GenBank-Updates@genbank.bio.net (05/22/91)
LOCUS XIPRKINV 6112 bp ss-mRNA VRT 22-MAY-1991
DEFINITION Xiphophorus maculatus Xmrk proto-oncogene DNA (INV invariably
present)
ACCESSION X56317
KEYWORDS Tyrosine kinase; Xmrk oncogene; proto-oncogene.
SOURCE Xiphophorus maculatus RNA.
ORGANISM Xiphophorus maculatus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Osteichthyes;
Actinopterygii; Atheriniformes; Cyprinodontoidei; Poeciliidae.
REFERENCE 1 (bases 1 to 6112)
AUTHORS Adam,D.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (sites)
AUTHORS Adam,D., Maeueler,W. and Schartl,M.
TITLE Transcriptional activation of the melanoma inducing Xmrk oncogene
in Xiphophorus
JOURNAL Oncogene 6, 73-80 (1991)
STANDARD full staff_review
COMMENT From EMBL 26 entry XMRKINV; dated 11-MAR-1991.
FEATURES Location/Qualifiers
mRNA join(77..232,321..396,1327..1473,1556..1653,1865..2002,
3466..3556,3714..5429)
/gene="Xmrk (INV proto-oncogene)"
CDS join(77..232,321..396,1327..1473,1556..1653,1865..2002,
3466..3556,3714..4048)
/partial
/product="Xmrk protein (INV)"
/gene="Xmrk (INV proto-oncogene)"
/codon_start=77
exon 77..232
/number=1
/gene="Xmrk (INV proto-oncogene)"
exon 77..232
/gene="Xmrk (INV proto-oncogene)"
exon 77..232
/note="exon t"
/gene="Xmrk (INV proto-oncogene)"
prim_transcript 77..5429
/gene="Xmrk (INV proto-oncogene)"
intron 233..320
/number=1
exon 321..396
/number=2
/gene="Xmrk (INV proto-oncogene)"
exon 321..396
/gene="Xmrk (INV proto-oncogene)"
exon 321..396
/note="exon u"
/gene="Xmrk (INV proto-oncogene)"
intron 397..1326
/number=2
exon 1327..1473
/number=3
/gene="Xmrk (INV proto-oncogene)"
exon 1327..1473
/gene="Xmrk (INV proto-oncogene)"
exon 1327..1473
/note="exon v"
/gene="Xmrk (INV proto-oncogene)"
intron 1474..1555
/number=3
exon 1556..1653
/number=4
/gene="Xmrk (INV proto-oncogene)"
exon 1556..1653
/gene="Xmrk (INV proto-oncogene)"
exon 1556..1653
/note="exon w"
/gene="Xmrk (INV proto-oncogene)"
intron 1654..1864
/number=4
exon 1865..2002
/number=5
/gene="Xmrk (INV proto-oncogene)"
exon 1865..2002
/gene="Xmrk (INV proto-oncogene)"
exon 1865..2002
/note="exon x"
/gene="Xmrk (INV proto-oncogene)"
intron 2003..3465
/number=5
exon 3466..3556
/number=6
/gene="Xmrk (INV proto-oncogene)"
exon 3466..3556
/gene="Xmrk (INV proto-oncogene)"
exon 3466..3556
/note="exon y"
/gene="Xmrk (INV proto-oncogene)"
intron 3557..3713
/number=6
exon 3714..5429
/number=7
/gene="Xmrk (INV proto-oncogene)"
exon 3714..5429
/note="exon z"
/gene="Xmrk (INV proto-oncogene)"
BASE COUNT 1723 a 1299 c 1252 g 1838 t
ORIGIN
1 gaattcaaat atttatttat ctatttagcg gttagttctg gtttgttaaa tgacacactc
61 tgtcctgctg gttcagggaa tgaactacct ggaagagcgc cacctggtgc accgcgacct
121 ggcagccagg aacgtcctgc tgaaaaaccc gaaccacgtc aagatcacag acttcggtct
181 gtccaagctg ctgacggctg acgagaagga ataccaagcc gacggaggaa aggtgccatg
241 gcaacgcctg actggtttct gtttgctgtt cggactgaaa acatgtcaga gatgaatcac
301 tgctgcatct ctgtgagcag gttcccatta agtggatggc tttggagtcg atcctccagt
361 ggacctacac ccatcagagc gacgtgtgga gctacggtga ggaatcgtcc ccacagcgcc
421 acctacctgc cttcaccctc tgcttcctgt tagccggttt aaacatctga aaccacacag
481 ccagaggatt tagactgaat aaaatacttc tacactatta gtgaatattg gttgcacatt
541 atcatctctt gttcaaaatg ttaaatgctt gagactcaaa ccagagtgag atttttgtac
601 actgaacaga tgctgaacat cagtgttagc atgtaaccct ggttatattg atttattcct
661 gattatattt aatctgatca tggaaatctt accagttttc ctgtttgaaa ttagactgag
721 tgatttgtat tactaaaaat taaaacttac ggcccttagt ttagctaaaa tcccatctta
781 cgttgaaagg acgtggcgtt catttatgga gctccagtag cagtcagtca agccacaaat
841 ctgaagaagc ctctgactgg agactgttgc agcttaacag ctccacatcc aggcaccaga
901 aacattagta acatagcaac acatcctgga tgactccatc cgttagcata ctctgctaat
961 ccgcctcatt tgcttttgct gctcgtcttt aaacctctgg ttggctgtga ggtcagaaag
1021 atgttggagt aggggatatg atcgatggaa cttgaacttc ttccttctct ctctgctctg
1081 catccatgaa gcctcctttc tacctcctct gggatttggg gtcaaagttc aggtgatatt
1141 ttatctacct gaggtccaca aatcgggtag acgaatccgt tgacaggaca gctatgagtc
1201 attctaacta taaatggcta agtgtgttcc tgcagaaaat gaggaaattg ttctttttcc
1261 ttttgtgcgg tgttattgct aggctaggct aggctaacca agctgaagtc actcctgtct
1321 ctgcaggtgt gacggtttgg gagttgatga cgttcggatc caaaccgtac gacggcatcc
1381 cggccaagga gatcgcctcg gtgctggaga acggggagcg gctgccgcag cctcccatct
1441 gcaccatcga agtctacatg atcatcctga agtgtaagag ctgaccctgc aggtggcgct
1501 gcaggctggc tgggctgttt cctcatggta gtgtgttgtc cccgtctccc tgcaggctgg
1561 atgatcgacc cgtccagcag acccaggttc agagagctgg tgggcgagtt ctcccagatg
1621 gcccgggacc cgtccaggta cctggtcata caggtacgcc accgccccca cctgacccta
1681 ctataaaaca ctaacagaac aattctgggt tttcacttta cgtttcagaa aatatatcca
1741 aagagtccaa atcaaaatct aaatgttttt cattaagtaa ctgaacatta agaagcgaat
1801 ctaatcaaat atggaataat aaagtatatt tgactgtttt ggttgcctct gacttgtttc
1861 ccagggcaac ctgccgagtc cgtctgatcg gaggcttttc tcccgcctgc tgagctctga
1921 tgacgacgtg gtcgacgccg atgaatacct gctgccgtac aaacggataa accgccaggg
1981 cagcgagccc tgcatcccgc cggtaaaaac tctgatgcta accgaacagc aacctgaaac
2041 aagtcctgga gtttctggag ttttcattct gacccggaaa gtccgaggtt cctcaccggc
2101 tgggtctcac aatccaacat ggctgccgct catacagaca gctgtcaaga ttttcatctg
2161 aatttgtgtc tcaataatct gattcttata aaaccataag accagctaat aaaactgttg
2221 ccacaaaatt aaattacata aatcaggatt tctgagcagt ctgggaaaat ctggacttta
2281 acttcagtaa ctttccaggt ctggatcagc aaaaacaact aaagtgtgga ggatgttgta
2341 tttgtaactg cttttccatt tggccatgtt tcatgttcgt ccttctttcc tgttccttct
2401 tcctatactt ccttgtgtcc ttcaatcctt cattgtcttc ttgtctcatt gaataagaga
2461 aacgagaaac ttttatttat ttattccttt gtccgtcatt ctttcatttg tacttttgtt
2521 ttttccttcc ttccttcctt cttctcctgt ccttcctacc ttccttaatt actttccttg
2581 ttccttcttt caattctttt cgttgtctct tgtttttgca gcttagatat ttaaaccatt
2641 ccttttattt acatatgtac cataaattta tcaacatttg gtgttttata ttttaactgg
2701 ttttcaaatt tacaatatag ttgttgttgg tattttagcc gtagacagta aagaagctct
2761 ctcacctgac gagacgtaga gcagtgaatc cgtctctcct taaagacatt tcccagttct
2821 tcctcacatc gtgtctttat gaaaccttca aaataaaaac agaaaacata taaataatat
2881 tctttgccac ctgtgtaata tttgctttgg attgttataa cacataatat tagaataata
2941 tatttataat tataaataaa attgttttat ttctaagata gcgctcttgt gtcaaataat
3001 ttaaatcaac gttagggaat aattcaaact ttttgaaaat ttacaaaatc tcagttatcc
3061 ttcatagcgt ggactgaaca ccggtgttac atcaagcact aaagctaata ttagctggcg
3121 tttcatggtg gacaaaaata caatataata acattctaat tataaaatat aaacaataat
3181 atgttcatct tacttgtgaa acattatccc cgagatctca tgtaaatagt ccgtcgagct
3241 caacaaaaat atgccgagtc tacttctgga acgacggctc caagatggcc gccgtatttc
3301 ctgtgcagcc aatgcggggt ttactcttta ctatgtctat gatgttagca cacatgtcct
3361 gttactgccg accaccaggg ggcagaacaa tacgtaaagt gaaataatgg gcatgtttta
3421 tccaacatgg acactgatcc atctgaactg tgtgtgtttt tttagaatgg gcatccagtg
3481 agagagaaca gcatggctct ccggtacatc tccgacccga cccagaacgc gctggagaaa
3541 gacctggatg gtcacggtag gttctgacca gcaatcactt tcttcaagaa atcaggaagt
3601 gatcacaata atggagtcaa acagacagga tacgagtcag atgcaaacaa ggagtttcac
3661 catagcaacc gagtccaggc tctaaataaa tcttcctgat gtttgtgttc cagagtacgt
3721 taaccagcct gggagtgaaa ccagcagcag gctgtcggat atctacaatc ccaactacga
3781 ggacctgacg gacggctggg gcccggtgtc gctgtcctcc caggaggcgg agaccaactt
3841 ctccagaccg gagtacctga acaccaacca aaactcgctc cccctggtgt ccagtggcag
3901 catggacgac cccgactacc aggccggcta ccaggctgcc ttcctaccgc agactggagc
3961 gctcactggg aacggcatgt ttctccctgc agcagagaac ctggagtacc tgggactggg
4021 aggcgcactg tacactcctg tccggtaggg ggcagcagcg ctccgactga agctgtggct
4081 ttgctcagat aaacagtggt ctgttttaaa ttggacagat aactggattt aactcagatg
4141 gttcactgtc ggttctccag aggaactgaa acagaacaag aacttcctgt tccttcaggc
4201 aaaggtccaa tctttggctc taagctgacg ggatgaacgc atctggaaaa tggagccaaa
4261 cattacccag ataaactgta aaaacataag ctaattcagg ttacattaaa aaagactcgc
4321 tcaactctcc tgctctcaca tgtgggtttg gatgctgcag gacgatgcag atgttttaat
4381 cctgggcgct tctgtttcca acatttacat tcatgaactg aaaatattta agttttctga
4441 agatatgatt tgactgtcag tcaacatgat gtttgtaacc ttaaatcttt cagaataaga
4501 gaaaacaggt tgaaactgga ttctcaggcc acactgctct actccagata tttataactg
4561 ccattttgta aaaaaaagaa tctgcattca cacaatctgt tggttttcta tcagaacaat
4621 tttatacaag ccttgcaaga gcaggtggaa ataaaattaa gcttactaaa attgaaattt
4681 tgtagaagac aacgttgggt gaacgaaata acacaaatgg ttccgtttta taggttgtag
4741 aaggacagag gaggacatgt ccaccatgtt ttttaatcct ctttggacat cacgttccca
4801 cagatacatc agtgttttta aaaatctcac caaaatctgt gtgcatgtcg acaggaggtg
4861 gagacgaagt ggaaaaattt taattttact aaacatcaga gttggtgggg agatttgaag
4921 agtttactaa tttttttaaa gattattcag taatctggaa taatcttaac ttgttttaaa
4981 tataggaagg aaaatgtgaa caaatcttct gactacttgg gagacagatc aacatctgta
5041 gggggcagtg ctcaccgtgt tgtgttcatt ctgtgtttta gaagaatcgt ctccaagcta
5101 gcttctgtta gcaaaacagg ctaattattt cccgctgacg gtttacagtg agttagagaa
5161 agtgtttgac ggatttgatt gaaatgtgtt actgtgactt agtgaggtgg aagccatgtt
5221 ggattttgac attctaagtc aaaacttcga cttaaaagaa gaactgttca agttagttca
5281 tttaaaaatg aataaggtaa atggaaagct ggcagaacag ctccccctgc tggtactgcc
5341 agggttctac aaaaaacacc acttccataa agaataggtc agcttcttgt taataatgac
5401 ttgtttctta tactattatt gtgaataaat gtactatgct tgtttctgta aatgtaactt
5461 taaagtgctt caaagtgaga atgtgtgttt aagttcagct ctggatggga accagtgcag
5521 aacctgtctg ctggttctca ctgaggaacg caattcagct aaacttcacg gaaccatttc
5581 agtccaaact gtagcacaag gagaacctcc tgttgttgtc tgacttgaaa tattcactct
5641 tgattgtttg tgttgttgaa tttttgaaag aaagtttgct ttacttgaca taaatgagcc
5701 aatccctgac gtcctgctgc tgaatattac tgctagtctc tgtttgtctt taatgtttat
5761 tgattaaaaa aaacaaagtt aagtttctga ctgtggttgc tggtttttat tcttagtatc
5821 tataagatac tatatatata tatatatata tatatatata tatatatata tatatatata
5881 tatatatata tataaaaaca ctaaaggttt acataacatt atggtgaaca cataaatgat
5941 ttaatttacc tttgagttct ttctgaagtt tcacatccag cttaaatcct gtgtcgttgt
6001 tgagactttt aaggacgtat gaataattct ataagcatta ttaatattaa tagctctgca
6061 gcgactgcta acatgttgcc tgcgcaccgg aagtgtctat gtgactaata aa
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