GenBank-Updates@genbank.bio.net (05/18/91)
LOCUS LEIHCPG 5150 bp ds-DNA INV 18-MAY-1991
DEFINITION Leishmania tarentolae H circle borne ltpgpA gene for P-glycoprotein
ACCESSION X17154
KEYWORDS P-glycoprotein; glycoprotein; ltpgpA gene; methotrexate resistance.
SOURCE Leishmania tarentolae DNA.
ORGANISM Leishmania tarentolae
Eukaryota; Animalia; Protozoa; Sarcomastigophora; Mastigophora;
Kinetoplastida; Trypanosomatina; Trypanosomatidae.
REFERENCE 1 (bases 1 to 5150)
AUTHORS Ouellette,M.
JOURNAL Unpublished (1989)
STANDARD full automatic
REFERENCE 2 (bases 1 to 5150)
AUTHORS Ouellette,M., Fase-Fowler,F. and Borst,P.
TITLE The amplified H circle of methotrexate-resistant Leishmania
tarentolae contains a novel P-glycoprotein gene.
JOURNAL EMBO J. 9, 1027-1033 (1990)
STANDARD full automatic
COMMENT *source: strain=TarII;
From EMBL 26 entry LTHCPG; dated 10-JUL-1990.
FEATURES Location/Qualifiers
CDS 173..4816
/note="P-glycoprotein (AA 1-1548)"
/codon_start=173
BASE COUNT 1039 a 1319 c 1680 g 1112 t
ORIGIN
1 acctctgaac tgtactagcc tatggggagg tgggcgctat agagatcgac tcatcgaggg
61 ggcatctaca gcgcgtagtg catgacaaca ccagactgtg tacgcgtgta accgattgac
121 gatcccagtg agctcagaat ttgtgctccc tcgcagcggc gccacatcca atatggtaga
181 caacggtcac gtcaccatcg cgatggctga tttggggaca gtggtcgaga tcgcacaggt
241 gcgctgccag caggaggcgc aacgcaagtt cgcggagcag ctagatgagc tgtggggcgg
301 cgaaccagcg tacacaccga cggtagagga ccaggcgagc tggtttcagc agctctacta
361 cgggtggatt ggggactaca tttacaaggc tgctgcggga aacatcaccg aggcggacct
421 gccaccgccg acgcggagca cacggactta ccacataggg cgcaagttgt cacggcaggc
481 gcatgccgac atcgacgcaa gtcggcggtg gcaggggtac atcgggtgcg aggtcgtgta
541 caagtcagag gcagaagcga agggcgtgct gcggtgggtt gggcatttgc agcagtcaga
601 ctacccgcga tcgctggtcg ctggggtaga gtggcgcatg ccgcctcggc accggcggct
661 ggccgtgctg ggcagtgcgg cagcacttca caacggcgtt gtgcatggtg agcgtctgtt
721 ttggccacat gaagacaact atctctgctc gtgcgagccg gtggagcagt tgtatgtaaa
781 gtcgaagtac aacctgattc ctccccggcc gccgccgtcg ccggatcttc tgcggacgtt
841 gttcaaggtg cactggtacc acgtgtgggc gcagatcctg ccaaagctgt tgtcggatgt
901 taccgcgttg atgctgccgg tgctgttgga gtactttgtg aaatatctga acgccgataa
961 cgcgacgtgg gggtggggtc tgggacttgc gctcacaatc ttccttacga acgtaattca
1021 gagctgctca gcgcacaagt atgaccacat cagcatccgc actgcagcgc tgtttgagac
1081 gtcatcgatg gcgcttctgt tcgagaagtg cttcacggtc tcgcggcgat cactgcagcg
1141 cccggacatg tccgtgggtc gcatcatgaa catggttggg aatgacgttg ataacatcgg
1201 tagccttaac tggtacgtga tgtacttttg gagcgcccca ctgcaactgg tgctatgcct
1261 tctgctgctc ataaggctgg tcgggtggct tcgcgtgccc ggcatggccg tcttgttcgt
1321 gacgctccca ttgcaagccg tcatttccaa gcacgttcag gacgtgtctg agcgaatggc
1381 gagcgtggtg gacctccgca tcaagcgcac gaacgagctt ctctccggtg ttcgaatcgt
1441 gaaattcatg ggctgggagc ctgtctttct cgcccgtatc caagacgcgc gcagtcgtga
1501 gcttcggtgt ttgcgagatg tgcatgtggc taatgtattc tttatgttcg tgaatgatgc
1561 aacaccgacg ttggtaattg cggtcgtctt cattttgtac catgtaagtg ggaaggtgct
1621 gaagccagag gttgtgttcc caacgattgc cctcctcaac actatgcgcg tgtcattctt
1681 catgatacca attatcatat cttccattct gcagtgcttt gtgtcggcaa agcgtgtgac
1741 ggcttttata gagtgcccag acacgcactc acaggtgcaa gacattgcta gcattgacgt
1801 gccggatgct gcagccatct tcaagggtgc gtccatccat acgtatttgc cggtgaaact
1861 ccctcgatgc aagtcgcgct tgacagccat gcagcgcagt acgctgtggt tccgccggcg
1921 cggtgtgccg gagacagagt ggtacgaggt ggacagcccc gatgcgagtg cgtcttcact
1981 ggcagtacac agcacaacgg tccacatggg cagcacacag accgtcatta cagacagcga
2041 tggggctgct ggtgaagacg agaagggaga agtggaagag ggagacagag agtactacca
2101 acttgtgtca aaggaactgc tacggaacgt gagcctgacc atcccgaaag ggaagctgac
2161 aatggtgatt ggctcgacag ggagcgggaa gtcaacactt ctgggtgcgc tgatgggcga
2221 gtacagcgta gagagcgggg agctgtgggc agagcggagc attgcgtacg tgccgcagca
2281 ggcgtggatc atgaacgcga cgctgcgtgg caatattctg ttcttcgacg aggagcgtgc
2341 cgaggacttg caggatgtga tacggtgctg ccagttggag gcggaccttg cgcagttttg
2401 cggtgggctg gacacggaga ttggggagat gggcgtaaac ctgagcggcg ggcaaaaggc
2461 acgcgtgagc ctcgcacgcg ccgtgtacgc gaaccgcgac gtgtacctgc tggacgaccc
2521 cctgtccgcg ctggacgcgc acgttggcca gcgcatcgtg caagacgtca tccttggacg
2581 gctgcgcggc aagacgcgcg tgcttgcaac gcaccagata catctactgc cgcttgcaga
2641 ttacattgtg gtactgcagc atggcagcat cgtgtttgct ggcgactttg ccgctttttc
2701 ggcaactgcc ctggaggaga cgctgcgtgg tgagctaaag gggagcaagg atgtggagtc
2761 ctgcagcagc gatgtggaca cagagtcagc aacagctgaa acggcaccgt atgttgccaa
2821 agcgaaaggt ctgaatgctg agcaagagac gagccttgca gggggcgaag atcccttgag
2881 gtctgatgtc gaggccggga ggctgatgac cacggaggag aaggcaaccg gtaaggtgcc
2941 gtggtcaacc tacgtcgctt atctgaagtc gtgtggcggc ctggaagcgt gggggtgcct
3001 gctagcgacc tttgcgctaa cagagtgtgt gaccgcagct agcagcgtgt ggctgtcgat
3061 atggtccacc ggctcgctga tgtggagcgc ggacacgtac ctctacgtct atcttttcat
3121 tgttttcctt gagatcttcg gatccccact gcgatttttc ttgtgctact accttattcg
3181 cattggcagc cgaaacatgc atcgcgacct tctcgagtct attggagttg cgcggatgtc
3241 tttctttgat acaacccccg taggacgcgt actcaaccgc tttaccaagg acatgagcat
3301 cctcgacaac acgttgaatg acgggtacct ttacctgctg gagtactttt tttccatgtg
3361 ctccaccgtc attatcatgg tggttgtgca accctttgtt ctggtggcca ttgtgccgtg
3421 cgtgtacagc tactacaagc tgatgcaggt ctacaacgca tcgaaccgcg agacacgccg
3481 catcaaaagt atcgcacact cgccagtatt cacgctgctg gaggagtcgc tccaagggca
3541 gcgcaccatc gcgacgtacg gcaagttaca tctcgtgctg caggaggcat tggggcggtt
3601 ggatgtggtg tatagcgctc tgtatatgca gaacgtctcc aaccgttggc tcggtgtccg
3661 tctcgagttt ttgagctgcg ttgtcacctt tatggtggcc ttcattggcg tgatagggaa
3721 gatggagggt gcatcgagcc agaacatcgg cctcatatcg ctttcactaa ccatgtcgat
3781 gacgctgaca gagacactca actggctggt gcgccaagtt gccatggtgg aagctaacat
3841 gaacagcgtg gaacgtgtgc tacactacac tcaggaagtg gaacacgagc acgttccgga
3901 gatgggggag ctcgtggcac agctggtaag gagcgagtca gggagagggg ctaacgtgac
3961 cgagacggtt gtgatcgagt ccgcgggcgc ggcgagcagc gcactgcacc cggtgcaggc
4021 cgggtcgctt gtgctcgagg gtgtgcagat gcggtaccgg gaggggctgc cgcttgtgct
4081 gcgcggcgtg agcttccaga tcgcgccgcg cgagaaggtc ggcattgtcg ggcggacagg
4141 gagtgggaag tcgacgctgc tgctgacgtt catgcggatg gttgaggtgt gcggcggggt
4201 gatccacgtg aacgggcgcg agatgagtgc gtacgggctg cgcgacgtgc ggcggcactt
4261 ctcgatgatc ccgcaggacc ctgtgctgtt cgacggcact gtgcggcaga acgtggaccc
4321 gttcctggag gcgtcgtccg cggaggtttg ggctgcgctg gagcttgtgg ggctgcgcga
4381 gcgcgttgcg tcggagagcg agggtatcga cagccgcgtg ctggagggcg ggtcgaacta
4441 cagcgttggg cagcggcagc tgatgtgcat ggcgcgcgcg ctgctgaaga gggggagcgg
4501 gttcatcctg atggacgagg cgacggcgaa catcgacccg gcgcttgacc ggcagatcca
4561 ggcgacggtg atgagcgcgt tctcggcgta cacggtgatc acgatcgcgc accggctgca
4621 cactgtcgcg cagtacgaca agatcatcgt gatggaccac ggtgttgttg ccgagatggg
4681 cagcccgcgc gagcttgtga tgaaccacca gtccatgttc cacagcatgg tggaatcgct
4741 gggcagccgt ggttcaaaag acttttatga gctccttatg ggacgtcgga ttgtgcagcc
4801 ggccgtgctg tctgattaac gactcgattg ccacctgaaa atcgtgaagc agaagccgct
4861 cgcctcgcac caccctggat gcagacgatg gggagaaagc gtggcacatc tgtggtgcct
4921 ggcatattgc tgttttgtct tatttacagg ctcatgcttg caggagggcg gtagccccgc
4981 cgctgtcgta ctcggggagg aggtcgcata gtggtggtgt gccagtgtgt agaagcacgt
5041 attacatccc tagcggctct taattgaatc tttatttatg tccaaagcca agtcttgcac
5101 aagagaggtt gtcagggcaa cacctcggaa gcatgtgtga gaatgttgac
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