GenBank-Updates@genbank.bio.net (05/22/91)
LOCUS HUMHOX51 6305 bp ds-DNA PRI 22-MAY-1991
DEFINITION Human HOX 5.1 gene for HOX 5.1 protein
ACCESSION X17360
KEYWORDS DNA-binding protein; Hox 5.1 gene; homeo box.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 6305)
AUTHORS Cianetti,L.
JOURNAL Unpublished (1989)
STANDARD full automatic
REFERENCE 2 (sites)
AUTHORS Cianetti,L., Di,C.A., Zappavigna,V., Bottero,L., Boccoli,G.,
Testa,U., Russo,G., Boncinelli,E. and Peschle,C.
TITLE Molecular mechanisms underlying the expression of the human HOX-5.1
gene
JOURNAL Nucleic Acids Res. 18, 4361-4368 (1990)
STANDARD full staff_review
COMMENT SWISS-PROT; P09016; HM51$HUMAN.
*source: developmental stage=adult; clone=lambda 13G. **map:
chromosome=chromosome 2; map position=2q31->37. See also <X04706>
(HSHOM4) for HHo.c13 clone.
From EMBL 26 entry HSHOX51; dated 12-MAR-1991.
FEATURES Location/Qualifiers
promoter 347..350
/note="TATA box"
precursor_RNA 376..6053
/note="primary transcript"
mRNA 376..2051
/note="exon 1"
CDS 1619..2051
/note="HOX 5.1 protein (AA 1 - 144) (2051 is 1st base in
codon)"
/codon_start=1619
intron 2052..2592
/note="intron I"
mRNA 2593..6053
/note="exon 2"
CDS 2593..2924
/note="HOX 5.1 protein (AA 145 - 255) (2593 is 2nd base in
codon)"
/codon_start=2593
misc_feature 2619..2801
/note="homeobox"
misc_feature 3192..3197
/note="polyA signal"
misc_feature 5971..5976
/note="polyA signal"
misc_feature 6039..6044
/note="polyA signal"
BASE COUNT 1587 a 1433 c 1686 g 1599 t
ORIGIN
1 ggatcctggt gggggagggt ggttaataaa gccgccatcc ttgggatgga ttatttttct
61 ttctttcttt ctttttttct ttcttaagaa gaatattctg gttgttcgcc tgcttggtaa
121 ccctgaccct ggcagaagaa tgagggaact cattgcttca aattgtcgcc aagcccatta
181 ggctacctga actgtctcag aaagtgcggg tggctgcgtc gaacggtggt ggctcagagg
241 aagagattgg ggccggcagc gacctaggta cctcactctg ggtgggaccc agaggttgta
301 acgttgtcta tatataccct gtagaaccga atttgtgtgg tatccgtata gtcacagatt
361 cgattctagg ggaatatatg gtcgatgcaa aaacttcacg tttcttcgga atagccagag
421 accaaagtgc gacatggaga ctagaagcag ccggcgctgg tcagccgcct cgttctgttt
481 tattaccttg gactccagga ggatcagctg cgcctggtga catagagcag cttttcctct
541 ccagaagctc ctcaccttta aacagagtat cctctgggtg ctgaaaagaa agaaagacag
601 aaagagagaa agagagagag agagagaaag agagaatgca agcctaattg gttgcatgga
661 tgcagggcca aagggctagg ttttggggta ctagggagtg aggtacaagg ccagcttgcc
721 cagtcccagc tctgccctcc aggaacatga ggtgcaaagg tacccaaatg ggggcttgct
781 tgtatttggg gcctgtggga agaaagcaag cttcaaagaa gcccagtggg gagctctagg
841 gtgcattttg acaaggtgga ggtgcccttg ccaccatccc agcccacccc cagctacatg
901 ggcaagggca gcgagggccc cctgctattt tggcagggcc cagctttggc tgggaacccc
961 cgggcctggg cactggtaga aagcatggcg gttactcatt gcctaatttg attcaagctg
1021 gccagattct ggtaactttt gggtgaccct gatgaagaca aagccaggac ggcggccttt
1081 gtatggcaga tccctgctcc cgccggctgc aggcagggcg ggcaggcagg aaccctcctc
1141 gcctggggca ctctgcccaa ctcagaggcg agttcaccca cccacctttc attgctctgt
1201 accccaatag gaggattcat tctcccttga gctgtgccta cttggtgtcg gggggcgggg
1261 gttgcattca gctgggggtg agtggaaggg ccacggaagg ttggcaaaat cagtggcaga
1321 caaaagctgg gattacctga ggggaatggg gtgctgggga ctggaactac attaatatct
1381 ggcaggggct ctcaaatgtg ccatagcaag ctacttgatt acacgtatgt tatttagtta
1441 aatttgtgaa aattatgaga tgctcaccaa cccggtgata aacttgctcc ctcgccattg
1501 gctggcctgg tcacatggct gcccaacttt attcagttga cagcaagtag gagggcccta
1561 tggaaggaga aaaaaagaca acacgagaaa aattagtatt ttctaccttc tgaaattaat
1621 ggtcatgagt tcgtatatgg tgaactccaa gtatgtggac cccaagttcc ctccgtgcga
1681 ggagtatttg cagggcggct acctaggcga gcagggcgcc gactactacg gcggcggcgc
1741 gcagggcgca gacttccagc ccccggggct ctacccacgg cccgacttcg gtgagcagcc
1801 tttcggaggc agcggccccg ggcctggctc ggcgctgcct gcgcggggtc acggacaaga
1861 gccaggcggc cccggcggtc actacgccgc tccaggagag ccttgcccag ctcccccggc
1921 gcctccgccg gcgcccctgc ctggcgcccg ggcctacagt cagtccgacc ccaagcagcc
1981 gccccccggg acggcactca agcagccggc cgtggtctac ccctggatga agaaggtgca
2041 cgtgaattcg ggtaaggcta gggtccagta acctttctgt ccacatccca gcccgttagc
2101 ctgggtcctc tggaaggggg tgcgagtagg tgggggcgtg tggagcttcc atgggcgccg
2161 caattactct ccccataaat ttttatagct gagggagcag gtcaggacca tgtggctggc
2221 tgctcggctg tgggcgcaaa agggggtggg gatggggggg tgggggagga ctccattttc
2281 agagcagggg gaaggctgtg gaggagcggg ggatttccaa aatgcttgag ggttccggac
2341 ctggtggtgg gcccagaaga aggagcacat ttggggatcc cgcaagcctg gggtatgtgg
2401 gtgtgtttga ggaggtgggt gggagtgagc gtgtgcgccg gggagagggc gggagggagg
2461 aagcaagcga gcttgggagc gcgcggggag ggccgcgggc ctcggggcgc gccaggaagt
2521 gagcggcgga ggcgaggggc ctaactagtg gccgggcgct gacctgcctg tcctgtctgt
2581 tttgtctcgc agtgaacccc aactacaccg gtggggaacc caagcggtcc cgaacggcct
2641 acacccggca gcaagtccta gaactggaaa aagaatttca ttttaacagg tatctgacaa
2701 ggcgccgtcg gattgaaatc gctcacaccc tgtgtctgtc ggagcgccag atcaagatct
2761 ggttccagaa ccggaggatg aagtggaaaa aagatcataa gctgcccaac actaaaggca
2821 ggtcatcgtc ctcatcttcc tcctcatctt gctcctcctc agtcgccccc agccagcatt
2881 tacagccgat ggccaaagac caccacacgg acctgacgac cttatagaag tggggaccct
2941 gggcccatct ctccctgcgc accaggctga gccgaagctg cggggcaggc cgggcctgct
3001 gtcacctcgc tgggctctaa ggtactgtgg ggtggacctg ggacaagcag gccgccctcg
3061 gactaggtta gcatcctgcc cgagggcagc cccctcccta gagcgggatg gggatgggag
3121 ggggggcggg attctctctc taagtatatt atatggcagg agctactgag aacataaaat
3181 cttggcgagt cattaaactt atgaaaatca ccgctcttgg attttgaatt tgcaaatgaa
3241 ggttggatgc tttatcccac tgtgaatttg gacattctcc cccactccac ccctccaggg
3301 tgctttgtgg cttaataatg tgggggagtt gaggcagaag gttggccacc cctgtgctag
3361 gtgctttcag tggaagccag agagctgggt caggatttct ggactttctg ggttgtctat
3421 ggaatttcat gtgattaaaa aatatatatt ttgctcccag tggccccacc tccaaagaaa
3481 tgggtctaag aaggaagtaa aaatgggtta ttttatgttt agatatttgc ttaaatattt
3541 atttgttggg aaatgtggta cagaaataac tgacaccttc atgccaaaaa tcttaaaaag
3601 gtgaaagggg ctgaacttca gggagcagaa tcagagatat gtgcacttac ttctgaactc
3661 cacccctccc cactctctgg aaatgtatat aggggggcct taacccttcc agaaggaagc
3721 aaaggattca ctcaaagttg cattcttgaa aatatatttc cacatgtgtt tttttcagca
3781 ctgtgcttac aaccagttct gggtgattaa aggaaaggga aaaaaaccaa caaatggtcc
3841 aacattttcc ttctggggaa agaaaacaaa acctctatgc actgggtcat tagataatga
3901 ctgaattttc tgttccaact ggattccaaa tgccctaaat accctcatat agcagtgttt
3961 tacaggaatt agtgtatggc ccgtgtaggg gaggggctgt gcagtgggga gaaagtggga
4021 aggtgaggaa ctcttgcttt aagaaggaaa aaaaaaaaac cctaattgaa tctagaagtc
4081 cacaaaagtt agccttagag tttttttccc cctgaagttt taattttttt aaaaaccaaa
4141 tctaaggaag ttttcctcag ctcattaatt agaagcagaa tttgtaaaag tataaaagtt
4201 ttcaagcact cgtctttgcc ttgagaatag tggtttttta aagaatcact ctcaacaggg
4261 gagatgtcct ctagtcgttt ttcttctgcc tctcctggga agggttcaaa gttcattttt
4321 ctaaaatgct gaccctcaag cataaggagg aagaagtcaa agttaatggc cagagttcat
4381 atactcagat gaaaccagtc ttcccaaggc ctcaggctcc aaaaaaggtt gtagctatca
4441 aaaagtgacc aaagtgggaa agggagaaag gataagctta aaatttaatt ttaagatcca
4501 gaaggggggt atttttttca gtacttcaaa aacactttag aaggtttctg ttgtaattta
4561 aaaaatatat ttaagtggga gggaaaaaag agtttctctg taggcttgtt ctttggctgt
4621 gtctcctgag agctgagggc aggtattcac tgcagtccct aggctgaaat tccgcttctc
4681 tgaagtgtct tccaagcctt ggtcttttgt attagaccct ggggactgct ctttgtttct
4741 ccttggggtg agcctggctc tcagacttgc acatggcaat acttgaatgt caccacgtcg
4801 ggatattaaa gatggatatt cgtgcattat tcacatcatt gtttctatga caaaaagcac
4861 agagttcata catagtcaag acgtcttttt ctgacgccct cacgttgaga agctgaaaag
4921 gtattttacc gaagttcggg taaattacag aatcaggttc atccagagga caaattttct
4981 atttgattag ctgtatttca gccgggagga ctgacctcta aacccctaac cttttggact
5041 ctaactaccc ttctcttctt ttttcctctc taacatggag agcagtcttt ggatgtacca
5101 tttgaaagga gccgctatcc ttaggcaagt tggaaagttg ctaagctgct ttcctaaaac
5161 ccaaatctgt ctatacattg aaccttctct ttgagaaggg gaaaaaggta tatattttca
5221 caacatccaa ttacatatat ataatagaga tttgttgtat agattttccc ccacctcaga
5281 agttcaggtt actcaccccc agtttcatac caaatgccac acaggcttaa ctgactgcat
5341 ccctgcccca gaggaaagcc aagaaacatg ttttcatgag gaaaacccaa gctccttctc
5401 aaacatagcc ccactacttt ggaaagtaac ttaatcagag aaacaacttc tttgtttata
5461 agtctcagct ctccttctca gcttggaggg attcttttga aatgttaatg gagcctggat
5521 ggcccagagt gcagccccca accctgaggt cccagtcgga ccccagcatc catttgggcc
5581 cacaggagtg ggccagggaa ggggtagggc cccgtaacca cttagggcag ggaaggaaat
5641 gggtttccat ctgagaacgt gctttggaga aagctaggtg tggaaaagct ccaatgccca
5701 tttgctatta tttgtttcca gtttgttcct ttaaatatga gccagaagtg tttgtgttgg
5761 tgttttaaaa acaaaaacaa aaaccgtgtt ggggtcctga ctgggggagg gggagagtga
5821 agtgtttgct gaggacattg ctcctctgac tcccatctca ctttgtccat cgcagccttt
5881 tgttgggaga tgacactgtc agtcagccca tgatgtctgt tcacacgaga tgctttttta
5941 atagaattga ccaatgtttt gctgccactg attaaagtat tatttatact aattgttgct
6001 tgtagttttg atgtaattca ttgatctata tttaaaataa taaaaggtgt agcaaaatct
6061 ccctcctgtt tggtgcctta acagaagcat tcatcctttg ttaagtcttc taaaagctaa
6121 catttaacat aaacaagtta ttattttctg caataaatta ggcaccattt tttggggggt
6181 gcctaaagtg tgaaggttaa accatgtaag gcttagcaat tctattatta ccacctcctt
6241 aatgtacaca cactcccagt tggccaccat attttgtgag cattgggaag cctggggttg
6301 aattc
//