggccgagc aggacaaggc caccaaggat caccagatcc gcaacttgaa
2461 cgacgagatc gcccaccagg atgagctcat caacaagttg aacaaggaga agaagatgca
2521 gggagagacc aaccagaaga ccggtgagga gctccaggcc gccgaggaca agatcaacca
2581 cttgaacaag gttaaggcca agctcgagca gaccctcgat gaactggagg attcgctgga
2641 gcgcgagaag aaggtgcgcg gcgatgttga gaagtccaag cgcaaggttg agggcgacct
2701 caagctcacc caggaggctg ttgccgatct ggagcgcaac aagaaggagc tcgagcagac
2761 catccagcgc aaggacaagg agctgtcctc catcaccgcc aagctcgagg acgagcaggt
2821 cgttgttctg aagcaccagc gccagatcaa ggaactgcag gcccgcatcg aggagctcga
2881 ggaagaggtc gaggctgagc gccaggcccg cgccaaggct gagaagcagc gcgccgatct
2941 ggcccgcgaa ctcgaggaat tgggcgagcg tcttgaggag gctggcggtg ccacctctgc
3001 ccagattgag ctcaacaaga agcgtgaggc tgagttgagc aaactgcgtc gcgatcttga
3061 ggaggccaac atccagcacg agtccaccct ggctaacctg cgcaagaagc acaacgatgc
3121 cgtcgccgag atggccgagc aggttgatca gctcaacaag ctgaaggcta agtaagtatt
3181 gcgaatatta ttagacttct ggctagcttt ttcaggtgcc aacgctatcg agatagagag
3241 atcttgaagg atctacagtt tacagtcttc tttcgaagag ctttggttgc cgaacccaac
3301 ataatagata ttttgctctt ttttacccat ttgctaatcc agggctgaac acgatcgcca
3361 gacttgccac aacgagctga atcagactcg taccgcctgc gatcagctgg gtcgcgataa
3421 ggtaatatgt cgtgataact ggcgcccgag caggacgtcc agcgattcat acatatacag
3481 atccatacac tgaacacagc atgttccaac caacaaataa aaaaaaaatg ctaccacaca
3541 actacgtaca aacgaactac gtctgtgtgt ccctctatct ctctctctct ctgtctaatg
3601 aaattgaagg ttatttggaa aaaaggttca acgcaaggaa agcaattctc tcgcttctcg
3661 cctctgtatt tgtctctgtc tctgtcttta tcccccacaa aacatgaact aacccgtgaa
3721 atacgaacct ctgtgtctct atctatctgt ctaaaccagg gctgagaagg agaagaacga
3781 gtactacggc cagttgaacg atctgcgcgc cggtgtcgac cacattacca acgagaaggt
3841 attgaatttg atctctacat atattattgc tctcatcgcg atgctgtaaa tttatatgct
3901 gaaagttcta gtttagccac gtctactaca tctgtgtata gtatcaacgt agttgcaacg
3961 caaccacacc gaaactccaa aagaaaattt gattatgtaa aaactaaaac gacccaccac
4021 cactaaagta atatccaagc ttgatctact aaaccccaaa tgccttgtac agccacttga
4081 cacgaaacca aaatgccaca cttacaatca attatgaatg ttcccaatcc ccatcgtgaa
4141 aactaatgaa catccattgc ttgaatcact aataggctgc ccaggagaag atcgccaagc
4201 agctgcagca caccctcaac gaggtgcagt cgaaactgga tgagaccaac aggactctga
4261 acgacttcga tgccagcaag aagaagctgt ccattgagaa ctccgatctg ctccgccagc
4321 tggaggaggc cgagtcccag gtgtctcagc tgtccaagat caagatctct ctgaccaccc
4381 agttggagga caccaagcgt ctggccgacg aggagtcgcg cgagcgtgcc acccttttgg
4441 gcaagttccg caacttggag cacgacctgg acaatctgcg cgagcaggtt gaggaggagg
4501 ctgagggcaa ggccgatctg cagcgccagc tgagcaaggc caacgctgag gcccaggtgt
4561 ggcgcagcaa gtacgagtcc gatggcgttg cccgctctga ggagctggag gaagccaaga
4621 ggaagctgca ggcccgtttg gccgaggccg aggagaccat cgagtccctc aaccagaagt
4681 gcattggcct ggagaagacc aagcagcgtc tgtccaccga ggtggaggat ctgcagctgg
4741 aggtcgaccg tgccaacgcc attgccaacg ctgccgagaa gaagcagaag gccttcgaca
4801 agatcatcgg cgagtggaag ctcaaggtcg acgatctggc tgctgagctg gatgcctccc
4861 agaaggagtg ccgcaactac tccaccgagc tgttccgtct taagggcgcc tacgaggagg
4921 gccaggagca gttggaggct gtgcgtcgtg agaacaagaa cctggccgat gaggtcaagg
4981 atctgctcga ccagatcggt gagggtggcc gcaacatcca tgagatcgag aaggcccgca
5041 agcgcctgga agccgagaag gacgagctcc aggctgccct cgaggaggct gaggccgctc
5101 ttgagcagga ggagaacaag gtgctccgcg ctcagcttga gctgtcccag gtgcgccagg
5161 agatcgaccg ccgcatccag gagaaggagg aggagttcga gaacacccgc aagaaccacc
5221 agcgtgccct cgactccatg caggcttccc tcgaagccga ggccaagggc aaggctgagg
5281 ccctgcgcat gaagaagaag ctggaggctg acatcaacga gcttgagatt gctctggatc
5341 acgccaacaa ggtaggttca accactgatg cctagtcaca ccgagatgac taaccttaat
5401 tcttatcctt tactttaggc taacgccgag gcccagaaga acatcaagcg ttaccagcag
5461 cagctgaagg acatccagac tgccctcgag gaggagcagc gcgcccgcga cgatgcccgc
5521 gaacagctgg gtatctccga gcgtcgtgca aacgccctcc agaacgaact ggaggagtct
5581 cgcactctgc tggaacaggc cgaccgtggc cgtcgccagg ccgaacagga gctggccgat
5641 gcccacgagc agctgaacga agtgtccgcc cagaacgcct ccatctccgc tgccaagagg
5701 aagctggagt ccgagctgca gaccctgcac tccgacctgg acgaactcct gaacgaagcc
5761 aagaactccg aggagaaggc caagaaggct atggtcgatg ccgcccgcct ggccgatgag
5821 ctccgcgctg agcaggatca tgcccagacc caggagaaat tgaggaaggc cctcgagcag
5881 cagatcaagg agctgcaggt ccgtctggac gaggctgagg ccaacgccct caagggaggc
5941 aagaaggcca ttcagaagct tgagcagcgc gtccgcgagc tcgagaacga gctggatggt
6001 gagcagagga ggcacgccga tgcccagaag aacctgcgca agtccgagcg tcgcgtcaag
6061 gagctgagct tccagtccga ggaggaccgc aagaaccacg agcgcatgca ggatctggtc
6121 gacaagctgc aacagaagat caagacatac aagaggcaga tcgaggaggc tgaggaaatc
6181 gccgccctca acttggccaa attccgcaag gctcagcagg agcttgagga ggccgaggag
6241 cgcgccgatc tggccgagca ggccatcagc aaattccgcg ccaagggacg tgccggttct
6301 gtcggtcgtg gtgccagccc agcggtaagt tattgaacaa tggcatcaaa tgccttcatc
6361 atcactaccc tttagccctt aagaccccac aatgacctta cccactcaga gaaaaaagta
6421 aatatgaaag cccatttgaa cttctctcaa tcgaacactt ctgagccttc attttgctgc
6481 atcagcgcca tctccattca cgttatttct ggatcagtta ttgaataatg tgtatattct
6541 tccctttcat attgctcgcg tatgctctgc ttccacttac gaaaacagat ctaagcctga
6601 ggcatcacca tcgaataaaa aatctatata gcgatccaat tatggttcat ttacgataat
6661 gagagaacaa aaaccatgca aagagaatta tagcttataa gaattattat aaaataaata
6721 ctaataacaa taatatagat gcatcacatg acattcgcta gcagacaaaa atgtataaat
6781 tagaggccac cccaatcaaa aatcaatgga tcaattcatc gaataccaac caagaatgcg
6841 ttcattttga cagaaaacca gacaaaaagc caaaaaaata ttgcaaataa aaaagcaagc
6901 aaccaacgca gcaccaggct aaatcaatcg aaatgctttc tttaccacta tttacaaaaa
6961 agagaaaaaa caatactatt cttccactat attattataa actgtatttg tacatgtgta
7021 ctgcagccga cagcgtcaaa gggccgcaag agcgcgctgc tggagcagta gaaactttct
7081 tgaaacattt gtaagtggac gtgttcgtgc acgtcttgac ccgttcttgt tgtgtcggaa
7141 ctcatccctc ccactcccgc acacgcacac cagtcagtca atcaaccgca gctcatctag
7201 ttgtctcgct cactcgttcg ttgtcgttgc tcatagtatc cgtatcgtct cgctgtcgta
7261 ctcgtcaagc gttctcgctc cactctcatt cgacacaagc aagacactct atctctcgct
7321 cgaagagcat ttacgtacct cagttaccgt tctttcaccg cgccactcgc tggcactaca
7381 aaacgtgttc agggagtgct agtcgtactc gttatcgttc tatcccgtgc agtcgatcca
7441 acatggcgac ttgtcccatc cccggcatgt ttaaatatac taattattct tgaactaatt
7501 ttaatcaacc gatttatctc tcttccgcag ccccgtgcga cgtccgttag gccacaattc
7561 gacggattgg ccttcccacc aagattcgac cttgctcctg aaaacgaatt ctaaatgcca
7621 tttcattttt taatttattt taaatgatat ttcataatga ttatgtttat gattttaatt
7681 taatttctta atttaaaaac aaaataataa aactataaca aaataaatat cgaaaacgac
7741 gggaggcaaa ccaccaacaa cgccagatgc acttaggcaa aaaaataaaa tcatataaca
7801 acaatcgatc accatcgatt agcatacata atacataagt gatcagtaac aggctattgt
7861 gtaagcgcga catttgccat ggggacactg ctcgctgaac ctgtatttgt atttgtattt
7921 atatattttt atacaacttt cgaaatgcat tcaaccaact aactatgaaa gaaccatcga
7981 ctctcaaccg aacaacatga gaataatcgc gaaacgtgag ccccgtcaaa atgaaggccc
8041 cgcggaggtg tccgcggtaa atgtcgcccg cagttcgaat attttgctct atatgtactc
8101 ccaatattgt ttgtcatgca gaccagacaa gacttacgga cgacacgagc tacacactgc
8161 gcttatgttt atgtttaact ctgactctat ctaacaatga tagggagata agatcatcac
8221 ttgacactaa atgaaaagta tacaaaaaag gaacaaaata aatgtaaatc aatttaacaa
8281 atgtgtatta ttttccgtga tcaaatcatt cgactgggac atattcattc atatttactg
8341 gccatacgtg ttaagaaatt gtcacaggtc ttttgtaaac taataagatg ttgtggatat
//