GenBank-Updates@genbank.bio.net (05/22/91)
LOCUS BPEBVG 5996 bp ds-DNA BCT 22-MAY-1991
DEFINITION B.pertussis bvg locus, bvgA and bvgS genes, complete cds.
ACCESSION M25401
KEYWORDS BvgA protein; BvgS protein; DNA binding protein;
periplasmic protein; protein kinase; sensory protein;
transcription regulatory element; transmembrane protein.
SOURCE B.pertussis (strain 165) DNA.
ORGANISM Bordetella pertussis
Prokaryota; Bacteria; Gracilicutes; Scotobacteria;
Aerobic rods and cocci; Alcaligenaceae.
REFERENCE 1 (bases 1 to 5996)
AUTHORS Arico',B., Miller,J.F., Roy,C., Stibitz,S., Monack,D., Falkow,S.,
Gross,R. and Rappuoli,R.
TITLE Sequences required for expression of Bordetella pertussis virulence
factors share homology with prokaryotic signal transduction
proteins
JOURNAL Proc. Natl. Acad. Sci. U.S.A. 86, 6671-6675 (1989)
STANDARD full staff_review
REFERENCE 2 (bases 1 to 5996)
AUTHORS Arico',B., Scarlato,V., Monack,D., Falkow,S. and Rappuoli,R.
TITLE Structural and genetic analysis of the bvg locus in bordetella
species
JOURNAL Mol. Microbiol. (1991) In press
STANDARD full staff_review
COMMENT Draft entry and computer-readable copy of sequence [1] kindly
submitted B.Arico', 14-JUN-1989.
FEATURES Location/Qualifiers
CDS 181..810
/note="BvgA positive transcription regulator (put.)"
/codon_start=181
CDS 819..4535
/note="The BvgS protein functions as a sensor protein"
/product="BvgS protein"
/gene="bvgS"
/codon_start=819
sig_peptide 819..908
/gene="bvgS"
/codon_start=819
BASE COUNT 1120 a 1995 c 1903 g 978 t
ORIGIN
1 gaattcagac ttttcctatt ttggtatagg atactgttta gcagcactca tgcccgtatc
61 gttgcttgct gacgtatagg agaatgtgaa atttcgcagc cattcctttg acgcatcaat
121 gacattacgc gttgcaggat ttttttctcg ccacgaaact caaagcatat tcttcttatc
181 atgtacaaca aagtcctcat cattgacgat caccctgtac tgagattcgc cgtccgggtc
241 ctgatggaaa aggaaggatt cgaagtcatc ggcgaaaccg ataacggcat tgacgggctc
301 aagatcgccc gcgagaaaat tcccaacctc gtcgtactcg acatcggcat tcccaagctg
361 gacgggctgg aagtcatcgc ccggctgcaa tcgctggggt tgccgctacg cgtgctggtg
421 ctgaccggcc agccgccttc gctgttcgcc cgccgctgcc tgaactccgg cgccgcaggc
481 ttcgtgtgca aacacgagaa cctgcacgag gtcatcaatg ccgccaaggc ggtgatggcc
541 ggctacacct acttccccag caccacgctc agcgagatgc gcatgggcga caacgccaag
601 agcgacagta cgctcatcag cgtgttgtcc aaccgcgaac tgaccgtcct gcaactgctg
661 gcgcaaggca tgtccaacaa ggacatcgct gacagcatgt tcctcagcaa caagaccgtc
721 agcacctaca agacgcgcct gctgcagaag ctgaacgcca cgtcgctggt ggaactgata
781 gacctcgcca aacgcaacaa tctcgcctag cgccgcgcat gcccgccccg caccgcctgt
841 acccccgcag tctgatctgc ctggctcagg cgctattggc atgggctttg ctggcatggg
901 cgcccgcgca ggcaagccag gagctgaccc tggtcggcaa ggctgccgtt cccgacgtcg
961 aggtcgcgct cgacggcgac gactggcgtt ggctggcccg caagcgggta ctgacgctgg
1021 gtgtgtacgc accggacatt cctccgttcg acgtcaccta tggcgaacgc tacgaaggcc
1081 tgacggccga ctacatggcg atcatcgcgc acaacctggg gatgcaggcg aaagtgctgc
1141 gataccccac gcgcgaacaa gccctcagcg cgctggaaag cgggcagatc gacctcatcg
1201 gcaccgtcaa tggcacggac ggccggcaac agagcctgcg tctgagcgtt ccctacgccg
1261 ccgaccaccc ggtgatcgtc atgcccatcg gcgcacgcca cgttccagcc tcgaacctgg
1321 ccggccagcg gctggcggtc gacatcaact acctgcccaa ggaaacgctc gcacgggcct
1381 acccgcaggc tacgctgcat tacttcccct catccgagca ggcgctggcc gcggtggcct
1441 atgggcaggc cgacgtattc atcggcgatg ccctgaccac ctcgcacctc gtatcgcaaa
1501 gctatttcaa tgacgttcgc gtagtcgccc cggcccatat cgcgacgggc ggagaatcct
1561 tcggcgtgcg cgccgacaac acccgcctgc tgcgggtggt caacgccgta ctcgaagcca
1621 ttccgccttc cgaacaccgc agcctgatct accgctgggg actgggcagc agcatttcgc
1681 tcgatttcgc gcaccccgcg tattccgcgc gcgagcagca atggatggca gaccaccccg
1741 tcgtcaaggt ggcggtcctg aatctgttcg cgcccttcac cctgttccgc accgacgaac
1801 agttcggcgg gatcagcgcc gccgtgctgc agctgctgca attgcgcacc ggcctggact
1861 tcgagatcat cggcgtcgac acggtcgagg aactgatagc caagctgcgt tcgggcgaag
1921 ccgacatggc cggcgccctg ttcgtcaaca gcgcgcggga gtccttcctc agtttcagcc
1981 ggccgtatgt gcgcaatggc atggtgatcg tcacgcgcca ggaccccgac gcgcccgtcg
2041 acgccgatca tctggacggc cgcacggtcg cgttggtgcg caacagcgcc gccattcccc
2101 tgctgcagcg gcgctatccc caggcgaagg tggtgaccgc cgacaacccg agcgaggcga
2161 tgctgatggt ggccaatgga caggccgacg ccgtcgtgca gacgcagatc agcgccagct
2221 attacgtcaa ccgctacttc gccggcaagc tgcgcatcgc ctcggcgctg gacctgcccc
2281 cggccgagat cgcgctggcg acgacgcgcg gccagaccga actgatgtcc atcctgaaca
2341 aggcgctcta cagcatttcg aacgacgagc tcgcctccat catcagccgc tggcgcggca
2401 gcgacggcga tccgcgcacc tggtacgcct accgcaacga gatctacctg ctgatcgggc
2461 tgggcctgtt gtcggccctg ctgttcctga gctggatcgt ctacctgcgg cgccagatcc
2521 gccagcgcaa gcgggccgag cgggcgctga acgaccagct ggaattcatg cgcgtgctca
2581 tcgacggcac gcctaacccc atctatgtgc gcgataagga aggccgcatg ctgttgtgca
2641 atgacgccta cctcgacacc tttggcgtga ctgccgatgc ggtactgggc aagaccattc
2701 cggaagccaa cgtggtgggc gacccggcgc tggcccgcga aatgcacgag ttcctgctca
2761 cgcgcgtggc cgccgagcgc gagccgcgct tcgaggaccg cgatgtcacg ctgcacggcc
2821 gcacccgcca tgtctaccag tggacgattc cgtacggcga ctcgctgggc gaactcaagg
2881 gcatcatcgg cggctggatc gacatcaccg aacgcgccga gctgctgcgc gagctgcacg
2941 acgccaagga aagcgccgac gccgccaacc gggccaagac cacgttcctg gcaacgatga
3001 gccacgagat ccgcacgccg atgaacgcga tcatcggcat gctggagctg gcgctgctcc
3061 gtccgaccga ccaggagccg gatcgccagt ccatccaggt cgcgtacgac tcggcccgca
3121 gcctgctgga gctgataggc gacatcctgg acattgcgaa gatcgaggcg ggaaaattcg
3181 acctggcgcc ggtgcgcacg gcgctgcgcg tcctgcccga aggggcgatc cgcgtcttcg
3241 acggattggc gcgccaaaaa ggcatagagc tggtattgaa gaccgacatc gtgggcgtcg
3301 acgatgtatt gatagacccc ttgcgcatga agcaagtgct ctcgaacctg gtgggcaacg
3361 ccatcaagtt caccaccgaa ggccaggttg tccttgccgt gaccgcacgc cccgacggcg
3421 acgccgcgca cgtgcagttc agcgtgagcg acaccggctg cggcatcagc gaggccgacc
3481 aacggcagct gttcaaaccg ttctcgcaag tgggtggcag cgccgaggcc gggccggcgc
3541 cgggcaccgg cctgggcctg tccatcagcc ggcgcctcgt cgaattgatg gggggaacgc
3601 tggtcatgcg cagcgcgcca ggggtgggca caacggtttc ggtggacctg aggctgacca
3661 tggtcgaaaa atccgtgcag gccgcgccgc ccgctgcggc cactgcggcc acgccgtcca
3721 agccgcaggt atcgctgcgc gtgctggtcg tcgatgacca caaacccaac ctgatgctgc
3781 tgcgccagca gctggactac ctgggccagc gtgtcatcgc cgccgactcc ggcgaagccg
3841 ccctggccct gtggcgcgag catgcgttcg acgtcgtgat caccgattgc aacatgcccg
3901 gtatcagcgg ctacgaattg gcgcgccgca tacgcgccgc cgaggccgcg cccggttacg
3961 gacgtacgcg gtgcattctg ttcggcttca cggcttcggc gcagatggac gaagcgcagg
4021 cctgccgcgc cgccggcatg gacgactgcc tgttcaagcc gatcggcgtg gacgccttgc
4081 ggcaacgctt gaacgaagcc gtggcacggg ccgcgctccc cacgcccccc tcgccccagg
4141 ctgccgcgcc ggccacggac gacgccaccc cgacggcgtt ctcggccgag tcgattcttg
4201 ccttgacgca gaacgatgag gcgctgatcc ggcaattgct cgaagaagtg attcgcacca
4261 accgggcgga cgtcgaccaa ttgcaaaagc tgcaccagca ggccgattgg ccgaaggtct
4321 cggacatggc gcacaggctg gccggcggcg cgcgcgtggt cgatgccaag gccatgatag
4381 acactgtgct ggcgctggag aaaaaagcgc aaggccaggc tggcccctca cccgaaatcg
4441 acggcctggt acgtacgctt gcggcgcagt ccgccgcgct ggagacgcaa ctgcgcgcct
4501 ggctggagca acggccgcat caagatcagc cctgaagcca cgaacccgcc cgaaccggca
4561 tccctgcttg cgcggacctt acggataatt gggcggcatc tcgcggcggt agtaccaata
4621 caggaagcgc tggcccgtca tgggcggggc cacatggtcg cccagcagat accggcatgg
4681 cagcagatcg gcggcctggg ccatggcctc gtcgaccacg ccggcggcca tgacgggaat
4741 ccgctgcgcc gaggcctgct gtgcgatggc acggcacgcc tcgccggccc tgccgccctg
4801 gcgcagggca tacatgagtt ctggcatcag ggcgatgccg cagatttcca gcgcgtccag
4861 gtgcggcggc gactcggcat cgaacgtgct gacggtaagc accaggttgc atccggcccg
4921 gtgcagccgc cgcagctatg caggctttgc tggccatagg gcgactgcag caggctgggc
4981 gaaacggcca gcgtcagcgc aaacgggggc aggccgcggt ggtccagatt gcgcaggacg
5041 tcgtcgctgt agctgcggct catgaggcat atgggctctg gctggatgaa cagccccaca
5101 tggcggttcg cggcgcatgg ccgcggccag gtcgaaaacc tgcgccagca gctgttgcgc
5161 cagcgcgata tgcaggttgt cgcgcaccaa ggcggccatg tagcagtgct cgggcaccag
5221 cccccaatgc cggtgcgccc actgtatcgt cgtggccacg ccgaacaggc tgcccgtgcc
5281 ggcatcgacc acgggctgga atgctggaat gaattcatcg cgcttgagcg cggcgccgag
5341 ttctgcgacg gtgggccctt cgacgggcgc cagcgggcgc gcagggtgcg ccgggacgga
5401 ctgagggaag cctcgaagct gctgcgagcg ctgttggtcc agtggatcat ggagcagtac
5461 tgacgttggc gaaatgaaca acgtcatatt gaaatggacc gatgccatcc aagccatagg
5521 atacaactca catgtccgcc gtacttttcc caatcgtact gcgtgggcgc gttcgcccat
5581 ctcttagaag gcggccagcc ggctgttgag cagatcgtga ccagcatgtg gccgggcgca
5641 tgggtgatgc agaattccgg acgcacggcc gcgacgaccg attgcggcgt aacgccgcag
5701 gcccagaaaa ccggtatctc gccggcgcgg atttcgaccg cgtcgccgta gtccggacgg
5761 ccgaggtcgg cgataccgat caatgcgggg tcgcccagat ggacgggcgc gccatgcacg
5821 gacggaaagc gcgacgtgac ctggatggcg cggattgcgt ccgcggcctt cagcggccgc
5881 atcgaaacca ccagcggccc cgagaacggg ccggctggat gcgtggcgat gttggtacgg
5941 tacatgggca cgttgcagcc ctgctcgatg tggcggaccg gcaggccatt ctcgag
//