GenBank-Updates@genbank.bio.net (05/22/91)
LOCUS RABIG07 642 bp ds-DNA MAM 22-MAY-1991
DEFINITION Rabbit germline gene V18b for immunoglobulin kappa light chain
variable region
ACCESSION X02336
KEYWORDS immunoglobulin light chain; kappa-immunoglobulin; signal peptide;
variable region.
SOURCE Oryctolagus cuniculus DNA.
ORGANISM Oryctolagus cuniculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Lagomorpha; Leporidae.
REFERENCE 1 (bases 1 to 642)
AUTHORS Heidmann,O. and Rougeon,F.
TITLE Immunoglobulin kappa light-chain diversity in rabbit is based on
the 3' length heterogeneity of germ-line variable genes
JOURNAL Nature 311, 74-76 (1984)
STANDARD full automatic
COMMENT From EMBL 26 entry OCIG07; dated 07-NOV-1985.
FEATURES Location/Qualifiers
mRNA 7..61
/note="exon 1"
CDS 7..61
/note="signal peptide (aa -22 to -5) (61 is 1st base in
codon)"
/codon_start=7
intron 62..184
/note="intron I"
mRNA 185..495
/note="Exon 2"
CDS 185..195
/note="signal peptide (aa -4 to -1) (185 is 2nd base in
codon)"
/codon_start=185
misc_feature 196..264
/note="framework 1 (FR1) (aa 1-23)"
CDS 196..495
/note="V18b gene (aa 1-100)"
/codon_start=196
misc_feature 265..303
/note="complementarity determining region 1 (cdr 1) (aa
24-36)"
misc_feature 304..348
/note="FR2 (aa 37-51)"
misc_feature 349..369
/note="CDR2 (aa 52-58)"
misc_feature 370..465
/note="FR3 (aa 59-90)"
misc_feature 466..495
/note="CDR3 (aa 91-100)"
misc_feature 496..502
/note="recombination signal"
misc_feature 515..523
/note="recombination signal"
BASE COUNT 136 a 179 c 185 g 142 t
ORIGIN
1 cccagcatgg acaccagggc ccccactcag ctgctggggc tcctgctgct ctggctccca
61 ggtaaggaag gccagcagca ggaacggcct cgggcagtgt ggccagggct gcccgtctct
121 gcaggagcgt cctcttagaa tgtgaggatg agtgtggtct ctgtgtttct gtttcccttc
181 tcaggtgcca catttgctca agtgctgacc cagactgaat cgcccgtgtc tgcacctgtg
241 ggaggcacag tcaccatcaa ttgccaggcc agtcagagtg tttatgataa caactggtta
301 tcctggtatc agcagaaacc agggcagcct cccaagctcc tgatctatga tgcatccaaa
361 ctggcatctg gggtcccatc acggttcagc ggcagtggat ctgggacaca gttcactctc
421 accatcagtg gcgtacagtg tgacgatgct gccacttact actgtcaagg cagttattat
481 agtagtggtt ggtaccacag tgttagaagc cctaacaaaa ccaccaggaa agcagaagtg
541 tgaggctggg ctgccccagc tgctcctcct ggaccccatc tgctgagagt gattctcaga
601 gcagccaggc ttgaaggtcc tgcagggtcg ggtggaaggg gc
//