GenBank-Updates@genbank.bio.net (05/22/91)
LOCUS HUMERS 6450 bp ss-mRNA PRI 22-MAY-1991
DEFINITION Human mRNA for oestrogen receptor
ACCESSION X03635 M11457
KEYWORDS dna binding protein; estrogen receptor; receptor;
steroid hormone receptor.
SOURCE Homo sapiens RNA.
ORGANISM Homo sapiens
Eukaryota; Animalia; Metazoa; Chordata; Vertebrata; Mammalia;
Theria; Eutheria; Primates; Haplorhini; Catarrhini; Hominidae.
REFERENCE 1 (bases 1 to 6450)
AUTHORS Green,S., Walter,P., Kumar,V., Krust,A., Bornert,J.M., Argos,P. and
Chambon,P.
TITLE Human oestrogen receptor cDNA: sequence, expression and homology to
v-erb-A
JOURNAL Nature 320, 134-139 (1986)
STANDARD full automatic
COMMENT EPD; 11141; Hs estrogen receptor. SWISS-PROT; P03372; ESTR$HUMAN.
Data kindly reviewed (28-OCT-1986) by P. Chambon
From EMBL 26 entry HSERR; dated 28-MAR-1991.
FEATURES Location/Qualifiers
promoter 26..32
/note="CAAT-box"
promoter 102..109
/note="TATA-box"
misc_RNA 129..129
/note="cap site"
misc_feature 247..306
/note="pot. ORF"
CDS 361..2145
/product="oestrogen receptor"
/codon_start=361
misc_feature 442..456
/note="pot. nuclear transfer signal"
misc_feature 1057..1068
/note="pot. cAMP-dependent kinase phosphorylation site"
misc_feature 1264..1275
/note="pot. cAMP-dependent kinase phosphorylation site"
misc_feature 4550..4555
/note="pot. alternate polyA signal"
misc_feature 5625..5630
/note="pot. alternate polyA signal"
polyA_signal 6435..6440
polyA_site 6450..6450
BASE COUNT 1642 a 1496 c 1534 g 1778 t
ORIGIN
1 gagttgtgcc tggagtgatg tttaagccaa tgtcagggca aggcaacagt ccctggccgt
61 cctccagcac ctttgtaatg catatgagct cgggagacca gtacttaaag ttggaggccc
121 gggagcccag gagctggcgg agggcgttcg tcctgggagc tgcacttgct ccgtcgggtc
181 gccggcttca ccggaccgca ggctcccggg gcagggccgg ggccagagct cgcgtgtcgg
241 cgggacatgc gctgcgtcgc ctctaacctc gggctgtgct ctttttccag gtggcccgcc
301 ggtttctgag ccttctgccc tgcggggaca cggtctgcac cctgcccgcg gccacggacc
361 atgaccatga ccctccacac caaagcatct gggatggccc tactgcatca gatccaaggg
421 aacgagctgg agcccctgaa ccgtccgcag ctcaagatcc ccctggagcg gcccctgggc
481 gaggtgtacc tggacagcag caagcccgcc gtgtacaact accccgaggg cgccgcctac
541 gagttcaacg ccgcggccgc cgccaacgcg caggtctacg gtcagaccgg cctcccctac
601 ggccccgggt ctgaggctgc ggcgttcggc tccaacggcc tggggggttt ccccccactc
661 aacagcgtgt ctccgagccc gctgatgcta ctgcacccgc cgccgcagct gtcgcctttc
721 ctgcagcccc acggccagca ggtgccctac tacctggaga acgagcccag cggctacacg
781 gtgcgcgagg ccggcccgcc ggcattctac aggccaaatt cagataatcg acgccagggt
841 ggcagagaaa gattggccag taccaatgac aagggaagta tggctatgga atctgccaag
901 gagactcgct actgtgcagt gtgcaatgac tatgcttcag gctaccatta tggagtctgg
961 tcctgtgagg gctgcaaggc cttcttcaag agaagtattc aaggacataa cgactatatg
1021 tgtccagcca ccaaccagtg caccattgat aaaaacagga ggaagagctg ccaggcctgc
1081 cggctccgca aatgctacga agtgggaatg atgaaaggtg ggatacgaaa agaccgaaga
1141 ggagggagaa tgttgaaaca caagcgccag agagatgatg gggagggcag gggtgaagtg
1201 gggtctgctg gagacatgag agctgccaac ctttggccaa gcccgctcat gatcaaacgc
1261 tctaagaaga acagcctggc cttgtccctg acggccgacc agatggtcag tgccttgttg
1321 gatgctgagc cccccatact ctattccgag tatgatccta ccagaccctt cagtgaagct
1381 tcgatgatgg gcttactgac caacctggca gacagggagc tggttcacat gatcaactgg
1441 gcgaagaggg tgccaggctt tgtggatttg accctccatg atcaggtcca ccttctagaa
1501 tgtgcctggc tagagatcct gatgattggt ctcgtctggc gctccatgga gcacccagtg
1561 aagctactgt ttgctcctaa cttgctcttg gacaggaacc agggaaaatg tgtagagggc
1621 atggtggaga tcttcgacat gctgctggct acatcatctc ggttccgcat gatgaatctg
1681 cagggagagg agtttgtgtg cctcaaatct attattttgc ttaattctgg agtgtacaca
1741 tttctgtcca gcaccctgaa gtctctggaa gagaaggacc atatccaccg agtcctggac
1801 aagatcacag acactttgat ccacctgatg gccaaggcag gcctgaccct gcagcagcag
1861 caccagcggc tggcccagct cctcctcatc ctctcccaca tcaggcacat gagtaacaaa
1921 ggcatggagc atctgtacag catgaagtgc aagaacgtgg tgcccctcta tgacctgctg
1981 ctggagatgc tggacgccca ccgcctacat gcgcccacta gccgtggagg ggcatccgtg
2041 gaggagacgg accaaagcca cttggccact gcgggctcta cttcatcgca ttccttgcaa
2101 aagtattaca tcacggggga ggcagagggt ttccctgcca cagtctgaga gctccctggc
2161 tcccacacgg ttcagataat ccctgctgca ttttaccctc atcatgcacc actttagcca
2221 aattctgtct cctgcataca ctccggcatg catccaacac caatggcttt ctagatgagt
2281 ggccattcat ttgcttgctc agttcttagt ggcacatctt ctgtcttctg ttgggaacag
2341 ccaaagggat tccaaggcta aatctttgta acagctctct ttcccccttg ctatgttact
2401 aagcgtgagg attcccgtag ctcttcacag ctgaactcag tctatgggtt ggggctcaga
2461 taactctgtg catttaagct acttgtagag acccaggcct ggagagtaga cattttgcct
2521 ctgataagca ctttttaaat ggctctaaga ataagccaca gcaaagaatt taaagtggct
2581 cctttaattg gtgacttgga gaaagctagg tcaagggttt attatagcac cctcttgtat
2641 tcctatggca atgcatcctt ttatgaaagt ggtacacctt aaagctttta tatgactgta
2701 gcagagtatc tggtgattgt caattcactt ccccctatag gaatacaagg ggccacacag
2761 ggaaggcaga tcccctagtt ggccaagact tattttaact tgatacactg cagattcaga
2821 gtgtcctgaa gctctgcctc tggctttccg gtcatgggtt ccagttaatt catgcctccc
2881 atggacctat ggagagcaac aagttgatct tagttaagtc tccctatatg agggataagt
2941 tcctgatttt tgtttttatt tttgtgttac aaaagaaagc cctccctccc tgaacttgca
3001 gtaaggtcag cttcaggacc tgttccagtg ggcactgtac ttggatcttc ccggcgtgtg
3061 tgtgccttac acaggggtga actgttcact gtggtgatgc atgatgaggg taaatggtag
3121 ttgaaaggag caggggccct ggtgttgcat ttagccctgg ggcatggagc tgaacagtac
3181 ttgtgcagga ttgttgtggc tactagagaa caagagggaa agtagggcag aaactggata
3241 cagttctgag cacagccaga cttgctcagg tggccctgca caggctgcag ctacctagga
3301 acattccttg cagaccccgc attgcctttg ggggtgccct gggatccctg gggtagtcca
3361 gctcttattc atttcccagc gtggccctgg ttggaagaag cagctgtcaa gttgtagaca
3421 gctgtgttcc tacaattggc ccagcaccct ggggcacggg agaagggtgg ggaccgttgc
3481 tgtcactact caggctgact ggggcctggt cagattacgt atgcccttgg tggtttagag
3541 ataatccaaa atcagggttt ggtttgggga agaaaatcct cccccttcct cccccgcccc
3601 gttccctacc gcctccactc ctgccagctc atttccttca atttcctttg acctataggc
3661 taaaaaagaa aggctcattc cagccacagg gcagccttcc ctgggccttt gcttctctag
3721 cacaattatg ggttacttcc tttttcttaa caaaaaagaa tgtttgattt cctctgggtg
3781 accttattgt ctgtaattga aaccctattg agaggtgatg tctgtgttag ccaatgaccc
3841 aggtagctgc tcgggcttct cttggtatgt cttgtttgga aaagtggatt tcattcattt
3901 ctgattgtcc agttaagtga tcaccaaagg actgagaatc tgggagggca aaaaaaaaaa
3961 aaaaagtttt tatgtgcact taaatttggg gacaatttta tgtatctgtg ttaaggatat
4021 gcttaagaac ataattcttt tgttgctgtt tgtttaagaa gcaccttagt ttgtttaaga
4081 agcaccttat atagtataat atatattttt ttgaaattac attgcttgtt tatcagacaa
4141 ttgaatgtag taattctgtt ctggatttaa tttgactggg ttaacatgca aaaaccaagg
4201 aaaaatattt agtttttttt tttttttttg tatacttttc aagctacctt gtcatgtata
4261 cagtcattta tgcctaaagc ctggtgatta ttcatttaaa tgaagatcac atttcatatc
4321 aacttttgta tccacagtag acaaaatagc actaatccag atgcctattg ttggatattg
4381 aatgacagac aatcttatgt agcaaagatt atgcctgaaa aggaaaatta ttcagggcag
4441 ctaattttgc ttttaccaaa atatcagtag taatattttt ggacagtagc taatgggtca
4501 gtgggttctt tttaatgttt atacttagat tttcttttaa aaaaattaaa ataaaacaaa
4561 aaaaatttct aggactagac gatgtaatac cagctaaagc caaacaatta tacagtggaa
4621 ggttttacat tattcatcca atgtgtttct attcatgtta agatactact acatttgaag
4681 tgggcagaga acatcagatg attgaaatgt tcgcccaggg gtctccagca actttggaaa
4741 tctctttgta tttttacttg aagtgccact aatggacagc agatattttc tggctgatgt
4801 tggtattggg tgtaggaaca tgatttaaaa aaaaaactct tgcctctgct ttcccccact
4861 ctgaggcaag ttaaaatgta aaagatgtga tttatctggg gggctcaggt atggtgggga
4921 agtggattca ggaatctggg gaatggcaaa tatattaaga agagtattga aagtatttgg
4981 aggaaaatgg ttaattctgg gtgtgcacca aggttcagta gagtccactt ctgccctgga
5041 gaccacaaat caactagctc catttacagc catttctaaa atggcagctt cagttctaga
5101 gaagaaagaa caacatcagc agtaaagtcc atggaatagc tagtggtctg tgtttctttt
5161 cgccattgcc tagcttgccg taatgattct ataatgccat catgcagcaa ttatgagagg
5221 ctaggtcatc caaagagaag accctatcaa tgtaggttgc aaaatctaac ccctaaggaa
5281 gtgcagtctt tgatttgatt tccctagtaa ccttgcagat atgtttaacc aagccatagc
5341 ccatgccttt tgagggctga acaaataagg gacttactga taatttactt ttgatcacat
5401 taaggtgttc tcaccttgaa atcttataca ctgaaatggc cattgattta ggccactggc
5461 ttagagtact ccttcccctg catgacactg attacaaata ctttcctatt catactttcc
5521 aattatgaga tggactgtgg gtactgggag tgatcactaa caccatagta atgtctaata
5581 ttcacaggca gatctgcttg gggaagctag ttatgtgaaa ggcaaataaa gtcatacagt
5641 agctcaaaag gcaaccataa ttctctttgg tgcaagtctt gggagcgtga tctagattac
5701 actgcaccat tcccaagtta atcccctgaa aacttactct caactggagc aaatgaactt
5761 tggtcccaaa tatccatctt ttcagtagcg ttaattatgc tctgtttcca actgcatttc
5821 ctttccaatt gaattaaagt gtggcctcgt ttttagtcat ttaaaattgt tttctaagta
5881 attgctgcct ctattatggc acttcaattt tgcactgtct tttgagattc aagaaaaatt
5941 tctattcatt tttttgcatc caattgtgcc tgaactttta aaatatgtaa atgctgccat
6001 gttccaaacc catcgtcagt gtgtgtgttt agagctgtgc accctagaaa caacatactt
6061 gtcccatgag caggtgcctg agacacagac ccctttgcat tcacagagag gtcattggtt
6121 atagagactt gaattaataa gtgacattat gccagtttct gttctctcac aggtgataaa
6181 caatgctttt tgtgcactac atactcttca gtgtagagct cttgttttat gggaaaaggc
6241 tcaaatgcca aattgtgttt gatggattaa tatgcccttt tgccgatgca tactattact
6301 gatgtgactc ggttttgtcg cagctttgct ttgtttaatg aaacacactt gtaaacctct
6361 tttgcacttt gaaaaagaat ccagcgggat gctcgagcac ctgtaaacaa ttttctcaac
6421 ctatttgatg ttcaaataaa gaattaaact
//