GenBank-Updates@genbank.bio.net (05/22/91)
LOCUS HUMIRBPH 4088 bp ds-DNA PRI 22-MAY-1991
DEFINITION Human gene for interphotoreceptor retinoid-binding protein (IRBP)
promoter region and first exon, partial.
ACCESSION X53044
KEYWORDS interphotoreceptor retinoid-binding protein;
retinoid binding protein.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 4088)
AUTHORS Albini,A.
JOURNAL Unpublished (1990)
STANDARD full automatic
REFERENCE 2 (bases 1 to 4088)
AUTHORS Albini,A., Toffenetti,J., Zhen,Z., Chader,G.J. and Noonan,D.M.
TITLE Hypomethylation of the interphotoreceptor retinoid-binding protein
(IRBP) promoter and first exon is linked to expression of the gene.
JOURNAL Nucleic Acids Res. 18, 5181-5187 (1990)
STANDARD full automatic
COMMENT SWISS-PROT; P10745; IRBP$HUMAN.
*source: library=EMBL3; clone=Clonetech commercial library; see
<M33864> - <M33866> and <M33875> for related sequences.
Data kindly reviewed (03-DEC-1990) by Noonan D.M.
From EMBL 26 entry HSIRBPG; dated 19-MAR-1991.
FEATURES Location/Qualifiers
misc_feature 1..2818
/note="promoter region"
mRNA 2819..>4088
/note="exon 1"
CDS 2941..>4088
/note="interphotoreceptor retinoid-binding protein
N-terminal fragment (383 AA) (4088 is 2nd base in codon)"
/codon_start=2941
BASE COUNT 908 a 1189 c 1044 g 947 t
ORIGIN
1 gctccttcct gtactgccca gctccgcttg ctccctgacc atccctgcag cagccctgat
61 gtgtcattgt ccccctctta acctgcgctg cagtgctgca gggctgggct ctggagctgg
121 gtctggtcat ttctccttag atatgtagag gcccaggaaa ggtttggagc ctaagaagcc
181 ctaggactcc aggtctccag ggcagcccca gcctcttgga atgactttcc ctaataccac
241 aggggtgttc taatcccagg cagacccaag ctgcccctca ccaactccta cgtcctcaac
301 ttcctttcat aacttctagg atggaaacac ctaatcctcc agcaatactg aggcttttct
361 ccttattctg ttttcccttt tgaagaagcc aaggctcaga gcagtcgagt cacctaatca
421 tggtctcatg tcgcctgatc aaggtctcat gtcaccttat caagatctca cccactcacc
481 tattcagttc tcaccagttc agttcaggat ggcttctaag ctaccctgca cagctctgcc
541 cacaggacat ttgtataagt gagggggtgc aggccttcca gccccctcca actccaaaac
601 tcagccccca agatcaagtg gactctctga acccaccctg gccctacagt tgtcagggtc
661 tggatgggaa gatgtagagc tctcggcttt cactctgggg acttacccag aacatattct
721 cctcatgagc taaggaggct ggctgccatc ttcctacatc cccccacggc ctgggggcaa
781 ggacaccctg gccccctgga gtctggagaa ctctgaggac agaacttgct cttccacctg
841 cttgggcctt acccacagga gaagcactgc ttctctaccc atgccccatc caactcaggc
901 accccaggga cttgcaacag tctgattttt tctcacgtcc ttcttaaggc tctgggctag
961 ccacacaaat caaatcccag tgataggtcc agacaatcct atcctgaaac tacatcttag
1021 taagactcca gggaatcctt tccccaaaga cagtcttact cctgttctcc ccccaagcct
1081 ttctgggcca gaagctttgc ctggactcaa gcaatggcag acaagtgccc tctgaggaca
1141 cggaagtgca tgctcagaac tgtgattctc caagtggagg cagaggagaa ggcccaggct
1201 tcccagcagg gctaaggata tgcaaggagt gcattcatcc ggaggtgttg gcagcatccc
1261 agccccaccc cattctcatc gtaaatcagg ctcacttcca ttggctgcat acggtggagt
1321 gatgtgacca tatgtcactt gagcattaca caaatcctaa tgagctaaaa atatgtttgt
1381 tttagctaat tgacctcttt ggccttcata aagcagttgg taaacatcct cagataatga
1441 tttccaaaga gcagattgtg ggtctcagct gtgcagagaa agcccacgtc cctgagacca
1501 ccttctccag ctgcctactg aggcacacag gggcgcctgc ctgctgcccg ctcagccaag
1561 gcggtgttgc tggagccagc ttgggacagc tctcccaacg ctctgccctg gccttgcgac
1621 cactctctgg gccgtagttg tctgtctgtt aagtgaggaa agtgcccatc tccagaggca
1681 ttcagcggca aagcagggct tccaggttcc gaccccatag caggacttct tggatttcta
1741 cagccagtca gttgcaagca gcacccatat tatttctata agaagtggca ggagctggga
1801 tctgaagagt tcagcagtct acctttccct gtttcttgtg ctttatgcag tcaggaggaa
1861 tgatctggat tccatgtgaa gcctgggacc acggagaccc aagacttcct gcttgattct
1921 ccctgcgaac tgcaggctgt gggctgagcc ttcaagaagc aggagtcccc tctagccatt
1981 aactctcaga gctaacctca tttgaatggg aacactagtc ctgtgatgtc tggaaggtgg
2041 gcgcctctac actccacacc ctacatggtg gtccagacac atcattccca gcattagaaa
2101 gctgtagggg gacccgttct gttccctgga ggcattaaag ggacatagaa ataaatctca
2161 agctctgagg ctgatgccag cctcagactc agcctctgca ctgtatgggc caattgtagc
2221 cccaaggact tcttcttgct gcacccccta tctgtccaca cctaaaacga tgggcttcta
2281 tttagttaca gaactctctg gcctgttttg ttttgctttg ctttgttttg ttttgttttt
2341 ttgttttttt gttttttagc tatgaaacag aggtaatatc taatacagat aacttaccag
2401 taatgagtgc ttcctactta ctgggtactg ggaagaagtg ctttacacat attttctcat
2461 ttaatctaca caataagtaa ttaagacatt tccctgaggc cacgggagag acagtggcag
2521 aacagttctc caaggaggac ttgcaagtta ataactggac tttgcaaggc tctggtggaa
2581 actgtcagct tgtaaaggat ggagcacagt gtctggcatg tagcaggaac taaaataatg
2641 gcagtgatta atgttatgat atgcagacac aacacagcaa gataagatgc aatgtacctt
2701 ctgggtcaaa ccaccctggc cactcctccc cgatacccag ggttgatgtg cttgaattag
2761 acaggattaa aggcttactg gagctggaag ccttgcccca actcaggagt ttagccccag
2821 accttctgtc caccagctga gaaggacaag ggcggaaggc agctgcacag agcagggcca
2881 cggccttgca cacagtccag ggagcttttg tgcaggagcc aggcctcccc ctgggtcccc
2941 atgatgagag aatgggttct gctcatgtcc gtgctgctct gtggcctggc tggccccaca
3001 cacctgttcc agccaagcct ggtgctggac atggccaagg tcctcttgga taactactgc
3061 ttcccggaga acctgctggg catgcaggaa gccatccagc aggccatcaa gagccatgag
3121 attctgagca tctcagaccc gcagacgctg gccagtgtgc tgacagccgg ggtgcagagc
3181 tccctgaacg atcctcgcct ggtcatctcc tatgagccca gcacccccga gcctccccca
3241 caagtcccag cactcaccag cctctcagaa gaggaactgc ttgcctggct gcaaaggggc
3301 ctccgccatg aggttctgga gggtaatgtg ggctacctgc gggtggacag cgtcccgggc
3361 caggaggtgc tgagcatgat gggggagttc ctggtggccc acgtgtgggg gaatctcatg
3421 ggcacctccg ccttagtgct ggatctccgg cactgcacag gaggccaggt ctctggcatt
3481 ccctacatca tctcctacct gcacccaggg aacaccatcc tgcacgtgga cactatctac
3541 aaccgcccct ccaacaccac cacggagatc tggaccttgc cccaggtcct gggagaaagg
3601 tacggtgccg acaaggatgt ggtggtcctc accagcagcc agaccagggg cgtggccgag
3661 gacatcgcgc acatccttaa gcagatgcgc agggccatcg tggtgggcga gcggactggg
3721 ggaggggccc tggacctccg gaagctgagg ataggcgagt ctgacttctt cttcacggtg
3781 cccgtgtcca ggtccctggg gccccttggt ggaggcagcc agacgtggga gggcagcggg
3841 gtgctgccct gtgtggggac tccggccgag caggccctgg agaaagccct ggccatcctc
3901 actctgcgca gcgcccttcc aggggtagtc cactgcctcc aggaggtcct gaaggactac
3961 tacacgctgg tggaccgtgt gcccaccctg ctgcagcact tggccagcat ggacttctcc
4021 acggtggtct ccgaggaaga tctggtcacc aagctcaatg ccggcctgca ggctgcgtct
4081 gaggatcc
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