GenBank-Updates@genbank.bio.net (05/22/91)
LOCUS RABIG08 765 bp ds-DNA MAM 22-MAY-1991
DEFINITION Rabbit germline gene V19a for immunoglobulin kappa light chain
variable region
ACCESSION X02337
KEYWORDS immunoglobulin; immunoglobulin light chain; kappa-immunoglobulin;
signal peptide; variable region.
SOURCE Oryctolagus cuniculus DNA.
ORGANISM Oryctolagus cuniculus
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Lagomorpha; Leporidae.
REFERENCE 1 (bases 1 to 765)
AUTHORS Heidmann,O. and Rougeon,F.
TITLE Immunoglobulin kappa light-chain diversity in rabbit is based on
the 3' length heterogeneity of germ-line variable genes
JOURNAL Nature 311, 74-76 (1984)
STANDARD full automatic
COMMENT From EMBL 26 entry OCIG08; dated 07-NOV-1985.
FEATURES Location/Qualifiers
misc_feature 37..40
/note="put. CAAT-like sequence"
misc_feature 74..78
/note="put. TATA-like sequence"
misc_feature 101..103
/note="inframe initiation codon"
mRNA 131..185
/note="exon 1"
CDS 131..185
/note="signal peptide (aa -22 to -5) (185 is 1st base in
codon)"
/codon_start=131
intron 186..308
/note="intron I"
mRNA 309..613
/note="exon 2"
CDS 309..319
/note="signal peptide (aa -4 to -1) (309 is 2nd base in
codon)"
/codon_start=309
misc_feature 320..388
/note="FR1 (aa 1-23)"
CDS 320..613
/note="V19a (aa 1-98)"
/codon_start=320
misc_feature 389..421
/note="CDR1 (aa 24-24)"
misc_feature 422..466
/note="FR2 (aa 35-49)"
misc_feature 467..487
/note="CDR2 (aa 50-56)"
misc_feature 488..583
/note="FR3 (aa 57-88)"
misc_feature 584..613
/note="CDR3 (aa 89-98)"
misc_feature 616..622
/note="recombination signal"
misc_feature 635..643
/note="recombination signal"
BASE COUNT 153 a 228 c 218 g 166 t
ORIGIN
1 ggcccttcag ctgcacagcc ctgccacgcc cctgctcatt gcactgtccc tagagcagcc
61 cacctctctg ggcatttagg gcccaggctg ctcccgcccc atgcaggagg cagtgcaggc
121 aggacccagc atggacacga gggcccccac tcagctgctg gggctcctgc tgctctggct
181 cccaggtaag gaaggccagc agcaggaacg gcctcgggca gtgtgtccag ggctgcccgt
241 ctctgcagga gtgtcctctt agaatgtgag gatgagtgtg gtctctgtgt ttctgtttcc
301 ctcgtcaggt gccacttttg cccaagtgct gacccagact ccagcctccg tgtctgcagc
361 tgtgggaggc acagtcacca tcaattgcca ggccagtgag agcattagta gctacttaaa
421 ctggtatcag cagaaactag ggcagcctcc caaactcctg atctattatg catccactct
481 ggcatctggg gtcccatcgc ggttcaaagg cagtggatct gggacagagt acactcttac
541 catcagcggt gtgcagtgtg acgatgctgc cacttactac tgtcagcatg gttatattta
601 tagtagtggt gataccacag tgttccaagc cctaacaaaa accccccagg aaagcagaag
661 tgtgaggctg ggctgcccca gctgctcctc cttgggcccc atctgctgag agtgattctc
721 agagcagcca ggcttgaagg tcctgcaggg tcgggtggaa ggggc
//