GenBank-Updates@genbank.bio.net (05/22/91)
LOCUS HUMENKB7 2275 bp ds-DNA PRI 22-MAY-1991
DEFINITION Human preproenkephalin B gene exon 4 and 3' flanking region
ACCESSION X00177 K02268
KEYWORDS dynorphin; endorphin; enkephalin; rimorphin; tandem repeat.
SOURCE Homo sapiens DNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 2275)
AUTHORS Horikawa,S., Takai,T., Toyosato,M., Takahashi,H., Noda,M.,
Kakidani,H., Kubo,T., Hirose,T., Inayama,S., Hayashida,H.,
Miyata,T. and Numa,S.
TITLE Isolation and structural organization of the human preproenkephalin
B gene
JOURNAL Nature 306, 611-614 (1983)
STANDARD full automatic
COMMENT SWISS-PROT; P01213; NDDB$HUMAN.
Data kindly reviewed (04-MAR-1986) by M. Noda
From EMBL 26 entry HSENKB4; dated 28-MAR-1991.
FEATURES Location/Qualifiers
intron <1..33
/note="intron III"
mRNA 34..2215
/note="exon 4"
CDS 34..661
/note="(aa 44-254)"
/product="prepro-enkephalin"
/codon_start=34
CDS 425..451
/note="(aa 175-183)"
/product="betaneoendorphin"
/codon_start=425
CDS 521..571
/note="(aa 207-223)"
/product="dynorphin"
/codon_start=521
CDS 578..616
/note="(aa 226-238)"
/product="rimorphin (aa 226-238)"
/codon_start=578
BASE COUNT 596 a 518 c 558 g 603 t
ORIGIN
1 tttgccactg tggtcttttt gggtcttttg cagatttgct ccctgcaatg ccaggctgcc
61 ctgctgccct ctgaggaatg ggagagatgc cagagctttc tgtctttttt caccccctcc
121 acccttgggc tcaatgacaa ggaggacttg gggagcaagt cggttgggga agggccctac
181 agtgagctgg ccaagctctc tgggtcattc ctgaaggagc tggagaaaag caagtttctc
241 ccaagtatct caacaaagga gaacactctg agcaagagcc tggaggagaa gctcaggggt
301 ctctctgacg ggtttaggga gggagcagag tctgagctga tgagggatgc ccagctgaac
361 gatggtgcca tggagactgg cacactctat ctcgctgagg aggaccccaa ggagcaggtc
421 aaacgctatg ggggcttttt gcgcaaatac cccaagagga gctcagaggt ggctggggag
481 ggggacgggg atagcatggg ccatgaggac ctgtacaaac gctatggggg cttcttgcgg
541 cgcattcgtc ccaagctcaa gtgggacaac cagaagcgct atggcggttt tctccggcgc
601 cagttcaagg tggtgactcg gtctcaggaa gatccgaatg cttactctgg agagcttttt
661 gatgcataag cacctctttt catggagtag agtcaggaga aacccctgac accttttcag
721 gttggagtgc attcattcat cctcttatat gtgccccttc cccatgctca gctcagcatt
781 gtgtacaaaa tatccaagcc cagcctatct ctcttctgcg tgggagtatg ttatttctct
841 ggggtctgtg atggggaagg gtggatgtcc cttccccaca ataggcttag tgcttggctc
901 agacacctag actctaaaac tatcagcagc ggcagcagca gcagcagcag cagtttgtga
961 tctgtccttc caacctgttc acgtgactcc tcaattccag ggaaccagag cgatgtgttc
1021 tttgtacctg taggtctatg atgtccaaac ttaacagatc acatgcccct cttagaagaa
1081 atatgagcat gctccctcat gcagatagta tacacatcat aaacaaagag tagaacttta
1141 aaagaaggta aataatcata cacagaaatc ctaacattat attcccaaat ctcaaaagat
1201 ctcctgtgca cctgactttg gagacgatgc tttaggtaaa aagcttaaac attgccttat
1261 attggatcag gaacccttac agtagagggt ccagtcttct agtgggttta atgtttagtc
1321 agtgtactct gagtcctcat tgttcagaaa agcacctctt gaagaactga cttcctgaac
1381 tcccagtcat gttggtaccc tggacagtgc ctaactcctt acagaaggga gtgaaaacct
1441 ctttcggaaa tgattgagag cagcctcttg aatgcttaaa tgatcaagga gggagaaagg
1501 caaaccaatt tgttctgtgc aacaaactca aaatgtggac cagttccctc agccctcatt
1561 aaactaatta aactgatggg tatcatgctt ctactccatg gtgaactgaa gcagagtcaa
1621 gctgatgaag ttaagcacaa ccatgttctt gagcagctga attggctgcc aagagtccaa
1681 gccatctggc ccaacatacg cactgggcat tgggtaaggg actccagaag cagcagctag
1741 aaagagaaaa agccctcttc aatccccata atgcttcttt cctcttaatg tctcaaaata
1801 aaaccagaaa gaggaataaa atgattaagt gcttgaggcc aaatgagttc ccttgattca
1861 aataaccctg aatcagaggc agagacctcc tgatgtcttg gtttccatca aagccctccc
1921 tgtctgtctg tctctctttt gctctctcat tcccaggcac tctcttttgg tttgtgggtc
1981 caggagatga ggctggatag gagaggaaaa ggcttgagtc tggataattt gtataagatg
2041 ctgctgagca catctcttca tgcgcagtcc ccaggtatct gatgatgttc tgaaatggat
2101 agattgtttt agagttattt tgtgtccttt aaaaaaatcc catttatgca atttacttgg
2161 aatttgctta gcctttaata ggcttgtgta atttcctgct cctccagtac aataaataaa
2221 agaaagatgc tgatgacttg gtgggtgtgt gtgtacgtgc acgtgcacat gtgtg
//